| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anthony Matta, Vanessa Nader, Michel Galinier, Jerome Roncall. Transplantation of CD34+ cells for myocardial ischemia. World journal of transplantation. vol 11. issue 5. 2021-05-30. PMID:34046316. |
they have an important paracrine activity in secreting factors to stimulate vasculogenesis, reduce endothelial cells and cardiomyocytes apoptosis, remodel extracellular matrix and activate additional progenitor cells. |
2021-05-30 |
2023-08-13 |
Not clear |
| Hao-Yu Guo, Ming-Ke Guo, Zhong-Yuan Wan, Fang Song, Hai-Qiang Wan. Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review. Arthritis research & therapy. vol 22. issue 1. 2021-05-28. PMID:33198793. |
apoptosis, aberrant proliferation, extracellular matrix degradation, and inflammatory abnormality are tetrad fundamental pathologic phenotypes in idd. |
2021-05-28 |
2023-08-13 |
Not clear |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
comparison of npc to control samples revealed upregulation of genes involved in inflammation (mmp3, thbs4), cytokine signalling (mmp3), extracellular matrix degradation (mmp3, ctsk), autophagy and apoptosis (ctsk, gpnmb, ptgis), immune response (akr1c3, rcan2, ptgis) and processes of neuronal development (rcan2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
downregulated genes were associated with cytoskeletal signalling (actg2, cnn1); inflammation and oxidative stress (cnn1); inhibition of cell proliferation, migration and differentiation; erk-mapk pathway (col4a1, col4a2, cpa4); cell adhesion (igfbp7); autophagy and apoptosis (cdh2, igfbp7, col4a2); neuronal function and development (csrp1); and extracellular matrix stability (plod2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Longhui Wang, Yuntao Gu, Hai Zhao, Rong Chen, Wensheng Chen, Hao Qi, Weisong Ga. Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-27. PMID:32841225. |
cell viability, extracellular matrix protein expression, catabolic factors, degree of apoptosis, inflammatory factors, and related signaling pathways were evaluated by western blotting, fluorescence immunostaining, tunel staining, and reverse transcription pcr. |
2021-05-27 |
2023-08-13 |
human |
| Wei Qi, Dong Ren, Pengcheng Wang, Zhaohui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Ba. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32866785. |
upregulation of sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of pi3k/akt pathway. |
2021-05-27 |
2023-08-13 |
human |
| Chih-Hung Guo, Simon Hsia, Chieh-Han Chung, Yi-Chun Lin, Min-Yi Shih, Pei-Chung Chen, Guoo-Shyng W Hsu, Ciou-Ting Fan, Chia-Lin Pen. Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice. Marine drugs. vol 19. issue 4. 2021-05-26. PMID:33805447. |
dose-dependent inhibition of down-stream targets including epithelial-to-mesenchymal transition transcription factors, nuclear cyclin and cyclin-dependent kinases, cancer stem cell markers, heat shock protein (hsp-90), hypoxia-inducible factors (hif-1α/-2α), matrix metalloprotease (mmp-9), and increased apoptosis were observed. |
2021-05-26 |
2023-08-13 |
mouse |
| Xingjia Mao, Yanyan Cao, Zijian Guo, Linlin Wang, Chuan Xian. Biological roles and therapeutic potential of circular RNAs in osteoarthritis. Molecular therapy. Nucleic acids. vol 24. 2021-05-26. PMID:34026329. |
recent studies have reported that various circrnas can delay or aggravate diverse aspects of the oa process, including extracellular matrix formation, apoptosis, proliferation, inflammation, and autophagy, via circrna/mirna/mrna pathways. |
2021-05-26 |
2023-08-13 |
Not clear |
| Shi-Cong Tao, Ji-Yan Huang, Yuan Gao, Zi-Xiang Li, Zhan-Ying Wei, Helen Dawes, Shang-Chun Gu. Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioactive materials. vol 6. issue 12. 2021-05-26. PMID:34027234. |
osteoarthritis (oa), characterized by chondrocyte apoptosis and disturbance of the balance between catabolism and anabolism of the extracellular matrix (ecm), is the most common age-related degenerative joint disease worldwide. |
2021-05-26 |
2023-08-13 |
Not clear |
| Abeer M Hegazy, Nan Chen, Hanzuo Lin, Sarath Babu V, Feng Li, Youcheng Yang, Zhendong Qin, Fei Shi, Jun Li, Li Li. Induction of apoptosis in SSN-1cells by Snakehead Fish Vesiculovirus (SHVV) via Matrix protein dependent intrinsic pathway. Fish & shellfish immunology. vol 113. 2021-05-25. PMID:33757800. |
induction of apoptosis in ssn-1cells by snakehead fish vesiculovirus (shvv) via matrix protein dependent intrinsic pathway. |
2021-05-25 |
2023-08-13 |
Not clear |
| Ali Raza Jahejo, Wen Xia Tia. Cellular, molecular and genetical overview of avian tibial dyschondroplasia. Research in veterinary science. vol 135. 2021-05-24. PMID:33066991. |
