| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihai Yuan, Zhen Yang, Weiqin Li, Aimei Wu, Zhixiang Su, Bin Jiang, Sakthivigneswari Ganesa. Triphlorethol-A attenuates U251 human glioma cancer cell proliferation and ameliorates apoptosis through JAK2/STAT3 and p38 MAPK/ERK signaling pathways. Journal of biochemical and molecular toxicology. 2022-07-15. PMID:35838116. |
the cytotoxicity, intracellular reactive oxygen species (ros), matrix metalloproteinase (mmp), and cell apoptosis activity of ta have been evaluated by the mtt assay and by dcfh-da, rh-123, ao/eb, and western blot analysis. |
2022-07-15 |
2023-08-14 |
human |
| Yu Jin, Zhen Liu, Zhenxia Li, Hairui Li, Cheng Zhu, Ruomei Li, Ting Zhou, Bing Fan. Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1. International journal of oral science. vol 14. issue 1. 2022-07-13. PMID:35831280. |
further experiments indicated that nr4a1 can regulate chondrocyte apoptosis, cartilage degeneration, extracellular matrix degradation, and inflammatory responses. |
2022-07-13 |
2023-08-14 |
Not clear |
| Salvatore Condello, Mayuri Prasad, Rula Atwani, Daniela Mate. Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer. The Journal of biological chemistry. 2022-07-10. PMID:35810788. |
oc cells have high proliferative capacity, are invasive, resist apoptosis, and tumors often display rearrangement of extracellular matrix (ecm) components, contributing to accelerated tumor progression. |
2022-07-10 |
2023-08-14 |
Not clear |
| Ziqi Zhang, Pei Yang, Chunsheng Wang, Run Tia. LncRNA CRNDE hinders the progression of osteoarthritis by epigenetic regulation of DACT1. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-08. PMID:35802196. |
we found that overexpression of crnde alleviated cartilage damage and synovitis in oa rats, and suppressed il-1β-induced apoptosis, inflammation, and extracellular matrix (ecm) degradation in chondrocyte‑like atdc5 cells, while silencing dact1 effectively antagonized the protective effect of crnde both in vivo and in vitro. |
2022-07-08 |
2023-08-14 |
rat |
| Min Zhao, Qin Qi, Shimin Liu, Rong Huang, Jiacheng Shen, Yi Zhu, Jing Chai, Handan Zheng, Huangan Wu, Huirong Li. MicroRNA-34a: A Novel Therapeutic Target in Fibrosis. Frontiers in physiology. vol 13. 2022-07-07. PMID:35795649. |
mir-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates tgf-β1/smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. |
2022-07-07 |
2023-08-14 |
Not clear |
| Hachiro Kamad. 12-oxoeicosatetraenoic acid, a candidate of signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells. Animal bioscience. 2022-07-07. PMID:35798033. |
12-oxoeicosatetraenoic acid, a candidate of signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells. |
2022-07-07 |
2023-08-14 |
cattle |
| Mengshi Tang, Yan Zeng, Weijun Peng, Xi Xie, Yongyu Yang, Biting Ji, Fen L. Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis. Drug design, development and therapy. vol 16. 2022-07-06. PMID:35791403. |
in general, for articular manifestations, que inhibited synovial membrane inflammation by reducing inflammatory cytokines and mediators, decreasing oxidative stress, inhibiting proliferation, migration and invasion, and promoting apoptosis of fibroblast-like synoviocytes (fls), regulated autoimmune response through modulating th17/treg imbalance and th17 cells differentiation, reducing autoantibodies levels and regulating ectonucleoside triphosphate diphosphohydrolase (e-ntpdase)/ectoadenosine deaminase (e-ada) activities, reduced bony damage via lowering matrix metalloproteinase (mmp)-1, mmp-3, receptor activator of nuclear factor kappa b ligand (rankl) expression and osteoclasts formation. |
2022-07-06 |
2023-08-14 |
Not clear |
| Haiyang Zhou, Lei Wang, Shuai Liu, Wei Wan. The role of phosphoinositide 3-kinases in immune-inflammatory responses: potential therapeutic targets for abdominal aortic aneurysm. Cell cycle (Georgetown, Tex.). 2022-07-06. PMID:35792922. |
the pathogenesis of abdominal aortic aneurysm (aaa) includes inflammatory responses, matrix metalloproteinases (mmps) degradation, vsmc apoptosis, oxidative stress, and angiogenesis, among which the inflammatory response plays a key role. |
2022-07-06 |
2023-08-14 |
Not clear |
| Sayyed Sajjad Moravveji, Samane Khoshbakht, Majid Mokhtari, Mahdieh Salimi, Hossein Lanjanian, Sajjad Nematzadeh, Mahsa Torkamanian-Afshar, Ali Masoudi-Neja. Impact of 5HydroxyMethylCytosine (5hmC) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers. BMC genomic data. vol 23. issue 1. 2022-06-29. PMID:35768769. |
impact of 5hydroxymethylcytosine (5hmc) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers. |
2022-06-29 |
2023-08-14 |
Not clear |
| Tian Xie, Jun Yuan, Ling Mei, Ping Li, Ruijie Pa. Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways Molecular medicine reports. vol 26. issue 2. 2022-06-22. PMID:35730622. |
