| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Yang, Lianqin Tao, Yani Xu, Sujian Li, Weiwei Yang, Lijuan Wang, Junfei Zh. CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis. Bioengineered. vol 13. issue 4. 2022-04-20. PMID:35441564. |
circmyc promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting mir-145/ matrix metallopeptidase 2 axis. |
2022-04-20 |
2023-08-13 |
human |
| Karen Jung, Megan A Pawluk, Michael Lane, Layla Nabai, David J Granvill. Granzyme B in Epithelial Barrier Dysfunction and Related Skin Diseases. American journal of physiology. Cell physiology. 2022-04-20. PMID:35442832. |
discovered in the 1980s, granzyme b is currently recognized for its intracellular roles in immune cell-mediated targeted apoptosis as well as extracellular roles in inflammation, chronic injuries, tissue remodeling, and processing of cytokines, matrix proteins, and autoantigens. |
2022-04-20 |
2023-08-13 |
Not clear |
| Zhijun Cai, Yi Cui, Jing Wang, Xin Qi, Pengju He, Pengfei Bu, Yongqing Xu, Yang L. A narrative review of the progress in the treatment of knee osteoarthritis. Annals of translational medicine. vol 10. issue 6. 2022-04-18. PMID:35433989. |
there is evidence that inflammatory factors, abnormal chondrocyte apoptosis, and extracellular matrix degradation are closely associated with the occurrence and development of oa. |
2022-04-18 |
2023-08-13 |
Not clear |
| Erika P New, Nihan Semerci, Asli Ozmen, Xiaofang Guo, Venkata A Jonnalagadda, Joung Woul Kim, Matthew L Anderson, Ozlem Guzeloglu-Kayisli, Anthony N Imudia, Charles J Lockwood, Umit A Kayisl. FKBP51 Contributes to Uterine Leiomyoma Pathogenesis by Inducing Cell Proliferation and Extracellular Matrix Deposition. Reproductive sciences (Thousand Oaks, Calif.). 2022-04-15. PMID:35426036. |
control (scramble) vs. fkbp5 sirna-transfected leiomyoma cell cultures were assessed for proliferation, apoptosis, and mrna levels of genes involved in cell survival and extracellular matrix (ecm) formation. |
2022-04-15 |
2023-08-13 |
human |
| Yao Hai, Cao Zhidong, Wu Wenya. Human umbilical cord mesenchymal stromal cells promotes the proliferation and osteogenic differentiation of autologous bone marrow stem cells by secreting exosomes. Bioengineered. vol 13. issue 4. 2022-04-12. PMID:35412945. |
the results indicated that humscs could increase the proliferation of abmscs, reduce apoptosis, and promote matrix metabolism. |
2022-04-12 |
2023-08-13 |
human |
| Liang Qi, Min Wang, Jinlong He, Bin Jia, Jing Ren, Shicheng Zhen. E3 ubiquitin ligase ITCH improves LPS-induced chondrocyte injury by mediating JAG1 ubiquitination in osteoarthritis. Chemico-biological interactions. 2022-04-06. PMID:35385713. |
overexpressing itch or silencing jag1 promoted proliferation, and restrained apoptosis, inflammation and extracellular matrix (ecm) degradation in lps-stimulated chondrocytes. |
2022-04-06 |
2023-08-13 |
mouse |
| Chao Gao, Xiaolei Lin, Fan Fan, Xin Liu, Huijuan Wan, Ting Yuan, Xinrong Zhao, Yi Lu. Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts. BMC ophthalmology. vol 22. issue 1. 2022-04-05. PMID:35379202. |
transforming growth factor (tgf) is a cytokine that acts on the proliferation, migration, differentiation, and apoptosis of cells and the accumulation of extracellular matrix components. |
2022-04-05 |
2023-08-13 |
Not clear |
| Ok Joo Sul, Jin Hyoung Kim, Taehoon Lee, Kwang Won Seo, Hee Jeong Cha, Byungsuk Kwon, Jong-Joon Ahn, You Sook Cho, Yeon-Mok Oh, Yangjin Jegal, Seung Won R. GSPE Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice via Ameliorating Epithelial Apoptosis through Inhibition of Oxidative Stress. Oxidative medicine and cellular longevity. vol 2022. 2022-03-31. PMID:35355866. |
