| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhidi Lin, Feizhou Lu, Xiaosheng Ma, Xinlei Xia, Fei Zou, Jianyuan Jian. Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-05. PMID:34603518. |
furthermore, they play important roles in the pathogenesis of idd, including proliferation, apoptosis, senescence, mitophagy, inflammation and extracellular matrix metabolism, mainly by acting as sponges for micrornas. |
2021-10-05 |
2023-08-13 |
Not clear |
| Song Guo, Qihang Su, Junxiang Wen, Kai Zhu, Jun Tan, Qiang Fu, Guixin Su. S100A9 induces nucleus pulposus cell degeneration through activation of the NF-κB signaling pathway. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33734570. |
we concluded that s100a9 induced np cell apoptosis, caused matrix degradation and amplified the inflammatory response through the activation of the nf-κb signalling pathway. |
2021-10-04 |
2023-08-13 |
Not clear |
| Jicheng Wang, Bo Yang, Changkun Wu, Yongzhi Guo, Xin Jiang, Yangyang Zhan. Role of circular RNAs in osteoarthritis (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-02. PMID:34594416. |
various studies have confirmed that certain circrnas are differentially expressed in oa cartilage and are closely associated with a variety of pathological processes of oa, including extracellular matrix degradation, inflammation and apoptosis. |
2021-10-02 |
2023-08-13 |
Not clear |
| Jacek Rysz, Anna Gluba-Brzózka, Robert Rokicki, Beata Franczy. Oxidative Stress-Related Susceptibility to Aneurysm in Marfan's Syndrome. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572356. |
the results of studies have indicated that reactive oxygen species may be involved in smooth muscle cell phenotype switching and apoptosis as well as matrix metalloproteinase activation, resulting in extracellular matrix (ecm) remodeling. |
2021-10-01 |
2023-08-13 |
Not clear |
| Saima Ali, Muhammad Rashid Khan, Riffat Batool, Sayed Afzal Shah, Javed Iqbal, Banzeer Ahsan Abbasi, Tabassum Yaseen, Nida Zahra, Adil Aldhahrani, Fayez Althobait. Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities. Saudi journal of biological sciences. vol 28. issue 10. 2021-10-01. PMID:34588860. |
phm induced apoptosis via downregulation of anti-apoptotic (survivin, b-cell lymphoma extra-large; bcl-xl, x-linked inhibitor of apoptosis protein; xiap, myelocytomatosis; c-myc), metastatic (matrix metallopeptidases 9/2; mmp9/2), and cell-cycle regulatory (cyclin d1 and e) proteins, whereas upregulation of pro-apoptotic proteins (bcl-2 homologous antagonist/killer; bak, bcl-2-associate x protein; bax, cleaved caspases; 3,7,8,9, and parp) and activation of mapk (jun amino-terminal kinase; jnk and p38) pathway. |
2021-10-01 |
2023-08-13 |
Not clear |
| Wesam Bassiouni, John M Seubert, Richard Schul. Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2. Canadian journal of physiology and pharmacology. 2021-10-01. PMID:34597523. |
however, many calpain inhibitors also inhibit matrix metalloproteinase-2 (mmp-2) activity, an intracellular and extracellular protease implicated in apoptosis. |
2021-10-01 |
2023-08-13 |
human |
| Yizheng Wu, Zhenghua Hong, Wenbin Xu, Junxin Chen, Qingxin Wang, Jiaxin Chen, Weiyu Ni, Zixuan Mei, Ziang Xie, Yan Ma, Jiying Wang, Jianhong Lu, Chao Chen, Shunwu Fan, Shuying She. Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33125858. |
the knockdown of circpde4d predominantly contributed to aggrecan loss and the upregulation of matrix catabolic enzymes, including mmp3, mmp13, adamts4, and adamts5, but not proliferation or apoptosis. |
2021-09-30 |
2023-08-13 |
human |
| Chengxiao Hu, Yangyang Zuo, Qian Ren, Xiaoli Sun, Shan Zhou, Jinlin Liao, Xue Hong, Jinhua Miao, Lili Zhou, Youhua Li. Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling. Cell death & disease. vol 12. issue 1. 2021-09-29. PMID:33436543. |
matrix metalloproteinase-10 (mmp-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling. |
2021-09-29 |
2023-08-13 |
Not clear |
| Kaisong Bai, Tong Zhao, Yilong Li, Xinjian Li, Zhantian Zhang, Zuchao Du, Zimin Wang, Yan Xu, Bei Sun, Xuewei Ba. Integrating Genetic and Transcriptomic Data to Reveal Pathogenesis and Prognostic Markers of Pancreatic Adenocarcinoma. Frontiers in genetics. vol 12. 2021-09-29. PMID:34567094. |
the combination of mutation matrix and gene expression profiles identified 31 driver genes that were closely associated with tumor cell invasion and apoptosis. |
2021-09-29 |
2023-08-13 |
Not clear |
| Yiqiong Yang, Jing Wang, Yu Zhang, Xiuxiu Hu, Li Li, Pingsheng Che. Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p. Human cell. 2021-09-29. PMID:34585365. |
mscs-delivered mir-186-5p markedly reduced the accumulation of extracellular matrix (ecm) protein, and inhibited epithelial-to-mesenchymal transition (emt) and apoptosis in tgf-β1-stimulated nrk52e cells. |
2021-09-29 |
2023-08-13 |
mouse |
