| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nele Wagener, Wolfgang Lehmann, Lukas Weiser, Katharina Jäckle, Pietro Di Fazio, Arndt F Schilling, Kai O Böke. Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142172. |
in bone formation assays, all three cognitive enhancers caused a significant decrease in the mineralized matrix and an early slight reduction of cell viability without triggering apoptosis or necrosis. |
2022-09-23 |
2023-08-14 |
human |
| Nada Oršolić, Maja Jazvinšćak Jembre. Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142391. |
anticancer activity of propolis and its compounds relies on various mechanisms: cell-cycle arrest and attenuation of cancer cells proliferation, reduction in the number of cancer stem cells, induction of apoptosis, modulation of oncogene signaling pathways, inhibition of matrix metalloproteinases, prevention of metastasis, anti-angiogenesis, anti-inflammatory effects accompanied by the modulation of the tumor microenvironment (by modifying macrophage activation and polarization), epigenetic regulation, antiviral and bactericidal activities, modulation of gut microbiota, and attenuation of chemotherapy-induced deleterious side effects. |
2022-09-23 |
2023-08-14 |
Not clear |
| Yeyang Wang, Xiaoyu Zheng, Dixin Luo, Wangyang Xu, Xiaozhong Zho. MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8. BMC musculoskeletal disorders. vol 23. issue 1. 2022-09-20. PMID:36127685. |
mir-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting fzd8. |
2022-09-20 |
2023-08-14 |
Not clear |
| Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan, Hengfeng Yua. Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis. Journal of nanobiotechnology. vol 20. issue 1. 2022-09-19. PMID:36123746. |
further bioinformatics analysis revealed that msn-ol suppressed clusters of genes associated with extracellular matrix organization, cell apoptosis and cellular response to oxidative stress. |
2022-09-19 |
2023-08-14 |
Not clear |
| Eduardo Cremonese Filippi-Chiela, Jose Eduardo Vargas, Mardja Manssur Bueno E Silva, Marcos Paulo Thomé, Guido Len. Vincristine promotes differential levels of apoptosis, mitotic catastrophe, and senescence depending on the genetic background of glioblastoma cells. Toxicology in vitro : an international journal published in association with BIBRA. 2022-09-18. PMID:36116745. |
a correlation matrix based on experimental cell analysis reported strong negative correlations between cell number, nuclear irregularities, senescence, or apoptosis, depending on the cells' genetic makeup and treatment regimen. |
2022-09-18 |
2023-08-14 |
Not clear |
| Yi Li, Fulei Li, Zongzong Sun, Juan L. A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2022-09-16. PMID:36112261. |
recent studies have also documented that tpt1-as1 modulates numerous biological processes through multiple mechanisms, including cell proliferation, apoptosis, autophagy, invasion, migration, radiosensitivity, chemosensitivity, stemness, and extracellular matrix (ecm) synthesis. |
2022-09-16 |
2023-08-14 |
human |
| Kaiqiang Sun, Jialin Jiang, Yuan Wang, Xiaofei Sun, Jian Zhu, Ximing Xu, Jingchuan Sun, Jiangang Sh. The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration. Ageing research reviews. 2022-09-16. PMID:36113765. |
abnormal apoptosis, senescence, and pyroptosis of ivd cells, extracellular matrix (ecm) degradation, and infiltration of immune cells are the major molecular alternations during ivdd. |
2022-09-16 |
2023-08-14 |
Not clear |
| Po-Yen Ko, Che-Chia Hsu, Shih-Yao Chen, Li-Chieh Kuo, Wei-Ren Su, I-Ming Jou, Fong-Chin Su, Po-Ting W. Cross-Linked Hyaluronate and Corticosteroid Combination Ameliorate the Rat Experimental Tendinopathy through Anti-Senescent and -Apoptotic Effects. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077161. |
cell viability, inflammatory cytokines, tendon-related proliferation markers, matrix metalloproteinases (mmps), senescent markers, and apoptosis were examined. |
2022-09-09 |
2023-08-14 |
human |
| Alexandra Ripszky Totan, Marina Melescanu Imre, Simona Parvu, Daniela Meghea, Radu Radulescu, Dan Sebastian Alexandru Enasescu, Mihai Radu Moisa, Silviu Mirel Pitur. Autophagy Plays Multiple Roles in the Soft-Tissue Healing and Osseointegration in Dental Implant Surgery-A Narrative Review. Materials (Basel, Switzerland). vol 15. issue 17. 2022-09-09. PMID:36079421. |
autophagy downregulation in fibroblasts induces apoptosis, leading to better wound healing by improving excessive deposition of extracellular matrix and inhibiting fibrosis progression. |
2022-09-09 |
2023-08-14 |
Not clear |
| Chao Jia, Xiucui Li, Jun Pan, Haiwei Ma, Dengying Wu, Hongwei Lu, Wei Wang, Xutong Zhang, Xianhong Y. Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF- Oxidative medicine and cellular longevity. vol 2022. 2022-09-08. PMID:36071864. |
