| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yusheng Li, Wenqing Xie, Yizi Zheng, Hengzhen Li, Zeqin Wen, Chen Wang, Siyu Chen, Zhenhan Den. The miR-548d-5p/SP1 signaling axis regulates chondrocyte proliferation and inflammatory responses in osteoarthritis. International immunopharmacology. vol 110. 2022-08-18. PMID:35978504. |
mir-548d-5p overexpression partially reversed il-1β-induced chondrocyte damage in vitro, evidenced by the promotion of cell growth, the inhibition of apoptosis and inflammatory cytokine release, and the improvement in extracellular matrix (ecm) deposition. |
2022-08-18 |
2023-08-14 |
rat |
| Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi L. The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights. Experimental & molecular medicine. 2022-08-17. PMID:35978054. |
the nrf2 antioxidant defense system regulates cell apoptosis, senescence, extracellular matrix (ecm) metabolism, the inflammatory response of the nucleus pulposus (np), and calcification of the cartilaginous endplates (ep) in idd. |
2022-08-17 |
2023-08-14 |
cat |
| Marjan Aghajani, Alireza Imani, Gholamali Kardar, Mahdieh Faghihi, Mozhgan Aghajan. Unfavorable Left Ventricular Remodeling due to Experience of Chronic Sleep Restriction after Myocardial Infarction: The role of Matrix Metalloproteinases & Oxidative stress. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2022-08-02. PMID:35917906. |
herein, we proposed that experience of sleep disruption and/or restriction after myocardial infarction (mi) may aggrevate cardiac extracellular matrix remodeling and induce apoptosis in the cardiomyocytes. |
2022-08-02 |
2023-08-14 |
rat |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| David S Dang, Chaoyu Zhai, Mahesh N Nair, Kara J Thornton, Mohammed N Sawalhah, Sulaiman K Matarne. Tandem mass tag labeling to assess proteome differences between intermediate and very tender beef steaks. Journal of animal science. vol 100. issue 8. 2022-07-31. PMID:35908783. |
the differentially identified proteins encompassed a wide array of biological processes related to muscle contraction, calcium signaling, metabolism, extracellular matrix organization, chaperone, and apoptosis. |
2022-07-31 |
2023-08-14 |
Not clear |
| Zheming Bao, Mengli Chen, Chen Li, Qing Shan, Yichen Wang, Wenshan Yan. Monosodium iodoacetate-induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis. Open life sciences. vol 17. issue 1. 2022-07-29. PMID:35903181. |
we found that intra-articular injection of mia increased chondrocyte apoptosis and promoted cartilage matrix degradation, such as cartilage surface defects and shallow or disappearing staining. |
2022-07-29 |
2023-08-14 |
rat |
| Zhao Zhang, Jingtao Wu, Cheng Teng, Jinquan Wang, Libo Wang, Long Wu, Wenhao Chen, Zhen Lin, Zhongke Li. Safranal Treatment Induces Sirt1 Expression and Inhibits Endoplasmic Reticulum Stress in Mouse Chondrocytes and Alleviates Osteoarthritis Progression in a Mouse Model. Journal of agricultural and food chemistry. 2022-07-28. PMID:35899925. |
oxidative stress (os) modulates oa pathogenesis by enhancing chondrocyte apoptosis and extracellular matrix (ecm) degeneration via activation of the endoplasmic reticulum (er) stress. |
2022-07-28 |
2023-08-14 |
mouse |
| Mamdouh Eldesoqui, Zienab Helmy Eldken, Sally Abdallah Mostafa, Rasha Hamed Al-Serwi, Mohamed El-Sherbiny, Nehal Elsherbiny, Zuhair M Mohammedsaleh, Noha Hammad Sak. Exercise Augments the Effect of SGLT2 Inhibitor Dapagliflozin on Experimentally Induced Diabetic Cardiomyopathy, Possible Underlying Mechanisms. Metabolites. vol 12. issue 7. 2022-07-27. PMID:35888760. |
dcm is associated with myocardial oxidative stress, inflammation, apoptosis, suppressed autophagy, extracellular matrix remodeling, and fibrosis. |
2022-07-27 |
2023-08-14 |
rat |
| Wei Tan, Yunyan Wang, Hongmei Dai, Junhui Deng, Zhifen Wu, Lirong Lin, Jurong Yan. Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products. Frontiers in pharmacology. vol 13. 2022-07-25. PMID:35873549. |
in this paper, we review the potential mechanisms of cordyceps against renal fibrosis, focusing on the effects of cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, reduction of extracellular matrix deposition, and fibroblast activation. |
2022-07-25 |
2023-08-14 |
Not clear |
| Daokuan Gao, Bo Hu, Baiyang Ding, Quanlai Zhao, Yu Zhang, Liang Xia. N6-Methyladenosine-induced miR-143-3p promotes intervertebral disc degeneration by regulating SOX5. Bone. 2022-07-25. PMID:35878746. |
mir-143-3p in nucleus pulposus cells was involved in the regulation of extracellular matrix metabolism and apoptosis after tnf-α stimulation, and intervertebral disc degeneration was relieved by effectively regulating mir-143-3p expression. |
2022-07-25 |
2023-08-14 |
human |
| Chu-Yang Zeng, Xi-Feng Wang, Fu-Zhou Hu. HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications. Frontiers in pharmacology. vol 13. 2022-07-22. PMID:35865944. |
