| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Min Li, Yu-Wei Pu, Bao-Song Zh. Blockade of NF-κB nuclear translocation results in the inhibition of the invasiveness of human gastric cancer cells. Oncology letters. vol 6. issue 2. 2021-10-21. PMID:24137341. |
on days 5, 10 and 15 following treatment, the tumor samples were observed and a selection of parameters were recorded, including the level of tumor growth inhibition, the pathological changes in the tumor specimens, the expression levels of matrix metalloproteinase-9 (mmp-9), proliferating cell nuclear antigen (pcna), tissue inhibitor of metalloproteinases type-1 (timp-1) and vascular endothelial growth factor (vegf) and the apoptosis indices in the tumor samples. |
2021-10-21 |
2023-08-12 |
mouse |
| Xinping Yue, Bin Shan, Joseph A Lask. TGF-β: Titan of Lung Fibrogenesis. Current enzyme inhibition. vol 6. issue 2. 2021-10-21. PMID:24187529. |
this overview includes information on tgf-β signal transduction pathways, the importance of tgf-β in the accumulation of myofibroblasts, the role of tgf-β in epithelial injury and apoptosis, the role of tgf-β in extracellular matrix remodeling, and the effects of inhibiting tgf-β signaling in animal models of lung fibrosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Simone Magagnin Wajner, Clarissa Capp, Beatriz Assis Brasil, Luise Meurer, Ana Luiza Mai. Reduced tissue inhibitor of metalloproteinase-2 expression is associated with advanced medullary thyroid carcinoma. Oncology letters. vol 7. issue 3. 2021-10-21. PMID:24527080. |
tissue inhibitor of matrix metalloproteinase (timp)-2, a member of the family of mmp inhibitors, induces apoptosis and inhibits various stages of angiogenesis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Charles J Malemu. Intracellular Signaling Pathways in Rheumatoid Arthritis. Journal of clinical & cellular immunology. vol 4. 2021-10-21. PMID:24619558. |
this is exemplified by immune-mediated chronic inflammation, up-regulated matrix metalloproteinase gene expression, induction of articular chondrocyte apoptosis and "apoptosis-resistance" in rheumatoid synovial tissue. |
2021-10-21 |
2023-08-12 |
Not clear |
| Jie Qian, Jun Liang, Yubin Wang, Huifang Wan. Effect of passive motion on articular cartilage in rat osteoarthritis. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009586. |
the proteoglycan content of the cartilage matrix, type ii collagen fibers and the number of cartilage cells undergoing apoptosis were semiquantified. |
2021-10-21 |
2023-08-13 |
rat |
| Ying Xu, Guo-Jing Dai, Qian Liu, Zhen-Li Liu, Zhi-Qian Song, Li Li, Wei-Heng Chen, Na Li. Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis. Experimental and therapeutic medicine. vol 8. issue 4. 2021-10-21. PMID:25187798. |
sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis. |
2021-10-21 |
2023-08-13 |
rat |
| Thomas W Owens, Andrew P Gilmore, Charles H Streuli, Fiona M Foste. Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy. Journal of carcinogenesis & mutagenesis. vol Suppl 14. 2021-10-21. PMID:25328816. |
the inhibitor of apoptosis (iap) proteins act downstream of a broad range of stimuli, such as cytokines and extracellular matrix interactions, to regulate cell survival, proliferation and migration. |
2021-10-21 |
2023-08-13 |
Not clear |
| Shiyu Tao, Yi Xiong, Dandan Han, Yu Pi, Hanlu Zhang, Junjun Wan. N-(3-oxododecanoyl)-l-homoserine lactone disrupts intestinal epithelial barrier through triggering apoptosis and collapsing extracellular matrix and tight junction. Journal of cellular physiology. vol 236. issue 8. 2021-10-20. PMID:33400297. |
n-(3-oxododecanoyl)-l-homoserine lactone disrupts intestinal epithelial barrier through triggering apoptosis and collapsing extracellular matrix and tight junction. |
2021-10-20 |
2023-08-13 |
Not clear |
| Horatiu C Dancea, Mohammed M Shareef, Mansoor M Ahme. Role of Radiation-induced TGF-beta Signaling in Cancer Therapy. Molecular and cellular pharmacology. vol 1. issue 1. 2021-10-20. PMID:20336170. |
tgf-β signaling regulates several different biological processes involving cell-growth, differentiation, apoptosis, motility, angiogenesis, epithelial mesenchymal transition and extracellular matrix production that affects embryonic development and pathogenesis of various diseases, including cancer, its effects depending on the cellular context and physiological environment. |
2021-10-20 |
2023-08-12 |
Not clear |
