| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhirong Wang, Genlin Wang, Xuesong Zhu, Dechun Geng, Huilin Yan. Interleukin-2 is upregulated in patients with a prolapsed lumbar intervertebral disc and modulates cell proliferation, apoptosis and extracellular matrix metabolism of human nucleus pulposus cells. Experimental and therapeutic medicine. vol 10. issue 6. 2020-10-01. PMID:26668654. |
the present study aimed to determine the expression levels of il-2 in the nucleus pulposus (np) tissues of patients with a prolapsed lumbar intervertebral disc; and to observe the changes in cell proliferation, apoptosis, extracellular matrix (ecm) metabolism and p38 mitogen-activated protein kinase (mapk) signaling in human np cells (hnpcs) following treatment with il-2. |
2020-10-01 |
2023-08-13 |
human |
| Tingting Ye, Jiadong Su, Chaohao Huang, Dinglai Yu, Shengjie Dai, Xince Huang, Bicheng Chen, Mengtao Zho. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. OncoTargets and therapy. vol 9. 2020-10-01. PMID:28003763. |
in pc, isoorientin strongly inhibited the survival of the cells, induced cell apoptosis, and decreased its malignancy by reversing the expression of epithelial-mesenchymal transition and matrix metalloproteinase and decreased vascular endothelial growth factor expression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xinghuo Wu, Yu Song, Wei Liu, Kun Wang, Yong Gao, Shuai Li, Zhenfeng Duan, Zengwu Shao, Shuhua Yang, Cao Yan. IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells. Cell death discovery. vol 3. 2020-10-01. PMID:28149534. |
iapp modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells. |
2020-10-01 |
2023-08-13 |
human |
| Jing Shi, Xu Zhang, Taoping Shi, Hongzhao L. Antitumor effects of curcumin in human bladder cancer Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693289. |
the present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways |
2020-10-01 |
2023-08-13 |
human |
| Qing-Yang Feng, Zi-Xuan Hu, Xi-Ling Song, Hong-Wei Pa. Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis. International journal of ophthalmology. vol 10. issue 6. 2020-10-01. PMID:28730091. |
in this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. |
2020-10-01 |
2023-08-13 |
human |
| Xinyu Yang, Yang Li, Yanda Li, Xiaomeng Ren, Xiaoyu Zhang, Dan Hu, Yonghong Gao, Yanwei Xing, Hongcai Shan. Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies. Frontiers in physiology. vol 8. 2020-10-01. PMID:28878685. |
atherogenesis, the formation of atherosclerotic plaques, is a complex process that involves several mechanisms, including endothelial dysfunction, neovascularization, vascular proliferation, apoptosis, matrix degradation, inflammation, and thrombosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| N Woolf, B E Pearson, P A Bondzie, R D Meyer, M Lavaei, A C Belkina, V Chitalia, N Rahim. Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy. Oncogenesis. vol 6. issue 9. 2020-10-01. PMID:28920928. |
adhesion to extracellular matrix (ecm) is crucially important for survival of normal epithelial cells as detachment from ecm triggers specific apoptosis known as anoikis. |
2020-10-01 |
2023-08-13 |
mouse |
| Qin Tian, Yifei Wang, Qiong Zhang, Jun Luo, He Jiang, Boyue Zhang, Mingzhu Mei, Fan Wu, Yuting Wu, Jiaojiao Peng, Teng Long, Yongwen Luo, Xiaofeng Gu. Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 Frontiers in microbiology. vol 8. 2020-10-01. PMID:28928726. |
phosphoprotein gene contributes to the enhanced apoptosis induced by wild-type rabies virus gd-sh-01 previous research demonstrated that the matrix protein (m) and glycoprotein (g) of attenuated rabies virus (rabv) strains are involved in the induction of host cell apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| A G D Vianna, C P Sanches, F C Barret. Review article: effects of type 2 diabetes therapies on bone metabolism. Diabetology & metabolic syndrome. vol 9. 2020-10-01. PMID:29021829. |
type 2 diabetes mellitus (t2dm) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shuan Liu, Hongping Yang, Bing Hu, Mingyong Zhan. Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways. Experimental and therapeutic medicine. vol 14. issue 5. 2020-10-01. PMID:29201214. |
sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the wnt/β-catenin signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shuan Liu, Hongping Yang, Bing Hu, Mingyong Zhan. Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways. Experimental and therapeutic medicine. vol 14. issue 5. 2020-10-01. PMID:29201214. |
therefore, the present study used 30 clinical oa chondrocyte to examine chondrocyte viability, apoptosis rate and the mrna and protein expression levels of sirt1 and relevant genes implicated in apoptosis, extracellular matrix (ecm) degradation and wnt/β-catenin signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata, Shuji Tera. Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases. Inflammation and regeneration. vol 37. 2020-10-01. PMID:29259715. |
mscs also produce a large amount of cytokines, chemokines, and growth factors, including exosomes that stimulate angiogenesis, prevent apoptosis, block oxidation reactions, promote remodeling of the extracellular matrix, and induce differentiation of tissue stem cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kun Lu, Gang Rui, Fan Liu, Ling Yang, Xiaoling Deng, Songlin Shi, Qifu L. 14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells. Oncology letters. vol 15. issue 1. 2020-10-01. PMID:29285195. |
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of mg-63 cells. |
2020-10-01 |
2023-08-13 |
human |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
furthermore, cell viability, cell apoptosis, cell autophagy and matrix synthesis, as well as the expressions of proteins associated with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway were detected. |
2020-10-01 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
in addition, the effects of mir-4262 on cell viability, cell apoptosis, cell autophagy and matrix synthesis were inhibited by sirt1 (p<0.05). |
2020-10-01 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
the present study revealed that the upregulation of mir-4262 may promote the occurrence and development of oa in rats by regulating cell viability, cell apoptosis, cell autophagy, and matrix synthesis. |
2020-10-01 |
2023-08-13 |
rat |
| Bo Diao, Ying Liu, Guo-Zheng Xu, Yi Zhang, Jun Xie, Jie Gon. The role of galectin-3 in the tumorigenesis and progression of pituitary tumors. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545898. |
meanwhile, bcl2 associated x, apoptosis regulator (bax), caspase-3 and matrix metalloproteinase 7 (mmp7) protein expression levels were analyzed by western blotting. |
2020-10-01 |
2023-08-13 |
rat |
| Yujie Ning, Xi Wang, Pan Zhang, Amin Liu, Xin Qi, Meidan Liu, Xiong Gu. Dietary exosome-miR-23b may be a novel therapeutic measure for preventing Kashin-Beck disease. Experimental and therapeutic medicine. vol 15. issue 4. 2020-10-01. PMID:29556257. |
recent international research studies have revealed a therapeutic role of dietary exosome micro (mi)rnas in repairing chondrocyte lesions by regulating genes and proteins associated with cellular apoptosis and extracellular matrix. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xin-Hui Xie, Xin-Luan Wang, Hui-Lin Yang, De-Wei Zhao, Ling Qi. Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview). Journal of orthopaedic translation. vol 3. issue 2. 2020-10-01. PMID:30035041. |
we summarised different pathophysiologies of saon which have adverse effects on multiple systems such as bone marrow stem cells (bmscs) pool, bone matrix, cell apoptosis, lipid metabolism, and angiogenesis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bin Yu, Anouar Hafiane, George Thanassoulis, Leah Ott, Nial Filwood, Marta Cerruti, Ophélie Gourgas, Dominique Shum-Tim, Hamood Al Kindi, Benoit de Varennes, Alawi Alsheikh-Ali, Jacques Genest, Adel Schwertan. Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification. JACC. Basic to translational science. vol 2. issue 4. 2020-10-01. PMID:30062157. |
lipoprotein(a), or lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased sox9 and matrix gla protein (p < 0.001). |
2020-10-01 |
2023-08-13 |
human |