| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaisong Bai, Tong Zhao, Yilong Li, Xinjian Li, Zhantian Zhang, Zuchao Du, Zimin Wang, Yan Xu, Bei Sun, Xuewei Ba. Integrating Genetic and Transcriptomic Data to Reveal Pathogenesis and Prognostic Markers of Pancreatic Adenocarcinoma. Frontiers in genetics. vol 12. 2021-09-29. PMID:34567094. |
the combination of mutation matrix and gene expression profiles identified 31 driver genes that were closely associated with tumor cell invasion and apoptosis. |
2021-09-29 |
2023-08-13 |
Not clear |
| Yiqiong Yang, Jing Wang, Yu Zhang, Xiuxiu Hu, Li Li, Pingsheng Che. Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p. Human cell. 2021-09-29. PMID:34585365. |
mscs-delivered mir-186-5p markedly reduced the accumulation of extracellular matrix (ecm) protein, and inhibited epithelial-to-mesenchymal transition (emt) and apoptosis in tgf-β1-stimulated nrk52e cells. |
2021-09-29 |
2023-08-13 |
mouse |
| Zhibin Zhou, Jun Ma, Jiajia Lu, Aimin Chen, Lei Zh. Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis. Journal of cellular physiology. vol 236. issue 5. 2021-09-28. PMID:33037617. |
the upregulation of circcdh13 in oa cartilage tissues significantly induces chondrocyte apoptosis, promotes extracellular matrix (ecm) catabolism, and inhibits ecm anabolism. |
2021-09-28 |
2023-08-13 |
mouse |
| Xiaoliang Mei, Hao Din, Jianning Zhao, Jian Tong, Wei Zh. Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34551684. |
the protein expression related to apoptosis, inflammation or extracellular matrix (ecm) degradation was detected by western blot. |
2021-09-27 |
2023-08-13 |
human |
| Maryam Abshirini, Bolaji Lilian Ilesanmi-Oyelere, Marlena C Kruge. Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism. Progress in lipid research. vol 83. 2021-09-24. PMID:34217732. |
omega-3 pufas reduce the expression of cartilage degrading enzyme matrix metalloproteinase-13 (mmp-13) and a disintegrin and metalloprotease with thrombospondin motifs-5 (adamts-5) protein, oxidative stress and thereby apoptosis via nuclear factor kappa-betta (nf-kβ) and inducible nitric oxide synthase (inos) pathways. |
2021-09-24 |
2023-08-13 |
Not clear |
| Tanzeela Awan, Aaron Babendreyer, Abid Mahmood Alvi, Stefan Düsterhöft, Daniela Lambertz, Jörg W Bartsch, Christian Liedtke, Andreas Ludwi. Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells. Journal of cellular and molecular medicine. vol 25. issue 4. 2021-09-23. PMID:33314720. |
these two complementary approaches revealed that adam8 expression levels correlated positively with proliferation, clonogenicity, migration and matrix invasion and negatively with apoptosis of hepatoma cells. |
2021-09-23 |
2023-08-13 |
human |
| Li Yang, Xiaoping Xu, Zhiyuan Chen, Yu Zhang, Hui Chen, Xiangyang Wan. miR-511-3p promotes hepatic sinusoidal obstruction syndrome by activating hedgehog pathway via targeting Ptch1. American journal of physiology. Gastrointestinal and liver physiology. vol 321. issue 3. 2021-09-23. PMID:34287088. |
depletion of mir-511-3p showed a protective effect against mct-induced hsos, as evidenced by decreased hsos pathogenesis factors, matrix metalloproteinases-2 (mmp-2), matrix metalloproteinases-9 (mmp-9), tumor necrosis factor-α (tnf-α), and interleukin 1 β (il-1β), and decreased lsec apoptosis rates. |
2021-09-23 |
2023-08-13 |
rat |
| Hui Long, Qin Li, Zhenping Xiao, Bo Yan. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway. Bioengineered. vol 12. issue 1. 2021-09-22. PMID:34187303. |
moreover, rescue experiments showed that mir22hg participated in the regulation of chondrocytes proliferation, apoptosis, and degradation of extracellular matrix via mir-9-3p/adamts5 pathway. |
2021-09-22 |
2023-08-13 |
human |
| Santosh Kumar, Qihua Duan, Rongxue Wu, Edward N Harris, Qiaozhu S. Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis. Advanced drug delivery reviews. vol 176. 2021-09-22. PMID:34280515. |
the progression of nafl to nash and liver fibrosis is closely associated with a series of liver injury resulting from lipotoxicity, oxidative stress, redox imbalance (excessive nitric oxide), er stress, inflammation and apoptosis that occur sequentially in different liver cells which ultimately leads to the activation of liver regeneration and fibrogenesis, augmenting collagen and extracellular matrix deposition and promoting liver fibrosis and cirrhosis. |
2021-09-22 |
2023-08-13 |
human |
| Xinwang Ying, Qingfeng Xie, Shengcun Li, Xiaolan Yu, Kecheng Zhou, Jingjing Yue, Xiaolong Chen, Wenzhan Tu, Guanhu Yang, Songhe Jian. Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury. Fluids and barriers of the CNS. vol 17. issue 1. 2021-09-21. PMID:33292360. |
