| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tingwen Cai, Hantao Ye, Hongyi Jiang, Chihao Lin, Chao Lou, Weidan Wang, Zijian Yan, Xinghe Xue, Xiaoyun Pan, Jian Li. Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo. International immunopharmacology. vol 115. 2023-01-11. PMID:36630751. |
the results show that svs slows extracellular matrix degradation and chondrocyte apoptosis. |
2023-01-11 |
2023-08-14 |
mouse |
| Xiaoliang Bai, Mingyan Yao, Xiaojuan Zhu, Yong Lian, Mingyuan Zhan. Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells. Immunopharmacology and immunotoxicology. 2023-01-09. PMID:36617937. |
baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells. |
2023-01-09 |
2023-08-14 |
human |
| Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yan. Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer. International journal of environmental research and public health. vol 20. issue 1. 2023-01-08. PMID:36612628. |
the tissue inhibitors of metalloproteinases-3 (timp3) are not only endogenous regulators of matrix metalloproteinases (mmps), but also induce apoptosis and inhibit endothelial cell migration and angiogenesis. |
2023-01-08 |
2023-08-14 |
Not clear |
| Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding, Hui Zen. Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review. Arthritis research & therapy. vol 25. issue 1. 2023-01-07. PMID:36609338. |
in vitro studies (n = 11) concluded that pth (1-34) was important for chondrocytes via increasing the proliferation and matrix synthesis but preventing apoptosis or hypertrophy. |
2023-01-07 |
2023-08-14 |
Not clear |
| Chao Song, Weiye Cai, Fei Liu, Kang Cheng, Daru Guo, Zongchao Li. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR spine. vol 5. issue 4. 2023-01-05. PMID:36601372. |
numerous factors, such as inflammatory factors, oxidative stress, apoptosis, matrix metalloproteinases, are linked to ivdd pathogenesis. |
2023-01-05 |
2023-08-14 |
Not clear |
| Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M Dreyfuss, Thiago M Batista, Bruna B Brandão, Matthias Mann, C Ronald Kah. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature communications. vol 14. issue 1. 2023-01-04. PMID:36599833. |
these lyk-i actions of the ir are linked to changes in phosphorylation of a network of proteins involved in the regulation of extracellular matrix organization, cell cycle, atm signaling and cellular senescence; and result in upregulation of expression of multiple extracellular matrix-related genes and proteins, down-regulation of immune/interferon-related genes and proteins, and increased sensitivity to apoptosis. |
2023-01-04 |
2023-08-14 |
Not clear |
| Fu Zhang, Songjuan Wang, Manman Gao, Baoliang Li, Zhongyuan He, Tao Tang, Zhengya Zhu, Shaoyu Liu, Zhiyu Zho. Hyaluronic acid ameliorates intervertebral disc degeneration Frontiers in bioengineering and biotechnology. vol 10. 2023-01-02. PMID:36588938. |
mitophagy, mitochondrial function, apoptosis, senescence and extracellular matrix (ecm) degradation were measured. |
2023-01-02 |
2023-08-14 |
cattle |
| Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li, Bin She. The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets. Arthritis research & therapy. vol 24. issue 1. 2022-12-30. PMID:36585687. |
mounting studies have revealed that disruption of extracellular matrix (ecm) homeostasis, aberrant chondrocyte metabolism, an increase in the number of senescent chondrocytes and abnormal activation of cell death such as chondrocyte apoptosis and autophagy, are the crucial steps in oa development. |
2022-12-30 |
2023-08-14 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Zhengwei Xu, Hao Yang, Dingjun Ha. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration. Frontiers in endocrinology. vol 13. 2022-12-26. PMID:36568075. |
ncrnas mainly participate in the process of idd through regulating apoptosis of nucleus pulposus (np) cells, metabolism of extracellular matrix (ecm) and inflammatory response; ii). |
2022-12-26 |
2023-08-14 |
Not clear |
| Cunliang Guo, Yungang Chen, Yuhe Wang, Yanke Ha. Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review). Experimental and therapeutic medicine. vol 25. issue 1. 2022-12-26. PMID:36569433. |
the key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. |
2022-12-26 |
2023-08-14 |
Not clear |
| Jieya Luo, Yuxuan Yang, Xuan Wang, Xingyu Chang, Songbo F. Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications. Biomolecules. vol 12. issue 12. 2022-12-23. PMID:36551232. |
