| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Penggui Zhang, Guangming Gao, Ziyu Zhou, Xuejun H. microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 4. 2021-02-25. PMID:33624729. |
the effect of mir-130b on the viability, inflammation, apoptosis, and extracellular matrix of oa chondrocytes was studied. |
2021-02-25 |
2023-08-13 |
Not clear |
| Janet Palacios-Martinez, Juan Caballero-Perez, Annie Espinal-Centeno, Gilberto Marquez-Chavoya, Hilda Lomeli, Enrique Salas-Vidal, Denhi Schnabel, Jesus Chimal-Monroy, Alfredo Cruz-Ramire. Multi-organ transcriptomic landscape of Ambystoma velasci metamorphosis. Developmental biology. vol 466. issue 1-2. 2021-02-23. PMID:32828730. |
in the case of the gills, the most prominent biological processes identified are degradation of extracellular matrix, apoptosis and keratin production. |
2021-02-23 |
2023-08-13 |
Not clear |
| Sabine Schäfer-Somi, Cordula Gabriel, Selim Asla. Embryo-maternal communication in dogs: Immune system related factors. Theriogenology. vol 150. 2021-02-22. PMID:32061404. |
secretory products are transported to the embryo-maternal interface and contribute to extra-cellular matrix (ecm) degradation, a change in the intrauterine immune milieu towards a reduction of immune cells and a change in lymphocyte subsets, cell differentiation, angiogenesis, and the balance between proliferation and apoptosis. |
2021-02-22 |
2023-08-13 |
Not clear |
| Guohua Lü, Lei Li, Bing Wang, Lei Kuan. LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes. Aging. vol 12. issue 4. 2021-02-18. PMID:32062610. |
chondrocyte apoptosis and extracellular matrix (ecm) degeneration have been implicated in the pathogenesis of osteoarthritis (oa). |
2021-02-18 |
2023-08-13 |
rat |
| Ming Li, Ruoyu Li, Sidong Yang, Dalong Yang, Xianda Gao, Jiayuan Sun, Wenyuan Ding, Lei M. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Prevent Acidic pH-Induced Damage in Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-18. PMID:32436493. |
conclusions in the pathological acid environment, msc-derived exo promotes the expression of chondrocyte extracellular matrix, collagen ii, and aggrecan, and reduces matrix degradation by downregulating matrix-degrading enzymes, protecting npcs from acidic ph-induced apoptosis. |
2021-02-18 |
2023-08-13 |
human |
| Yongjie Wang, Mingxue Che, Jingguo Xin, Zhi Zheng, Jiangbi Li, Shaokun Zhan. The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32853910. |
they are also upregulated in the degenerative ivds, and they are closely related to various pathological idd processes, including inflammatory response, matrix destruction, cellular senescence, autophagy, apoptosis, pyroptosis, and proliferation. |
2021-02-17 |
2023-08-13 |
Not clear |
| Jiajie Tu, Wei Huang, Weiwei Zhang, Jiawei Mei, Chen Zh. The emerging role of lncRNAs in chondrocytes from osteoarthritis patients. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32927251. |
recent studies have demonstrated that lncrnas are involved in the pathogenesis of oa by affecting various essential cellular features of chondrocytes, such as proliferation, apoptosis, inflammation, and degradation of the extracellular matrix (ecm). |
2021-02-17 |
2023-08-13 |
Not clear |
| Petra Cazzanelli, Karin Wuertz-Koza. MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32443722. |
key characteristics of the pathological changes connected with degenerative disc disease (ddd) are the degradation of the extracellular matrix (ecm), apoptosis and senescence, as well as inflammation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
mir-423-5p regulates cells apoptosis and extracellular matrix degradation via nucleotide-binding, leucine-rich repeat containing x1 (nlrx1) in interleukin 1 beta (il-1β)-induced human nucleus pulposus cells. |
2021-02-16 |
2023-08-13 |
human |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
background disc degeneration is characterized partly by the degradation in the extracellular matrix (ecm) and excess apoptosis of nucleus pulposus (np) cells. |
2021-02-16 |
2023-08-13 |
human |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
then, nlrx1 was overexpressed in il-1β-induced np cells to detect apoptosis-related proteins and the extracellular matrix (ecm) by western blot, along with the detection of apoptosis levels using flow cytometry. |
2021-02-16 |
2023-08-13 |
human |
