| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin Sunderland, Jingfeng Jiang, Feng Zha. Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review. Journal of cellular physiology. 2021-09-06. PMID:34486114. |
disturbed flow is associated with altered cellular morphology, upregulated expression of proteins modulating inflammation, decreased regulation of vascular permeability, degraded extracellular matrix, and heightened cellular apoptosis. |
2021-09-06 |
2023-08-13 |
Not clear |
| Christian R D'Andrea, Ausilah Alfraihat, Anita Singh, Jason B Anari, Patrick J Cahill, Thomas Schaer, Brian D Snyder, Dawn Elliott, Sriram Balasubramania. Part 2. Review and meta-analysis of studies on modulation of longitudinal bone growth and growth plate activity: A micro-scale perspective. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 5. 2021-09-03. PMID:33458882. |
gene and protein expressions related to matrix synthesis and degradation, as well as regulation of chondrocyte apoptosis were shown to exhibit magnitude-, frequency-, and duration-dependent responses to loading regimen. |
2021-09-03 |
2023-08-13 |
Not clear |
| Zhineng Fan, Shuan Liu, Houqing Zho. LncRNA H19 Regulates Proliferation, Apoptosis and ECM Degradation of Aortic Smooth Muscle Cells Via miR-1-3p/ADAM10 Axis in Thoracic Aortic Aneurysm. Biochemical genetics. 2021-09-03. PMID:34478010. |
h19 was increased in taa aorta tissues and serum and vascular smooth muscle cell (vsmc), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ecm) degradation of vsmc. |
2021-09-03 |
2023-08-13 |
Not clear |
| Tomonori Itsuji, Hitoshi Tonomura, Hidenobu Ishibashi, Yasuo Mikami, Masateru Nagae, Ryota Takatori, Takashi Tanida, Ken-Ichi Matsuda, Masaki Tanaka, Toshikazu Kub. Hepatocyte growth factor regulates HIF-1α-induced nucleus pulposus cell proliferation through MAPK-, PI3K/Akt-, and STAT3-mediated signaling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 6. 2021-09-02. PMID:32242977. |
we previously reported that hepatocyte growth factor (hgf) promotes cell proliferation and suppresses apoptosis, inflammation, and matrix degradation in nucleus pulposus (np) cells. |
2021-09-02 |
2023-08-13 |
Not clear |
| Mingli Feng, Lin Jing, Jingbo Cheng, Shuai An, Jiang Huang, Qi Ya. Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b. Molecular and cellular biochemistry. vol 476. issue 10. 2021-09-01. PMID:34046827. |
circ_0020093 ameliorates il-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating spry1 via targeting mir-23b. |
2021-09-01 |
2023-08-13 |
human |
| Jun-Ichi Takino, Takuma Sato, Kentaro Nagamine, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hor. Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products. Biological & pharmaceutical bulletin. vol 44. issue 1. 2021-08-31. PMID:33390537. |
these results suggested that the suppression of apoptosis in activated lx-2 cells by tgf-β1 and tage co-treatment is related to an increase in the production of the extracellular matrix such as collagen i. |
2021-08-31 |
2023-08-13 |
Not clear |
| Ali Mohammadi, Behzad Mansoori, Pascal H G Duijf, Elham Safarzadeh, Leila Tebbi, Souzan Najafi, Behrooz Shokouhi, Grith L Sorensen, Uffe Holmskov, Behzad Baradara. Restoration of miR-330 expression suppresses lung cancer cell viability, proliferation, and migration. Journal of cellular physiology. vol 236. issue 1. 2021-08-27. PMID:32583462. |
these findings are substantiated by increased mrna and protein expression of markers for apoptosis via the intrinsic pathway, such as caspase 9, and decreased mrna and protein expression of markers for cell migration, such as vimentin, c-x-c chemokine receptor type 4, and matrix metalloproteinase 9. |
2021-08-27 |
2023-08-13 |
Not clear |
| Zhilin Cao, Wenguang Liu, Xiaoyi Qu, Haiyong Bi, Xiujiang Sun, Qian Yu, Gong Chen. miR-296-5p inhibits IL-1β-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-β1/CTGF/p38MAPK pathway. Cell cycle (Georgetown, Tex.). vol 19. issue 12. 2021-08-26. PMID:32378978. |
osteoarthritis (oa) is characterized by apoptosis of chondrocytes and an imbalance of extracellular matrix (ecm) synthesis and catabolism. |
2021-08-26 |
2023-08-13 |
human |
| Zhilin Cao, Wenguang Liu, Xiaoyi Qu, Haiyong Bi, Xiujiang Sun, Qian Yu, Gong Chen. miR-296-5p inhibits IL-1β-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-β1/CTGF/p38MAPK pathway. Cell cycle (Georgetown, Tex.). vol 19. issue 12. 2021-08-26. PMID:32378978. |
overexpressed mir-296-5p enhanced cell proliferation and inhibited apoptosis and matrix degrading enzyme expression in response to il-1β stimulation, and knockdown of mir-296-5p showed the opposite effect. |
2021-08-26 |
2023-08-13 |
human |
| E Boloori, T Schoenmaker, C J Kleverlaan, B G Loos, T J de Vrie. Gingival epithelium attachment to well- or partially cured resin composites. European cells & materials. vol 40. 2021-08-25. PMID:33242338. |
effects of resin composite on the ca9-22 gingival epithelial cell-line were assessed by measuring the cytotoxicity, viability and gene expression for attachment, apoptosis, ros-production, pro-inflammatory cytokines, and matrix metalloproteinases. |
2021-08-25 |
2023-08-13 |
cattle |
| Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-Tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Rua. Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33437038. |
lsi administration led to the histologic change of disc degeneration, disruption of the matrix metabolism, promotion of apoptosis of ivd cells and invasion of sensory nerves into annulus fibrosus, as well as induction of pyroptosis. |
2021-08-25 |
2023-08-13 |
mouse |
| Oona Paavolainen, Emilia Peuh. Integrin-mediated adhesion and mechanosensing in the mammary gland. Seminars in cell & developmental biology. vol 114. 2021-08-23. PMID:33187835. |
morphological changes in the mammary epithelium involve cell proliferation, differentiation, apoptosis, and migration which, in turn, are affected by cell adhesion to the extracellular matrix (ecm). |
2021-08-23 |
2023-08-13 |
Not clear |
| Shengqiang Fu, Qiaoyun Fan, Juntao Xu, Shengjun Yu, Ming Sun, Yuan Ji, Dun Li. Circ_0008956 contributes to IL-1β-induced osteoarthritis progression via miR-149-5p/NAMPT axis. International immunopharmacology. vol 98. 2021-08-23. PMID:34153672. |
cell viability, apoptosis, cell cycle and extracellular matrix (ecm) degradation were analyzed using cell counting kit-8, flow cytometry, and western blot assays, respectively. |
2021-08-23 |
2023-08-13 |
Not clear |
| Liang Tan, Yifang Xie, Ye Yuan, Kai H. LncRNA GAS5 as miR-26a-5p Sponge Regulates the PTEN/PI3K/Akt Axis and Affects Extracellular Matrix Synthesis in Degenerative Nucleus Pulposus Cells Frontiers in neurology. vol 12. 2021-08-21. PMID:34413821. |
lncrna gas5 as mir-26a-5p sponge regulates the pten/pi3k/akt axis and affects extracellular matrix synthesis in degenerative nucleus pulposus cells the role of lncrna growth arrest specific 5 (gas5) in degenerative nucleus pulposus cell (npc) apoptosis has been reported, but the mechanism of gas5 in extracellular matrix (ecm) synthesis in intervertebral disc degeneration (idd) remains unknown. |
2021-08-21 |
2023-08-13 |
Not clear |
| Ya-Pei Zhu, Ting Xie, Tao Guo, Zhi-Jing Sun, Lan Zhu, Jing-He Lan. Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. International urogynecology journal. vol 32. issue 8. 2021-08-20. PMID:32737532. |
evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. |
2021-08-20 |
2023-08-13 |
Not clear |
| Ya-Pei Zhu, Ting Xie, Tao Guo, Zhi-Jing Sun, Lan Zhu, Jing-He Lan. Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. International urogynecology journal. vol 32. issue 8. 2021-08-20. PMID:32737532. |
this study aimed to compare the expression levels of extracellular matrix (ecm) and apoptosis proteins in the uterosacral ligament (usl) of patients with and without pelvic organ prolapse (pop). |
2021-08-20 |
2023-08-13 |
Not clear |
| Si-Yang Li, Jin Shang, Xiao-Mei Mao, Rui Fan, Hui-Qi Li, Rui-Han Li, Dong-Yan She. Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer. European journal of pharmacology. vol 908. 2021-08-20. PMID:34324855. |
here, we reported that dsg inhibited proliferation of crc cells in dose- and time-dependent manner, induced apoptosis by modulating p53 and bcl-2 family proteins expression to mediate mitochondrial apoptosis pathway, suppressed migration and invasion by reducing mmp-9 (matrix metalloproteinase) and decreased aerobic glycolysis by mediating glucose transporter (glut) like glut3 and glut4, and pyruvate carboxylase pc downregulation. |
2021-08-20 |
2023-08-13 |
mouse |
| Yu Ji, Michael A Garland, Bo Sun, Shuwen Zhang, Kurt Reynolds, Moira McMahon, Ratheya Rajakumar, Mohammad S Islam, Yue Liu, YiPing Chen, Chengji J Zho. Cellular and developmental basis of orofacial clefts. Birth defects research. vol 112. issue 19. 2021-08-18. PMID:32725806. |
the cellular basis of ofcs involves defective execution in any one or several of the following processes: neural crest induction, epithelial-mesenchymal transition, migration, proliferation, differentiation, apoptosis, primary cilia formation and its signaling transduction, epithelial seam formation and disappearance, periderm formation and peeling, convergence and extrusion of palatal epithelial seam cells, cell adhesion, cytoskeleton dynamics, and extracellular matrix function. |
2021-08-18 |
2023-08-13 |
Not clear |
| Yucong Xue, Muqing Zhang, Miaomiao Liu, Yu Liu, Li Li, Xue Han, Zhenqing Sun, Li Ch. 8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393792. |
8-gin also could lead to down-regulation of the activities of matrix metalloproteinases-9 (mmp-9), caspase-9, and bax protein, up-regulation of the activity of bcl-2 protein, and alleviation of cardiomyocyte apoptosis. |
2021-08-17 |
2023-08-13 |
mouse |
| Lingfeng Shi, Xiaoli Xu, Biying Meng, Kaiyue He, Yin Sun, Jiayue Tong, Jinling Xu, Yangyang Cheng, Guosheng Gan, Guangda Xian. Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice. Calcified tissue international. 2021-08-12. PMID:34383111. |
(3) murine recombinant nrg4 (rnrg4) suppressed inflammation and apoptosis of chondrocytes and decreased the degradation of extracellular matrix in vitro. |
2021-08-12 |
2023-08-13 |
mouse |