| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhilin Cao, Wenguang Liu, Xiaoyi Qu, Haiyong Bi, Xiujiang Sun, Qian Yu, Gong Chen. miR-296-5p inhibits IL-1β-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-β1/CTGF/p38MAPK pathway. Cell cycle (Georgetown, Tex.). vol 19. issue 12. 2021-08-26. PMID:32378978. |
overexpressed mir-296-5p enhanced cell proliferation and inhibited apoptosis and matrix degrading enzyme expression in response to il-1β stimulation, and knockdown of mir-296-5p showed the opposite effect. |
2021-08-26 |
2023-08-13 |
human |
| E Boloori, T Schoenmaker, C J Kleverlaan, B G Loos, T J de Vrie. Gingival epithelium attachment to well- or partially cured resin composites. European cells & materials. vol 40. 2021-08-25. PMID:33242338. |
effects of resin composite on the ca9-22 gingival epithelial cell-line were assessed by measuring the cytotoxicity, viability and gene expression for attachment, apoptosis, ros-production, pro-inflammatory cytokines, and matrix metalloproteinases. |
2021-08-25 |
2023-08-13 |
cattle |
| Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-Tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Rua. Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33437038. |
lsi administration led to the histologic change of disc degeneration, disruption of the matrix metabolism, promotion of apoptosis of ivd cells and invasion of sensory nerves into annulus fibrosus, as well as induction of pyroptosis. |
2021-08-25 |
2023-08-13 |
mouse |
| Oona Paavolainen, Emilia Peuh. Integrin-mediated adhesion and mechanosensing in the mammary gland. Seminars in cell & developmental biology. vol 114. 2021-08-23. PMID:33187835. |
morphological changes in the mammary epithelium involve cell proliferation, differentiation, apoptosis, and migration which, in turn, are affected by cell adhesion to the extracellular matrix (ecm). |
2021-08-23 |
2023-08-13 |
Not clear |
| Shengqiang Fu, Qiaoyun Fan, Juntao Xu, Shengjun Yu, Ming Sun, Yuan Ji, Dun Li. Circ_0008956 contributes to IL-1β-induced osteoarthritis progression via miR-149-5p/NAMPT axis. International immunopharmacology. vol 98. 2021-08-23. PMID:34153672. |
cell viability, apoptosis, cell cycle and extracellular matrix (ecm) degradation were analyzed using cell counting kit-8, flow cytometry, and western blot assays, respectively. |
2021-08-23 |
2023-08-13 |
Not clear |
| Liang Tan, Yifang Xie, Ye Yuan, Kai H. LncRNA GAS5 as miR-26a-5p Sponge Regulates the PTEN/PI3K/Akt Axis and Affects Extracellular Matrix Synthesis in Degenerative Nucleus Pulposus Cells Frontiers in neurology. vol 12. 2021-08-21. PMID:34413821. |
lncrna gas5 as mir-26a-5p sponge regulates the pten/pi3k/akt axis and affects extracellular matrix synthesis in degenerative nucleus pulposus cells the role of lncrna growth arrest specific 5 (gas5) in degenerative nucleus pulposus cell (npc) apoptosis has been reported, but the mechanism of gas5 in extracellular matrix (ecm) synthesis in intervertebral disc degeneration (idd) remains unknown. |
2021-08-21 |
2023-08-13 |
Not clear |
| Ya-Pei Zhu, Ting Xie, Tao Guo, Zhi-Jing Sun, Lan Zhu, Jing-He Lan. Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. International urogynecology journal. vol 32. issue 8. 2021-08-20. PMID:32737532. |
evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. |
2021-08-20 |
2023-08-13 |
Not clear |
| Ya-Pei Zhu, Ting Xie, Tao Guo, Zhi-Jing Sun, Lan Zhu, Jing-He Lan. Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse. International urogynecology journal. vol 32. issue 8. 2021-08-20. PMID:32737532. |
this study aimed to compare the expression levels of extracellular matrix (ecm) and apoptosis proteins in the uterosacral ligament (usl) of patients with and without pelvic organ prolapse (pop). |
2021-08-20 |
2023-08-13 |
Not clear |
| Si-Yang Li, Jin Shang, Xiao-Mei Mao, Rui Fan, Hui-Qi Li, Rui-Han Li, Dong-Yan She. Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer. European journal of pharmacology. vol 908. 2021-08-20. PMID:34324855. |
here, we reported that dsg inhibited proliferation of crc cells in dose- and time-dependent manner, induced apoptosis by modulating p53 and bcl-2 family proteins expression to mediate mitochondrial apoptosis pathway, suppressed migration and invasion by reducing mmp-9 (matrix metalloproteinase) and decreased aerobic glycolysis by mediating glucose transporter (glut) like glut3 and glut4, and pyruvate carboxylase pc downregulation. |
2021-08-20 |
2023-08-13 |
mouse |
| Yu Ji, Michael A Garland, Bo Sun, Shuwen Zhang, Kurt Reynolds, Moira McMahon, Ratheya Rajakumar, Mohammad S Islam, Yue Liu, YiPing Chen, Chengji J Zho. Cellular and developmental basis of orofacial clefts. Birth defects research. vol 112. issue 19. 2021-08-18. PMID:32725806. |
the cellular basis of ofcs involves defective execution in any one or several of the following processes: neural crest induction, epithelial-mesenchymal transition, migration, proliferation, differentiation, apoptosis, primary cilia formation and its signaling transduction, epithelial seam formation and disappearance, periderm formation and peeling, convergence and extrusion of palatal epithelial seam cells, cell adhesion, cytoskeleton dynamics, and extracellular matrix function. |
2021-08-18 |
2023-08-13 |
Not clear |