| Weikun Xiao, Shanshan Wang, Rongyu Zhang, Alireza Sohrabi, Qi Yu, Sihan Liu, Arshia Ehsanipour, Jesse Liang, Rebecca D Bierman, David A Nathanson, Stephanie K Seidlit. Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma. Matrix biology : journal of the International Society for Matrix Biology. vol 85-86. 2021-02-12. PMID:31028838. |
while numerous studies have investigated mechanisms enabling gbm cells to evade chemotherapy-induced apoptosis, few have addressed how their surrounding extracellular matrix (ecm) acts to promote their survival. |
2021-02-12 |
2023-08-13 |
Not clear |
| Ling-Ling Guo, Meng-Tao Wu, Li-Wei Zhang, Yong-Xin Chu, Peng Tian, Zai-Ping Jing, Jia-Si Li, Yu-Dong Sun, Kak K Yeung, Lei Zhan. Blocking Interleukin-1 Beta Reduces the Evolution of Thoracic Aortic Dissection in a Rodent Model. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. vol 60. issue 6. 2021-02-09. PMID:33004280. |
this study aimed to investigate the role of il-1β, matrix metalloproteinase (mmp)-2, mmp-9, smooth muscle cell apoptosis, and elastic fibre fracture in the development of tad in a rat model. |
2021-02-09 |
2023-08-13 |
rat |
| Yue Teng, Gang Ni, Wen Zhang, Jiong Hua, Lin Sun, Min Zheng, Qirong Dong, Weijie Huan. TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway. Biochemical and biophysical research communications. vol 529. issue 1. 2021-02-08. PMID:32560815. |
overexpression of trim59 suppressed interleukin 1 beta (il-1β)-induced extracellular matrix (ecm) metabolic imbalance, proinflammatory cytokine production, apoptosis and decrease in cell viability. |
2021-02-08 |
2023-08-13 |
rat |
| Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo, Zhongxu Ca. Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress. Journal of inflammation (London, England). vol 18. issue 1. 2021-02-06. PMID:33531032. |
increased cell apoptosis and inflammation, decreased extracellular matrix are associated with ivdd. |
2021-02-06 |
2023-08-13 |
Not clear |
| Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wan. Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-02-06. PMID:33542744. |
prostaglandin g/h synthase 2 (ptgs2), heat shock protein 90 (hsp90), cell division protein kinase 6 (cdk6), caspase 3 (casp3), apoptosis regulator bcl-2 (bcl-2), and matrix metalloproteinase-9 (mmp9) were identified as key targets of fa in the treatment of multiple diseases. |
2021-02-06 |
2023-08-13 |
Not clear |
| Yinhe Tang, Naijing Ma, Hao Luo, Shizuan Chen, Fuxiang Y. Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1. Journal of biochemistry. vol 167. issue 5. 2021-02-05. PMID:32044992. |
the apoptosis of hepatocytes contributes to the activation of hepatic stellate cells (hscs), thus promoting the accumulation of extracellular matrix proteins and aggravating liver fibrosis. |
2021-02-05 |
2023-08-13 |
mouse |
| Hai-Rong Ma, Li Cao, Fei Wang, Chao Cheng, Rendong Jiang, Haikang Zhou, Zhenzi Xie, Shalitanati Wuermanbieke, Zhenghao Qia. Filamin B extensively regulates transcription and alternative splicing, and is associated with apoptosis in HeLa cells. Oncology reports. vol 43. issue 5. 2021-02-05. PMID:32323860. |
reverse transcription‑quantitative‑pcr identified flnb‑regulated transcription and alternative splicing of genes, such as nlr family apoptosis inhibitory protein, interleukin 23 subunit α, metastasis associated lung adenocarcinoma transcript 1, phosphofurin acidic cluster sorting protein 2, bone morphogenetic protein 7, matrix metallopeptidase 13, collagen type ii α 1 chain, fibroblast growth factor receptor 2 and vitamin d receptor. |
2021-02-05 |
2023-08-13 |
Not clear |
| Buhrmann Constanze, Bastian Popper, Bharat B Aggarwal, Mehdi Shakibae. Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2. Cell and tissue research. vol 381. issue 1. 2021-02-03. PMID:32140928. |
we found that tnf-β inhibits, in a similar way to nam or sirt1-aso, the early stage of osteogenic differentiation of mscs and this was accompanied with downregulation of bone-specific matrix, β1-integrin, runx2 and with upregulation of nf-κb phosphorylation and nf-κb-regulated gene products involved in the inflammatory, degradative processes and apoptosis. |
2021-02-03 |
2023-08-13 |
Not clear |
| Yuan Tan, Yuejin Li, Faqing Tan. Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis. Molecular cancer. vol 19. issue 1. 2021-02-02. PMID:32278350. |
the recent reports showed that oncogenic serna implicates in a widespread range of cytopathological processes in cancer progression including cell proliferation, apoptosis, autophagy, epithelial-mesenchymal transition, extracellular matrix stiffness and angiogenesis. |
2021-02-02 |
2023-08-13 |
Not clear |