| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pengcheng Dou, Yu He, Bo Yu, Juan Dua. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging. vol 13. issue 5. 2021-07-22. PMID:33177241. |
moreover, the pthlh upregulation induced by mir-29b methylation led to the enhancement of chondrocyte growth and suppression of their apoptosis and extracellular matrix degradation, which was achieved by the upregulation cyclin-dependent kinase 4 (cdk4) expression. |
2021-07-22 |
2023-08-13 |
mouse |
| Qian Qian Yang, Luzhong Zhang, Fei Ju, You Lang Zho. Sustained-Release Hydrogel-Based Rhynchophylline Delivery System Improved Injured Tendon Repair. Colloids and surfaces. B, Biointerfaces. vol 205. 2021-07-20. PMID:34087778. |
but for adhesion tissues, rhy promoted the apoptosis and accelerated the degradation of extracellular matrix. |
2021-07-20 |
2023-08-13 |
Not clear |
| Francesca Velotti, Ilaria Barchetta, Flavia Agata Cimini, Maria Gisella Cavall. Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis. Frontiers in immunology. vol 11. 2021-07-16. PMID:33262766. |
granzyme b in inflammatory diseases: apoptosis, inflammation, extracellular matrix remodeling, epithelial-to-mesenchymal transition and fibrosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wan. circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. International journal of molecular medicine. vol 47. issue 5. 2021-07-16. PMID:33649815. |
finally, the biological functions of fxr1, mir‑503‑3p, and mir‑503‑5p in keloid‑derived fibroblast proliferation, apoptosis and extracellular matrix accumulation were confirmed. |
2021-07-16 |
2023-08-13 |
Not clear |
| Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wan. circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. International journal of molecular medicine. vol 47. issue 5. 2021-07-16. PMID:33649815. |
knockdown of fxr1, mir‑503‑3p and mir‑503‑5p also inhibited proliferation and extracellular matrix accumulation in keloid‑derived fibroblasts and increased levels of cell apoptosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Zhirong Wang, Kai Yan, Gaoran Ge, Di Zhang, Jiaxiang Bai, Xiaobin Guo, Jing Zhou, Tianpeng Xu, Menglei Xu, Xiao Long, Yuefeng Hao, Dechun Gen. Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33099657. |
exosomes derived from mir-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. |
2021-07-15 |
2023-08-13 |
mouse |
| Zhirong Wang, Kai Yan, Gaoran Ge, Di Zhang, Jiaxiang Bai, Xiaobin Guo, Jing Zhou, Tianpeng Xu, Menglei Xu, Xiao Long, Yuefeng Hao, Dechun Gen. Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33099657. |
cck-8, transwell, and western blot analyses were used to detect proliferation, migration, extracellular matrix (ecm) secretion, and apoptosis of osteoarthritic chondrocytes. |
2021-07-15 |
2023-08-13 |
mouse |
| Flavia Agata Cimini, Ilaria Barchetta, Valentina Ceccarelli, Caterina Chiappetta, Alberto Di Biasio, Laura Bertoccini, Federica Sentinelli, Frida Leonetti, Gianfranco Silecchia, Claudio Di Cristofano, Marco Giorgio Baroni, Francesca Velotti, Maria Gisella Cavall. Granzyme B Expression in Visceral Adipose Tissue Associates With Local Inflammation and Glyco-Metabolic Alterations in Obesity. Frontiers in immunology. vol 11. 2021-07-15. PMID:33312176. |
granzyme b (grb) is a serine protease produced by immune and non-immune cells, able to promote multiple processes, like apoptosis, inflammation, extracellular matrix remodeling and fibrosis. |
2021-07-15 |
2023-08-13 |
human |
| Jiawei Jiang, Jinlong Zhang, Chunshuai Wu, Chu Chen, Guofeng Bao, Guanhua Xu, Pengfei Xue, Yong Zhou, Yuyu Sun, Zhiming Cu. Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis. Molecular and cellular biochemistry. vol 476. issue 4. 2021-07-14. PMID:33502650. |
knockdown of traf6 suppressed the expression of matrix metallopeptidase-13 (mmp-13) and interleukin-6 (il-6) induced by lps, and alleviated cell apoptosis. |
2021-07-14 |
2023-08-13 |
human |
| Xiaolei Chen, Ri Chen, Yang Xu, Chun Xi. PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL-1β-treated rat chondrocytes. FEBS open bio. vol 11. issue 2. 2021-07-13. PMID:33326693. |
plcγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in il-1β-treated rat chondrocytes. |
2021-07-13 |
2023-08-13 |
rat |
