| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhan. Nanomaterial-based Reactive Oxygen Species Scavengers for Osteoarthritis Therapy. Acta biomaterialia. 2023-03-26. PMID:36967052. |
recent studies on osteoarthritis (oa) have suggested that ros plays a crucial role in its development and progression, serving as key mediators in the degradation of the extracellular matrix, mitochondrial dysfunction, chondrocyte apoptosis, and oa progression. |
2023-03-26 |
2023-08-14 |
Not clear |
| Dong Chen, Xin Jiang, Haibo Zo. hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration. Journal of orthopaedic translation. vol 39. 2023-03-23. PMID:36950198. |
intervertebral disc degeneration (idd) is a complex chronic disease involving nucleus pulposus cells (npcs) senescence, apoptosis, autophagy and extracellular matrix (ecm) degradation. |
2023-03-23 |
2023-08-14 |
human |
| Shing-Hsien Chou, Hung-Chen Lin, Shao-Wei Chen, Yu-Ting Tai, Shih-Ming Jung, Fu-Hsiang Ko, Jong-Hwei Su Pang, Pao-Hsien Ch. Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-23. PMID:36958389. |
cd also induced the apoptosis of cardiomyocytes and increased the expression levels of matrix metalloproteinase (mmp)-2 and mmp-14 in cardiac tissues. |
2023-03-23 |
2023-08-14 |
mouse |
| Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huan. TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo. Arthritis research & therapy. vol 25. issue 1. 2023-03-22. PMID:36945021. |
inflammation, apoptosis and extracellular matrix (ecm) degradation contribute to disc degeneration in nucleus pulposus cells (npcs). |
2023-03-22 |
2023-08-14 |
Not clear |
| Hao Yu, Yun Teng, Jun Ge, Ming Yang, Haifeng Xie, Tianyi Wu, Qi Yan, Mengting Jia, Qing Zhu, Yanping Shen, Lianxue Zhang, Jun Zo. Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells. Journal of nanobiotechnology. vol 21. issue 1. 2023-03-21. PMID:36941611. |
excessive reactive oxygen species (ros) in nucleus pulposus cells (npcs) promote extracellular matrix (ecm) degradation and cellular inflammatory responses by activating a variety of cellular pathways, ultimately inducing cell apoptosis and leading to the development of low back pain. |
2023-03-21 |
2023-08-14 |
rat |
| J Bai, T Liu, M Ren, X Wan. Neobavaisoflavone improves medial collateral ligament-induced osteoarthritis through repressing the nuclear factor -κB/hypoxia-inducible factor-2α axis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 73. issue 5. 2023-03-21. PMID:36942811. |
as indicated by the results, nbif mitigated cartilage matrix degradation and chondrocyte apoptosis in the oa rat model. |
2023-03-21 |
2023-08-14 |
rat |
| Liang Liu, Wanying Zhang, Tanghao Liu, Yangfan Tan, Cheng Chen, Jun Zhao, Huan Geng, Chi M. The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress. Redox biology. vol 62. 2023-03-16. PMID:36924682. |
chondrocyte proliferation and apoptosis, synthesis and degradation of extracellular matrix, and inflammation mediators were analyzed. |
2023-03-16 |
2023-08-14 |
human |
| Shane T Killarney, Rachel Washart, Ryan S Soderquist, Jacob P Hoj, Jamie Lebhar, Kevin H Lin, Kris C Woo. Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. Nature communications. vol 14. issue 1. 2023-03-15. PMID:36918588. |
during apoptosis, mitochondrial outer membrane permeabilization (momp) enables certain mitochondrial matrix macromolecules to escape into the cytosol. |
2023-03-15 |
2023-08-14 |
Not clear |
| Marcin Czop, Karolina Gasińska, Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Janusz Kocki, Tomasz Żarnowsk. Twenty Novel MicroRNAs in the Aqueous Humor of Pseudoexfoliation Glaucoma Patients. Cells. vol 12. issue 5. 2023-03-11. PMID:36899874. |
functional analysis and enrichment analysis showed that the mechanisms that can be regulated by these mirnas are: extracellular matrix (ecm) imbalance, cell apoptosis (possibly retinal ganglion cells (rgcs)), autophagy, and elevated calcium cation levels. |
2023-03-11 |
2023-08-14 |
Not clear |
| Malik A Tanveer, Haroon Rashid, Sheikh A Tasdu. Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review. Heliyon. vol 9. issue 3. 2023-03-10. PMID:36895391. |
in the mechanistic section of the convoluted procedure of photoaging, we described the effect of uv radiation (uvr) on different cellular macromolecules (direct damage) and subsequently, the deleterious consequences of uvr-generated reactive oxygen species (indirect damage) and signaling pathways activated or inhibited by uv induced ros generation in various cellular pathologies of skin photoaging like inflammation, extracellular matrix degradation, apoptosis, mitochondrial dysfunction, and immune suppression. |
2023-03-10 |
2023-08-14 |
Not clear |
| Gao-Feng Zhao, Le-Bin Huan. Zinc finger E-box binding homebox 2 alleviated experimental osteoarthritis in rats. Connective tissue research. 2023-03-07. PMID:36880168. |