the failure of angiogenesis attributed improper nutrients supply to the chondrocytes; ultimately, bone development stopped, poor calcification of cartilage matrix, and apoptosis of chondrocytes occurred. |
2021-05-24 |
2023-08-13 |
chicken |
| Júlia Chaumel, Merlind Schotte, Joseph J Bizzarro, Paul Zaslansky, Peter Fratzl, Daniel Baum, Mason N Dea. Co-aligned chondrocytes: Zonal morphological variation and structured arrangement of cell lacunae in tessellated cartilage. Bone. vol 134. 2021-05-17. PMID:32058019. |
during this process, cartilage cells (chondrocytes) mineralize the extracellular matrix and undergo apoptosis, giving way to bone cells (osteocytes). |
2021-05-17 |
2023-08-13 |
Not clear |
| Talita Pizza Anunciato Casarini, Luiza Abrahão Frank, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterre. Dermatological applications of the flavonoid phloretin. European journal of pharmacology. vol 889. 2021-05-14. PMID:32971088. |
phloretin has been shown to inhibit elastase and matrix metalloproteinase-1 activity, to reduce cellular tyrosinase activity and melanin content, and induce apoptosis in b16 mouse melanoma 4a5 cells. |
2021-05-14 |
2023-08-13 |
mouse |
| Shan-Shan Wang, Chen Wang, Han Che. MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33089928. |
in the last decade, a variety of micrornas have been identified as key regulators for the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition in vascular smooth muscle cells during vascular calcification. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chuchu Lin, Xuan Yang, Huatian Li, Yiqing Zou, Imran Shair Mohammad, Hehui Rong, Yiqin Rao, Jia Song, Sharon S Y Leung, Haiyan H. Self-assembled nanomedicine combining a berberine derivative and doxorubicin for enhanced antitumor and antimetastatic efficacy via mitochondrial pathways. Nanoscale. vol 13. issue 13. 2021-05-14. PMID:33885540. |
driven by delocalized lipophilic cations, nanodrugs could escape from lysosomes and reach mitochondria to induce a cascade reaction and finally cell apoptosis, as well as suppressing matrix metalloprotease (mmp)-2 and -9 activities and finally cell migration and invasion. |
2021-05-14 |
2023-08-13 |
mouse |
| Masaaki Ito, Takashi Yurube, Yutaro Kanda, Yuji Kakiuchi, Yoshiki Takeoka, Toru Takada, Ryosuke Kuroda, Kenichiro Kakutan. Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism. International journal of molecular sciences. vol 22. issue 8. 2021-05-12. PMID:33921398. |
inhibition of autophagy at different stages by atg5 knockdown and chloroquine supplementation enhances consistent human disc cellular apoptosis and senescence induction rather than extracellular matrix catabolism. |
2021-05-12 |
2023-08-13 |
human |
| Junwei Yan, Xuejiao Yang, Xuefei Jiao, Xian Yang, Mingjin Guo, Yunqing Chen, Lu Zhan, Wenshi Che. Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K-Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31680442. |
previous studies found that some pathways were related to glaucoma, such as extracellular matrix (ecm)-receptor interaction, phosphatidylinositol 3-kinase (pi3k)-protein kinase b (akt) and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Regan J Hayward, James W Marsh, Michael S Humphrys, Wilhelmina M Huston, Garry S A Myer. Chromatin accessibility dynamics of Chlamydia-infected epithelial cells. Epigenetics & chromatin. vol 13. issue 1. 2021-05-10. PMID:33109274. |
these regions and motifs were linked to genomic features and genes associated with immune responses, re-direction of host cell nutrients, intracellular signalling, cell-cell adhesion, extracellular matrix, metabolism and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Masanari Umemura, Masatoshi Narikawa, Ryo Tanaka, Hiroko Nemoto, Rina Nakakaji, Akane Nagasako, Yoshihiro Ishikaw. [Doxorubicin directly induced fibrotic change of cardiac fibroblasts]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 156. issue 3. 2021-05-10. PMID:33952842. |
dox also increased the mrna and protein expression of matrix metalloproteinase (mmp)-1 in less than 0.1 μm which did not induce cell apoptosis of hcfs cells via pi3k/akt pathway in hcfs. |
2021-05-10 |
2023-08-13 |
mouse |
| Vadivel Dinesh Babu, Anandasadagopan Suresh Kumar, Ganapasam Sudhandira. Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis. Drug and chemical toxicology. 2021-05-07. PMID:32924642. |
a consequent disturbance of fibroblast proliferation and apoptosis results in subsequent release of pro-inflammatory and pro-fibrotic mediators coupled with accumulation of extracellular matrix within the interstitium. |
2021-05-07 |
2023-08-13 |
rat |