| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca Louisthelmy, Brycen M Burke, R Chase Corneliso. Brain cancer cell-derived matrices and effects on astrocyte migration. Cells, tissues, organs. 2022-02-15. PMID:35168244. |
we focused on ficoll mmc matrices, which were isolated using the small molecule raptinal to induce cancer cell apoptosis and matrix decellularization. |
2022-02-15 |
2023-08-13 |
mouse |
| Zuo-Long Wu, Ya-Jun Chen, Guang-Zhi Zhang, Qi-Qi Xie, Ke-Ping Wang, Xin Yang, Tai-Cong Liu, Zhi-Qiang Wang, Guang-Hai Zhao, Hai-Hong Zhan. SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration. Apoptosis : an international journal on programmed cell death. 2022-02-11. PMID:35147801. |
ski knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the wnt/β-catenin pathway and ameliorates disc degeneration. |
2022-02-11 |
2023-08-13 |
human |
| Zuo-Long Wu, Ya-Jun Chen, Guang-Zhi Zhang, Qi-Qi Xie, Ke-Ping Wang, Xin Yang, Tai-Cong Liu, Zhi-Qiang Wang, Guang-Hai Zhao, Hai-Hong Zhan. SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration. Apoptosis : an international journal on programmed cell death. 2022-02-11. PMID:35147801. |
western blotting, immunofluorescence, and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining were used to detect np cell apoptosis, extracellular matrix (ecm) metabolism, and related protein expression changes in the wnt/β-catenin signaling pathway. |
2022-02-11 |
2023-08-13 |
human |
| Chenglong Wang, Liqiang Cui, Qinwen Gu, Sheng Guo, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen L. The Mechanism and Function of miRNA in Intervertebral Disc Degeneration. Orthopaedic surgery. 2022-02-10. PMID:35142050. |
current studies on the effects of mirna in idd have confirmed that a variety of mirnas play a crucial role in the process of idd via nucleus pulposus cells (npc) apoptosis, abnormal proliferation, inflammatory factors, the extracellular matrix (ecm) degradation, and annulus fibrosus (af) degeneration. |
2022-02-10 |
2023-08-13 |
Not clear |
| Peng Yan, Chong Sun, Liangrui Luan, Jialuo Han, Yang Qu, Chuanli Zhou, Derong X. Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578. Cell death discovery. vol 8. issue 1. 2022-02-09. PMID:35136049. |
intervertebral disc degeneration (idd) is a chronic degenerative and age-dependent process characterized by aberrant apoptosis, proliferation, synthesis, and catabolism of the extracellular matrix of the nucleus pulposus (np) cells. |
2022-02-09 |
2023-08-13 |
Not clear |
| A P S Mesquita, M Matsuoka, S A Lopes, P C A Pernambuco Filho, A S Cruz, H B Nader, C C Lope. Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 55. 2022-02-09. PMID:35137850. |
anoikis is a type of apoptosis that occurs in response to the loss of adhesion to the extracellular matrix (ecm). |
2022-02-09 |
2023-08-13 |
Not clear |
| Jun-Nan Kang, Ze-Hui Chen, Chen Tia. [Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia --Review]. Zhongguo shi yan xue ye xue za zhi. vol 30. issue 1. 2022-02-06. PMID:35123647. |
bmsc participates in and regulate signaling pathways related to proliferation or apoptosis of all cells by secretes cytokines or extracellular matrix proteins, thus affecting the survival of all cells. |
2022-02-06 |
2023-08-13 |
Not clear |
| Xiaoling Zhang, Si Wang, Yuyan Cai, Weihong He, Qing Yang, Chen L. Regulatory Mechanism of MicroRNA-9 / Long Non-Coding RNA XIST Expression on Mouse Macrophage RAW264.7 Apoptosis Induced by Oxidized Low Density Lipoprotein. Bioengineered. vol 13. issue 2. 2022-02-03. PMID:35109760. |
methylthiazolyl tetrazolium (mtt) method, flow cytometry, and western blot were used to detect and compare the differences of cell proliferation, apoptosis, and the expression levels of apoptosis signal-regulating kinase 1 (ask1), c-jun n-terminal kinase (jnk), matrix metalloproteinase-9 (mmp-9), and b-cell lymphoma-2 (bcl-2) after ox-ldl induction and transfection of mir-9 mimic, mir-9 inhibitor and xist expression vector, respectively. |
2022-02-03 |
2023-08-13 |
mouse |
| Jintao Liu, Pengfei Yu, Feng Dai, Hong Jiang, Zhijia M. Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy. Bioengineered. vol 13. issue 2. 2022-02-03. PMID:35109761. |
tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy. |
2022-02-03 |
2023-08-13 |
rat |
| Yin Zhuang, Sheng Song, Dan Xiao, Xueguang Liu, Xiaofei Han, Shihao Du, Yuan Li, Yanming He, Shujun Zhan. Exosomes Secreted by Nucleus Pulposus Stem Cells Derived From Degenerative Intervertebral Disc Exacerbate Annulus Fibrosus Cell Degradation Frontiers in molecular biosciences. vol 8. 2022-02-03. PMID:35111808. |
