| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Chen, Zhenhong Ni, Junlan Huang, Ruobin Zhang, Jinfan Zhang, Bin Zhang, Liang Kuang, Xianding Sun, Dali Zhang, Nan Su, Huabing Qi, Jing Yang, Min Jin, Fengtao Luo, Hangang Chen, Siru Zhou, Xiaolan Du, Junjie Ouyang, Zuqiang Wang, Yangli Xie, Qiaoyan Tan, Lin Che. Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. International journal of biological sciences. vol 17. issue 15. 2021-11-24. PMID:34803488. |
further studies showed that dex leads to calcification of extracellular matrix of chondrocytes partially through activation of akt, as well as promotes apoptosis of chondrocytes in calcified cartilage layer. |
2021-11-24 |
2023-08-13 |
mouse |
| b' Oskar Zakiyanov, Marta Kalousov\\xc3\\xa1, Tom\\xc3\\xa1\\xc5\\xa1 Zima, Vladim\\xc3\\xadr Tesa\\xc5\\x9. Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease. Advances in clinical chemistry. vol 105. 2021-11-24. PMID:34809827.' |
mmps function in close interaction with the endogenous tissue inhibitors of matrix metalloproteinases (timps), both of which regulate cell turnover, modulate various growth factors, and participate in the progression of tissue fibrosis and apoptosis. |
2021-11-24 |
2023-08-13 |
Not clear |
| Zhen Lin, Libin Ni, Cheng Teng, Zhao Zhang, Long Wu, Yu Jin, Xinlei Lu, Zhongke Li. Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-11-23. PMID:34805156. |
eicosapentaenoic acid-induced autophagy attenuates intervertebral disc degeneration by suppressing endoplasmic reticulum stress, extracellular matrix degradation, and apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Xingmei Luo, Jing Wu, Guofeng W. PPARγ activation suppresses the expression of MMP9 by downregulating NF-κB post intracerebral hemorrhage. Neuroscience letters. vol 752. 2021-11-22. PMID:33636289. |
we have previously reported that rosiglitazone, an agonist of pparγ, was effective to prevent microglia from apoptosis and ameliorate neuronal injuries post intracerebral hemorrhage (ich) with suppression of matrix metalloproteinase-9 (mmp9) expression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Raziyeh Abooshahab, Hani Al-Salami, Crispin R Das. The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target. Biochemical pharmacology. vol 193. 2021-11-22. PMID:34571004. |
it has been ascertained that pedf regulates multiple metastatic processes through various plausible mechanisms, including inhibiting angiogenesis, inducing apoptosis, stimulating extracellular matrix (ecm) degradation, and suppressing the epithelial-to-mesenchymal transition (emt) process. |
2021-11-22 |
2023-08-13 |
Not clear |
| Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng, Jing-Hong Che. Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology. vol 464. 2021-11-22. PMID:34673134. |
t-2 toxin leads to chondrocyte apoptosis and excessive extracellular matrix degradation. |
2021-11-22 |
2023-08-13 |
rat |
| Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng, Jing-Hong Che. Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology. vol 464. 2021-11-22. PMID:34673134. |
this study found that the expressions of grp78, chop, and caspase-12 is higher in t-2 toxin group than in control group both in vivo and in vitro, and the t-2 toxin administration promoted chondrocyte apoptosis, suppressed matrix synthesis, and accelerated cellular catabolism via the ers signaling pathway. |
2021-11-22 |
2023-08-13 |
rat |
| Shuai Hu, Sheng Wang, Jie He, Yangyang Bia. Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes. Molecular medicine reports. vol 25. issue 1. 2021-11-22. PMID:34779501. |
excessive apoptosis of chondrocytes and degradation of the extracellular matrix (ecm) contribute to the typical pathological characteristics of osteoarthritis (oa). |
2021-11-22 |
2023-08-13 |
rat |
| Shaojiong Zhou, Shuo Liu, Xiaoqiang Liu, Weiduan Zhuan. Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke. Journal of molecular neuroscience : MN. vol 71. issue 5. 2021-11-19. PMID:33155176. |
inflammation, immunity, extracellular matrix degradation, blood coagulation, apoptosis and nerve degeneration were the primary physiopathological processes in uap-related stroke. |
2021-11-19 |
2023-08-13 |
Not clear |
| Fabrizio Luppi, Meena Kalluri, Paola Faverio, Michael Kreuter, Giovanni Ferrar. Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management. Respiratory research. vol 22. issue 1. 2021-11-19. PMID:33865386. |