silencing of angiopoietin-like protein 4 (angptl4) decreases inflammation, extracellular matrix degradation, and apoptosis in osteoarthritis via the sirtuin 1/nf- osteoarthritis (oa) is a frequently observed condition in aged people. |
2022-09-08 |
2023-08-14 |
mouse |
| Chao Jia, Xiucui Li, Jun Pan, Haiwei Ma, Dengying Wu, Hongwei Lu, Wei Wang, Xutong Zhang, Xianhong Y. Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF- Oxidative medicine and cellular longevity. vol 2022. 2022-09-08. PMID:36071864. |
oa cartilage is characterized by chondrocyte apoptosis, chondrocyte inflammation, and hyperactive catabolism of extracellular matrix. |
2022-09-08 |
2023-08-14 |
mouse |
| Manabu Sakai, Takayoshi Saka. Establishment of a Mouse Submandibular Salivary Gland Organ Culture. Current protocols. vol 2. issue 9. 2022-09-07. PMID:36069677. |
under physiological conditions, cells constantly interact with other cells and the extracellular matrix, which controls complex biological functions such as cell migration and apoptosis, and can modulate gene expression. |
2022-09-07 |
2023-08-14 |
mouse |
| Lorena Cayetano-Salazar, Dania A Nava-Tapia, Kevin D Astudillo-Justo, Adán Arizmendi-Izazaga, César Sotelo-Leyva, Mayra Herrera-Martinez, Sócrates Villegas-Comonfort, Napoleón Navarro-Tit. Flavonoids as regulators of TIMPs expression in cancer: Consequences, opportunities, and challenges. Life sciences. 2022-09-06. PMID:36067841. |
these inhibitors regulate tissue extracellular matrix (ecm) turnover; they inhibit matrix metalloproteinases (mmps), cell migration, invasion, and angiogenesis and induce apoptosis in tumor cells. |
2022-09-06 |
2023-08-14 |
Not clear |
| ChuanCai Liang, Hengte Xing, ChenYu Wang, XiongFeng Xu, Yarong Hao, Bo Qi. Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-09-05. PMID:36064420. |
this study investigated the effects of resveratrol (res) on extracellular matrix (ecm), autophagy, and apoptosis in oa pathogenesis via the sirt1/foxo1 pathway. |
2022-09-05 |
2023-08-14 |
Not clear |
| Rais Reskiawan A Kadir, Mansour Alwjwaj, Kamini Rakkar, Othman Ahmad Othman, Nikola Sprigg, Philip M Bath, Ulvi Bayraktuta. Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms. Stem cell reviews and reports. 2022-09-02. PMID:36056287. |
effective suppression of anti-angiogenic factor endostatin, stress fiber formation, oxidative stress, and apoptosis along with concomitant improvements in extracellular matrix adhesive and tubulogenic properties of brain microvascular endothelial cells and oecs played an important role in oec-cm-mediated benefits. |
2022-09-02 |
2023-08-14 |
human |
| Chao Wan, Wei Liu, Limin Jiang, Shengjie Dong, Weihua Ma, Shijun Wang, Dan Li. Knockdown of MKL1 ameliorates oxidative stress-induced chondrocyte apoptosis and cartilage matrix degeneration by activating TWIST1-mediated PI3K/AKT signaling pathway in rats. Autoimmunity. 2022-09-01. PMID:36046946. |
knockdown of mkl1 ameliorates oxidative stress-induced chondrocyte apoptosis and cartilage matrix degeneration by activating twist1-mediated pi3k/akt signaling pathway in rats. |
2022-09-01 |
2023-08-14 |
rat |
| Chao Wan, Wei Liu, Limin Jiang, Shengjie Dong, Weihua Ma, Shijun Wang, Dan Li. Knockdown of MKL1 ameliorates oxidative stress-induced chondrocyte apoptosis and cartilage matrix degeneration by activating TWIST1-mediated PI3K/AKT signaling pathway in rats. Autoimmunity. 2022-09-01. PMID:36046946. |
this study aimed to investigate the regulatory role of mkl1 in oxidative stress-induced chondrocyte apoptosis and cartilage matrix degeneration. |
2022-09-01 |
2023-08-14 |
rat |
| Anna Ruiz-Mitjana, Raúl Navaridas, Maria Vidal-Sabanés, Aida Perramon-Güell, Andree Yeramian, Isidre Felip, Núria Eritja, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolce. Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition. Scientific reports. vol 12. issue 1. 2022-09-01. PMID:36050359. |
lack of extracellular matrix switches tgf-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition. |
2022-09-01 |
2023-08-14 |
Not clear |
| Anna Ruiz-Mitjana, Raúl Navaridas, Maria Vidal-Sabanés, Aida Perramon-Güell, Andree Yeramian, Isidre Felip, Núria Eritja, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolce. Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition. Scientific reports. vol 12. issue 1. 2022-09-01. PMID:36050359. |
here, we have demonstrated that the lack of extracellular matrix and consequent loss of cell polarity inhibits tgf-β-induced apoptosis, observed when endometrial epithelial cells are polarized in presence of extracellular matrix. |
2022-09-01 |
2023-08-14 |
Not clear |
| Chenyu Rao, Sirong Sh. Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy. Frontiers in molecular biosciences. vol 9. 2022-08-29. PMID:36032667. |
after administration, the dds and targeted nano therapeutical molecules can specifically react with the components, including cartilage and synovium of a joint in oa, furthermore attenuate the chondrocyte apoptosis, matrix degradation, and macrophage recruitment. |
2022-08-29 |
2023-08-14 |
Not clear |