| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiufang Dong, Baoyu He, Di Jiang, Chenxu Yu, Beiwei Zhu, Hang Q. Proteome analysis reveals the important roles of protease during tenderization of sea cucumber Apostichopus japonicus using iTRAQ. Food research international (Ottawa, Ont.). vol 131. 2021-03-12. PMID:32247476. |
furthermore, proteins involved in oxidative stress response, innate immune response, apoptosis and reorganization of cytoskeleton and extracellular matrix were upregulated, which could be the potential biomarkers. |
2021-03-12 |
2023-08-13 |
Not clear |
| Jing Li, Sufang Wang, Yuhui Li, Nu Zhang, Michael Gribskov, Xi Zhang, Min Lin, Dongyan Shao, Chen Zhang, Liangliang Dai, Chuanguang Qin, Xianglong Duan, Juntang Li, Feng Xu, Hui Yan. miRNA-mediated macrophage behaviors responding to matrix stiffness and ox-LDL. Journal of cellular physiology. vol 235. issue 9. 2021-03-11. PMID:32020590. |
in this study, we developed a model system to investigate the synergistic role of ox-ldl and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. |
2021-03-11 |
2023-08-13 |
Not clear |
| Chao Peng He, Xin Chen Jiang, Cheng Chen, Hai Bin Zhang, Wen Dong Cao, Qi Wu, Chi M. The function of lncRNAs in the pathogenesis of osteoarthritis. Bone & joint research. vol 10. issue 2. 2021-03-10. PMID:33560158. |
in recent years, a large number of lncrnas have been found to be differentially expressed in a variety of pathological processes of oa, including extracellular matrix (ecm) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. |
2021-03-10 |
2023-08-13 |
Not clear |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
microrna-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating smad7. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, smad7 upregulation significantly inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs compared with the control-plasmid group. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, the results indicated that, compared with the inhibitor control group, mir-497-5p inhibitor inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs, which were significantly reversed by smad7 knockdown. |
2021-03-10 |
2023-08-13 |
human |
| Amany Tawfik, Yara A Samra, Nehal M Elsherbiny, Mohamed Al-Shabrawe. Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. Biomolecules. vol 10. issue 8. 2021-03-09. PMID:32751132. |
different mechanisms have been proposed to explain hhcy-induced visual dysfunction, including oxidative stress, upregulation of inflammatory mediators, retinal ganglion cell apoptosis, and extracellular matrix remodeling. |
2021-03-09 |
2023-08-13 |
Not clear |
| Chenggang Zhao, Zhiyang Zhao, Zhen Wang, Lizhu Hu, Hongzhi Wang, Zhiyou Fan. Supervillin promotes tumor angiogenesis in liver cancer. Oncology reports. vol 44. issue 2. 2021-03-08. PMID:32468064. |
svil knockdown inhibited vm formation and induced tumor cell apoptosis via the vegf‑p38 signaling axis and through various vm‑associated transcriptional factors, including vascular endothelial‑cadherin, matrix metalloproteinase 9/12 and migration‑inducing protein 7. |
2021-03-08 |
2023-08-13 |
mouse |
| Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fa. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626948. |
further studies demonstrated that the plcsa‑bnps promoted the apoptosis of cancer cells more effectively and inhibited their proliferation, invasion and migration, accompanied by downregulation of matrix metalloproteinase (mmp)‑2, mmp‑9 and b‑cell cll/lymphoma 2 (bcl2) levels, but upregulation of bcl2‑associated x protein bax and cleaved caspase‑3 levels. |
2021-03-08 |
2023-08-13 |
Not clear |
| Frederic Shapiro, Kathleen Maguire, Srilatha Swami, Hui Zhu, Evelyn Flynn, Jamie Wang, Joy Y W. Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy. Bone reports. vol 14. 2021-03-06. PMID:33665234. |
at differing levels of microscopic resolution: lamellar bone is characterized by short, obliquely oriented lamellae with a mosaic appearance in progressively deforming forms; polarization defines tissue conformations and localizes initiation of lamellar formation; ultrastructure of bone forming cells shows markedly dilated rough endoplasmic reticulum (rer) and prominent golgi bodies with disorganized cisternae and swollen dispersed tubules and vesicles, structural indications of storage disorder/stress responses and mitochondrial swelling in cells with massively dilated rer indicating apoptosis; ultrastructural matrix assessments in woven bone show randomly oriented individual fibrils but also short pericellular bundles of parallel oriented fibrils positioned obliquely and oriented randomly to one another and in lamellar bone show unidirectional fibrils that deviate at slight angles to adjacent bundles and obliquely oriented fibril groups consistent with twisted plywood fibril organization. |
