| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Lv, Longbiao Yang, Jianxiu Wang, Zhixiang Chen, Qizhao Sun, Peiguo Zhang, Chentong Guan, Yanbin Li. Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway. Neurochemical research. vol 46. issue 6. 2021-10-12. PMID:33713325. |
intervertebral disc degeneration (idd) is accompanied by nucleus pulposus (np) cell apoptosis, inflammation, and extracellular matrix degradation. |
2021-10-12 |
2023-08-13 |
human |
| Ling Dong, Bo Don. miR-489-3p overexpression inhibits lipopolysaccharide-induced nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via targeting Toll-like receptor 4. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630677. |
mir-489-3p overexpression inhibits lipopolysaccharide-induced nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via targeting toll-like receptor 4. |
2021-10-12 |
2023-08-13 |
human |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the brd7-pi3k-yap1 signaling axis. |
2021-10-11 |
2023-08-13 |
human |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
in addition, pi3k inhibition augmented matrix degradation, enhanced apoptosis, and reduced yap1 expression, whereas yap1 overexpression promoted matrix synthesis, suppressed apoptosis and promoted pi3k expression. |
2021-10-11 |
2023-08-13 |
human |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
in summary, our results demonstrate that brd7 can regulate matrix metabolism and apoptosis in human np cells through the brd7-pi3k-yap1 signaling axis. |
2021-10-11 |
2023-08-13 |
human |
| Xipeng Wang, Xiaoping Zhang, Tao Qiu, Yang Yang, Qingle Li, Xiaoming Zhan. Dexamethasone reduces the formation of thoracic aortic aneurysm and dissection in a murine model. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34118251. |
dex reduced infiltration of macrophages and neutrophils, apoptosis of vascular smooth muscle cells (vsmcs), expression of metalloproteinase 2/9, and extracellular matrix degradation in bapn-treated taad mice. |
2021-10-11 |
2023-08-13 |
mouse |
| Ning Gao, Yuzhen Zhang, Lei Lei, Li Li, Ping Cao, Xuan Zhao, Lin Lin, Rui X. Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 43. issue 11. 2021-10-11. PMID:32439914. |
increased extracellular matrix of the glomerulus and an increased glomerular sclerosis index, podocyte foot process effacement and fusion, as well as increased podocyte apoptosis, were observed in the hhcy group compared with the control group; these effects were associated with increased expression of nox2 and nox4 and decreased nephrin expression in renal tissue from shrs with hhcy. |
2021-10-11 |
2023-08-13 |
rat |
| Chetan, Uthirapathy Vijayalakshm. A systematic review of the interaction and effects generated by antimicrobial metallic substituents in bone tissue engineering. Metallomics : integrated biometal science. vol 12. issue 10. 2021-10-08. PMID:32744267. |
although most of these elements interact with genetic material, resulting in denaturation to produce apoptosis of pathogenic cells, some create adverse effects in the cellular matrix, which interfere with normal cellular metabolism and inhibit cellular activity, reducing the further growth and formation of bacterial colonies. |
2021-10-08 |
2023-08-13 |
human |
| Yan Zhou, Jianghua Ming, Ming Deng, Yaming Li, Bochun Li, Jia Li, Yonggang Ma, Zhonghui Chen, Guirong Wang, Shiqing Li. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. Journal of molecular medicine (Berlin, Germany). vol 98. issue 10. 2021-10-08. PMID:32860098. |
herein, we aim to assess the chondroprotective effect and underlying mechanisms of a novel chemically modified curcumin, cmc2.24, in modulating extracellular matrix (ecm) homeostasis and inhibiting chondrocyte apoptosis. |
2021-10-08 |
2023-08-13 |
rat |
| Yan Zhou, Jianghua Ming, Ming Deng, Yaming Li, Bochun Li, Jia Li, Yonggang Ma, Zhonghui Chen, Guirong Wang, Shiqing Li. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. Journal of molecular medicine (Berlin, Germany). vol 98. issue 10. 2021-10-08. PMID:32860098. |
results from in vivo studies demonstrated that the intra-articular administration of cmc2.24 ameliorated osteoarthritic cartilage destruction by promoting collagen 2a1 production and inhibited cartilage degradation and apoptosis by suppressing hypoxia-inducible factor-2a (hif-2α), matrix metalloproteinase-3, runt-related transcription factor 2, cleaved caspase-3, and vascular endothelial growth factor and the phosphorylation of iκbα and nf-κb p65. |
2021-10-08 |
2023-08-13 |
rat |