| Yucong Xue, Muqing Zhang, Miaomiao Liu, Yu Liu, Li Li, Xue Han, Zhenqing Sun, Li Ch. 8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393792. |
8-gin also could lead to down-regulation of the activities of matrix metalloproteinases-9 (mmp-9), caspase-9, and bax protein, up-regulation of the activity of bcl-2 protein, and alleviation of cardiomyocyte apoptosis. |
2021-08-17 |
2023-08-13 |
mouse |
| Lingfeng Shi, Xiaoli Xu, Biying Meng, Kaiyue He, Yin Sun, Jiayue Tong, Jinling Xu, Yangyang Cheng, Guosheng Gan, Guangda Xian. Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice. Calcified tissue international. 2021-08-12. PMID:34383111. |
(3) murine recombinant nrg4 (rnrg4) suppressed inflammation and apoptosis of chondrocytes and decreased the degradation of extracellular matrix in vitro. |
2021-08-12 |
2023-08-13 |
mouse |
| Alexandra Z Crawford, Jie Zhang, Akilesh Gokul, Charles N J McGhee, Sue E Ormond. The Enigma of Environmental Factors in Keratoconus. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). vol 9. issue 6. 2021-08-10. PMID:33284230. |
the first 4 factors can induce ocular surface inflammation, matrix metalloproteinase release, and keratocyte apoptosis, consistent with the postulated etiology of keratoconus. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yan Zhou, David Lagare. Methods for Studying Myofibroblast Apoptotic Pathways. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028739. |
evasion of apoptosis by myofibroblasts is a hallmark of fibrotic diseases, ultimately leading to persistent myofibroblast activation, extracellular matrix (ecm) deposition, and remodeling. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yan Zhou, David Lagare. Methods for Studying Myofibroblast Apoptotic Pathways. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028739. |
we have recently discovered that in the process of fibroblast-to-myofibroblast transdifferentiation driven by matrix stiffness, the "mitochondrial priming" (readiness to undergo apoptosis) is dramatically increased in stiffness-activated myofibroblasts. |
2021-08-10 |
2023-08-13 |
Not clear |
| Volha I Summerhill, Vasily N Sukhorukov, Ali H Eid, Ludmila V Nedosugova, Igor A Sobenin, Alexander N Orekho. Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations. Biomolecular concepts. vol 12. issue 1. 2021-08-09. PMID:34115932. |
the pathogenesis of aaa involves several biological processes, including aortic mural inflammation, oxidative stress, vascular smooth muscle cell apoptosis, elastin depletion, and degradation of the extracellular matrix. |
2021-08-09 |
2023-08-13 |
Not clear |
| Roman Pawla. Vitamin B12 status is a risk factor for bone fractures among vegans. Medical hypotheses. vol 153. 2021-08-09. PMID:34116377. |
the detrimental impact of inadequate b12 status on bone tissue is both direct, via the impairment of the insulin-like growth hormone 1 and taurine synthesis, and indirect, induced through its hyperhomocysteinemic effect, via at least the following mechanisms: 1) reducing bone mineral content and density by accumulating in the extracellular matrix, 2) reducing osteoblasts and increasing osteoclasts function, 3) reducing blood flow to bone tissue, 4) inducing apoptosis via the reactive oxygen-species-mediated mitochondrial pathway, and 5) obstructing the formation of collagen cross-links, impeding lyslyl oxidase, and hampering insolubility of fibrils. |
2021-08-09 |
2023-08-13 |
Not clear |
| Takeshi Uemura, Takehiro Suzuki, Kenta Ko, Mizuho Nakamura, Naoshi Dohmae, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarash. Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction. Cytoskeleton (Hoboken, N.J.). vol 77. issue 10. 2021-08-04. PMID:33070462. |
these findings indicate that a dysfunction of the cytoskeleton by acrolein is strongly involved in the tissue damage during brain infarction, together with the apoptosis caused by glyceraldehyde-3-phosphate dehydrogenase and protein degradation by matrix metalloproteinase-9. |
2021-08-04 |
2023-08-13 |
mouse |
| Anastasiya Muntyanu, Michelle Le, Zainab Ridha, Elizabeth O'Brien, Ivan V Litvinov, Philippe Lefrançois, Elena Netchiporou. Novel role of long non-coding RNAs in autoimmune cutaneous disease. Journal of cell communication and signaling. 2021-08-04. PMID:34346026. |
in ssc, negative regulator of ifn response (nrir) was thought to modulate interferon (ifn) response in monocytes, anti-sense gene to x-inactivation specific transcript (tsix) to regulate increased collagen stability, hox transcript antisense rna (hotair) to increase numbers of myofibroblasts, otud6b-anti-sense rna 1 to decrease fibroblast apoptosis, ncrna00201 to regulate pathways in ssc pathogenesis and carcinogenesis, h19x potentiating tgf-β-driven extracellular matrix production, and finally psmb8-as1 potentiates ifn response. |
2021-08-04 |
2023-08-13 |
Not clear |
| Olivier Schussler, Juan C Chachques, Marco Alifano, Yves Lecarpentie. Key Roles of RGD-Recognizing Integrins During Cardiac Development, on Cardiac Cells, and After Myocardial Infarction. Journal of cardiovascular translational research. 2021-08-03. PMID:34342855. |
cardiac cells interact with the extracellular matrix (ecm) proteins through integrin mechanoreceptors that control many cellular events such as cell survival, apoptosis, differentiation, migration, and proliferation. |
2021-08-03 |
2023-08-13 |
Not clear |