in summary, hyperoside ameliorated tnf‑α‑induced inflammation, extracellular matrix degradation, and endoplasmic reticulum stress‑mediated apoptosis, which may be associated with the regulation of the sirt1/nf‑κb and nrf2/antioxidant responsive element signaling pathways by hyperoside. |
2022-06-22 |
2023-08-14 |
human |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Joanne E Murphy-Ullric. Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma. Frontiers in cell and developmental biology. vol 10. 2022-06-13. PMID:35693935. |
at the cellular level, tsp-1 can modulate cell adhesion and migration, protease activity, growth factor activity, anoikis resistance, apoptosis, and collagen secretion and matrix assembly and cross-linking. |
2022-06-13 |
2023-08-14 |
Not clear |
| Alejandro Pallares Robles, Vincent Ten Cate, Andreas Schulz, Jürgen H Prochaska, Steffen Rapp, Thomas Koeck, Marina Panova-Noeva, Stefan Heitmeier, Stephan Schwers, Kirsten Leineweber, Hans-Jürgen Seyfarth, Christian F Opitz, Henri Spronk, Christine Espinola-Klein, Karl J Lackner, Thomas Münzel, Miguel A Andrade-Navarro, Stavros V Konstantinides, Hugo Ten Cate, Philipp S Wil. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Scientific reports. vol 12. issue 1. 2022-06-13. PMID:35697739. |
association of fxi activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. |
2022-06-13 |
2023-08-14 |
human |
| Alejandro Pallares Robles, Vincent Ten Cate, Andreas Schulz, Jürgen H Prochaska, Steffen Rapp, Thomas Koeck, Marina Panova-Noeva, Stefan Heitmeier, Stephan Schwers, Kirsten Leineweber, Hans-Jürgen Seyfarth, Christian F Opitz, Henri Spronk, Christine Espinola-Klein, Karl J Lackner, Thomas Münzel, Miguel A Andrade-Navarro, Stavros V Konstantinides, Hugo Ten Cate, Philipp S Wil. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Scientific reports. vol 12. issue 1. 2022-06-13. PMID:35697739. |
these fxi-related proteins were enriched in immune pathways related to causes of thrombo-inflammation, extracellular matrix interaction, lipid metabolism, and apoptosis. |
2022-06-13 |
2023-08-14 |
human |
| Zhe Ji, Rui Guo, Zhigang Ma, Hongwei L. Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating miR-483-3p. Journal of clinical laboratory analysis. 2022-06-11. PMID:35689566. |
arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating mir-483-3p. |
2022-06-11 |
2023-08-14 |
human |
| Ling-Hui Zeng, Muhammad Qasim Barkat, Shahzada Khurram Syed, Shahid Shah, Ghulam Abbas, Chengyun Xu, Amina Mahdy, Nadia Hussain, Liaqat Hussain, Abdul Majeed, Kashif-Ur-Rehman Khan, Ximei Wu, Musaddique Hussai. Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. Cells. vol 11. issue 11. 2022-06-10. PMID:35681469. |
on the other hand, abnormal expression or loss of regulation of hh signaling leads to airway asthmatic remodeling, which is characterized by cellular matrix modification in the respiratory system, goblet cell hyperplasia, deposition of collagen, epithelial cell apoptosis, proliferation, and activation of fibroblasts. |
2022-06-10 |
2023-08-14 |
Not clear |
| Shang Gao, Nianhu Li, Renchang Chen, Youxiang Su, Yun Song, Songlin Lian. Bushen Huoxue Formula Modulates Autophagic Flux and Inhibits Apoptosis to Protect Nucleus Pulposus Cells by Restoring the AMPK/SIRT1 Pathway. BioMed research international. vol 2022. 2022-06-07. PMID:35669720. |
the typical features of ivdd are extracellular matrix (ecm) degradation and nucleus pulposus cell (np) apoptosis. |
2022-06-07 |
2023-08-14 |
Not clear |
| H Allison, L M O'Sullivan, L M McNamar. Temporal changes in cortical microporosity during estrogen deficiency associated with perilacunar resorption and osteocyte apoptosis: A pilot study. Bone reports. vol 16. 2022-06-06. PMID:35663377. |
we propose that microporosity changes arise due to processes driven by distinct populations of osteocytes, which are either actively resorbing their matrix or have undergone apoptosis and are infilling lacunae by micropetrosis. |
2022-06-06 |
2023-08-14 |
rat |
| Zhiquan Li, Yingchun Wang, Yaoping Wu, Yanwu Liu, Yinan Zhao, Xiaochao Chen, Mo Li, Rui Zha. Role of BLACAT1 in IL-1β-induced human articular chondrocyte apoptosis and extracellular matrix degradation via the miR-149-5p/HMGCR axis. Protein and peptide letters. 2022-06-03. PMID:35657039. |
role of blacat1 in il-1β-induced human articular chondrocyte apoptosis and extracellular matrix degradation via the mir-149-5p/hmgcr axis. |
2022-06-03 |
2023-08-14 |
human |
| Rachana Vaidya, Spencer P Lake, Jennifer A Zeller. Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking. Journal of diabetes science and technology. 2022-06-02. PMID:35652696. |
in addition to dysfunction of the extracellular matrix, tendon cells such as tenocytes and tendon stem/progenitor cells show significant abnormalities in proliferation, apoptosis, and remodeling capacity in the presence of hyperglycemia and advanced glycation end-products, thus contributing to the disruption of tendon homeostasis and healing. |
2022-06-02 |
2023-08-14 |
Not clear |