| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiawei Jiang, Jinlong Zhang, Chunshuai Wu, Chu Chen, Guofeng Bao, Guanhua Xu, Pengfei Xue, Yong Zhou, Yuyu Sun, Zhiming Cu. Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis. Molecular and cellular biochemistry. vol 476. issue 4. 2021-07-14. PMID:33502650. |
knockdown of traf6 suppressed the expression of matrix metallopeptidase-13 (mmp-13) and interleukin-6 (il-6) induced by lps, and alleviated cell apoptosis. |
2021-07-14 |
2023-08-13 |
human |
| Xiaolei Chen, Ri Chen, Yang Xu, Chun Xi. PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL-1β-treated rat chondrocytes. FEBS open bio. vol 11. issue 2. 2021-07-13. PMID:33326693. |
plcγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in il-1β-treated rat chondrocytes. |
2021-07-13 |
2023-08-13 |
rat |
| Yu Sun, Jihang Dai, Rui Jiao, Qing Jiang, Jingcheng Wan. Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis. Journal of orthopaedic surgery and research. vol 16. issue 1. 2021-07-12. PMID:33407698. |
homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via pi3k/akt/mtor pathway-mediated apoptosis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Yijun Liu, Ding Zhao, Xue Wang, Ying Dong, Fupeng Din. LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis. Cell and tissue research. vol 385. issue 1. 2021-07-12. PMID:33783609. |
in addition, upregulation of kcnq1ot1 significantly enhanced the viability of osteoarthritic chondrocytes, inhibited cell apoptosis, and reduced the release of inflammatory cytokines and metal matrix enzymes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Yijun Liu, Ding Zhao, Xue Wang, Ying Dong, Fupeng Din. LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis. Cell and tissue research. vol 385. issue 1. 2021-07-12. PMID:33783609. |
we found that the expression of mir-218-5p was significantly upregulated in osteoarthritic chondrocytes, and knockdown of mir-218-5p significantly enhanced the viability of osteoarthritic chondrocytes, inhibited apoptosis, and decreased the abundance of inflammatory cytokines and metal matrix enzymes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
overexpression of wisp1 inhibited the proliferation of chondrocytes, which induced apoptosis, degradation of chondrocyte matrix, production of proinflammatory cytokines, and activated the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2021-07-09 |
2023-08-13 |
human |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
moreover, the pi3k allosteric activator 740 y-p abolished the inhibition of mir-128-3p in apoptosis, degradation of chondrocyte matrix, and inflammation. |
2021-07-09 |
2023-08-13 |
human |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
our results showed that mir-128-3p targets wisp1 to regulate chondrocyte proliferation, apoptosis, degradation of chondrocyte matrix, and production of proinflammatory cytokines via the pi3k/akt/nf-κb pathway, which plays a suppressed role in oa. |
2021-07-09 |
2023-08-13 |
human |
| Qubo Ni, Haitao Chen, Wei Li, Kaihang Lu, Bin Li, Yang Tan, Hui Wang, Liaobin Che. Pravastatin ameliorated osteoarthritis susceptibility in male offspring rats induced by prenatal ethanol exposure. Bone. vol 149. 2021-07-09. PMID:33915333. |
we found that pravastatin ameliorated papain-induced high expression of inflammatory factors [interleukin (il)-1, il-6], matrix degradation enzymes [matrix metalloproteinase (mmp)-3, mmp-13], and apoptosis factors (caspase-3 and caspase-8) in the cartilage of the pee group. |
2021-07-09 |
2023-08-13 |
rat |
| Seyed Ali Mosaddad, Yalda Salari, Samira Amookhteh, Reza Sayyad Soufdoost, Alexander Seifalian, Shahin Bonakdar, Fahimeh Safaeinejad, Mehrdad Moosazadeh Moghaddam, Hamid Tebyania. Response to Mechanical Cues by Interplay of YAP/TAZ Transcription Factors and Key Mechanical Checkpoints of the Cell: A Comprehensive Review. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 55. issue 1. 2021-07-08. PMID:33474906. |
for many years, growth factors have been considered as the pivotal cell behavior regulators, whereas recent studies emphasize also the key role of physical factors such as mechanical forces, cell shape, surface topographies, and extracellular matrix (ecm) in regulating the cell proliferation, apoptosis, differentiation, etc. |
2021-07-08 |
2023-08-13 |
Not clear |
| Eva Otoupalova, Sam Smith, Guangjie Cheng, Victor J Thannicka. Oxidative Stress in Pulmonary Fibrosis. Comprehensive Physiology. vol 10. issue 2. 2021-07-08. PMID:32163196. |
we discuss the recent findings on the role of reactive oxygen species (ros) in specific fibrotic processes such as macrophage polarization and immunosenescence, alveolar epithelial cell apoptosis and senescence, myofibroblast differentiation and senescence, and alterations in the acellular extracellular matrix. |