the activation of hif-1α could regulate autophagy and apoptosis of chondrocytes, decrease inflammatory cytokine synthesis, and regulate the chondrocyte extracellular matrix environment. |
2022-07-22 |
2023-08-14 |
Not clear |
| Yonggan Ying, Zhaopeng Tang, Feng Niu, Taotao Xu, Chenjie Xia, Shuijun Zhan. Network pharmacology-based pharmacological mechanism prediction on Eucommia ulmoides against rheumatoid arthritis. Medicine. vol 101. issue 29. 2022-07-22. PMID:35866805. |
go enrichment analysis indicated that eu exerted antira effects depending on regulating multiple biological processes including inflammatory response, oxidative stress, cell apoptosis and matrix catabolism. |
2022-07-22 |
2023-08-14 |
Not clear |
| Zhihai Yuan, Zhen Yang, Weiqin Li, Aimei Wu, Zhixiang Su, Bin Jiang, Sakthivigneswari Ganesa. Triphlorethol-A attenuates U251 human glioma cancer cell proliferation and ameliorates apoptosis through JAK2/STAT3 and p38 MAPK/ERK signaling pathways. Journal of biochemical and molecular toxicology. 2022-07-15. PMID:35838116. |
the cytotoxicity, intracellular reactive oxygen species (ros), matrix metalloproteinase (mmp), and cell apoptosis activity of ta have been evaluated by the mtt assay and by dcfh-da, rh-123, ao/eb, and western blot analysis. |
2022-07-15 |
2023-08-14 |
human |
| Yu Jin, Zhen Liu, Zhenxia Li, Hairui Li, Cheng Zhu, Ruomei Li, Ting Zhou, Bing Fan. Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1. International journal of oral science. vol 14. issue 1. 2022-07-13. PMID:35831280. |
further experiments indicated that nr4a1 can regulate chondrocyte apoptosis, cartilage degeneration, extracellular matrix degradation, and inflammatory responses. |
2022-07-13 |
2023-08-14 |
Not clear |
| Salvatore Condello, Mayuri Prasad, Rula Atwani, Daniela Mate. Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer. The Journal of biological chemistry. 2022-07-10. PMID:35810788. |
oc cells have high proliferative capacity, are invasive, resist apoptosis, and tumors often display rearrangement of extracellular matrix (ecm) components, contributing to accelerated tumor progression. |
2022-07-10 |
2023-08-14 |
Not clear |
| Ziqi Zhang, Pei Yang, Chunsheng Wang, Run Tia. LncRNA CRNDE hinders the progression of osteoarthritis by epigenetic regulation of DACT1. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-08. PMID:35802196. |
we found that overexpression of crnde alleviated cartilage damage and synovitis in oa rats, and suppressed il-1β-induced apoptosis, inflammation, and extracellular matrix (ecm) degradation in chondrocyte‑like atdc5 cells, while silencing dact1 effectively antagonized the protective effect of crnde both in vivo and in vitro. |
2022-07-08 |
2023-08-14 |
rat |
| Min Zhao, Qin Qi, Shimin Liu, Rong Huang, Jiacheng Shen, Yi Zhu, Jing Chai, Handan Zheng, Huangan Wu, Huirong Li. MicroRNA-34a: A Novel Therapeutic Target in Fibrosis. Frontiers in physiology. vol 13. 2022-07-07. PMID:35795649. |
mir-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates tgf-β1/smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. |
2022-07-07 |
2023-08-14 |
Not clear |
| Hachiro Kamad. 12-oxoeicosatetraenoic acid, a candidate of signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells. Animal bioscience. 2022-07-07. PMID:35798033. |
12-oxoeicosatetraenoic acid, a candidate of signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells. |
2022-07-07 |
2023-08-14 |
cattle |
| Mengshi Tang, Yan Zeng, Weijun Peng, Xi Xie, Yongyu Yang, Biting Ji, Fen L. Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis. Drug design, development and therapy. vol 16. 2022-07-06. PMID:35791403. |
in general, for articular manifestations, que inhibited synovial membrane inflammation by reducing inflammatory cytokines and mediators, decreasing oxidative stress, inhibiting proliferation, migration and invasion, and promoting apoptosis of fibroblast-like synoviocytes (fls), regulated autoimmune response through modulating th17/treg imbalance and th17 cells differentiation, reducing autoantibodies levels and regulating ectonucleoside triphosphate diphosphohydrolase (e-ntpdase)/ectoadenosine deaminase (e-ada) activities, reduced bony damage via lowering matrix metalloproteinase (mmp)-1, mmp-3, receptor activator of nuclear factor kappa b ligand (rankl) expression and osteoclasts formation. |
2022-07-06 |
2023-08-14 |
Not clear |
| Haiyang Zhou, Lei Wang, Shuai Liu, Wei Wan. The role of phosphoinositide 3-kinases in immune-inflammatory responses: potential therapeutic targets for abdominal aortic aneurysm. Cell cycle (Georgetown, Tex.). 2022-07-06. PMID:35792922. |
the pathogenesis of abdominal aortic aneurysm (aaa) includes inflammatory responses, matrix metalloproteinases (mmps) degradation, vsmc apoptosis, oxidative stress, and angiogenesis, among which the inflammatory response plays a key role. |
2022-07-06 |
2023-08-14 |
Not clear |