| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
background disc degeneration is characterized partly by the degradation in the extracellular matrix (ecm) and excess apoptosis of nucleus pulposus (np) cells. |
2021-02-16 |
2023-08-13 |
human |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
then, nlrx1 was overexpressed in il-1β-induced np cells to detect apoptosis-related proteins and the extracellular matrix (ecm) by western blot, along with the detection of apoptosis levels using flow cytometry. |
2021-02-16 |
2023-08-13 |
human |
| Weikun Xiao, Shanshan Wang, Rongyu Zhang, Alireza Sohrabi, Qi Yu, Sihan Liu, Arshia Ehsanipour, Jesse Liang, Rebecca D Bierman, David A Nathanson, Stephanie K Seidlit. Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma. Matrix biology : journal of the International Society for Matrix Biology. vol 85-86. 2021-02-12. PMID:31028838. |
while numerous studies have investigated mechanisms enabling gbm cells to evade chemotherapy-induced apoptosis, few have addressed how their surrounding extracellular matrix (ecm) acts to promote their survival. |
2021-02-12 |
2023-08-13 |
Not clear |
| Ling-Ling Guo, Meng-Tao Wu, Li-Wei Zhang, Yong-Xin Chu, Peng Tian, Zai-Ping Jing, Jia-Si Li, Yu-Dong Sun, Kak K Yeung, Lei Zhan. Blocking Interleukin-1 Beta Reduces the Evolution of Thoracic Aortic Dissection in a Rodent Model. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. vol 60. issue 6. 2021-02-09. PMID:33004280. |
this study aimed to investigate the role of il-1β, matrix metalloproteinase (mmp)-2, mmp-9, smooth muscle cell apoptosis, and elastic fibre fracture in the development of tad in a rat model. |
2021-02-09 |
2023-08-13 |
rat |
| Yue Teng, Gang Ni, Wen Zhang, Jiong Hua, Lin Sun, Min Zheng, Qirong Dong, Weijie Huan. TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway. Biochemical and biophysical research communications. vol 529. issue 1. 2021-02-08. PMID:32560815. |
overexpression of trim59 suppressed interleukin 1 beta (il-1β)-induced extracellular matrix (ecm) metabolic imbalance, proinflammatory cytokine production, apoptosis and decrease in cell viability. |
2021-02-08 |
2023-08-13 |
rat |
| Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo, Zhongxu Ca. Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress. Journal of inflammation (London, England). vol 18. issue 1. 2021-02-06. PMID:33531032. |
increased cell apoptosis and inflammation, decreased extracellular matrix are associated with ivdd. |
2021-02-06 |
2023-08-13 |
Not clear |
| Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wan. Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-02-06. PMID:33542744. |
prostaglandin g/h synthase 2 (ptgs2), heat shock protein 90 (hsp90), cell division protein kinase 6 (cdk6), caspase 3 (casp3), apoptosis regulator bcl-2 (bcl-2), and matrix metalloproteinase-9 (mmp9) were identified as key targets of fa in the treatment of multiple diseases. |
2021-02-06 |
2023-08-13 |
Not clear |
| Yinhe Tang, Naijing Ma, Hao Luo, Shizuan Chen, Fuxiang Y. Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. Journal of biochemistry. vol 167. issue 5. 2021-02-05. PMID:32044992. |
the apoptosis of hepatocytes contributes to the activation of hepatic stellate cells (hscs), thus promoting the accumulation of extracellular matrix proteins and aggravating liver fibrosis. |
2021-02-05 |
2023-08-13 |
mouse |
| Hai-Rong Ma, Li Cao, Fei Wang, Chao Cheng, Rendong Jiang, Haikang Zhou, Zhenzi Xie, Shalitanati Wuermanbieke, Zhenghao Qia. Filamin B extensively regulates transcription and alternative splicing, and is associated with apoptosis in HeLa cells. Oncology reports. vol 43. issue 5. 2021-02-05. PMID:32323860. |
reverse transcription‑quantitative‑pcr identified flnb‑regulated transcription and alternative splicing of genes, such as nlr family apoptosis inhibitory protein, interleukin 23 subunit α, metastasis associated lung adenocarcinoma transcript 1, phosphofurin acidic cluster sorting protein 2, bone morphogenetic protein 7, matrix metallopeptidase 13, collagen type ii α 1 chain, fibroblast growth factor receptor 2 and vitamin d receptor. |
2021-02-05 |
2023-08-13 |
Not clear |
| Buhrmann Constanze, Bastian Popper, Bharat B Aggarwal, Mehdi Shakibae. Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2. Cell and tissue research. vol 381. issue 1. 2021-02-03. PMID:32140928. |
we found that tnf-β inhibits, in a similar way to nam or sirt1-aso, the early stage of osteogenic differentiation of mscs and this was accompanied with downregulation of bone-specific matrix, β1-integrin, runx2 and with upregulation of nf-κb phosphorylation and nf-κb-regulated gene products involved in the inflammatory, degradative processes and apoptosis. |
2021-02-03 |
2023-08-13 |
Not clear |
