| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Tao Wu, Yong-Xiang Wang, Xin-Min Feng, Min Feng, Hui-Hui Su. Update on the roles of macrophages in the degeneration and repair process of intervertebral discs. Joint bone spine. 2022-12-18. PMID:36529418. |
the process of ivd degeneration involves a complex of pathologic changes on both extracellular matrix degradation and resident cell apoptosis. |
2022-12-18 |
2023-08-14 |
Not clear |
| Yanrong Sun, E Liu, Yanhong Pei, Qinhan Yao, Haowen Ma, Yakun Mu, Yingjie Wang, Yan Zhang, Xiaomei Yang, Xing Wang, Jiajia Xue, Jiliang Zhai, Roxana O Carare, Lihua Qin, Junhao Ya. The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage. Acta neuropathologica communications. vol 10. issue 1. 2022-12-18. PMID:36529767. |
after sah, there was significant impairment in the ipad system: marked expansion of perivascular spaces, and isf clearance rate was significantly decreased, associated with the apoptosis of endothelial cells, activation of astrocytes, over-expression of matrix metalloproteinase 9 and loss of collagen type iv. |
2022-12-18 |
2023-08-14 |
rat |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Rui Ran, Yi Wu, Hai-Hong Zhan. Acid-Sensing Ion Channels: Implications For Intervertebral Disc Degeneration. Current pharmaceutical biotechnology. 2022-12-12. PMID:36503387. |
matrix acidity potentially negatively affects gene expression, activity, proliferation, and apoptosis of ivd cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Teng Ma, Xiangpeng Wang, Wenjing Qu, Lingsen Yang, Cheng Jing, Bingrui Zhu, Yongkui Zhang, Wenpeng Xi. Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway. Molecules (Basel, Switzerland). vol 27. issue 23. 2022-12-11. PMID:36500713. |
we found that osthole inhibited il-1β-induced apoptosis and cartilage matrix degeneration by activating autophagy in rat chondrocytes. |
2022-12-11 |
2023-08-14 |
rat |
| Samantha B Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V Brown, Jared B Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P Vostrejs, Kia Z Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R Donahue, Caius G Radu, Cynthia Clendenin, James G Christensen, Robert H Vonderheide, Ben Z Stange. Efficacy of a small molecule inhibitor of KrasG12D in immunocompetent models of pancreatic cancer. Cancer discovery. 2022-12-06. PMID:36472553. |
concomitant with tumor cell apoptosis and proliferative arrest, drug treatment led to marked shifts in the tumor microenvironment (tme), including changes in fibroblasts, matrix, and macrophages. |
2022-12-06 |
2023-08-14 |
Not clear |
| Yue-Liang Yue, Meng-Yu Zhang, Jian-Yu Liu, Li-Jun Fang, Yi-Qing Q. The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies. Therapeutic advances in respiratory disease. vol 16. 2022-12-05. PMID:36468453. |
this review focused on the six steps of autophagy, as well as the interplay between autophagy and other seven pulmonary fibrosis related mechanisms, which include extracellular matrix deposition, myofibroblast differentiation, epithelial-mesenchymal transition, pulmonary epithelial cell dysfunction, apoptosis, tgf-β1 pathway, and the renin-angiotensin system. |
2022-12-05 |
2023-08-14 |
Not clear |
| Yue Li, Bin Shen, Cunxian Lv, Xinyi Zhu, Qiqige Naren, Dong Xu, He Chen, Fengmiao W. Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression. International immunopharmacology. vol 114. 2022-12-02. PMID:36459925. |
osteoarthritis (oa) is a common age-related degenerative disease involving various pathological processes, among which apoptosis in chondrocyte and extracellular matrix (ecm) degradation are the main pathologies. |
2022-12-02 |
2023-08-14 |
mouse |
| Farzad Sattari Fard, Nazila Jalilzadeh, Amir Mehdizadeh, Fakhrosadat Sajjadian, Kobra Velae. Understanding and targeting anoikis in metastasis for cancer therapies. Cell biology international. 2022-12-01. PMID:36453448. |
one of those driving mechanisms is anoikis, a special type of apoptosis, which is induced by losing anchorage from the extracellular matrix (ecm). |
2022-12-01 |
2023-08-14 |
Not clear |
| Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yi. 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Frontiers in pharmacology. vol 13. 2022-11-28. PMID:36438802. |
3,3'-diindolylmethane inhibits lps-induced human chondrocytes apoptosis and extracellular matrix degradation by activating pi3k-akt-mtor-mediated autophagy. |
2022-11-28 |
2023-08-14 |
mouse |
| Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yi. 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Frontiers in pharmacology. vol 13. 2022-11-28. PMID:36438802. |
