| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Li, Bin Shen, Cunxian Lv, Xinyi Zhu, Qiqige Naren, Dong Xu, He Chen, Fengmiao W. Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression. International immunopharmacology. vol 114. 2022-12-02. PMID:36459925. |
osteoarthritis (oa) is a common age-related degenerative disease involving various pathological processes, among which apoptosis in chondrocyte and extracellular matrix (ecm) degradation are the main pathologies. |
2022-12-02 |
2023-08-14 |
mouse |
| Farzad Sattari Fard, Nazila Jalilzadeh, Amir Mehdizadeh, Fakhrosadat Sajjadian, Kobra Velae. Understanding and targeting anoikis in metastasis for cancer therapies. Cell biology international. 2022-12-01. PMID:36453448. |
one of those driving mechanisms is anoikis, a special type of apoptosis, which is induced by losing anchorage from the extracellular matrix (ecm). |
2022-12-01 |
2023-08-14 |
Not clear |
| Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yi. 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Frontiers in pharmacology. vol 13. 2022-11-28. PMID:36438802. |
3,3'-diindolylmethane inhibits lps-induced human chondrocytes apoptosis and extracellular matrix degradation by activating pi3k-akt-mtor-mediated autophagy. |
2022-11-28 |
2023-08-14 |
mouse |
| Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yi. 3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Frontiers in pharmacology. vol 13. 2022-11-28. PMID:36438802. |
we found that lps stimulation significantly inhibited autophagy, induced chondrocyte apoptosis and extracellular matrix (ecm) degradation, which could be ameliorated by dim. |
2022-11-28 |
2023-08-14 |
mouse |
| Liang Cai, Jingyuan Huang, Daiqiang Huang, Haigang Lv, Dezhi Wang, Haili Wang, Hailong Miao, Li Wu, Fang Wan. Deficiency of immune-responsive gene 1 exacerbates interleukin-1beta-elicited the inflammatory response of chondrocytes via enhancing the activation of NLRP3 inflammasome. International immunopharmacology. vol 114. 2022-11-28. PMID:36442283. |
the knockdown of irg1 exacerbated il-1β-elicited apoptosis and degradation of the extracellular matrix in chondrocytes. |
2022-11-28 |
2023-08-14 |
Not clear |
| Kushi Ranganath, Allen L Feng, Ramon A Franco, Mark A Varvares, William C Faquin, Matthew R Naunheim, Srinivas Vinod Salad. Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428690. |
these markers are involved in a wide range of cellular processes in head and neck carcinogenesis, including extracellular matrix degradation, cell motility and invasion, cell-cell adhesion, solute transport, immortalization, metabolism, the cell cycle and apoptosis, transcription, and cell signaling. |
2022-11-26 |
2023-08-14 |
Not clear |
| Hee Su Sohn, Jeong Won Choi, JooYeon Jhun, Sung Pil Kwon, Mungyo Jung, Sangmin Yong, Hyun Sik Na, Jin-Hong Kim, Mi-La Cho, Byung-Soo Ki. Tolerogenic nanoparticles induce type II collagen-specific regulatory T cells and ameliorate osteoarthritis. Science advances. vol 8. issue 47. 2022-11-25. PMID:36427299. |
consequently, lnp-col ii-r injection inhibited chondrocyte apoptosis and cartilage matrix degradation and relieved pain, while injection of lnps loaded with a control peptide and rapamycin did not induce these events. |
2022-11-25 |
2023-08-14 |
mouse |
| Xinqi Huang, Xuefeng Pan, Xiner Xiong, Zhihe Zhao, Xiao Ce. Drug delivery systems for treatment of temporomandibular joint osteoarthritis. Frontiers in pharmacology. vol 13. 2022-11-24. PMID:36419625. |
chondrocyte apoptosis, extracellular matrix degradation, synovitis, and subchondral bone remodeling are the main pathological features of tmjoa. |
2022-11-24 |
2023-08-14 |
Not clear |
| Omar Ramos-Lope. Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease. Genes. vol 13. issue 11. 2022-11-24. PMID:36421817. |
mafld is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. |
2022-11-24 |
2023-08-14 |
human |
| Dongdong Wang, Ji Zhu, Yuanqing Yang, Zhizhou Wang, Zhengran Ying, Hailong Zhan. The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration. Cellular signalling. 2022-11-24. PMID:36423859. |
to determine the mechanism by which mir-4306 was involved in idd pathogenesis, we examined the effects of overexpressing or silencing mir-4306 on extracellular matrix (ecm) synthesis/degradation, proliferation, autophagy and apoptosis of human degenerated np cells isolated from idd patients. |
2022-11-24 |
2023-08-14 |
human |
