| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Fei Shen, Yi Cheng, Qi-Rong Dong, Min-Qian Zhen. MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. Biochemical and biophysical research communications. vol 527. issue 2. 2021-01-04. PMID:32336544. |
the overexpression of mir-675-3p inhibited apoptosis and cartilage matrix degradation and promoted cell proliferation in human chondrocytes. |
2021-01-04 |
2023-08-13 |
human |
| Muraly Puttabyatappa, Xingzi Guo, John Dou, Daniel Dumesic, Kelly M Bakulski, Vasantha Padmanabha. Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone. Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32516392. |
these data indicate that follicular function is affected by genes involved in transforming growth factor signaling, extracellular matrix, mitochondria, epigenetics, and apoptosis both in a common as well as a cell-specific manner and suggest possible mechanistic pathways for prenatal t treatment-induced pco morphology in sheep. |
2021-01-04 |
2023-08-13 |
Not clear |
| Yuchao Li, Guoning Guo, Jie Song, Zhiping Cai, Jin Yang, Zhiwen Chen, Yun Wang, Yaqin Huang, Qiangguo Ga. B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway. Journal of Cancer. vol 8. issue 5. 2021-01-03. PMID:28382144. |
b7-h3 did not affect cell proliferation and apoptosis, but cell migration and invasion were changed through the regulation of matrix metalloproteinase (mmp) 2/9. |
2021-01-03 |
2023-08-13 |
human |
| Yuuri Yasuok. Morphogenetic mechanisms forming the notochord rod: The turgor pressure-sheath strength model. Development, growth & differentiation. vol 62. issue 6. 2020-12-31. PMID:32275068. |
attributes of notochord cells, such as vacuolation, membrane trafficking, extracellular matrix formation, and apoptosis, can be understood in terms of two properties: turgor pressure of vacuoles and strength of the notochord sheath. |
2020-12-31 |
2023-08-13 |
zebrafish |
| Dong Wang, Xin He, Di Wang, Pandi Peng, Xiaolong Xu, Bo Gao, Chao Zheng, Han Wang, Haoruo Jia, Qiliang Shang, Zhen Sun, Zhuojing Luo, Liu Yan. Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway. Frontiers in cell and developmental biology. vol 8. 2020-12-29. PMID:33363176. |
previous studies demonstrated that the apoptosis of nucleus pulposus (np) cells and the dyshomeostasis of extracellular matrix (ecm) contributed to the pathogenesis of idd, and effective therapies were still lacking. |
2020-12-29 |
2023-08-13 |
Not clear |
| Qian Xiang, Liang Kang, Juntan Wang, Zhiwei Liao, Yu Song, Kangcheng Zhao, Kun Wang, Cao Yang, Yukun Zhan. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. vol 53. 2020-12-17. PMID:32114390. |
as a high-risk factor for idd, compression stress was reported to induce apoptosis of nucleus pulposus (np) cells and extracellular matrix (ecm) degradation during idd progression. |
2020-12-17 |
2023-08-13 |
human |
| Sun Tae Hwang, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Kwang Seok Ah. Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells. Molecules (Basel, Switzerland). vol 25. issue 6. 2020-12-16. PMID:32183146. |
then, we noted that evo arrested the cell cycle, caused apoptosis, and downregulated the expression of various carcinogenic markers such as b-cell lymphoma 2 (bcl-2), b-cell lymphoma-extra large (bcl-xl), cyclin d1, cyclooxygenase 2 (cox-2), survivin, vascular endothelial growth factor (vegf), and matrix metallopeptidases 9 (mmp-9). |
2020-12-16 |
2023-08-13 |
Not clear |
| Fang Xie, Yong-Li Liu, Xiu-Yuan Chen, Qian Li, Jia Zhong, Bin-Yu Dai, Xian-Fang Shao, Guan-Bao W. Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature. Orthopaedic surgery. vol 12. issue 3. 2020-12-16. PMID:32436304. |
in this review, we emphasized that different microrna, lncrna, and exosomes have different regulatory effects on chondrocyte proliferation and apoptosis, extracellular matrix degradation and inflammation. |
2020-12-16 |
2023-08-13 |
Not clear |
| Hai Ke, Xiaping Mou, Qing Xi. Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation. Annals of translational medicine. vol 8. issue 22. 2020-12-16. PMID:33313232. |
remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits il-1β-induced apoptosis of articular chondrocytes via inhibition of pi3k/akt/nf-κb phosphorylation. |
2020-12-16 |
2023-08-13 |
Not clear |
| Steven E Wilson, Andre A M Torricelli, Gustavo K Marin. Corneal epithelial basement membrane: Structure, function and regeneration. Experimental eye research. vol 194. 2020-12-15. PMID:32179076. |
transparency is subsequently restored if the ebm is fully regenerated, myofibroblasts are deprived of tgf-β and undergo apoptosis, and keratocytes reoccupy the anterior stroma and reabsorb the disordered extracellular matrix. |
2020-12-15 |
2023-08-13 |
Not clear |
| Laura M Marquardt, Vanessa M Doulames, Alice T Wang, Karen Dubbin, Riley A Suhar, Michael J Kratochvil, Zachary A Medress, Giles W Plant, Sarah C Heilshor. Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy. Science advances. vol 6. issue 14. 2020-12-15. PMID:32270042. |
we present a materials-based strategy that addresses three common causes of transplanted cell death: (i) membrane damage during injection, (ii) cell leakage from the injection site, and (iii) apoptosis due to loss of endogenous matrix. |
