| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Viktoria Heine, Carina Dey, Pavla Bojarová, Vladimír Křen, Lothar Ellin. Methods of in vitro study of galectin-glycomaterial interaction. Biotechnology advances. 2022-02-21. PMID:35189272. |
galectins are a family of carbohydrate-binding lectins modulating cell events such as cell proliferation, apoptosis, adhesion, or migration by cross-linking the glycan structures of cell membranes and/or extracellular matrix components. |
2022-02-21 |
2023-08-13 |
Not clear |
| Yueyang Tian, Jiaqi Duan, Yang Cao, Huichao Zhou, Ashish D Diwan, Ji T. Bardoxolone Methyl Ameliorates Compression-Induced Oxidative Stress Damage of Nucleus Pulposus Cells and Intervertebral Disc Degeneration Frontiers in bioengineering and biotechnology. vol 9. 2022-02-18. PMID:35178384. |
according to reports, excessive compression is a high-risk factor for idd; compressive stress can induce oxidative stress in nucleus pulposus (np) cells during idd progression that, in turn, promotes cell apoptosis and extracellular matrix (ecm) degradation. |
2022-02-18 |
2023-08-13 |
Not clear |
| Hui Lin, Shuo Tian, Yizhong Peng, Ling Wu, Yan Xiao, Xiangcheng Qing, Zengwu Sha. IGF Signaling in Intervertebral Disc Health and Disease. Frontiers in cell and developmental biology. vol 9. 2022-02-18. PMID:35178405. |
the activation of igf signaling retards ivdd by increasing cell proliferation, promoting extracellular matrix (ecm) synthesis, inhibiting ecm decomposition, and preventing apoptosis and senescence of disc cells. |
2022-02-18 |
2023-08-13 |
Not clear |
| Zilong Zhang, Teng Zhao, Haiwei Xu, Xing W. Circ_0008365 Suppresses Apoptosis, Inflammation and Extracellular Matrix Degradation of IL-1β-treated Chondrocytes in Osteoarthritis by Regulating miR-324-5p/BMPR2/NF-κB Signaling Axis. Immunological investigations. 2022-02-17. PMID:35172669. |
circ_0008365 suppresses apoptosis, inflammation and extracellular matrix degradation of il-1β-treated chondrocytes in osteoarthritis by regulating mir-324-5p/bmpr2/nf-κb signaling axis. |
2022-02-17 |
2023-08-13 |
Not clear |
| Xiao-Chuan Li, Shao-Jian Luo, Wu Fan, Tian-Li Zhou, Chun-Ming Huang, Mao-Sheng Wan. M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022-02-16. PMID:35170802. |
after 2-14 days, cell proliferation, extracellular matrix synthesis, apoptosis, and npc senescence were assessed. |
2022-02-16 |
2023-08-13 |
mouse |
| Xiao-Chuan Li, Shao-Jian Luo, Wu Fan, Tian-Li Zhou, Chun-Ming Huang, Mao-Sheng Wan. M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022-02-16. PMID:35170802. |
therefore, co-culture with m2cm promotes cell proliferation and extracellular matrix synthesis and inhibits inflammation, apoptosis, and npc senescence. |
2022-02-16 |
2023-08-13 |
mouse |
| Verónica A García-García, Josefa P Alameda, Angustias Page, Antonio Mérida-García, Manuel Navarro, Adrián Tejero, Jesús M Paramio, Rosa A García-Fernández, M Llanos Casanov. IKKα Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163299. |
these emt-related changes include a shift toward a migratory phenotype and induction of the expression of proteins involved in cell matrix degradation, cell survival and resistance to apoptosis. |
2022-02-15 |
2023-08-13 |
mouse |
| Gilda Aiello, Francesca Rescigno, Marisa Meloni, Giovanna Baron, Giancarlo Aldini, Marina Carini, Alfonsina D'Amat. Oxidative Stress Modulation by Carnosine in Scaffold Free Human Dermis Spheroids Model: A Proteomic Study. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163388. |
of the several modulated pathways, most are involved in mitochondrial functionality, such as oxidative phosphorylation, tca cycle, extracellular matrix reorganization and apoptosis. |
2022-02-15 |
2023-08-13 |
human |
| Rebecca Louisthelmy, Brycen M Burke, R Chase Corneliso. Brain cancer cell-derived matrices and effects on astrocyte migration. Cells, tissues, organs. 2022-02-15. PMID:35168244. |
we focused on ficoll mmc matrices, which were isolated using the small molecule raptinal to induce cancer cell apoptosis and matrix decellularization. |
2022-02-15 |
2023-08-13 |
mouse |
| Zuo-Long Wu, Ya-Jun Chen, Guang-Zhi Zhang, Qi-Qi Xie, Ke-Ping Wang, Xin Yang, Tai-Cong Liu, Zhi-Qiang Wang, Guang-Hai Zhao, Hai-Hong Zhan. SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration. Apoptosis : an international journal on programmed cell death. 2022-02-11. PMID:35147801. |
ski knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the wnt/β-catenin pathway and ameliorates disc degeneration. |
2022-02-11 |
2023-08-13 |
human |
| Zuo-Long Wu, Ya-Jun Chen, Guang-Zhi Zhang, Qi-Qi Xie, Ke-Ping Wang, Xin Yang, Tai-Cong Liu, Zhi-Qiang Wang, Guang-Hai Zhao, Hai-Hong Zhan. SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration. Apoptosis : an international journal on programmed cell death. 2022-02-11. PMID:35147801. |