we found that lps stimulation significantly inhibited autophagy, induced chondrocyte apoptosis and extracellular matrix (ecm) degradation, which could be ameliorated by dim. |
2022-11-28 |
2023-08-14 |
mouse |
| Liang Cai, Jingyuan Huang, Daiqiang Huang, Haigang Lv, Dezhi Wang, Haili Wang, Hailong Miao, Li Wu, Fang Wan. Deficiency of immune-responsive gene 1 exacerbates interleukin-1beta-elicited the inflammatory response of chondrocytes via enhancing the activation of NLRP3 inflammasome. International immunopharmacology. vol 114. 2022-11-28. PMID:36442283. |
the knockdown of irg1 exacerbated il-1β-elicited apoptosis and degradation of the extracellular matrix in chondrocytes. |
2022-11-28 |
2023-08-14 |
Not clear |
| Kushi Ranganath, Allen L Feng, Ramon A Franco, Mark A Varvares, William C Faquin, Matthew R Naunheim, Srinivas Vinod Salad. Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428690. |
these markers are involved in a wide range of cellular processes in head and neck carcinogenesis, including extracellular matrix degradation, cell motility and invasion, cell-cell adhesion, solute transport, immortalization, metabolism, the cell cycle and apoptosis, transcription, and cell signaling. |
2022-11-26 |
2023-08-14 |
Not clear |
| Hee Su Sohn, Jeong Won Choi, JooYeon Jhun, Sung Pil Kwon, Mungyo Jung, Sangmin Yong, Hyun Sik Na, Jin-Hong Kim, Mi-La Cho, Byung-Soo Ki. Tolerogenic nanoparticles induce type II collagen-specific regulatory T cells and ameliorate osteoarthritis. Science advances. vol 8. issue 47. 2022-11-25. PMID:36427299. |
consequently, lnp-col ii-r injection inhibited chondrocyte apoptosis and cartilage matrix degradation and relieved pain, while injection of lnps loaded with a control peptide and rapamycin did not induce these events. |
2022-11-25 |
2023-08-14 |
mouse |
| Xinqi Huang, Xuefeng Pan, Xiner Xiong, Zhihe Zhao, Xiao Ce. Drug delivery systems for treatment of temporomandibular joint osteoarthritis. Frontiers in pharmacology. vol 13. 2022-11-24. PMID:36419625. |
chondrocyte apoptosis, extracellular matrix degradation, synovitis, and subchondral bone remodeling are the main pathological features of tmjoa. |
2022-11-24 |
2023-08-14 |
Not clear |
| Omar Ramos-Lope. Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease. Genes. vol 13. issue 11. 2022-11-24. PMID:36421817. |
mafld is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. |
2022-11-24 |
2023-08-14 |
human |
| Dongdong Wang, Ji Zhu, Yuanqing Yang, Zhizhou Wang, Zhengran Ying, Hailong Zhan. The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration. Cellular signalling. 2022-11-24. PMID:36423859. |
to determine the mechanism by which mir-4306 was involved in idd pathogenesis, we examined the effects of overexpressing or silencing mir-4306 on extracellular matrix (ecm) synthesis/degradation, proliferation, autophagy and apoptosis of human degenerated np cells isolated from idd patients. |
2022-11-24 |
2023-08-14 |
human |
| Min Hu, Hao Li, Guangzhen Li, Yuan Wang, Jing Liu, Meihua Zhang, Di Shen, Xietong Wan. NETs promote ROS production to induce human amniotic epithelial cell apoptosis via ERK1/2 signaling in spontaneous preterm birth. American journal of reproductive immunology (New York, N.Y. : 1989). 2022-11-21. PMID:36409534. |
premature birth is a common obstetric complication but its pathogenesis is unclear. inflammation at the maternal-fetal interface in preterm labor leads to the infiltration of neutrophils, which promotes inflammatory responses and induces the degradation of extracellular matrix and cell apoptosis, thus contributing to preterm labor. it is unclear whether neutrophil extracellular traps (nets), a functional form of neutrophils, are involved in preterm labor. |
2022-11-21 |
2023-08-14 |
human |
| Alexa J Cohen, Neda Nikbakht, Jouni Uitt. Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin. Cold Spring Harbor perspectives in biology. 2022-11-21. PMID:36411063. |
transforming growth factor-β1/smad signaling regulates the expression of genes encoding extracellular matrix proteins and also controls cell proliferation and apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen L. Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration. Clinical physiology and functional imaging. 2022-11-18. PMID:36400723. |
intervertebral disc degeneration (idd) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ecm), which will impair the structure and function of the intervertebral disc(ivd), and cause low back pain. |
2022-11-18 |
2023-08-14 |
Not clear |