| Yu Sun, Jihang Dai, Rui Jiao, Qing Jiang, Jingcheng Wan. Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis. Journal of orthopaedic surgery and research. vol 16. issue 1. 2021-07-12. PMID:33407698. |
homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via pi3k/akt/mtor pathway-mediated apoptosis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Yijun Liu, Ding Zhao, Xue Wang, Ying Dong, Fupeng Din. LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis. Cell and tissue research. vol 385. issue 1. 2021-07-12. PMID:33783609. |
in addition, upregulation of kcnq1ot1 significantly enhanced the viability of osteoarthritic chondrocytes, inhibited cell apoptosis, and reduced the release of inflammatory cytokines and metal matrix enzymes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Yijun Liu, Ding Zhao, Xue Wang, Ying Dong, Fupeng Din. LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis. Cell and tissue research. vol 385. issue 1. 2021-07-12. PMID:33783609. |
we found that the expression of mir-218-5p was significantly upregulated in osteoarthritic chondrocytes, and knockdown of mir-218-5p significantly enhanced the viability of osteoarthritic chondrocytes, inhibited apoptosis, and decreased the abundance of inflammatory cytokines and metal matrix enzymes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
overexpression of wisp1 inhibited the proliferation of chondrocytes, which induced apoptosis, degradation of chondrocyte matrix, production of proinflammatory cytokines, and activated the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2021-07-09 |
2023-08-13 |
human |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
moreover, the pi3k allosteric activator 740 y-p abolished the inhibition of mir-128-3p in apoptosis, degradation of chondrocyte matrix, and inflammation. |
2021-07-09 |
2023-08-13 |
human |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
our results showed that mir-128-3p targets wisp1 to regulate chondrocyte proliferation, apoptosis, degradation of chondrocyte matrix, and production of proinflammatory cytokines via the pi3k/akt/nf-κb pathway, which plays a suppressed role in oa. |
2021-07-09 |
2023-08-13 |
human |
| Qubo Ni, Haitao Chen, Wei Li, Kaihang Lu, Bin Li, Yang Tan, Hui Wang, Liaobin Che. Pravastatin ameliorated osteoarthritis susceptibility in male offspring rats induced by prenatal ethanol exposure. Bone. vol 149. 2021-07-09. PMID:33915333. |
we found that pravastatin ameliorated papain-induced high expression of inflammatory factors [interleukin (il)-1, il-6], matrix degradation enzymes [matrix metalloproteinase (mmp)-3, mmp-13], and apoptosis factors (caspase-3 and caspase-8) in the cartilage of the pee group. |
2021-07-09 |
2023-08-13 |
rat |
| Eva Otoupalova, Sam Smith, Guangjie Cheng, Victor J Thannicka. Oxidative Stress in Pulmonary Fibrosis. Comprehensive Physiology. vol 10. issue 2. 2021-07-08. PMID:32163196. |
we discuss the recent findings on the role of reactive oxygen species (ros) in specific fibrotic processes such as macrophage polarization and immunosenescence, alveolar epithelial cell apoptosis and senescence, myofibroblast differentiation and senescence, and alterations in the acellular extracellular matrix. |
2021-07-08 |
2023-08-13 |
Not clear |
| Seyed Ali Mosaddad, Yalda Salari, Samira Amookhteh, Reza Sayyad Soufdoost, Alexander Seifalian, Shahin Bonakdar, Fahimeh Safaeinejad, Mehrdad Moosazadeh Moghaddam, Hamid Tebyania. Response to Mechanical Cues by Interplay of YAP/TAZ Transcription Factors and Key Mechanical Checkpoints of the Cell: A Comprehensive Review. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 55. issue 1. 2021-07-08. PMID:33474906. |
for many years, growth factors have been considered as the pivotal cell behavior regulators, whereas recent studies emphasize also the key role of physical factors such as mechanical forces, cell shape, surface topographies, and extracellular matrix (ecm) in regulating the cell proliferation, apoptosis, differentiation, etc. |
2021-07-08 |
2023-08-13 |
Not clear |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
the pathogenesis is complicated, and the main pathological changes are ivd cell apoptosis and extracellular matrix (ecm) degradation. |
2021-07-06 |
2023-08-13 |
Not clear |