unlike apoptosis, pyroptosis is characterized by the rupture of the plasma membrane and the release of inflammatory mediators, accelerating the destruction of the extracellular matrix (ecm). |
2022-12-23 |
2023-08-14 |
Not clear |
| Jin Han, Donghwi Park, Ji Young Park, Seungwoo Ha. Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552552. |
increased oxidative stress in osteoarthritis (oa) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis. |
2022-12-23 |
2023-08-14 |
mouse |
| Qian Lin, Bin Gen. The Role of Hydrogen Sulfide in Plaque Stability. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552564. |
although the initiation, procession, and precise time of controlling plaque rupture are unclear, foam cell formation and apoptosis, cell death, extracellular matrix components, protease expression and activity, local inflammation, intraplaque hemorrhage, and calcification contribute to the plaque instability. |
2022-12-23 |
2023-08-14 |
Not clear |
| Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Eloisa Helena Ribeiro Olivieri, Eduardo Caetano Abilio da Silva, Alexandre Muxfeldt Ab' Saber, Teresa Yae Takagaki, Vera Luiza Capelozz. Proposing Specific Neuronal Epithelial-to-Mesenchymal Transition Genes as an Ancillary Tool for Differential Diagnosis among Pulmonary Neuroendocrine Neoplasms. Genes. vol 13. issue 12. 2022-12-23. PMID:36553576. |
functional enrichment analysis of the emt genes differentially expressed among pnens subtypes showed that they are involved in cellular proliferation, extracellular matrix degradation, regulation of cell apoptosis, oncogenesis, and tumor cell invasion. |
2022-12-23 |
2023-08-14 |
Not clear |
| Min Hu, Hui Qiu, Tao He, Minyu Zhon. Effect of miRNA-218-5p on Proliferation, Migration, Apoptosis and Inflammation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm and Extracellular Matrix Protein. Iranian journal of public health. vol 51. issue 11. 2022-12-23. PMID:36561253. |
effect of mirna-218-5p on proliferation, migration, apoptosis and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm and extracellular matrix protein. |
2022-12-23 |
2023-08-14 |
Not clear |
| Fengqi Cheng, Honghao Yang, Yunzhong Cheng, Yuzeng Liu, Yong Hai, Yangpu Zhan. The role of oxidative stress in intervertebral disc cellular senescence. Frontiers in endocrinology. vol 13. 2022-12-23. PMID:36561567. |
reactive oxygen species (ros) and reactive nitrogen species (rns) could regulate matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and aging of intervertebral disc cells. |
2022-12-23 |
2023-08-14 |
Not clear |
| Nancy Husseiny Hassan, Doaa Mohammed Yousef, Amira Ebrahim Alseme. Hesperidin protects against aluminum-induced renal injury in rats via modulating MMP-9 and apoptosis: biochemical, histological, and ultrastructural study. Environmental science and pollution research international. 2022-12-22. PMID:36547838. |
the study verified the nephroprotective effects of hesperidin on alcl3-induced renal damage and confirmed the critical role of extracellular matrix (ecm) remodeling and apoptosis inhibition. |
2022-12-22 |
2023-08-14 |
rat |
| Kevin Montagne, Katsuko S Furukawa, Yuki Taninaka, Brandon Ngao, Takashi Ushid. Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells. PloS one. vol 17. issue 12. 2022-12-20. PMID:36538560. |
osteoarthritis (oa) is the most common joint disease in older adults and is characterized by a gradual degradation of articular cartilage due to decreased cartilage matrix gene expression and increased expression of genes involved in protein degradation, apoptosis and inflammation. |
2022-12-20 |
2023-08-14 |
Not clear |
| Yong-Hua Yang, Xiao-Peng Gu, Hong Hu, Bin Hu, Xiang-Lian Wan, Zhi-Ping Gu, Shao-Jin Zhon. Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-12-20. PMID:36539815. |
ginsenoside rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the yap1/taz pathway in rats with intervertebral disc degeneration. |
2022-12-20 |
2023-08-14 |
rat |
| Wanzhen Xu, Manfeng Wang, Yang Bai, Yong Chen, Xiaoshan Ma, Zhiqing Yang, Liyan Zhao, Yunqian L. The role of microfibrillar-associated protein 2 in cancer. Frontiers in oncology. vol 12. 2022-12-19. PMID:36530974. |
recent studies have shown that mfap2, an effective prognostic molecule for various tumors, is associated with tumor occurrence and development and may be involved in remodeling the extracellular matrix and regulating proliferation, apoptosis, invasion, tumor cell metastasis, and tumor angiogenesis. |
2022-12-19 |
2023-08-14 |
Not clear |