ageing and senescence, through interactions with environmental factors, may contribute to the pathogenesis of ipf by various mechanisms, causing lung epithelium damage and increasing the resistance of myofibroblasts to apoptosis, eventually resulting in extracellular matrix accumulation and pulmonary fibrosis. |
2021-11-19 |
2023-08-13 |
human |
| Zhou Cai, Jianhua Huang, Junxiao Yang, Baihong Pan, Wei Wang, Yangyang Ou, Xianwei Wang, Pu Yan. LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. Bosnian journal of basic medical sciences. vol 21. issue 3. 2021-11-18. PMID:32903173. |
lncrna sencr suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. |
2021-11-18 |
2023-08-13 |
Not clear |
| Zhou Cai, Jianhua Huang, Junxiao Yang, Baihong Pan, Wei Wang, Yangyang Ou, Xianwei Wang, Pu Yan. LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. Bosnian journal of basic medical sciences. vol 21. issue 3. 2021-11-18. PMID:32903173. |
in vivo, overexpression of sencr improved the pathological change in aortic tissues and the damage in arterial wall elastic fibers induced by ang-ii, as well as suppressed ang-ii-induced cell apoptosis and extracellular matrix degradation. |
2021-11-18 |
2023-08-13 |
Not clear |
| Zhou Cai, Jianhua Huang, Junxiao Yang, Baihong Pan, Wei Wang, Yangyang Ou, Xianwei Wang, Pu Yan. LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. Bosnian journal of basic medical sciences. vol 21. issue 3. 2021-11-18. PMID:32903173. |
overexpression of sencr inhibited aaa formation via inhibition of vsmc apoptosis and extracellular matrix degradation. |
2021-11-18 |
2023-08-13 |
Not clear |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
results showed that quercetin could reduce lps-induced c28/i2 cell apoptosis, extracellular matrix (ecm) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (nlr) family, pyrin domain-containing 3 (nlrp3) revealed that quercetin reduced chondrocyte apoptosis and ecm degradation by inhibiting nlrp3-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Zheng Zheng, Yan Chen, Yinzhou Wang, Yongkun Li, Qiong Chen. MicroRNA-513b-5p targets COL1A1 and COL1A2 associated with the formation and rupture of intracranial aneurysm. Scientific reports. vol 11. issue 1. 2021-11-17. PMID:34290266. |
the effects of the mir-513b-5p mimic and inhibitor on the proliferation, apoptosis, and death of hasmc and the rip1-rip3-mlkl and matrix metalloproteinase pathways were also explored. |
2021-11-17 |
2023-08-13 |
human |
| Kai Sun, Xingzhi Jing, Jiachao Guo, Xudong Yao, Fengjing Gu. Mitophagy in degenerative joint diseases. Autophagy. vol 17. issue 9. 2021-11-16. PMID:32967533. |
ivdd and oa are similar joint diseases involving the degradation of cartilaginous tissues that are mainly caused by oxidative stress, cell apoptosis and extracellular matrix (ecm) degradation. |
2021-11-16 |
2023-08-13 |
Not clear |
| Suman Dalal, Paige L Shook, Mahipal Singh, Krishna Sing. Cardioprotective Potential of Exogenous Ubiquitin. Cardiovascular drugs and therapy. vol 35. issue 6. 2021-11-15. PMID:32910339. |
recent studies provide evidence for cardioprotective potential of exogenous ub in the remodeling process of the heart in ihd, including effects on cardiac myocyte apoptosis, inflammatory response, and reorganization of the vasculature and extracellular matrix. |
2021-11-15 |
2023-08-13 |
Not clear |
| Kaiqiang Sun, Jian Zhu, Jingchuan Sun, Xiaofei Sun, Le Huan, Bin Zhang, Feng Lin, Bing Zheng, Jialin Jiang, Xi Luo, Ximing Xu, Jiangang Sh. Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation. Cell cycle (Georgetown, Tex.). vol 20. issue 10. 2021-11-15. PMID:33966606. |
neuropeptide y prevents nucleus pulposus cells from cell apoptosis and il‑1β‑induced extracellular matrix degradation. |
2021-11-15 |
2023-08-13 |
human |
| Kaiqiang Sun, Jian Zhu, Jingchuan Sun, Xiaofei Sun, Le Huan, Bin Zhang, Feng Lin, Bing Zheng, Jialin Jiang, Xi Luo, Ximing Xu, Jiangang Sh. Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation. Cell cycle (Georgetown, Tex.). vol 20. issue 10. 2021-11-15. PMID:33966606. |
rat nucleus pulposus (np) cells were used to investigate the effect of npy on the proliferation, apoptosis, and extracellular matrix (ecm) in np cell induced by il-1βin vitro. |
2021-11-15 |
2023-08-13 |
human |