2021-07-08 |
2023-08-13 |
Not clear |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
the pathogenesis is complicated, and the main pathological changes are ivd cell apoptosis and extracellular matrix (ecm) degradation. |
2021-07-06 |
2023-08-13 |
Not clear |
| Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M Benneker, Lisbet Haglund, R Geoff Richards, Mauro Alini, Marianna Peroglio, Sibylle Gra. Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem cell research & therapy. vol 12. issue 1. 2021-07-05. PMID:33413584. |
in intervertebral disc (ivd) cells, application of msc secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ecm). |
2021-07-05 |
2023-08-13 |
Not clear |
| Rou Wan, Joshua P Weissman, Kendra Grundman, Lin Lang, Damian J Grybowski, Robert D Galian. Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 4. 2021-07-02. PMID:34157786. |
based on these studies, hyperglycaemic conditions can interfere with cytokine signalling pathways (such as growth factor-β pathway) affecting fibroblast differentiation, alter fibroblast apoptosis, dysregulate dermal lipolysis, and enhance hypoxia damage, thus leading to damaged microenvironment for myofibroblast formation, inappropriate extracellular matrix modulation, and weakened wound contraction. |
2021-07-02 |
2023-08-13 |
Not clear |
| Haitao Jiang, Jian Dai, Cheng Zhang, Hailang Sun, Xiaoming Tan. Circ_0045714 alleviates TNF-α-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis. Journal of bioenergetics and biomembranes. vol 53. issue 1. 2021-07-01. PMID:33394311. |
circ_0045714 expression was decreased in oa and tnf-α-induced chondrocytes, ectopic overexpression of circ_0045714 abolished tnf-α-induced cell apoptosis, inflammation, extracellular matrix (ecm) degradation promotion and proliferation inhibition. |
2021-07-01 |
2023-08-13 |
Not clear |
| Fengguang Yang, Jizu Wang, Zhixin Chen, Yuping Yang, Wenhui Zhang, Shifang Guo, Qingshan Yan. Role of microRNAs in intervertebral disc degeneration (Review). Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-29. PMID:34178133. |
abnormal expression of mirnas in the intervertebral disc is implicated in various pathological processes underlying the development of idd, including nucleus pulposus (np) cell (npc) proliferation, npc apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. |
2021-06-29 |
2023-08-13 |
Not clear |
| Manjunath Supriya, Rita Christopher, Bhagavatula Indira Devi, Dhananjaya Ishwar Bhat, Dhaval Shukla, Saligrama Ramegowda Kalpan. Altered MicroRNA Expression in Intracranial Aneurysmal Tissues: Possible Role in TGF-β Signaling Pathway. Cellular and molecular neurobiology. 2021-06-29. PMID:34185228. |
we suggest that mir-26b, mir-199a, mir-497and mir-365, could target multiple genes in tgf-β and mapk signaling cascades to influence inflammatory processes, extracellular matrix and vascular smooth muscle cell degradation and apoptosis, and ultimately cause vessel wall degradation and rupture. |
2021-06-29 |
2023-08-13 |
Not clear |
| Li Yue, Brian Vuong, Hongwei Yao, Brett D Owen. Doxycycline preserves chondrocyte viability and function in human and calf articular cartilage ex vivo. Physiological reports. vol 8. issue 17. 2021-06-28. PMID:32918797. |
incubation of doxycycline protects against chondrocyte apoptosis, reduced extracellular matrix, and impaired mechanical properties in cartilage plugs. |
2021-06-28 |
2023-08-13 |
human |
| Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo L. Heme oxygenase-1(HO-1) regulates Golgi stress and attenuates endotoxin-induced acute lung injury through hypoxia inducible factor-1α (HIF-1α)/HO-1 signaling pathway. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33493554. |
the knockout of heme oxygenase-1(ho-1) aggravated oxidative stress, inflammation, apoptosis and reduced the expression of golgi matrix protein 130 (gm130), mannosidase Ⅱ, golgi-associated protein golgin a1 (golgin 97), and increased the expression of golgi phosphoprotein 3 (golph3), which caused the fragmentation of golgi. |
2021-06-28 |
2023-08-13 |
Not clear |
| Yu Chen, Yukun Huang, Songlei Zhou, Minli Sun, Liang Chen, Jiahao Wang, Minjun Xu, Shanshan Liu, Kaifan Liang, Qian Zhang, Tianze Jiang, Qingxiang Song, Gan Jiang, Xuyi Tang, Xiaoling Gao, Jun Che. Tailored Chemodynamic Nanomedicine Improves Pancreatic Cancer Treatment via Controllable Damaging Neoplastic Cells and Reprogramming Tumor Microenvironment. Nano letters. vol 20. issue 9. 2021-06-24. PMID:32809834. |
pancreatic ductal adenocarcinoma (pdac) strongly resists standard therapies since kras-mutated cancer cells harbor endogenous resistance toward chemotherapy-induced apoptosis and tumor-associated macrophages (tams) activate stroma cells to create the nearly impenetrable matrix. |
2021-06-24 |
2023-08-13 |
Not clear |