| Min Hu, Hao Li, Guangzhen Li, Yuan Wang, Jing Liu, Meihua Zhang, Di Shen, Xietong Wan. NETs promote ROS production to induce human amniotic epithelial cell apoptosis via ERK1/2 signaling in spontaneous preterm birth. American journal of reproductive immunology (New York, N.Y. : 1989). 2022-11-21. PMID:36409534. |
premature birth is a common obstetric complication but its pathogenesis is unclear. inflammation at the maternal-fetal interface in preterm labor leads to the infiltration of neutrophils, which promotes inflammatory responses and induces the degradation of extracellular matrix and cell apoptosis, thus contributing to preterm labor. it is unclear whether neutrophil extracellular traps (nets), a functional form of neutrophils, are involved in preterm labor. |
2022-11-21 |
2023-08-14 |
human |
| Alexa J Cohen, Neda Nikbakht, Jouni Uitt. Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin. Cold Spring Harbor perspectives in biology. 2022-11-21. PMID:36411063. |
transforming growth factor-β1/smad signaling regulates the expression of genes encoding extracellular matrix proteins and also controls cell proliferation and apoptosis. |
2022-11-21 |
2023-08-14 |
Not clear |
| Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen L. Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration. Clinical physiology and functional imaging. 2022-11-18. PMID:36400723. |
intervertebral disc degeneration (idd) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ecm), which will impair the structure and function of the intervertebral disc(ivd), and cause low back pain. |
2022-11-18 |
2023-08-14 |
Not clear |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Yiming Wang, Aoyuan Fan, Liangyu Lu, Zhangyi Pan, Min Ma, Shulin Luo, Zheng Liu, Liqing Yang, Junfeng Cai, Feng Yi. Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis. Biochemical pharmacology. 2022-11-12. PMID:36370754. |
osteoarthritis (oa) is characterized by cartilage matrix degeneration and chondrocyte apoptosis. |
2022-11-12 |
2023-08-14 |
rat |
| Yiming Wang, Aoyuan Fan, Liangyu Lu, Zhangyi Pan, Min Ma, Shulin Luo, Zheng Liu, Liqing Yang, Junfeng Cai, Feng Yi. Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis. Biochemical pharmacology. 2022-11-12. PMID:36370754. |
administration of exogenous mir-486-5p could inhibit the er stress, alleviate chondrocytes apoptosis and promote matrix regeneration. |
2022-11-12 |
2023-08-14 |
rat |
| Lei Ye, Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Mohammad Rizwan Khan, Rosa Busquets, Zhao-Jun We. Isorhamnetin Induces Apoptosis and Suppresses Metastasis of Human Endometrial Carcinoma Ishikawa Cells via Endoplasmic Reticulum Stress Promotion and Matrix Metalloproteinase-2/9 Inhibition In Vitro and In Vivo. Foods (Basel, Switzerland). vol 11. issue 21. 2022-11-11. PMID:36360027. |
isorhamnetin induces apoptosis and suppresses metastasis of human endometrial carcinoma ishikawa cells via endoplasmic reticulum stress promotion and matrix metalloproteinase-2/9 inhibition in vitro and in vivo. |
2022-11-11 |
2023-08-14 |
human |
| Yuh-Fung Chen, Kuo-Jen Wu, Lian-Ru Siao, Huei-Yann Tsa. Trilinolein, a Natural Triacylglycerol, Protects Cerebral Ischemia through Inhibition of Neuronal Apoptosis and Ameliorates Intimal Hyperplasia via Attenuation of Migration and Modulation of Matrix Metalloproteinase-2 and RAS/MEK/ERK Signaling Pathway in VSMCs. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361610. |
trilinolein, a natural triacylglycerol, protects cerebral ischemia through inhibition of neuronal apoptosis and ameliorates intimal hyperplasia via attenuation of migration and modulation of matrix metalloproteinase-2 and ras/mek/erk signaling pathway in vsmcs. |
2022-11-11 |
2023-08-14 |
Not clear |
| Zhenglin Zhu, Shengqiang Gao, Cheng Chen, Wei Xu, Pengcheng Xiao, Zhiyu Chen, Chengcheng Du, Bowen Chen, Yan Gao, Chunli Wang, Junyi Liao, Wei Huan. The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway. Experimental & molecular medicine. 2022-11-10. PMID:36357568. |
inflammatory factors, cartilage matrix degeneration markers, and cell proliferation and apoptosis markers were detected at the mrna and protein levels. |
2022-11-10 |
2023-08-14 |
rat |
| Zhenglin Zhu, Shengqiang Gao, Cheng Chen, Wei Xu, Pengcheng Xiao, Zhiyu Chen, Chengcheng Du, Bowen Chen, Yan Gao, Chunli Wang, Junyi Liao, Wei Huan. The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway. Experimental & molecular medicine. 2022-11-10. PMID:36357568. |
we found that sa rescued tnf-α-induced degeneration of the cartilage matrix, inhibition of chondrocyte proliferation, and promotion of chondrocyte apoptosis. |
2022-11-10 |
2023-08-14 |
rat |