| Nivedita K Naresh, Tamar Ben-Mordechai, Jonathan Leor, Frederick H Epstei. Molecular Imaging of Healing After Myocardial Infarction. Current cardiovascular imaging reports. vol 4. issue 1. 2021-10-20. PMID:21869911. |
specifically, we cover recent advances in imaging the various phases of mi and infarct healing such as apoptosis, inflammation, angiogenesis, extracellular matrix deposition, and scar formation. |
2021-10-20 |
2023-08-12 |
Not clear |
| Maryam Kaviani, Somayeh Keshtkar, Fatemeh Sabet Sarvestani, Negar Azarpira, Ramin Yaghobi, Mahdokht Hossein Aghdaei, Bita Geramizadeh, Elaheh Esfandiari, Alireza Shamsaeefar, Saman Nikeghbalian, Ismail H Al-Abdullah, Mohammad Hossein Karimi, Nasrin Motazedia. The potential of the incorporated collagen microspheres in alginate hydrogel as an engineered three-dimensional microenvironment to attenuate apoptosis in human pancreatic islets. Acta histochemica. vol 123. issue 7. 2021-10-19. PMID:34450327. |
in the present study, the effect of alginate hydrogel and collagen microspheres integrated with extracellular matrix components were evaluated in the decrement of apoptosis in human pancreatic islets. |
2021-10-19 |
2023-08-13 |
human |
| Maria Tsingas, Olivia K Ottone, Abdul Haseeb, Ruteja A Barve, Irving M Shapiro, Véronique Lefebvre, Makarand V Risbu. Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes. Matrix biology : journal of the International Society for Matrix Biology. vol 94. 2021-10-18. PMID:33027692. |
sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes. |
2021-10-18 |
2023-08-13 |
Not clear |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
ectopic mir27a expression inhibited apoptosis, suppressed the inflammatory response and attenuated the catabolism of the extracellular matrix by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
at the same time, mir27a is up-regulated by tnf-α via the p38 signalling pathway, which ameliorates inflammation, apoptosis and matrix degradation by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J Wilson, Juan J Marugan, Alexander I Agoulni. Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction. Frontiers in physiology. vol 12. 2021-10-15. PMID:34305630. |
in the present study, we tested the hypothesis that ml290, a small molecule agonist of the human relaxin receptor (rxfp1), is able to target the kidney to remodel the extracellular matrix and reduce apoptosis induced by unilateral ureteral obstruction (uuo). |
2021-10-15 |
2023-08-13 |
mouse |
| Hua Jiang, Abu Moro, Jiaqi Wang, Dihua Meng, Xinli Zhan, Qingjun We. MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34531509. |
our functional studies showed that mir-338-3p significantly influenced the expression of extracellular matrix synthesis genes, as well as the proliferation and apoptosis of np cells. |
2021-10-15 |
2023-08-13 |
mouse |
| Jiapeng Bao, Changjian Lin, Xing Zhou, Diana Ma, Lujie Ge, Kai Xu, Safwat Adel Abdo Moqbel, Yuzhe He, Chiyuan Ma, Jisheng Ran, Lidong W. circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3. Oxidative medicine and cellular longevity. vol 2021. 2021-10-15. PMID:34646424. |
while overexpression of circfam160a2 decreased the production of extracellular matrix (ecm) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of mir-505-3p could reverse the protective effect of circfam160a2 on the oa phenotype both in vitro and in vivo. |
2021-10-15 |
2023-08-13 |
human |
| William H Miller, Danny W Scot. Follicular Dysplasia of the Portuguese Water Dog. Veterinary dermatology. vol 6. issue 2. 2021-10-14. PMID:34644864. |
unique histopathologic findings included prominent apoptosis of keratinocytes in the inner and outer root sheath, and dissolution of the hair matrix of anagen hair follicles. |
2021-10-14 |
2023-08-13 |
dog |
| Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xi. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-13. PMID:34536759. |
furthermore, the mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) signaling pathway is closely related to various pathological processes in idd, and the activation of the mapk/erk pathway promotes the degradation of the ivd extracellular matrix, cell aging, apoptosis, and inflammatory responses. |
2021-10-13 |
2023-08-13 |
Not clear |
| Chi-Yung Chai, I-Chun Tai, Rui Zhou, Junlong Song, Chaoying Zhang, Shengrong Su. MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β. Biology open. vol 9. issue 12. 2021-10-12. PMID:33355167. |
in this paper, we firstly disclosed that mir-9-5p hampered extracellular matrix deposition and proliferation, and induced apoptosis by targeting pparβ in hs fibroblasts. |
2021-10-12 |
2023-08-13 |
human |