| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang, Jiang-Feng W. The roles of microRNA families in hepatic fibrosis. Cell & bioscience. vol 7. 2020-09-30. PMID:28680559. |
during the process of hepatic fibrosis, mir-29 family primarily induces cell apoptosis by modulating phosphatidylinositol 3-kinase/akt signaling pathway and regulates extracellular matrix accumulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yingqiu Xie, Aidana Mustafa, Adina Yerzhan, Dalmira Merzhakupova, Perizat Yerlan, Askarbek N Orakov, Xiao Wang, Yi Huang, Lixia Mia. Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment. Cell death discovery. vol 3. 2020-09-30. PMID:28811933. |
matrix metalloproteinase (mmp) is defined as an endopeptidase in the extracellular matrix (ecm), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. |
2020-09-30 |
2023-08-13 |
Not clear |
| Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna, Fellype de Carvalho Barret. The impact of type 2 diabetes on bone metabolism. Diabetology & metabolic syndrome. vol 9. 2020-09-30. PMID:29075333. |
type 2 diabetes mellitus (t2dm) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. |
2020-09-30 |
2023-08-13 |
Not clear |
| Prajakta Oak, Anne Hilgendorf. The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease. Molecular and cellular pediatrics. vol 4. issue 1. 2020-09-30. PMID:29116547. |
disease development is characterized by inflammation, extracellular matrix remodeling, and apoptosis, closely intertwined with the dysregulation of growth factor signaling. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mohamed B Fouda, Finosh G Thankam, Matthew F Dilisio, Devendra K Agrawa. Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118899. |
but, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pasquale Cocchiaro, Valeria De Pasquale, Rossella Della Morte, Simona Tafuri, Luigi Avallone, Anne Pizard, Anna Moles, Luigi Michele Pavon. The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease. Frontiers in cell and developmental biology. vol 5. 2020-09-30. PMID:29312937. |
specifically in the kidney, cathepsins b, d, l and s have been shown to regulate extracellular matrix homeostasis, autophagy, apoptosis, glomerular permeability, endothelial function, and inflammation. |
2020-09-30 |
2023-08-13 |
human |
| Nolan B Ayers, Chen-Ming Sun, Shi-You Che. Transforming growth factor-β signaling in systemic sclerosis. Journal of biomedical research. vol 32. issue 1. 2020-09-30. PMID:29353817. |
various processes, including cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis are regulated by tgf-β, a type of cytokine secreted by macrophages and many other cell types. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wei Zhao, Yuping Yang, Lingling Song, Tianyi Kang, Ting Du, Yujiao Wu, Meimei Xiong, Li Luo, Jianlin Long, Ke Men, Lan Zhang, Xiaoxin Chen, Meijuan Huang, Maling Go. A Vesicular Stomatitis Virus-Inspired DNA Nanocomplex for Ovarian Cancer Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 5. issue 3. 2020-09-30. PMID:29593949. |
this dna nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)-poly (d,l-lactide) (mpeg-pla) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (vsvmp) that plays a critical role in the vsv-induced apoptosis of cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Guowei Shang, Yang Mi, Yingwu Mei, Guanghui Wang, Yadong Wang, Xinjie Li, Yisheng Wang, Yuebai Li, Guoqiang Zha. MicroRNA-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731885. |
microrna-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11. |
2020-09-30 |
2023-08-13 |
Not clear |
| Sai Wang Seto, Dennis Chang, Hosen Kiat, Ning Wang, Alan Bensoussa. Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm. Frontiers in cardiovascular medicine. vol 5. 2020-09-30. PMID:29732374. |
multiple mechanisms are involved in the development and progression of aaa, including chronic inflammation, oxidative stress, vascular smooth muscle (vsmc) apoptosis, immune cell infiltration and extracellular matrix (ecm) degradation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Gabriela Sofía Gómez-Macías, María Lourdes Garza-Rodríguez, Raquel Garza-Guajardo, Daniela Monsiváis-Ovalle, Jesús Ancer-Rodríguez, Hugo Alberto Barrera-Saldaña, Oralia Barboza-Quintan. Overexpression of the matrix metalloproteinase 11 gene is a potential biomarker for type 1 endometrial cancer. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963184. |
metalloproteinase matrix 11 (mmp11) is a member of the matrix metalloproteinase family, which are able to degrade extracellular matrix components, and may serve a central function in the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Tian Li, Kewei Xu, Yifan Li. Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP-9 signaling pathways in human bladder cancer cells. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127910. |