here, we show that exosomes secreted by nucleus pulposus stem cells derived from degenerative intervertebral disc (d-dpsc-exo) can exacerbate afc degeneration via inhibiting cell proliferation, migration, matrix synthesis, and promoting apoptosis. |
2022-02-03 |
2023-08-13 |
Not clear |
| Yin Zhuang, Sheng Song, Dan Xiao, Xueguang Liu, Xiaofei Han, Shihao Du, Yuan Li, Yanming He, Shujun Zhan. Exosomes Secreted by Nucleus Pulposus Stem Cells Derived From Degenerative Intervertebral Disc Exacerbate Annulus Fibrosus Cell Degradation Frontiers in molecular biosciences. vol 8. 2022-02-03. PMID:35111808. |
transfection of let-7b-5p mimic was found to promote apoptosis and inhibit proliferation migration and matrix synthesis of afcs. |
2022-02-03 |
2023-08-13 |
Not clear |
| Longlong Du, Xuefeng Li, Qimeng Gao, Puwei Yuan, Yindi Sun, Yingpu Chen, Bo Huang, Yu Deng, Baohui Wan. LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35094651. |
lncrna nuclear receptor subfamily 2 group f member 1 antisense rna 1 (nr2f1-as1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. |
2022-01-31 |
2023-08-13 |
Not clear |
| Xinjie Wu, Wei Su. Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration. Frontiers in cell and developmental biology. vol 9. 2022-01-31. PMID:35096823. |
intervertebral disc degeneration (ivdd) is the leading cause of low back pain related to degradation of cartilaginous tissues, mainly resulting from oxidative stress, cell apoptosis, and extracellular matrix degradation. |
2022-01-31 |
2023-08-13 |
Not clear |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
high hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the wnt/β-catenin pathway. |
2022-01-31 |
2023-08-13 |
human |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
appropriate hydrostatic stimulation (3 atm) enhanced the viability and proteoglycan synthesis yet inhibited the apoptosis of hnpcs, which also up-regulated extracellular matrix and collagen-ii levels, and down-regulated mmp3, wnt-3a and β-catenin levels in treated hnpcs. |
2022-01-31 |
2023-08-13 |
human |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
furthermore, high hydrostatic pressure (30 atm) inhibited the viability and proteoglycan synthesis, and promoted the morphological change and apoptosis of hnpcs, which also down-regulated extracellular matrix and collagen-ii levels and up-regulated mmp3, wnt-3a and β-catenin levels. |
2022-01-31 |
2023-08-13 |
human |
| Shuo Yang, Wenbo Lia. Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069863. |
hydroxysafflor yellow a attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via ca xii. |
2022-01-24 |
2023-08-13 |
cat |
| Guoshuai Cao, Sidong Yang, Jianye Cao, Zixuan Tan, Linyu Wu, Fang Dong, Wenyuan Ding, Feng Zhan. The Role of Oxidative Stress in Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2022. 2022-01-24. PMID:35069969. |
idd is known to be associating with a complex process involving in extracellular matrix and cellular damage, and in recent years, there is increasing evidence that oxidative stress is an important activation mechanism of idd and that reactive oxygen and reactive nitrogen species regulate matrix metabolism, proinflammatory phenotype, autophagy and senescence in intervertebral disc cells, apoptosis, autophagy, and senescence. |
2022-01-24 |
2023-08-13 |
Not clear |
| Derong Xu, Xuexiao Ma, Chong Sun, Jialuo Han, Chuanli Zhou, Sunny Hei Wong, Matthew T V Chan, William K K W. Circular RNAs in Intervertebral Disc Degeneration: An Updated Review. Frontiers in molecular biosciences. vol 8. 2022-01-24. PMID:35071323. |
emerging evidence suggests that circular rnas (circrnas), a major type of regulatory non-coding rna, play critical roles in cellular processes that are pertinent to idd development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition. |
2022-01-24 |
2023-08-13 |
Not clear |
| Mi Na Kim, Jung Yeon Hong, Eun Gyul Kim, Jae Woo Lee, Soo Yeon Lee, Kyung Won Kim, Hyo Sup Shim, Chun Geun Lee, Jack A Elias, Yong Ju Lee, Myung Hyun Soh. A Novel Regulatory Role of ALCAM in the Pathogenesis of Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022-01-24. PMID:35073245. |
idiopathic pulmonary fibrosis is a chronic, progressive lung disease characterized by fibroproliferative matrix molecule accumulation, collagen deposition, and apoptosis. |
2022-01-24 |
2023-08-13 |
mouse |