| Jingbo Zhou, Shu Zhang, Xinyi Sun, Yan Lou, Jinjing Bao, Jiangyi Y. Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. Journal of pharmacological sciences. vol 146. issue 1. 2021-10-06. PMID:33858650. |
western blot analysis was conducted for detection of extracellular matrix accumulation, inflammatory response and cell apoptosis. |
2021-10-06 |
2023-08-13 |
mouse |
| Bei Zhao, Jun Xie, Xiyuan Zhou, Lixia Zhang, Xiankui Cheng, Chenglin Lian. YAP activation in melanoma contributes to anoikis resistance and metastasis. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 8. 2021-10-05. PMID:33307801. |
anoikis resistance is a hallmark feature of metastatic melanoma to escape apoptosis when cells lose contact with adjacent cells or extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |
| Zhidi Lin, Feizhou Lu, Xiaosheng Ma, Xinlei Xia, Fei Zou, Jianyuan Jian. Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-05. PMID:34603518. |
furthermore, they play important roles in the pathogenesis of idd, including proliferation, apoptosis, senescence, mitophagy, inflammation and extracellular matrix metabolism, mainly by acting as sponges for micrornas. |
2021-10-05 |
2023-08-13 |
Not clear |
| Song Guo, Qihang Su, Junxiang Wen, Kai Zhu, Jun Tan, Qiang Fu, Guixin Su. S100A9 induces nucleus pulposus cell degeneration through activation of the NF-κB signaling pathway. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33734570. |
we concluded that s100a9 induced np cell apoptosis, caused matrix degradation and amplified the inflammatory response through the activation of the nf-κb signalling pathway. |
2021-10-04 |
2023-08-13 |
Not clear |
| Jicheng Wang, Bo Yang, Changkun Wu, Yongzhi Guo, Xin Jiang, Yangyang Zhan. Role of circular RNAs in osteoarthritis (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-02. PMID:34594416. |
various studies have confirmed that certain circrnas are differentially expressed in oa cartilage and are closely associated with a variety of pathological processes of oa, including extracellular matrix degradation, inflammation and apoptosis. |
2021-10-02 |
2023-08-13 |
Not clear |
| Jacek Rysz, Anna Gluba-Brzózka, Robert Rokicki, Beata Franczy. Oxidative Stress-Related Susceptibility to Aneurysm in Marfan's Syndrome. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572356. |
the results of studies have indicated that reactive oxygen species may be involved in smooth muscle cell phenotype switching and apoptosis as well as matrix metalloproteinase activation, resulting in extracellular matrix (ecm) remodeling. |
2021-10-01 |
2023-08-13 |
Not clear |
| Saima Ali, Muhammad Rashid Khan, Riffat Batool, Sayed Afzal Shah, Javed Iqbal, Banzeer Ahsan Abbasi, Tabassum Yaseen, Nida Zahra, Adil Aldhahrani, Fayez Althobait. Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities. Saudi journal of biological sciences. vol 28. issue 10. 2021-10-01. PMID:34588860. |
phm induced apoptosis via downregulation of anti-apoptotic (survivin, b-cell lymphoma extra-large; bcl-xl, x-linked inhibitor of apoptosis protein; xiap, myelocytomatosis; c-myc), metastatic (matrix metallopeptidases 9/2; mmp9/2), and cell-cycle regulatory (cyclin d1 and e) proteins, whereas upregulation of pro-apoptotic proteins (bcl-2 homologous antagonist/killer; bak, bcl-2-associate x protein; bax, cleaved caspases; 3,7,8,9, and parp) and activation of mapk (jun amino-terminal kinase; jnk and p38) pathway. |
2021-10-01 |
2023-08-13 |
Not clear |
| Wesam Bassiouni, John M Seubert, Richard Schul. Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2. Canadian journal of physiology and pharmacology. 2021-10-01. PMID:34597523. |
however, many calpain inhibitors also inhibit matrix metalloproteinase-2 (mmp-2) activity, an intracellular and extracellular protease implicated in apoptosis. |
2021-10-01 |
2023-08-13 |
human |
| Yizheng Wu, Zhenghua Hong, Wenbin Xu, Junxin Chen, Qingxin Wang, Jiaxin Chen, Weiyu Ni, Zixuan Mei, Ziang Xie, Yan Ma, Jiying Wang, Jianhong Lu, Chao Chen, Shunwu Fan, Shuying She. Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33125858. |
the knockdown of circpde4d predominantly contributed to aggrecan loss and the upregulation of matrix catabolic enzymes, including mmp3, mmp13, adamts4, and adamts5, but not proliferation or apoptosis. |
2021-09-30 |
2023-08-13 |
human |
| Chengxiao Hu, Yangyang Zuo, Qian Ren, Xiaoli Sun, Shan Zhou, Jinlin Liao, Xue Hong, Jinhua Miao, Lili Zhou, Youhua Li. Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling. Cell death & disease. vol 12. issue 1. 2021-09-29. PMID:33436543. |
matrix metalloproteinase-10 (mmp-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling. |
2021-09-29 |
2023-08-13 |
Not clear |