salidroside induced autophagy, promoted the protein expression of nucleoporin p62 and the microtubule-associated proteins 1a/1b light chain 3b, suppressed phosphoinositide 3-kinase (pi3k) and phosphorylated protein kinase b (p-akt) expression, inhibited matrix metalloproteinase-9 (mmp-9) expression and increased that of bcl-2-associated x protein, which functions as an apoptosis regulator in t24 cells. |
2020-09-30 |
2023-08-13 |
human |
| Sang Hwan Kim, Ji Hye Lee, Jong Taek Yoo. Expression of matrix metalloproteinases to induce the expression of genes associated with apoptosis during corpus luteum development in bovine. PeerJ. vol 7. 2020-09-30. PMID:30729068. |
expression of matrix metalloproteinases to induce the expression of genes associated with apoptosis during corpus luteum development in bovine. |
2020-09-30 |
2023-08-13 |
cattle |
| Shu-Hai Chen, Bing-Yuan Zhang, Bin Zhou, Cheng-Zhan Zhu, Le-Qi Sun, Yu-Jie Fen. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. American journal of cancer research. vol 9. issue 1. 2020-09-30. PMID:30755808. |
pni occurs through changes in nerve cells and supporting cells in the background of cancer; change and migration of the perineural matrix; enhancement of the viability, mobility, and invasiveness of the tumor cells; injury and regeneration of nerve cells; interaction, chemotactic movement, contact, and adherence of the nerve cells and the tumor cells; escape from autophagy, apoptosis, and immunological surveillance of tumor cells; and so on. |
2020-09-30 |
2023-08-13 |
Not clear |
| Joseph P Miller, Brandon H Borde, Francois Bordeleau, Matthew R Zanotelli, Danielle J LaValley, Dylan J Parker, Lawrence J Bonassar, Susan C Pannullo, Cynthia A Reinhart-Kin. Clinical doses of radiation reduce collagen matrix stiffness. APL bioengineering. vol 2. issue 3. 2020-09-30. PMID:31069314. |
cells receive mechanical cues from their extracellular matrix (ecm), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. |
2020-09-30 |
2023-08-13 |
Not clear |
| Negar Sharifi, Anneh Mohammad Gharrav. Shear bioreactors stimulating chondrocyte regeneration, a systematic review. Inflammation and regeneration. vol 39. 2020-09-30. PMID:31410225. |
mechanism of shear stress on chondrocyte, briefly can be hypothesized as (1) altered expression of aggrecan and collagen type ii, (2) altered cartilage oligomeric matrix protein (comp) serum levels, consequently, organizing the arrangement binding of glycosaminoglycans, integrins, and collagen, (3) induction of apoptosis signals, (4) altered expression of integrin. |
2020-09-30 |
2023-08-13 |
human |
| Xuyang Zhang, Jian Chen, Bao Huang, Jiasheng Wang, Zhi Shan, Junhui Liu, Yilei Chen, Shengyun Li, Shunwu Fan, Fengdong Zha. Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration. Frontiers in physiology. vol 10. 2020-09-30. PMID:31649558. |
obesity mediates apoptosis and extracellular matrix metabolic imbalances via mapk pathway activation in intervertebral disk degeneration. |
2020-09-30 |
2023-08-13 |
human |
| Yinguang Zhang, Qiang Dong, Xiang Su. Positive Feedback Loop LINC00511/miR-150-5p/SP1 Modulates Chondrocyte Apoptosis and Proliferation in Osteoarthritis. DNA and cell biology. vol 39. issue 9. 2020-09-29. PMID:32635763. |
knockdown of linc00511 facilitated proliferation, and repressed the apoptosis and extracellular matrix (ecm) synthesis of chondrocyte. |
2020-09-29 |
2023-08-13 |
Not clear |
| M W Roomi, T Kalinovsky, J Cha, N W Roomi, A Niedzwiecki, M Rat. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. Experimental and therapeutic medicine. vol 9. issue 2. 2020-09-29. PMID:25574189. |
tumor growth was measured and immunohistochemical staining was evaluated for the following cancer markers: ki67 (proliferation); matrix metalloproteinase (mmp)-2 and -9 (invasion/metastasis); vascular endothelial growth factor (vegf) (angiogenesis); terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) and b-cell lymphoma 2 (bcl-2) (apoptosis); cyclooxygenase 2 (cox-2) and inducible nitric oxide synthase (inos) (inflammation); and glutathione s-transferase π (gstπ) (a general cancer marker). |
2020-09-29 |
2023-08-13 |
mouse |
| Dorothy Ndishabandi, Cameron Duquette, Ghita El-Moatassim Billah, Millys Reyes, Mark Duquette, Jack Lawler, Shideh Kazerounia. Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro. Discoveries (Craiova, Romania). vol 2. issue 4. 2020-09-29. PMID:26273699. |
this inhibitory function of tsp-1 is actuated either by inhibiting mmp9 activation and the release of vegf from extracellular matrix or by an interaction with cd36 on the surface of endothelial cells resulting in an increase in apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |