| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Litao Yan, Xing W. Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity. Cell biology and toxicology. vol 36. issue 2. 2021-06-10. PMID:31820164. |
the in vitro experiments indicated that both 2d-exos and 3d-exos can stimulate chondrocyte proliferation, migration, and matrix synthesis, and inhibit apoptosis, with 3d-exos exerting a stronger effect than 2d-exos. |
2021-06-10 |
2023-08-13 |
Not clear |
| Laura Seclì, Federica Fusella, Lidia Avalle, Mara Brancacci. The dark-side of the outside: how extracellular heat shock proteins promote cancer. Cellular and molecular life sciences : CMLS. vol 78. issue 9. 2021-06-09. PMID:33544155. |
ehsps are implicated in extracellular matrix remodelling, resistance to apoptosis, promotion of cell migration and invasion, induction of epithelial to mesenchymal transition, angiogenesis and activation of stromal cells, supporting ultimately, metastasis dissemination. |
2021-06-09 |
2023-08-13 |
Not clear |
| Ying Chen, Yingjie Xu, Zhoufeng Deng, Yin Wang, Ying Zheng, Weihua Jiang, Li Jian. MicroRNA expression profiling involved in doxorubicin-induced cardiotoxicity using high-throughput deep-sequencing analysis. Oncology letters. vol 22. issue 1. 2021-06-08. PMID:34093775. |
these mirnas were involved in the regulation of different pathways, whose functions included apoptosis, cell proliferation, extracellular matrix remodeling, oxidative stress and lipid metabolism. |
2021-06-08 |
2023-08-13 |
Not clear |
| Lin Qiu, Shaolei Yi, Tingting Yu, Yan Ha. Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells. Frontiers in cardiovascular medicine. vol 8. 2021-06-08. PMID:34095262. |
reactive oxygen species (ros) promote degradation of the extracellular matrix and vascular smooth muscle cell (vsmc) apoptosis. |
2021-06-08 |
2023-08-13 |
Not clear |
| Fangyuan Wang, Jingjing Li, Haixia Wang, Fan Zhang, Jin Ga. Activating transcription factor 3 inhibits endometrial carcinoma aggressiveness via JunB suppression. International journal of oncology. vol 57. issue 3. 2021-06-07. PMID:32582999. |
the properties of ec cells, including the expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, the cell cycle and apoptosis were all altered by overexpression of atf3. |
2021-06-07 |
2023-08-13 |
Not clear |
| Alan M Elder, Alexander R Stoller, Sarah A Black, Traci R Lyon. Macphatics and PoEMs in Postpartum Mammary Development and Tumor Progression. Journal of mammary gland biology and neoplasia. vol 25. issue 2. 2021-06-04. PMID:32535810. |
this event is characterized by apoptosis and lysosomal-mediated cell death of the majority of the lactational mammary epithelium, followed by remodeling of the extracellular matrix, influx of immune cell populations (in particular, t helper cells, monocytes, and macrophages), and neo-lymphangiogenesis. |
2021-06-04 |
2023-08-13 |
Not clear |
| Mingzhu Xu, Mengqiu Yi, Na L. MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling. Environmental toxicology. vol 36. issue 7. 2021-06-04. PMID:33835671. |
smoc2 regulated cell viability, apoptosis and extracellular matrix (ecm) deposition in ang ii-induced podocytes via tgfβ signaling, and smoc2 regulated inflammation in ang ii-induced podocytes through nf-κb signaling. |
2021-06-04 |
2023-08-13 |
Not clear |
| Christian David Hernández-Silva, Julio César Villegas-Pineda, Ana Laura Pereira-Suáre. Expression and Role of the G Protein-Coupled Estrogen Receptor (GPR30/GPER) in the Development and Immune Response in Female Reproductive Cancers. Frontiers in endocrinology. vol 11. 2021-06-03. PMID:32973677. |
besides, the g protein-coupled estrogen receptor (gper, formerly known as gpr30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, camp synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (egfr), and the subsequent activation of pi3k and mapk signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion. |
2021-06-03 |
2023-08-13 |
Not clear |
| Dorit Schleinitz, Kerstin Krause, Tobias Wohland, Claudia Gebhardt, Nicolas Linder, Michael Stumvoll, Matthias Blüher, Ingo Bechmann, Peter Kovacs, Martin Gericke, Anke Tönje. Identification of distinct transcriptome signatures of human adipose tissue from fifteen depots. European journal of human genetics : EJHG. vol 28. issue 12. 2021-06-02. PMID:32661330. |
moreover, the epicardial fat transcriptome was enriched for genes involved in extracellular matrix remodeling, inflammation, immune signaling, coagulation, thrombosis, beigeing, and apoptosis. |
2021-06-02 |
2023-08-13 |
human |
| Hiroyuki Jinnouchi, Yu Sato, Atsushi Sakamoto, Anne Cornelissen, Masayuki Mori, Rika Kawakami, Neel V Gadhoke, Frank D Kolodgie, Renu Virmani, Aloke V Fin. Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability. Atherosclerosis. vol 306. 2021-05-31. PMID:32654790. |
pro-inflammatory cytokines observed in unstable plaques may provoke an early phase of osteogenic differentiation of smooth muscle cells (smcs), a release of calcifying extracellular matrix vesicles, and/or induce apoptosis of macrophages and smcs, which also calcify. |
2021-05-31 |
2023-08-13 |
Not clear |
| Shishen Pei, Jinwei Ying, Yan Zhang, Linhao Su, Shi Cheng, Dike Rua. RhTSG-6 inhibits IL-1β-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells. Folia histochemica et cytobiologica. vol 58. issue 3. 2021-05-31. PMID:32936927. |
rhtsg-6 inhibits il-1β-induced extracellular matrix degradation and apoptosis by suppressing the p38, and jnk pathways in nucleus pulposus cells. |
2021-05-31 |
2023-08-13 |
human |
| Zhao-Hui Yu, Yi-Chao Ji, Kun Li, Ting Liang, Bo Liu, Hai-Lei Chen, Li Ni, Zong-Ping Luo, Hui-Lin Yan. Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein. Cellular signalling. vol 84. 2021-05-31. PMID:33862152. |
stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the trpv2 channel protein. |
2021-05-31 |
2023-08-13 |
Not clear |
| Anthony Matta, Vanessa Nader, Michel Galinier, Jerome Roncall. Transplantation of CD34+ cells for myocardial ischemia. World journal of transplantation. vol 11. issue 5. 2021-05-30. PMID:34046316. |
they have an important paracrine activity in secreting factors to stimulate vasculogenesis, reduce endothelial cells and cardiomyocytes apoptosis, remodel extracellular matrix and activate additional progenitor cells. |
2021-05-30 |
2023-08-13 |
Not clear |
| Hao-Yu Guo, Ming-Ke Guo, Zhong-Yuan Wan, Fang Song, Hai-Qiang Wan. Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review. Arthritis research & therapy. vol 22. issue 1. 2021-05-28. PMID:33198793. |
apoptosis, aberrant proliferation, extracellular matrix degradation, and inflammatory abnormality are tetrad fundamental pathologic phenotypes in idd. |
2021-05-28 |
2023-08-13 |
Not clear |
| Longhui Wang, Yuntao Gu, Hai Zhao, Rong Chen, Wensheng Chen, Hao Qi, Weisong Ga. Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-27. PMID:32841225. |
cell viability, extracellular matrix protein expression, catabolic factors, degree of apoptosis, inflammatory factors, and related signaling pathways were evaluated by western blotting, fluorescence immunostaining, tunel staining, and reverse transcription pcr. |
2021-05-27 |
2023-08-13 |
human |
| Wei Qi, Dong Ren, Pengcheng Wang, Zhaohui Song, Haotian Wu, Shuangquan Yao, Lindan Geng, Yunshan Su, Xiaoliang Ba. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of PI3K/Akt pathway. International immunopharmacology. vol 88. 2021-05-27. PMID:32866785. |
upregulation of sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1β-stimulated human nucleus pulposus cells through activation of pi3k/akt pathway. |
2021-05-27 |
2023-08-13 |
human |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
comparison of npc to control samples revealed upregulation of genes involved in inflammation (mmp3, thbs4), cytokine signalling (mmp3), extracellular matrix degradation (mmp3, ctsk), autophagy and apoptosis (ctsk, gpnmb, ptgis), immune response (akr1c3, rcan2, ptgis) and processes of neuronal development (rcan2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
downregulated genes were associated with cytoskeletal signalling (actg2, cnn1); inflammation and oxidative stress (cnn1); inhibition of cell proliferation, migration and differentiation; erk-mapk pathway (col4a1, col4a2, cpa4); cell adhesion (igfbp7); autophagy and apoptosis (cdh2, igfbp7, col4a2); neuronal function and development (csrp1); and extracellular matrix stability (plod2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Chih-Hung Guo, Simon Hsia, Chieh-Han Chung, Yi-Chun Lin, Min-Yi Shih, Pei-Chung Chen, Guoo-Shyng W Hsu, Ciou-Ting Fan, Chia-Lin Pen. Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice. Marine drugs. vol 19. issue 4. 2021-05-26. PMID:33805447. |
dose-dependent inhibition of down-stream targets including epithelial-to-mesenchymal transition transcription factors, nuclear cyclin and cyclin-dependent kinases, cancer stem cell markers, heat shock protein (hsp-90), hypoxia-inducible factors (hif-1α/-2α), matrix metalloprotease (mmp-9), and increased apoptosis were observed. |
2021-05-26 |
2023-08-13 |
mouse |
| Xingjia Mao, Yanyan Cao, Zijian Guo, Linlin Wang, Chuan Xian. Biological roles and therapeutic potential of circular RNAs in osteoarthritis. Molecular therapy. Nucleic acids. vol 24. 2021-05-26. PMID:34026329. |
recent studies have reported that various circrnas can delay or aggravate diverse aspects of the oa process, including extracellular matrix formation, apoptosis, proliferation, inflammation, and autophagy, via circrna/mirna/mrna pathways. |
2021-05-26 |
2023-08-13 |
Not clear |