2020-12-15 |
2023-08-13 |
Not clear |
| Manisha Agarwal, Mitchell Goheen, Shijing Jia, Song Ling, Eric S White, Kevin K Ki. Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through α American journal of respiratory cell and molecular biology. vol 63. issue 5. 2020-12-09. PMID:32692932. |
fibroblasts cultured on type i collagen or fibrotic decellularized lung matrix had augmented activation in response to tgf-β, whereas aecs on cultured on type i collagen or fibrotic lung matrix were more resistant to tgf-β-induced apoptosis. |
2020-12-09 |
2023-08-13 |
Not clear |
| Chanchal Garg, Hitender Sharma, Munish Gar. Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling-An overview. Ageing research reviews. vol 62. 2020-12-04. PMID:32721499. |
the contribution of phytochemicals to the downregulation of expression of oxidative-stress sensitive transcription factors (nrf2, nf-kb, ap-1 and p53) and protein kinases (msk, erk, jnk, p38 mapk, p90rsk2 and camks) involved in inflammation, apoptosis, immune suppression, extracellular matrix remodelling, senescence, photo ageing and photo-carcinogenesis, is also discussed. |
2020-12-04 |
2023-08-13 |
Not clear |
| Zhiyong Shu, Xiaogang Miao, Tainhua Tang, Peng Zhan, Langqing Zeng, Yuwen Jian. The GSK‑3β/β‑catenin signaling pathway is involved in HMGB1‑induced chondrocyte apoptosis and cartilage matrix degradation. International journal of molecular medicine. vol 45. issue 3. 2020-11-30. PMID:31922219. |
the gsk‑3β/β‑catenin signaling pathway is involved in hmgb1‑induced chondrocyte apoptosis and cartilage matrix degradation. |
2020-11-30 |
2023-08-13 |
Not clear |
| JinYoung Park, Ji-Hyun Lee, Youngbin Lee, Donghoon Lee, Moon Jong Kim, Kwang-Min Cho. Necrotic cell death induces melanotic mass formation in Drosophila. Biochemical and biophysical research communications. vol 526. issue 4. 2020-11-25. PMID:32312516. |
upon the loss of cell matrix attachment, endocycling polyploid tissues of the drosophila larva undergo autophagy instead of apoptosis; we employed this system as a model to examine cell death modalities and immunity. |
2020-11-25 |
2023-08-13 |
drosophila_melanogaster |
| Jing Zhao, Yiran Hou, Chun Yin, Jing Hu, Tian Gao, Xiaojun Huang, Xiaohong Zhang, Jinliang Xing, Jiaze An, Shaogui Wan, Jibin L. Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma. Oncogene. vol 39. issue 8. 2020-11-24. PMID:31740780. |
functional experiments revealed that h1hr promoted both the growth and metastasis of hcc cells by inducing cell cycle progression, formation of lamellipodia, production of matrix metalloproteinase 2, and suppression of cell apoptosis. |
2020-11-24 |
2023-08-13 |
mouse |
| Yunfang Cai, Wen Zhang, Runze Zhang, Xiaoying Cui, Jun Fan. Combined Use of Three Machine Learning Modeling Methods to Develop a Ten-Gene Signature for the Diagnosis of Ventilator-Associated Pneumonia. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:32031163. |
upregulated genes included matrix metallopeptidase 8 (mmp8), arginase 1 (arg1), haptoglobin (hp), interleukin 18 receptor 1 (il18r1), and nlr family apoptosis inhibitory protein (naip). |
2020-11-24 |
2023-08-13 |
Not clear |
| Weitian Li, Qiyu Tang, Na Dai, Weikuan Feng, Changqing Xie, Guofu Cheng, Xiaoli Liu, Wanpo Zhang, Xueying Hu, Changqin G. Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida. Scientific reports. vol 10. issue 1. 2020-11-24. PMID:32286320. |
the inflammatory factors hmgb1 and il-6, intercellular matrix mmp, the cell apoptosis-associated caspase-3 and necrotic apoptosis signal molecules ripk1 and ripk3 were widely expressed in the lungs of group q and were significantly different compared with those of 1g1 group and uninfected group (p < 0.05). |
2020-11-24 |
2023-08-13 |
chicken |
| Jing Chen, Ye Yang, Jingjing Wu, Xue Rui, Wei Wang, Rongrong Ren, Qingqing Zhang, Qingqing Chen, Dengke Yi. Spatiotemporal variations of contact stress between liquid-crystal films and fibroblasts Guide cell fate and skin regeneration. Colloids and surfaces. B, Biointerfaces. vol 188. 2020-11-23. PMID:31881410. |
but the gradually weakening cellular contact stress, induced by the decreasing of liquid crystal domains of matrix polymer during degradation, triggers the apoptosis of fibroblasts and myofibroblasts, resulting in non-excessive collagen accumulation. |
2020-11-23 |
2023-08-13 |
Not clear |
| Jun Shirakawa, Yasuo Terauch. Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality. Endocrine journal. vol 67. issue 1. 2020-11-19. PMID:31694991. |
glucokinase-mediated glucose metabolism (1) suppresses endoplasmic reticulum (er) stress-induced β-cell apoptosis via inducing insulin receptor substrate-2 (irs-2) expression and expression of er stress-related molecules, (2) promotes adaptive β-cell proliferation through activation of the forkhead box m1 (foxm1)/polo-like kinase-1 (plk1)/centromere protein-a (cenp-a) pathway, (3) induces islet inflammation by promoting interaction of islet-derived s100 calcium-binding protein a8 (s100a8) with macrophages, (4) induces the expression of fibulin-5 (fbln5), an extracellular matrix protein to regulate β-cell functions, and (5) activates other unknown pathways. |
2020-11-19 |
2023-08-13 |
mouse |