western blotting, immunofluorescence, and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining were used to detect np cell apoptosis, extracellular matrix (ecm) metabolism, and related protein expression changes in the wnt/β-catenin signaling pathway. |
2022-02-11 |
2023-08-13 |
human |
| Chenglong Wang, Liqiang Cui, Qinwen Gu, Sheng Guo, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen L. The Mechanism and Function of miRNA in Intervertebral Disc Degeneration. Orthopaedic surgery. 2022-02-10. PMID:35142050. |
current studies on the effects of mirna in idd have confirmed that a variety of mirnas play a crucial role in the process of idd via nucleus pulposus cells (npc) apoptosis, abnormal proliferation, inflammatory factors, the extracellular matrix (ecm) degradation, and annulus fibrosus (af) degeneration. |
2022-02-10 |
2023-08-13 |
Not clear |
| Peng Yan, Chong Sun, Liangrui Luan, Jialuo Han, Yang Qu, Chuanli Zhou, Derong X. Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578. Cell death discovery. vol 8. issue 1. 2022-02-09. PMID:35136049. |
intervertebral disc degeneration (idd) is a chronic degenerative and age-dependent process characterized by aberrant apoptosis, proliferation, synthesis, and catabolism of the extracellular matrix of the nucleus pulposus (np) cells. |
2022-02-09 |
2023-08-13 |
Not clear |
| A P S Mesquita, M Matsuoka, S A Lopes, P C A Pernambuco Filho, A S Cruz, H B Nader, C C Lope. Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 55. 2022-02-09. PMID:35137850. |
anoikis is a type of apoptosis that occurs in response to the loss of adhesion to the extracellular matrix (ecm). |
2022-02-09 |
2023-08-13 |
Not clear |
| Jun-Nan Kang, Ze-Hui Chen, Chen Tia. [Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia --Review]. Zhongguo shi yan xue ye xue za zhi. vol 30. issue 1. 2022-02-06. PMID:35123647. |
bmsc participates in and regulate signaling pathways related to proliferation or apoptosis of all cells by secretes cytokines or extracellular matrix proteins, thus affecting the survival of all cells. |
2022-02-06 |
2023-08-13 |
Not clear |
| Xiaoling Zhang, Si Wang, Yuyan Cai, Weihong He, Qing Yang, Chen L. Regulatory Mechanism of MicroRNA-9 / Long Non-Coding RNA XIST Expression on Mouse Macrophage RAW264.7 Apoptosis Induced by Oxidized Low Density Lipoprotein. Bioengineered. vol 13. issue 2. 2022-02-03. PMID:35109760. |
methylthiazolyl tetrazolium (mtt) method, flow cytometry, and western blot were used to detect and compare the differences of cell proliferation, apoptosis, and the expression levels of apoptosis signal-regulating kinase 1 (ask1), c-jun n-terminal kinase (jnk), matrix metalloproteinase-9 (mmp-9), and b-cell lymphoma-2 (bcl-2) after ox-ldl induction and transfection of mir-9 mimic, mir-9 inhibitor and xist expression vector, respectively. |
2022-02-03 |
2023-08-13 |
mouse |
| Jintao Liu, Pengfei Yu, Feng Dai, Hong Jiang, Zhijia M. Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy. Bioengineered. vol 13. issue 2. 2022-02-03. PMID:35109761. |
tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy. |
2022-02-03 |
2023-08-13 |
rat |
| Yin Zhuang, Sheng Song, Dan Xiao, Xueguang Liu, Xiaofei Han, Shihao Du, Yuan Li, Yanming He, Shujun Zhan. Exosomes Secreted by Nucleus Pulposus Stem Cells Derived From Degenerative Intervertebral Disc Exacerbate Annulus Fibrosus Cell Degradation Frontiers in molecular biosciences. vol 8. 2022-02-03. PMID:35111808. |
here, we show that exosomes secreted by nucleus pulposus stem cells derived from degenerative intervertebral disc (d-dpsc-exo) can exacerbate afc degeneration via inhibiting cell proliferation, migration, matrix synthesis, and promoting apoptosis. |
2022-02-03 |
2023-08-13 |
Not clear |
| Yin Zhuang, Sheng Song, Dan Xiao, Xueguang Liu, Xiaofei Han, Shihao Du, Yuan Li, Yanming He, Shujun Zhan. Exosomes Secreted by Nucleus Pulposus Stem Cells Derived From Degenerative Intervertebral Disc Exacerbate Annulus Fibrosus Cell Degradation Frontiers in molecular biosciences. vol 8. 2022-02-03. PMID:35111808. |
transfection of let-7b-5p mimic was found to promote apoptosis and inhibit proliferation migration and matrix synthesis of afcs. |
2022-02-03 |
2023-08-13 |
Not clear |
| Longlong Du, Xuefeng Li, Qimeng Gao, Puwei Yuan, Yindi Sun, Yingpu Chen, Bo Huang, Yu Deng, Baohui Wan. LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35094651. |
lncrna nuclear receptor subfamily 2 group f member 1 antisense rna 1 (nr2f1-as1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. |
2022-01-31 |
2023-08-13 |
Not clear |