| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Volker Schirrmache. Molecular Mechanisms of Anti-Neoplastic and Immune Stimulatory Properties of Oncolytic Newcastle Disease Virus. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327364. |
the anti-neoplastic activities of ndv include (i) the endocytic targeting of the gtpase rac1 in ras-transformed human tumorigenic cells; (ii) the switch from cellular protein to viral protein synthesis and the induction of autophagy mediated by viral nucleoprotein np; (iii) the virus replication mediated by viral rna polymerase (large protein (l), associated with phosphoprotein (p)); (iv) the facilitation of ndv spread in tumors via the membrane budding of the virus progeny with the help of matrix protein (m) and fusion protein (f); and (v) the oncolysis via apoptosis, necroptosis, pyroptosis, or ferroptosis associated with immunogenic cell death. |
2022-03-25 |
2023-08-13 |
human |
| Wilke M Post, Joanna Widomska, Hilde Grens, Marieke J H Coenen, Frank M J Martens, Dick A W Janssen, Joanna IntHout, Geert Poelmans, Egbert Oosterwijk, Kirsten B Kluiver. Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328824. |
resulting from the most examined processes, the evidence suggests that sui is associated with altered extracellular matrix metabolism, estrogen receptors, oxidative stress, apoptosis, inflammation, neurodegenerative processes, and muscle cell differentiation and contractility. |
2022-03-25 |
2023-08-13 |
mouse |
| Dan Wang, Hao Qu, Hui Kang, Feng Xu, Wei Huang, Xianhua Ca. Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. Bioengineered. vol 13. issue 4. 2022-03-25. PMID:35333664. |
kukoamine a attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the p13k/akt pathway. |
2022-03-25 |
2023-08-13 |
Not clear |
| Dan Wang, Hao Qu, Hui Kang, Feng Xu, Wei Huang, Xianhua Ca. Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. Bioengineered. vol 13. issue 4. 2022-03-25. PMID:35333664. |
then, the experiments following the treatment of kua in lps-induced npcs included cell proliferation assessment by 5-ethynyl-2'-deoxyuridine (edu) kit, cell apoptosis and extracellular matrix degradation (ecm) analysis by terminal dutp nick-end labeling (tunel) and western blot, the detection of inflammatory cytokines by western blot and enzyme-linked immunosorbent assay (elisa), p13k/akt pathway-related protein levels analysis by western blot. |
2022-03-25 |
2023-08-13 |
Not clear |
| Wei Peng, Xingcheng Zhou, Tingting Xu, Yanwen Mao, Xiaohuan Zhang, Huiming Liu, Luqun Liang, Lingling Liu, Lirong Liu, Ying Xiao, Fan Zhang, Shuang Li, Mingjun Shi, Yuxia Zhou, Lei Tang, Yuanyuan Wang, Bing Gu. BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease. Cell death & disease. vol 13. issue 3. 2022-03-22. PMID:35314669. |
transforming growth factor β1 (tgf-β1) is involved in the extensive fibrosis of renal tissue by facilitating the partial epithelial-mesenchymal transition (emt), increasing the synthesis of extracellular matrix (ecm), inhibiting degradation, inducing apoptosis of renal parenchyma cells, and activating renal interstitial fibroblasts and inflammatory cells. |
2022-03-22 |
2023-08-13 |
mouse |
| Liuxie Yang, Zhenhuan Li, Yueping Ouyan. Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Molecular medicine reports. vol 25. issue 5. 2022-03-22. PMID:35315493. |
nucleus pulposus (np) apoptosis and subsequent excessive degradation of the extracellular matrix (ecm) are key pathological characteristics of intervertebral disc degeneration (idd). |
2022-03-22 |
2023-08-13 |
Not clear |
| Shang Xian Bo, Wang Chen, Liu Chang, Yu Hao Ran, Guo Hui Hui, Zhu Ya Kun, Xie Wu Kun, Fan Hai Tao, Cheng Wen Da. The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Therapeutic Effect. Frontiers in pharmacology. vol 13. 2022-03-21. PMID:35308214. |
recent studies have shown that exosomes participate in oa treatment by regulating the proliferation, apoptosis, inflammation, and extracellular matrix synthesis of chondrocytes. |
2022-03-21 |
2023-08-13 |
Not clear |
| Bing-Tao Zhai, Huan Tian, Jing Sun, Jun-Bo Zou, Xiao-Fei Zhang, Jiang-Xue Cheng, Ya-Jun Shi, Yu Fan, Dong-Yan Gu. Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer. Journal of translational medicine. vol 20. issue 1. 2022-03-19. PMID:35303878. |
upar is closely related to the invasion and metastasis of malignant tumours, plays important roles in the degradation of extracellular matrix (ecm), tumour angiogenesis, cell proliferation and apoptosis, and is associated with the multidrug resistance (mdr) of tumour cells, which has important guiding significance for the judgement of tumor malignancy and prognosis. |
2022-03-19 |
2023-08-13 |
Not clear |
| Jamal J Shahri, Shirin Saberianpour, Saeed N Bayeg. Comparison of tissue biomarkers in arterial and vein (arteriovenous fistula) aneurysms. Phlebology. 2022-03-08. PMID:35255762. |
aneurysms are distinguished by inflammation, matrix degradation, and apoptosis of smooth muscle cells. |
2022-03-08 |
2023-08-13 |
Not clear |