2021-03-06 |
2023-08-13 |
Not clear |
| Dongmei Gao, Long Hao, Zilong Zha. Long non-coding RNA PART1 promotes intervertebral disc degeneration through regulating the miR‑93/MMP2 pathway in nucleus pulposus cells. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319551. |
the levels of the cell proliferation marker ki‑67 and the apoptosis marker cleaved caspase‑3, and the levels of genes related to extracellular matrix (ecm) synthesis and degradation, were also evaluated by western blotting and rt‑qpcr, as appropriate. |
2021-03-05 |
2023-08-13 |
Not clear |
| Fu-Xing-Zi Li, Feng Xu, Xiao Lin, Feng Wu, Jia-Yu Zhong, Yi Wang, Bei Guo, Ming-Hui Zheng, Su-Kang Shan, Ling-Qing Yua. The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity. Frontiers in endocrinology. vol 11. 2021-03-02. PMID:32180759. |
previous studies have shown that bone and chondrocytes can synthesize and secrete sensory neuropeptides and express their receptors, and can promote proliferation, differentiation, apoptosis, matrix synthesis, and the degradation of target cells through autocrine/paracrine modes. |
2021-03-02 |
2023-08-13 |
Not clear |
| Nandini Nai. Epidemiology and pathogenesis of heart failure with preserved ejection fraction. Reviews in cardiovascular medicine. vol 21. issue 4. 2021-03-02. PMID:33387998. |
newer insights into myocardial remodeling have led to an interesting finding of abnormal fibroblasts in hfpef which are apoptosis resistant and initiate the development of an abnormal myocardial matrix resulting in initiation and progression of the disease. |
2021-03-02 |
2023-08-13 |
Not clear |
| Shih-Hung Tsai, Lung-An Hsu, Hsiao-Ya Tsai, Yung-Hsin Yeh, Cheng-Yo Lu, Po-Chuan Chen, Jen-Chun Wang, Yi-Lin Chiu, Chih-Yuan Lin, Yu-Juei Hs. Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32463165. |
reactive oxygen species (ros) promote degradation of the extracellular matrix (ecm) and vascular smooth muscle cell (vsmc) apoptosis. |
2021-03-01 |
2023-08-13 |
mouse |
| Hao Yang, Cheng Chen, Hao Chen, Xiaojun Duan, Juan Li, Yi Zhou, Weinan Zeng, Liu Yan. Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis. Aging. vol 12. issue 13. 2021-03-01. PMID:32611834. |
we found that abt263 reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in oa chondrocyte pellet culture by inducing snc apoptosis. |
2021-03-01 |
2023-08-13 |
rat |
| Xing Zhang, Chao-Ran Huang, Sheng Pan, Yong Pang, Ye-Shuai Chen, Guo-Chun Zha, Kai-Jin Guo, Xin Zhen. Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression. International immunopharmacology. vol 83. 2021-02-26. PMID:32247266. |
the lower expression of snhg15 was negatively associated with the observed modified mankin scale scores, extracellular matrix (ecm) degradation and chondrocyte apoptosis. |
2021-02-26 |
2023-08-13 |
Not clear |
| Yunke Liu, Ke Liu, Chao Tang, Zuxuan Shi, Kai Jing, Jia Zhen. Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-02-26. PMID:32521454. |
xist knockdown promoted cell viability but restrained cell apoptosis and extracellular matrix (ecm) protein degradation in il-1β-treated chondrocytes. |
2021-02-26 |
2023-08-13 |
rat |
| Nao Komatsu, Mikihito Kajiya, Shin Morimoto, Souta Motoike, Hiroki Yoshii, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihar. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Biochemical and biophysical research communications. vol 530. issue 2. 2021-02-25. PMID:32553627. |
cox2-mediated pge2 production via p38/jnk-c-fos signaling inhibits cell apoptosis in 3d floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. |
2021-02-25 |
2023-08-13 |
Not clear |
| Roos J Leguit, Reinier A P Raymakers, Konnie M Hebeda, Roel Goldschmedin. CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis. Journal of cell communication and signaling. vol 15. issue 1. 2021-02-25. PMID:33428075. |
furthermore, ccn2 and its fragments have been implicated in the regulation of a multitude of biological processes, including cell proliferation, differentiation, adhesion, migration, cell survival, apoptosis and the production of extracellular matrix products, as well as in more complex processes such as embryonic development, angiogenesis, chondrogenesis, osteogenesis, fibrosis, mechanotransduction and inflammation. |
2021-02-25 |
2023-08-13 |
Not clear |
| Penggui Zhang, Guangming Gao, Ziyu Zhou, Xuejun H. microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 4. 2021-02-25. PMID:33624729. |
the effect of mir-130b on the viability, inflammation, apoptosis, and extracellular matrix of oa chondrocytes was studied. |
2021-02-25 |
2023-08-13 |
Not clear |