idiopathic pulmonary fibrosis (ipf) is a chronic, progressive interstitial lung disease of unknown cause which leads to alveolar epithelial cell apoptosis followed by basement membrane disruption and accumulation of extracellular matrix, destroying the lung architecture. |
2022-03-31 |
2023-08-13 |
mouse |
| Siam-Yee Lee, Pooi-Fong Wong, Juliana Jamal, Margaret M Roebuc. Naturally-derived endoplasmic reticulum stress inhibitors for osteoarthritis? European journal of pharmacology. 2022-03-30. PMID:35351442. |
chondrocytes have limited proliferative capacity and their apoptosis eventually leads to extracellular matrix loss and cartilage degeneration. |
2022-03-30 |
2023-08-13 |
Not clear |
| Fangyuan Chen, Jingyue Deng, Lishi Luo, Ying Zhu, Yuying Dong, Yuanting Yang, Rijia Zhang, Jian Chen, Qing Zho. Crosslinked Decellularized Porcine Pericardium as a Substrate for Conjunctival Reconstruction. Stem cells international. vol 2022. 2022-03-28. PMID:35342430. |
in vitro dpp showed lower apoptosis, highly desirable, well preservation of extracellular matrix components, and favorable macro-microstructure, which was confirmed by histology, immunofluorescence, electron microscopy, collagen and dna quantification, and cytotoxicity assay, compared to the native porcine pericardium (npp). |
2022-03-28 |
2023-08-13 |
human |
| Bessi Qorri, Reza Bayat Mokhtari, William W Harless, Myron R Szewczu. Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression. Cancers. vol 14. issue 6. 2022-03-25. PMID:35326525. |
to assess the key survival pathways critical for pancreatic cancer progression, we used the alamarblue cytotoxicity assay to determine the cell viability and combination index for the drug combinations, flow cytometric analysis of annexin v apoptosis assay to detect apoptotic and necrotic cells, fluorometric qcm™ chemotaxis migration assay to assess cellular migration, fluorometric extracellular matrix (ecm) cell adhesion array kit to assess the expression of the ecm proteins, scratch wound assay using the 96-well woundmaker™, and the methylcellulose clonogenic assay to assess clonogenic potential. |
2022-03-25 |
2023-08-13 |
human |
| Bessi Qorri, Reza Bayat Mokhtari, William W Harless, Myron R Szewczu. Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression. Cancers. vol 14. issue 6. 2022-03-25. PMID:35326525. |
the combination of asa and op with gem significantly upended miapaca-2 and panc-1 pancreatic cancer cell viability, clonogenic potential, expression of critical extracellular matrix proteins, migration, and promoted apoptosis. |
2022-03-25 |
2023-08-13 |
human |
| Volker Schirrmache. Molecular Mechanisms of Anti-Neoplastic and Immune Stimulatory Properties of Oncolytic Newcastle Disease Virus. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327364. |
the anti-neoplastic activities of ndv include (i) the endocytic targeting of the gtpase rac1 in ras-transformed human tumorigenic cells; (ii) the switch from cellular protein to viral protein synthesis and the induction of autophagy mediated by viral nucleoprotein np; (iii) the virus replication mediated by viral rna polymerase (large protein (l), associated with phosphoprotein (p)); (iv) the facilitation of ndv spread in tumors via the membrane budding of the virus progeny with the help of matrix protein (m) and fusion protein (f); and (v) the oncolysis via apoptosis, necroptosis, pyroptosis, or ferroptosis associated with immunogenic cell death. |
2022-03-25 |
2023-08-13 |
human |
| Wilke M Post, Joanna Widomska, Hilde Grens, Marieke J H Coenen, Frank M J Martens, Dick A W Janssen, Joanna IntHout, Geert Poelmans, Egbert Oosterwijk, Kirsten B Kluiver. Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328824. |