| Ashay D Bhatwadekar, Viral Kansara, Qianyi Luo, Thomas Ciull. Anti-integrin therapy for retinovascular diseases. Expert opinion on investigational drugs. vol 29. issue 9. 2021-02-02. PMID:32657172. |
integrins are a family of multi-functional cell-adhesion molecules, heterodimeric receptors that connect extracellular matrix (ecm) to actin cytoskeleton in the cell cortex, thus regulating cellular adhesion, migration, proliferation, invasion, survival, and apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Yuan Tan, Yuejin Li, Faqing Tan. Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis. Molecular cancer. vol 19. issue 1. 2021-02-02. PMID:32278350. |
the recent reports showed that oncogenic serna implicates in a widespread range of cytopathological processes in cancer progression including cell proliferation, apoptosis, autophagy, epithelial-mesenchymal transition, extracellular matrix stiffness and angiogenesis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K Mainig. How transforming growth factor contributes to atrial fibrillation? Life sciences. vol 266. 2021-02-01. PMID:33309721. |
the transforming growth factor-β (tgf-β) superfamily are cytokines that have the ability to regulate numerous cell functions including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix. |
2021-02-01 |
2023-08-13 |
Not clear |
| Hussam Alkaissi, Srinivas Kolla, Cameron Page, Latif Salam, Moro O Salifu, Isabel M McFarlan. Fluoroquinolone-Induced Rotator Cuff Tendinopathy: A Case Report. American journal of medical case reports. vol 9. issue 2. 2021-01-31. PMID:33511269. |
the postulated mechanisms for quinolone-associated tendinopathy are alteration of the tendon extracellular matrix, impairment of tenocyte proliferation, and enhanced apoptosis due to the quinolone cation chelation properties. |
2021-01-31 |
2023-08-13 |
Not clear |
| Steven E Wilso. Biology of keratorefractive surgery- PRK, PTK, LASIK, SMILE, inlays and other refractive procedures. Experimental eye research. vol 198. 2021-01-28. PMID:32653492. |
this article details what is known about these specific wound healing responses that include apoptosis of keratocytes and myofibroblasts, mitosis of corneal fibroblasts and myofibroblast precursors, the development of myofibroblasts from keratocyte-derived corneal fibroblasts and bone marrow-derived fibrocytes, deposition of disordered extracellular matrix by corneal fibroblasts and myofibroblasts, healing of the epithelial injury, and regeneration of the epithelial basement membrane. |
2021-01-28 |
2023-08-13 |
Not clear |
| Kalpana K Bhanumathy, Amrutha Balagopal, Frederick S Vizeacoumar, Franco J Vizeacoumar, Andrew Freywald, Vincenzo Giambr. Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. Cancers. vol 13. issue 2. 2021-01-26. PMID:33430292. |
tyrosine kinases execute their biological functions by controlling a variety of cellular responses, such as cell division, metabolism, migration, cell-cell and cell matrix adhesion, cell survival and apoptosis. |
2021-01-26 |
2023-08-13 |
human |
| Eun-Ju Jang, Jee Young Sung, Ha-Eun Yoo, Hyonchol Jang, Jaegal Shim, Eok-Soo Oh, Sung-Ho Goh, Yong-Nyun Ki. FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo. Cancers. vol 13. issue 2. 2021-01-26. PMID:33440835. |
anoikis is a type of apoptosis induced by cell detachment from the extracellular matrix (ecm), which removes mislocalized cells. |
2021-01-26 |
2023-08-13 |
mouse |
| Tian Tian, Rujia Xie, Kaize Ding, Bing Han, Qin Yang, Xue Yan. IOX1 protects from TGF-β induced fibrosis in LX-2 cells via the regulation of extracellular matrix protein expression. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-26. PMID:33488789. |
cellular proliferation, apoptosis, histone h3k9 dimethylation (h3k9me2), protein expression of extracellular matrix (ecm)-related proteins α-smooth muscle actin (sma), type i collagen (col i), mmp-1 and timp-1 were measured. |
2021-01-26 |
2023-08-13 |
human |
| Ying Liu, Jia-Wei Song, Jian-Yu Lin, Ran Miao, Jiu-Chang Zhon. Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32856216. |
mir-122 overexpression appears to exacerbate the angiotensin ii-mediated loss of autophagy and increased inflammation, apoptosis, extracellular matrix deposition, cardiovascular fibrosis and dysfunction by modulating the sirt6-elabela-ace2, lgr4-β-catenin, tgfβ-ctgf and pten-pi3k-akt signaling pathways. |
2021-01-25 |
2023-08-13 |
Not clear |
| Jun He, Xiaotao Su, Wenwei Xi. MiR-582-3p alleviates osteoarthritis progression by targeting YAP1. Molecular immunology. vol 128. 2021-01-25. PMID:33190006. |
functional investigations indicated that mir-582-3p inhibited chondrocyte apoptosis, reduced the proinflammatory cytokine production and suppressed extracellular matrix (ecm) degradation. |
2021-01-25 |
2023-08-13 |
rat |