the destruction of the bscb mediated by matrix metalloproteinases (mmps) leads to inflammation, neurotoxin production, and neuronal apoptosis. |
2021-09-21 |
2023-08-13 |
rat |
| Jinsong Kong, Jiacheng Wang, Xiaokang Gong, Xin Zheng, Tao Che. Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis. Drug design, development and therapy. vol 14. 2021-09-21. PMID:33364748. |
punicalagin inhibits tert-butyl hydroperoxide-induced apoptosis and extracellular matrix degradation in chondrocytes by activating autophagy and ameliorates murine osteoarthritis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Congmeng Lin, Dabing Chen, Tingting Xiao, Dandan Lin, Dayi Lin, Luhui Lin, Haojie Zhu, Jingjing Xu, Wenwen Huang, Ting Yan. DNA methylation-mediated silencing of microRNA-204 enhances T cell acute lymphoblastic leukemia by up-regulating MMP-2 and MMP-9 via NF-κB. Journal of cellular and molecular medicine. vol 25. issue 5. 2021-09-21. PMID:33566449. |
moreover, overexpression of mir-204 inhibited t-all cell proliferation while enhancing their apoptosis through interleukin receptor-associated kinase 1 (irak1), which enhanced the expression of matrix metalloproteinase-2 (mmp-2) and mmp-9 through activation of p-p65. |
2021-09-21 |
2023-08-13 |
Not clear |
| Wei Song, Yuan-Jing Ren, Lu-Lu Liu, Ya-Ying Zhao, Qi-Fu Li, Hai-Bo Yan. Curcumin induced the cell death of immortalized human keratinocytes (HaCaT) through caspase-independent and caspase-dependent pathways. Food & function. vol 12. issue 18. 2021-09-21. PMID:34351351. |
we identified 16 differentially expressed nuclear matrix (nm) proteins, including apoptosis inducing factor (aif) and caspase 3, by 2-de and maldi-tof/tof mass spectrometry. |
2021-09-21 |
2023-08-13 |
human |
| Brandon M Fox, Kirsten B Dorschel, Michael T Lawton, John E Waneb. Pathophysiology of Vascular Stenosis and Remodeling in Moyamoya Disease. Frontiers in neurology. vol 12. 2021-09-21. PMID:34539540. |
several molecular pathways have been implicated in the pathophysiology of stenosis in mmd with functions in cellular proliferation and migration, extracellular matrix remodeling, apoptosis, and vascular inflammation. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhenzhu Jiang, Jing Yin, Guangyao Peng, Xiaoping Lon. Circ_0074027 contributes to the progression of non-small cell lung cancer via microRNA-362-3p/clathrin heavy chain axis. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932275. |
western blot assay was utilized to measure the levels of clathrin heavy chain (cltc), cyclin d1, bcl2-associated x, apoptosis regulator bax (bax), vimentin and matrix metallopeptidase 9. |
2021-09-20 |
2023-08-13 |
human |
| Tao Li, Ting Guo, Houqin Liu, Hongtao Jiang, Yi Wan. Platelet‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway. Oncology reports. vol 45. issue 1. 2021-09-20. PMID:33416116. |
anoikis resistance is an important mechanism by which metastatic cells avoid apoptosis when detaching from adjacent cells or the extracellular matrix. |
2021-09-20 |
2023-08-13 |
human |
| Shuwen Zhang, Weidong Liang, Yakefu Abulizi, Tao Xu, Rui Cao, Chuanhui Xun, Jian Zhang, Weibin Shen. Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy. BioMed research international. vol 2021. 2021-09-20. PMID:34055990. |
oxidative stress is a major pathogenic factor of aging that results in the apoptosis of nucleus pulposus cells (npcs) and extracellular matrix (ecm) degradation. |
2021-09-20 |
2023-08-13 |
Not clear |
| Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhan. Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes. Clinical science (London, England : 1979). vol 135. issue 4. 2021-09-17. PMID:33491733. |
further analysis indicated that bbr activated trxr1, suppressed its downstream jnk signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase (mmp) 9 (mmp9) and up-regulated transforming growth factor-β1 (tgf-β1) and tissue inhibitors of mmp 1 (timp1), resulting in accelerated wound healing. |
2021-09-17 |
2023-08-13 |
rat |
| Batara Sirait, Budi Wiweko, Ahmad Aulia Jusuf, Dein Iftitah, R Muhara. Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review. Frontiers in cell and developmental biology. vol 9. 2021-09-17. PMID:34527670. |
the biomarkers were reviewed according to the respective oocyte maturation events namely: nuclear maturation, apoptosis, and extracellular matrix remodeling, and steroid metabolism. |
2021-09-17 |
2023-08-13 |
Not clear |
| Zhiying Pang, Zengxin Jiang, Runwen Zhu, Chunfeng Song, Han Tang, Lu Cao, Changan Gu. Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo. Drug design, development and therapy. vol 15. 2021-09-14. PMID:34511883. |
bardoxolone-methyl prevents oxidative stress-mediated apoptosis and extracellular matrix degradation in vitro and alleviates osteoarthritis in vivo. |
2021-09-14 |
2023-08-13 |
Not clear |