| Cong-Qiu Ch. Highlights of Strategies Targeting Fibroblasts for Novel Therapies for Rheumatoid Arthritis. Frontiers in medicine. vol 9. 2022-03-07. PMID:35252279. |
exploring fibroblast targeted therapies have been focused on inducing cell death via fibroblast associated proteins; interrupting fibroblast binding to matrix protein; blocking intercellular signaling between fibroblasts and endothelial cells; inhibiting fibroblast proliferation and invasion; promoting cell apoptosis and inducing cellular senescence, and modulating fibroblast glucose metabolism. |
2022-03-07 |
2023-08-13 |
Not clear |
| Tao-Cheng Wu, Wei-Hung Chang, Hsin-Ying Lu, Chun-Che Shi. Tolvaptan reduces angiotensin II-induced experimental abdominal aortic aneurysm and dissection. Vascular pharmacology. 2022-03-01. PMID:35227907. |
in vitro study showed that tolvaptan suppressed matrix metalloproteinase (mmp) expressions (mmp-2 and mmp-9) and apoptosis in ang ii-stimulated hasmcs. |
2022-03-01 |
2023-08-13 |
mouse |
| Dong Chen, Xin Jian. Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Experimental cell research. 2022-03-01. PMID:35231441. |
the study aimed to explore the effects of normal cesc-derived exosomes (n-cesc-exo) on autophagy, apoptosis and extracellular matrix (ecm) metabolism of nucleus pulposus cells (npcs) and their underlying molecular mechanisms in vivo and in vitro. |
2022-03-01 |
2023-08-13 |
Not clear |
| Zirui Yu, Fei Cong, Wentao Zhang, Tao Song, Shihui Zhang, Renqi Jian. Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis. Bosnian journal of basic medical sciences. 2022-02-28. PMID:35225755. |
il-1β treatment induced cell injury by promoting inflammation and apoptosis, and inhibiting cell viability and extracellular matrix (ecm) accumulation in chondrocytes. |
2022-02-28 |
2023-08-13 |
Not clear |
| Yawei Zhang, Hengheng Zheng, Baitong L. Circ_0110251 overexpression alleviates IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis. Autoimmunity. 2022-02-24. PMID:35196925. |
circ_0110251 overexpression alleviates il-1β-induced chondrocyte apoptosis and extracellular matrix degradation by regulating mir-3189-3p/spry1 axis in osteoarthritis. |
2022-02-24 |
2023-08-13 |
human |
| Chukwuebuka ThankGod Eze, Obianuju Oluchukwu Eze, Tochukwu Ernest Ugochukwu, Nnamdi Henry Amaeze, Emeka Bright Ogbuene, Adebayo Akeem Otitoloj. In vitro cytotoxic assessment of e-waste-related chemical pollution in impacted soil matrix. Environmental monitoring and assessment. vol 194. issue 3. 2022-02-23. PMID:35194689. |
in addition, toxicity mechanisms such as apoptosis, necrosis and necroptosis were analysed in order to determine the effect of the actual chemical mixture present in the e-waste soil matrix. |
2022-02-23 |
2023-08-13 |
Not clear |
| Haoxi Li, Wenhao Li, Li Zhang, Jicheng He, Lin Tang, Zhuhai Li, Feng Chen, Qie Fan, Jianxun We. Comprehensive Network Analysis Identified SIRT7, NTRK2, and CHI3L1 as New Potential Markers for Intervertebral Disc Degeneration. Journal of oncology. vol 2022. 2022-02-22. PMID:35190738. |
functional enrichment analysis showed that the red module was mainly related to neutrophil activation and regulation of cytokine-mediated signaling pathway and apoptosis, whereas the midnightblue module was mainly related to extracellular matrix organization, bone development, extracellular matrix, extracellular matrix component, and other extracellular matrices. |
2022-02-22 |
2023-08-13 |
Not clear |
| Jin Yang, Qi Li, Tingting Wang, Ke L. Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis. Bioengineered. vol 13. issue 3. 2022-02-22. PMID:35191807. |
knockdown circtrio facilitates chondrocyte viability, but suppresses the inflammation, the apoptosis, and matrix metalloproteinases (mmp)-3 and mmp-13 expression, whereas up-regulation aggravates oa. |
2022-02-22 |
2023-08-13 |
rat |
| Hao Li, Lijun Tian, Jianhua Li, Yongjin Li, Lilong Du, Zhenxin Huo, Baoshan X. The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis. Analytical cellular pathology (Amsterdam). vol 2022. 2022-02-21. PMID:35186669. |
the roles of circrnas in intervertebral disc degeneration: inflammation, extracellular matrix metabolism, and apoptosis. |
2022-02-21 |
2023-08-13 |
human |
| Hao Li, Lijun Tian, Jianhua Li, Yongjin Li, Lilong Du, Zhenxin Huo, Baoshan X. The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis. Analytical cellular pathology (Amsterdam). vol 2022. 2022-02-21. PMID:35186669. |
circular rnas (circrnas), as a kind of noncoding rna (ncrna), participate in the regulation of genetic transcription and translation and further affect the expression of inflammatory cytokine, metabolism of extracellular matrix (ecm), the proliferation and apoptosis of cells, etc. |
2022-02-21 |
2023-08-13 |
human |
| Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Kha. The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes. Frontiers in cell and developmental biology. vol 10. 2022-02-21. PMID:35186918. |
epithelial cancer cells that lose attachment from the extracellular matrix (ecm) to seed in a distant organ often undergo anoikis's specialized form of apoptosis. |
2022-02-21 |
2023-08-13 |
Not clear |