| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina L Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbau. Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32417168. |
the aim of this study was to investigate the effect of a maternal diet enriched in olive oil on the levels of components and regulators of the extracellular matrix, on prooxidant markers and on apoptosis rate in the heart of 21-day-old offspring of diabetic rats. |
2021-04-28 |
2023-08-13 |
rat |
| Albert J Pedroza, Tiffany Koyano, Jeffrey Trojan, Adam Rubin, Itai Palmon, Kevin Jaatinen, Grayson Burdon, Paul Chang, Yasushi Tashima, Jason Z Cui, Gerry Berry, Cristiana Iosef, Michael P Fischbei. Divergent effects of canonical and non-canonical TGF-β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms. Journal of cellular and molecular medicine. vol 24. issue 3. 2021-04-27. PMID:31886938. |
reversing notch3 overexpression with sirna demonstrated that notch3 promotes several protective remodelling pathways, including increased smc proliferation, decreased apoptosis and reduced matrix metalloproteinase activity, in vitro. |
2021-04-27 |
2023-08-13 |
human |
| Kexin Zheng, Qilong Li, Dongdong Lin, Xiaoyan Zong, Xue Luo, Mei Yang, Xiqing Yue, Shiliang M. Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites. Food & function. vol 11. issue 9. 2021-04-26. PMID:32789330. |
pawps activated the expression of cleaved-caspase3 and increased tumor apoptosis, resulting in the reduction of platelet-endothelial cell adhesion molecule (pecam-1/cd31) expression and the number of blood vessels, as well as the inhibition of matrix metalloproteinase (mmp) 2 and 9, increasing the ratio of cadherin-1 (cdh1)/cadherin-2 (cdh2) and inhibiting epithelial-mesenchymal transition (emt) in these tumors. |
2021-04-26 |
2023-08-13 |
mouse |
| Zhonghui Chen, Weibing Zhang, Ming Deng, Yaming Li, Yan Zho. CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging. vol 12. issue 21. 2021-04-23. PMID:33159017. |
circglce alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of mir-587/stap1. |
2021-04-23 |
2023-08-13 |
mouse |
| Sizhen Li, Qingsong Yang, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Li. SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress. Environmental toxicology. vol 36. issue 6. 2021-04-23. PMID:33522089. |
snhg3 cooperates with elavl2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing snai2 in human trabecular meshwork cells under oxidative stress. |
2021-04-23 |
2023-08-13 |
human |
| J S Lawson, H M Syme, C P D Wheeler-Jones, J Elliot. Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. Veterinary journal (London, England : 1997). vol 267. 2021-04-22. PMID:33375963. |
the aims of this study were to explore the interaction between increased extracellular phosphate and the tgf-β1 signalling pathway by investigating: (a) the effect of a commercially available, phosphate-restricted, diet on urinary tgf-β1 excretion in cats with ckd; and (b) the role of increased extracellular phosphate in regulating proliferation, apoptosis, and expression of genes related to tgf-β1 signalling and extracellular matrix (ecm) production in feline proximal tubular epithelial cells (fptec) and cortical fibroblasts from cats with azotaemic ckd (ckd-fcf). |
2021-04-22 |
2023-08-13 |
Not clear |
| Federica Morani, Luisa Bisceglia, Giulia Rosini, Luciano Mutti, Ombretta Melaiu, Stefano Landi, Federica Gemignan. Identification of Overexpressed Genes in Malignant Pleural Mesothelioma. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33800494. |
seven genes were involved in cell adhesion and extracellular matrix organization, with the others in control of the mitotic cell division or apoptosis inhibition. |
2021-04-22 |
2023-08-13 |
Not clear |
| Motomichi Fujita, Manabu Sasada, Takuya Iyoda, Reo Nagai, Chikako Kudo, Tetsuya Yamamoto, Satoshi Osada, Hiroaki Kodama, Fumio Fuka. Anoikis resistance conferred by tenascin-C-derived peptide TNIIIA2 and its disruption by integrin inactivation. Biochemical and biophysical research communications. vol 536. 2021-04-21. PMID:33360093. |
in general, cancer cells often acquire an additional malignant property that confers resistance to apoptosis due to loss of adhesion to the extracellular matrix, termed anoikis resistance. |
2021-04-21 |
2023-08-13 |
human |
| Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhan. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nature communications. vol 12. issue 1. 2021-04-21. PMID:33846342. |
cel-loaded prnps (cel-prnps) dually target ocs and inflammatory macrophages derived from patients with ra via an rgd-αvβ3 integrin interaction after peg cleavage by matrix metalloprotease 9, leading to increased apoptosis of these cells. |
2021-04-21 |
2023-08-13 |
rat |
| Ting Su, Xian-Yang Qin, Yutaka Furutan. Transglutaminase 2 as a Marker for Inflammation and Therapeutic Target in Sepsis. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33672962. |
tg2 plays important roles in diverse cellular processes, including extracellular matrix stabilization, cytoskeletal function, cell motility, adhesion, signal transduction, apoptosis, and cell survival. |
2021-04-19 |
2023-08-13 |
Not clear |
| Jian Jiang, Yuefeng Sun, Gaoran Xu, Hong Wang, Ling Wan. The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review). Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-16. PMID:33850527. |
dysregulated phenotypes of nucleus pulposus (np) cells and endplate chondrocytes, such as proliferation, senescence and apoptosis, along with aberrant expression of extracellular matrix components, including type ii collagen and aggrecan, are involved in the pathological process of ivdd. |
2021-04-16 |
2023-08-13 |
Not clear |
| Bashdar Mahmud Hussen, Hamed Shoorei, Mahdi Mohaqiq, Marcel E Dinger, Hazha Jamal Hidayat, Mohammad Taheri, Soudeh Ghafouri-Far. The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition. Frontiers in molecular biosciences. vol 8. 2021-04-13. PMID:33842553. |
epithelial to mesenchymal transition (emt) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly higher-order formation of extracellular matrix elements. |
2021-04-13 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
circserpine2 weakens il-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating mir-495/tgfbr2 axis. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
circserpine2 overexpression mitigated il-1β-caused apoptosis and extracellular matrix degradation. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
mir-495 up-regulation reversed overexpression of circserpine2-mediated inhibition of apoptosis and extracellular matrix degradation. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
as a conclusion, circserpine2 attenuated il-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating mir-495/tgfbr2 axis, indicating a new target for oa treatment. |
2021-04-12 |
2023-08-13 |
Not clear |
| Liping Xue, Cheng Xiong, Juanjuan Li, Yuling Ren, Liwei Zhang, Kangwei Jiao, Chen Chen, Peng Din. miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33150936. |
subsequently, overexpression of mir-200a-3p significantly promoted cell proliferation, reduced apoptosis, as well as inhibited the levels of inflammatory cytokines secreted, matrix metalloprotease 2/9 (mmp2/9), and vascular endothelial growth factor (vegf) in hg-injured arpe-19 cells. |
2021-04-12 |
2023-08-13 |
rat |
| Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S Park, Mary-Ellen Harper, Yan Burelle, Ruth S Slac. MCL-1 Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32371858. |
mcl-1 is an anti-apoptotic bcl-2 protein localized to mitochondria either in the outer membrane (om) or inner membrane (matrix), which have distinct roles in inhibiting apoptosis and promoting bioenergetics, respectively. |
2021-04-07 |
2023-08-13 |
Not clear |
| Peng Shen, Yanfeng Chen. Long noncoding RNA lncARSR confers resistance to Adriamycin and promotes osteosarcoma progression. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32404870. |
further investigation revealed that the upregulation of lncarsr enhanced multidrug resistance-associated protein-1 (mrp1), apoptosis inhibitor survivin, and matrix metalloproteinase-2 (mmp2) through activating akt. |
2021-04-07 |
2023-08-13 |
mouse |
| Yong Zhou, Mingsi Deng, Jiqing Su, Wei Zhang, Dongbiao Liu, Zhengguang Wan. The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential. Frontiers in cell and developmental biology. vol 9. 2021-04-06. PMID:33816484. |
overexpression of mir-31-5p facilitates nucleus pulposus cell proliferation, inhibits apoptosis, facilitates ecm formation, and inhibits the level of matrix degrading enzymes in np cells. |
2021-04-06 |
2023-08-13 |
mouse |