resulting from the most examined processes, the evidence suggests that sui is associated with altered extracellular matrix metabolism, estrogen receptors, oxidative stress, apoptosis, inflammation, neurodegenerative processes, and muscle cell differentiation and contractility. |
2022-03-25 |
2023-08-13 |
mouse |
| Dan Wang, Hao Qu, Hui Kang, Feng Xu, Wei Huang, Xianhua Ca. Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. Bioengineered. vol 13. issue 4. 2022-03-25. PMID:35333664. |
kukoamine a attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the p13k/akt pathway. |
2022-03-25 |
2023-08-13 |
Not clear |
| Dan Wang, Hao Qu, Hui Kang, Feng Xu, Wei Huang, Xianhua Ca. Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. Bioengineered. vol 13. issue 4. 2022-03-25. PMID:35333664. |
then, the experiments following the treatment of kua in lps-induced npcs included cell proliferation assessment by 5-ethynyl-2'-deoxyuridine (edu) kit, cell apoptosis and extracellular matrix degradation (ecm) analysis by terminal dutp nick-end labeling (tunel) and western blot, the detection of inflammatory cytokines by western blot and enzyme-linked immunosorbent assay (elisa), p13k/akt pathway-related protein levels analysis by western blot. |
2022-03-25 |
2023-08-13 |
Not clear |
| Wei Peng, Xingcheng Zhou, Tingting Xu, Yanwen Mao, Xiaohuan Zhang, Huiming Liu, Luqun Liang, Lingling Liu, Lirong Liu, Ying Xiao, Fan Zhang, Shuang Li, Mingjun Shi, Yuxia Zhou, Lei Tang, Yuanyuan Wang, Bing Gu. BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease. Cell death & disease. vol 13. issue 3. 2022-03-22. PMID:35314669. |
transforming growth factor β1 (tgf-β1) is involved in the extensive fibrosis of renal tissue by facilitating the partial epithelial-mesenchymal transition (emt), increasing the synthesis of extracellular matrix (ecm), inhibiting degradation, inducing apoptosis of renal parenchyma cells, and activating renal interstitial fibroblasts and inflammatory cells. |
2022-03-22 |
2023-08-13 |
mouse |
| Liuxie Yang, Zhenhuan Li, Yueping Ouyan. Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Molecular medicine reports. vol 25. issue 5. 2022-03-22. PMID:35315493. |
nucleus pulposus (np) apoptosis and subsequent excessive degradation of the extracellular matrix (ecm) are key pathological characteristics of intervertebral disc degeneration (idd). |
2022-03-22 |
2023-08-13 |
Not clear |
| Shang Xian Bo, Wang Chen, Liu Chang, Yu Hao Ran, Guo Hui Hui, Zhu Ya Kun, Xie Wu Kun, Fan Hai Tao, Cheng Wen Da. The Research Progress of Exosomes in Osteoarthritis, With Particular Emphasis on the Therapeutic Effect. Frontiers in pharmacology. vol 13. 2022-03-21. PMID:35308214. |
recent studies have shown that exosomes participate in oa treatment by regulating the proliferation, apoptosis, inflammation, and extracellular matrix synthesis of chondrocytes. |
2022-03-21 |
2023-08-13 |
Not clear |
| Bing-Tao Zhai, Huan Tian, Jing Sun, Jun-Bo Zou, Xiao-Fei Zhang, Jiang-Xue Cheng, Ya-Jun Shi, Yu Fan, Dong-Yan Gu. Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer. Journal of translational medicine. vol 20. issue 1. 2022-03-19. PMID:35303878. |
upar is closely related to the invasion and metastasis of malignant tumours, plays important roles in the degradation of extracellular matrix (ecm), tumour angiogenesis, cell proliferation and apoptosis, and is associated with the multidrug resistance (mdr) of tumour cells, which has important guiding significance for the judgement of tumor malignancy and prognosis. |
2022-03-19 |
2023-08-13 |
Not clear |