osteoarthritis (oa) is a chronic inflammatory disease, characterized by degradation of extracellular matrix, apoptosis of chondrocytes and inflammation in articular cartilage. |
2023-03-07 |
2023-08-14 |
rat |
| Zheng-Wei Shi, Lei Zhu, Zong-Rang Song, Tuan-Jiang Liu, Ding-Jun Ha. Roles of p38 MAPK signalling in intervertebral disc degeneration. Cell proliferation. 2023-03-06. PMID:36872558. |
p38 mitogen-activated protein kinase (mapk) signalling, part of the serine and threonine (ser/thr) protein kinases family, is associated with the progression of ivdd, by mediating the inflammatory response, increasing extracellular matrix (ecm) degradation, promoting cell apoptosis and senescence and suppressing cell proliferation and autophagy. |
2023-03-06 |
2023-08-14 |
Not clear |
| Liang Kang, Huaqing Zhang, Chongyu Jia, Renjie Zhang, Cailiang She. Epigenetic Modifications of Inflammation in Intervertebral Disc Degeneration. Ageing research reviews. 2023-03-05. PMID:36871778. |
numerous studies have revealed that inflammation is closely related to various pathological processes of idd, including the continuous loss of extracellular matrix, cell apoptosis, and senescence, indicating the important role of inflammation in the pathological mechanism of idd. |
2023-03-05 |
2023-08-14 |
Not clear |
| Yang Xu, Qian Wang, Xiangxiu Wang, Xiaona Xiang, Jialei Peng, Jiangyin Zhang, Hongchen H. [Effect of pulsed electromagnetic fields on mesenchymal stem cell-derived exosomes in inhibiting chondrocyte apoptosis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 40. issue 1. 2023-02-28. PMID:36854553. |
the study demonstrated that the exposure of 75 hz pemf was superior to 15 and 45 hz pemf in enhancing the effect of exosomes in alleviating chondrocyte apoptosis and promoting cell matrix synthesis. |
2023-02-28 |
2023-08-14 |
rat |
| Xunshan Ren, Huangming Zhuang, Bin Li, Fuze Jiang, Yuelong Zhang, Panghu Zho. Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835440. |
in vivo, gsmtx4, a piezo1 inhibitor, markedly ameliorated the progression of oa, inhibited the chondrocyte apoptosis, and accelerated the production of the cartilage matrix. |
2023-02-25 |
2023-08-14 |
Not clear |
| Xunshan Ren, Huangming Zhuang, Bin Li, Fuze Jiang, Yuelong Zhang, Panghu Zho. Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835440. |
overall, our findings revealed that piezo1 was the essential molecule response to mechanical signals and regulated apoptosis and cartilage matrix metabolism via the can/nfat1 signaling axis in chondrocytes, and that gsmtx4 could be an attractive therapeutic drug for oa treatment. |
2023-02-25 |
2023-08-14 |
Not clear |
| Zhaoran Chen, Jianqiang Wu, Wei Wang, Xiaoyue Tang, Lei Zhou, Yanze Lv, Yuehong Zhen. Investigation of the Pathogenic Mechanism of Ciprofloxacin in Aortic Aneurysm and Dissection by an Integrated Proteomics and Network Pharmacology Strategy. Journal of clinical medicine. vol 12. issue 4. 2023-02-25. PMID:36835806. |
the functional analysis emphasized the important roles of metabolism, extracellular matrix homeostasis, mitochondrial damage, focal adhesion, and apoptosis in cip-stimulated vsmcs. |
2023-02-25 |
2023-08-14 |
human |
| Liping Xiong, Han Bao, Size Li, Deao Gu, Yuyang Li, Qianwen Yin, Wen Li, Leiying Miao, Chao Li. Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress Frontiers in bioengineering and biotechnology. vol 11. 2023-02-23. PMID:36815898. |
cnps could reduce the ros levels in chondrocytes and cartilage explants and reverse the il-1β-induced imbalance of cartilage matrix metabolism and apoptosis. |
2023-02-23 |
2023-08-14 |
Not clear |
| Muzhe Li, Han Yin, Mingxue Chen, Haotian Deng, Guangzhao Tian, Weimin Guo, Guoliang Yi, Quanyi Guo, Zhiwei Chen, Shuyun Li. STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration Biomaterials science. 2023-02-22. PMID:36810435. |
moreover, sts attenuates interleukin (il)-1β-induced inflammation, oxidative stress, apoptosis, and extracellular matrix (ecm) degradation in mfcs, possibly by inhibiting the interleukin-1 receptor-associated kinase 4 (irak4)/tnfr-associated factor 6 (traf6)/nuclear factor-kappab (nf-κb) signaling pathway. |
2023-02-22 |
2023-08-14 |
Not clear |
| Liujie Zheng, Zhiwei Han, Dasheng Luo, Jiale Li, Nanyu Pang, Mingyang Ding, Houlong Ye, Keyan Zhu, Yunfeng Ya. IL-6, IL-1β and TNF-α regulation of the chondrocyte phenotype: a possible mechanism of haemophilic cartilage destruction. Hematology (Amsterdam, Netherlands). vol 28. issue 1. 2023-02-17. PMID:36799502. |
proinflammatory cytokines are considered to be one of the key causes of haemophilic cartilage destruction by inducing chondrocyte apoptosis and extracellular matrix degradation. |
2023-02-17 |
2023-08-14 |
Not clear |