| Zhibin Zhou, Jun Ma, Jiajia Lu, Aimin Chen, Lei Zh. Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis. Journal of cellular physiology. vol 236. issue 5. 2021-09-28. PMID:33037617. |
the upregulation of circcdh13 in oa cartilage tissues significantly induces chondrocyte apoptosis, promotes extracellular matrix (ecm) catabolism, and inhibits ecm anabolism. |
2021-09-28 |
2023-08-13 |
mouse |
| Xiaoliang Mei, Hao Din, Jianning Zhao, Jian Tong, Wei Zh. Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34551684. |
the protein expression related to apoptosis, inflammation or extracellular matrix (ecm) degradation was detected by western blot. |
2021-09-27 |
2023-08-13 |
human |
| Maryam Abshirini, Bolaji Lilian Ilesanmi-Oyelere, Marlena C Kruge. Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism. Progress in lipid research. vol 83. 2021-09-24. PMID:34217732. |
omega-3 pufas reduce the expression of cartilage degrading enzyme matrix metalloproteinase-13 (mmp-13) and a disintegrin and metalloprotease with thrombospondin motifs-5 (adamts-5) protein, oxidative stress and thereby apoptosis via nuclear factor kappa-betta (nf-kβ) and inducible nitric oxide synthase (inos) pathways. |
2021-09-24 |
2023-08-13 |
Not clear |
| Tanzeela Awan, Aaron Babendreyer, Abid Mahmood Alvi, Stefan Düsterhöft, Daniela Lambertz, Jörg W Bartsch, Christian Liedtke, Andreas Ludwi. Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells. Journal of cellular and molecular medicine. vol 25. issue 4. 2021-09-23. PMID:33314720. |
these two complementary approaches revealed that adam8 expression levels correlated positively with proliferation, clonogenicity, migration and matrix invasion and negatively with apoptosis of hepatoma cells. |
2021-09-23 |
2023-08-13 |
human |
| Li Yang, Xiaoping Xu, Zhiyuan Chen, Yu Zhang, Hui Chen, Xiangyang Wan. miR-511-3p promotes hepatic sinusoidal obstruction syndrome by activating hedgehog pathway via targeting Ptch1. American journal of physiology. Gastrointestinal and liver physiology. vol 321. issue 3. 2021-09-23. PMID:34287088. |
depletion of mir-511-3p showed a protective effect against mct-induced hsos, as evidenced by decreased hsos pathogenesis factors, matrix metalloproteinases-2 (mmp-2), matrix metalloproteinases-9 (mmp-9), tumor necrosis factor-α (tnf-α), and interleukin 1 β (il-1β), and decreased lsec apoptosis rates. |
2021-09-23 |
2023-08-13 |
rat |
| Hui Long, Qin Li, Zhenping Xiao, Bo Yan. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway. Bioengineered. vol 12. issue 1. 2021-09-22. PMID:34187303. |
moreover, rescue experiments showed that mir22hg participated in the regulation of chondrocytes proliferation, apoptosis, and degradation of extracellular matrix via mir-9-3p/adamts5 pathway. |
2021-09-22 |
2023-08-13 |
human |
| Santosh Kumar, Qihua Duan, Rongxue Wu, Edward N Harris, Qiaozhu S. Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis. Advanced drug delivery reviews. vol 176. 2021-09-22. PMID:34280515. |
the progression of nafl to nash and liver fibrosis is closely associated with a series of liver injury resulting from lipotoxicity, oxidative stress, redox imbalance (excessive nitric oxide), er stress, inflammation and apoptosis that occur sequentially in different liver cells which ultimately leads to the activation of liver regeneration and fibrogenesis, augmenting collagen and extracellular matrix deposition and promoting liver fibrosis and cirrhosis. |
2021-09-22 |
2023-08-13 |
human |
| Xinwang Ying, Qingfeng Xie, Shengcun Li, Xiaolan Yu, Kecheng Zhou, Jingjing Yue, Xiaolong Chen, Wenzhan Tu, Guanhu Yang, Songhe Jian. Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury. Fluids and barriers of the CNS. vol 17. issue 1. 2021-09-21. PMID:33292360. |
the destruction of the bscb mediated by matrix metalloproteinases (mmps) leads to inflammation, neurotoxin production, and neuronal apoptosis. |
2021-09-21 |
2023-08-13 |
rat |
| Jinsong Kong, Jiacheng Wang, Xiaokang Gong, Xin Zheng, Tao Che. Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis. Drug design, development and therapy. vol 14. 2021-09-21. PMID:33364748. |
punicalagin inhibits tert-butyl hydroperoxide-induced apoptosis and extracellular matrix degradation in chondrocytes by activating autophagy and ameliorates murine osteoarthritis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Congmeng Lin, Dabing Chen, Tingting Xiao, Dandan Lin, Dayi Lin, Luhui Lin, Haojie Zhu, Jingjing Xu, Wenwen Huang, Ting Yan. DNA methylation-mediated silencing of microRNA-204 enhances T cell acute lymphoblastic leukemia by up-regulating MMP-2 and MMP-9 via NF-κB. Journal of cellular and molecular medicine. vol 25. issue 5. 2021-09-21. PMID:33566449. |
moreover, overexpression of mir-204 inhibited t-all cell proliferation while enhancing their apoptosis through interleukin receptor-associated kinase 1 (irak1), which enhanced the expression of matrix metalloproteinase-2 (mmp-2) and mmp-9 through activation of p-p65. |
2021-09-21 |
2023-08-13 |
Not clear |