| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. Tamoxifen offers long-term neuroprotection after hippocampal silent infarct in male rats. Hormones and behavior. vol 136. 2021-11-29. PMID:34749277. |
exploratory data analyses using a scatterplot matrix and principal component analysis indicated that si-tamoxifen rats were indistinguishable from sham controls while they differed from si rats, who were characterized by enhanced cell loss, apoptosis and gliosis, lower ers, and recognition memory deficit. |
2021-11-29 |
2023-08-13 |
rat |
| Shaikh Jamal Uddin, Md Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A Shilpi, Mohammad S Mubara. Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:32981501. |
available pre-clinical data suggest the ameliorating effect of curcumin in pain and inflammation is rendered through the modulation of pain pathways, including inhibition of a number of pro-inflammatory mediators, inhibition of oxidative stress and cyclooxygenase-2 (cox-2), down-regulation of ca2+/calmodulin-depend protein kinase ii (camkiiα) and calcium channels like transient receptor potential (trp), modulation of metabotropic glutamate receptor-2 (mglu2), modulation of monoamine system, inhibition of jak2/stat3 signaling pathway, remodeling of extracellular matrix proteins, inhibition of apoptosis, inhibition of jnk/mapk and erk/creb signaling pathway, and activation of the opioid system. |
2021-11-26 |
2023-08-13 |
Not clear |
| Narayanappa Amruta, Gregory Bi. ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34420157. |
atn-161 treatment (10 µm) effectively inhibited ogd/r-induced extracellular matrix (ecm) deposition by reducing integrin α5, mmp-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ros, inflammation by reducing nlrp3 inflammasome, tight junction loss by reducing claudin-5 and zo-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-fak and p-akt levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Sriram Rao, Thanh-Lan Bui, Ali Sasani, Ben Sadeghi, Anvesh Macherla, Roozbeh Houshyar, Nadine Abi-Jaoude. Irreversible electroporation for pancreatic cancer using intraprocedural cone-beam computed tomography fusion navigation: a case report. Journal of medical case reports. vol 15. issue 1. 2021-11-26. PMID:34819143. |
irreversible electroporation is a nonthermal minimally invasive ablation technique that uses electrical pulses to induce apoptosis of tumor cells without damage to the extracellular matrix, thus preserving ducts and vessels. |
2021-11-26 |
2023-08-13 |
Not clear |
| Manica Negahdaripour, Hajar Owji, Sedigheh Eskandari, Mozhdeh Zamani, Bahareh Vakili, Navid Nezafa. Small extracellular vesicles (sEVs): discovery, functions, applications, detection methods and various engineered forms. Expert opinion on biological therapy. vol 21. issue 3. 2021-11-25. PMID:32945228. |
such evs play a key role in the immunoregulation, cns development, nervous system physiology, mammary gland development, induction of immunosuppression in pregnancy, the developmental signaling pathways, regeneration of different tissues, inflammation, angiogenesis, coagulation, apoptosis, stem cell differentiation, and extracellular matrix turnover. |
2021-11-25 |
2023-08-13 |
Not clear |
| Neal L Millar, Karin G Silbernagel, Kristian Thorborg, Paul D Kirwan, Leesa M Galatz, Geoffrey D Abrams, George A C Murrell, Iain B McInnes, Scott A Rode. Tendinopathy. Nature reviews. Disease primers. vol 7. issue 1. 2021-11-25. PMID:33414454. |
the prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. |
2021-11-25 |
2023-08-13 |
Not clear |
| Alessandra Caligiuri, Alessandra Gentilini, Mirella Pastore, Stefano Gitto, Fabio Marr. Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression. Cells. vol 10. issue 10. 2021-11-25. PMID:34685739. |
the mechanisms of liver fibrosis resolution can be recapitulated in the following main points: removal of injurious factors causing chronic hepatic damage, elimination, or inactivation of myofibroblasts (through various cell fates, including apoptosis, senescence, and reprogramming), inactivation of inflammatory response and induction of anti-inflammatory/restorative pathways, and degradation of extracellular matrix. |
2021-11-25 |
2023-08-13 |
Not clear |
| Rina Wu, Zheli Niu, Guangwei Ren, Lin Ruan, Lijun Su. CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition. Diabetology & metabolic syndrome. vol 13. issue 1. 2021-11-25. PMID:34801077. |
circsmad4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving mir-377-3p-mediated bmp7 inhibition. |
2021-11-25 |
2023-08-13 |
mouse |
| Huiyu Zhang, Yue Lu, BingBing Wu, Fei Xi. Semaphorin 3A mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to Neuropilin-1. Bioengineered. vol 12. issue 2. 2021-11-25. PMID:34821196. |
semaphorin 3a mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to neuropilin-1. |
2021-11-25 |
2023-08-13 |
Not clear |
| Huiyu Zhang, Yue Lu, BingBing Wu, Fei Xi. Semaphorin 3A mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to Neuropilin-1. Bioengineered. vol 12. issue 2. 2021-11-25. PMID:34821196. |
this study was aimed at exploring whether sema3a participates in lipopolysaccharide (lps)-induced chondrocyte inflammation, apoptosis and extracellular matrix (ecm) degradation. |
2021-11-25 |
2023-08-13 |
Not clear |
| Mari Nakashima, Mari Gotoh, Kei Hashimoto, Misaki Endo, Kimiko Murakami-Murofushi, Hiroko Ikeshima-Kataoka, Yasunori Miyamot. The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury. Journal of neuroimmunology. vol 361. 2021-11-24. PMID:34688067. |
first, we found 2ccpa suppressed neuronal apoptosis after the injury, and increased the immunoreactivity of tenascin-c (tn-c), an extracellular matrix protein by 2ccpa in the vicinity of the wound region. |
2021-11-24 |
2023-08-13 |
Not clear |
| Liang Chen, Zhenhong Ni, Junlan Huang, Ruobin Zhang, Jinfan Zhang, Bin Zhang, Liang Kuang, Xianding Sun, Dali Zhang, Nan Su, Huabing Qi, Jing Yang, Min Jin, Fengtao Luo, Hangang Chen, Siru Zhou, Xiaolan Du, Junjie Ouyang, Zuqiang Wang, Yangli Xie, Qiaoyan Tan, Lin Che. Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. International journal of biological sciences. vol 17. issue 15. 2021-11-24. PMID:34803488. |
long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. |
2021-11-24 |
2023-08-13 |
mouse |
| Liang Chen, Zhenhong Ni, Junlan Huang, Ruobin Zhang, Jinfan Zhang, Bin Zhang, Liang Kuang, Xianding Sun, Dali Zhang, Nan Su, Huabing Qi, Jing Yang, Min Jin, Fengtao Luo, Hangang Chen, Siru Zhou, Xiaolan Du, Junjie Ouyang, Zuqiang Wang, Yangli Xie, Qiaoyan Tan, Lin Che. Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. International journal of biological sciences. vol 17. issue 15. 2021-11-24. PMID:34803488. |
further studies showed that dex leads to calcification of extracellular matrix of chondrocytes partially through activation of akt, as well as promotes apoptosis of chondrocytes in calcified cartilage layer. |
2021-11-24 |
2023-08-13 |
mouse |
| b' Oskar Zakiyanov, Marta Kalousov\\xc3\\xa1, Tom\\xc3\\xa1\\xc5\\xa1 Zima, Vladim\\xc3\\xadr Tesa\\xc5\\x9. Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease. Advances in clinical chemistry. vol 105. 2021-11-24. PMID:34809827.' |
mmps function in close interaction with the endogenous tissue inhibitors of matrix metalloproteinases (timps), both of which regulate cell turnover, modulate various growth factors, and participate in the progression of tissue fibrosis and apoptosis. |
2021-11-24 |
2023-08-13 |
Not clear |
| Zhen Lin, Libin Ni, Cheng Teng, Zhao Zhang, Long Wu, Yu Jin, Xinlei Lu, Zhongke Li. Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-11-23. PMID:34805156. |
eicosapentaenoic acid-induced autophagy attenuates intervertebral disc degeneration by suppressing endoplasmic reticulum stress, extracellular matrix degradation, and apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Xingmei Luo, Jing Wu, Guofeng W. PPARγ activation suppresses the expression of MMP9 by downregulating NF-κB post intracerebral hemorrhage. Neuroscience letters. vol 752. 2021-11-22. PMID:33636289. |
we have previously reported that rosiglitazone, an agonist of pparγ, was effective to prevent microglia from apoptosis and ameliorate neuronal injuries post intracerebral hemorrhage (ich) with suppression of matrix metalloproteinase-9 (mmp9) expression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Raziyeh Abooshahab, Hani Al-Salami, Crispin R Das. The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target. Biochemical pharmacology. vol 193. 2021-11-22. PMID:34571004. |
it has been ascertained that pedf regulates multiple metastatic processes through various plausible mechanisms, including inhibiting angiogenesis, inducing apoptosis, stimulating extracellular matrix (ecm) degradation, and suppressing the epithelial-to-mesenchymal transition (emt) process. |
2021-11-22 |
2023-08-13 |
Not clear |
| Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng, Jing-Hong Che. Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology. vol 464. 2021-11-22. PMID:34673134. |
t-2 toxin leads to chondrocyte apoptosis and excessive extracellular matrix degradation. |
2021-11-22 |
2023-08-13 |
rat |
| Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng, Jing-Hong Che. Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology. vol 464. 2021-11-22. PMID:34673134. |
this study found that the expressions of grp78, chop, and caspase-12 is higher in t-2 toxin group than in control group both in vivo and in vitro, and the t-2 toxin administration promoted chondrocyte apoptosis, suppressed matrix synthesis, and accelerated cellular catabolism via the ers signaling pathway. |
2021-11-22 |
2023-08-13 |
rat |
| Shuai Hu, Sheng Wang, Jie He, Yangyang Bia. Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes. Molecular medicine reports. vol 25. issue 1. 2021-11-22. PMID:34779501. |
excessive apoptosis of chondrocytes and degradation of the extracellular matrix (ecm) contribute to the typical pathological characteristics of osteoarthritis (oa). |
2021-11-22 |
2023-08-13 |
rat |