| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sayyed Sajjad Moravveji, Samane Khoshbakht, Majid Mokhtari, Mahdieh Salimi, Hossein Lanjanian, Sajjad Nematzadeh, Mahsa Torkamanian-Afshar, Ali Masoudi-Neja. Impact of 5HydroxyMethylCytosine (5hmC) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers. BMC genomic data. vol 23. issue 1. 2022-06-29. PMID:35768769. |
impact of 5hydroxymethylcytosine (5hmc) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers. |
2022-06-29 |
2023-08-14 |
Not clear |
| Tian Xie, Jun Yuan, Ling Mei, Ping Li, Ruijie Pa. Hyperoside ameliorates TNF‑α‑induced inflammation, ECM degradation and ER stress‑mediated apoptosis via the SIRT1/NF‑κB and Nrf2/ARE signaling pathways Molecular medicine reports. vol 26. issue 2. 2022-06-22. PMID:35730622. |
in summary, hyperoside ameliorated tnf‑α‑induced inflammation, extracellular matrix degradation, and endoplasmic reticulum stress‑mediated apoptosis, which may be associated with the regulation of the sirt1/nf‑κb and nrf2/antioxidant responsive element signaling pathways by hyperoside. |
2022-06-22 |
2023-08-14 |
human |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Joanne E Murphy-Ullric. Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma. Frontiers in cell and developmental biology. vol 10. 2022-06-13. PMID:35693935. |
at the cellular level, tsp-1 can modulate cell adhesion and migration, protease activity, growth factor activity, anoikis resistance, apoptosis, and collagen secretion and matrix assembly and cross-linking. |
2022-06-13 |
2023-08-14 |
Not clear |
| Alejandro Pallares Robles, Vincent Ten Cate, Andreas Schulz, Jürgen H Prochaska, Steffen Rapp, Thomas Koeck, Marina Panova-Noeva, Stefan Heitmeier, Stephan Schwers, Kirsten Leineweber, Hans-Jürgen Seyfarth, Christian F Opitz, Henri Spronk, Christine Espinola-Klein, Karl J Lackner, Thomas Münzel, Miguel A Andrade-Navarro, Stavros V Konstantinides, Hugo Ten Cate, Philipp S Wil. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Scientific reports. vol 12. issue 1. 2022-06-13. PMID:35697739. |
association of fxi activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. |
2022-06-13 |
2023-08-14 |
human |
| Alejandro Pallares Robles, Vincent Ten Cate, Andreas Schulz, Jürgen H Prochaska, Steffen Rapp, Thomas Koeck, Marina Panova-Noeva, Stefan Heitmeier, Stephan Schwers, Kirsten Leineweber, Hans-Jürgen Seyfarth, Christian F Opitz, Henri Spronk, Christine Espinola-Klein, Karl J Lackner, Thomas Münzel, Miguel A Andrade-Navarro, Stavros V Konstantinides, Hugo Ten Cate, Philipp S Wil. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Scientific reports. vol 12. issue 1. 2022-06-13. PMID:35697739. |
these fxi-related proteins were enriched in immune pathways related to causes of thrombo-inflammation, extracellular matrix interaction, lipid metabolism, and apoptosis. |
2022-06-13 |
2023-08-14 |
human |
| Zhe Ji, Rui Guo, Zhigang Ma, Hongwei L. Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating miR-483-3p. Journal of clinical laboratory analysis. 2022-06-11. PMID:35689566. |
arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up-regulating mir-483-3p. |
2022-06-11 |
2023-08-14 |
human |
| Ling-Hui Zeng, Muhammad Qasim Barkat, Shahzada Khurram Syed, Shahid Shah, Ghulam Abbas, Chengyun Xu, Amina Mahdy, Nadia Hussain, Liaqat Hussain, Abdul Majeed, Kashif-Ur-Rehman Khan, Ximei Wu, Musaddique Hussai. Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. Cells. vol 11. issue 11. 2022-06-10. PMID:35681469. |
on the other hand, abnormal expression or loss of regulation of hh signaling leads to airway asthmatic remodeling, which is characterized by cellular matrix modification in the respiratory system, goblet cell hyperplasia, deposition of collagen, epithelial cell apoptosis, proliferation, and activation of fibroblasts. |
2022-06-10 |
2023-08-14 |
Not clear |
| Shang Gao, Nianhu Li, Renchang Chen, Youxiang Su, Yun Song, Songlin Lian. Bushen Huoxue Formula Modulates Autophagic Flux and Inhibits Apoptosis to Protect Nucleus Pulposus Cells by Restoring the AMPK/SIRT1 Pathway. BioMed research international. vol 2022. 2022-06-07. PMID:35669720. |
the typical features of ivdd are extracellular matrix (ecm) degradation and nucleus pulposus cell (np) apoptosis. |
2022-06-07 |
2023-08-14 |
Not clear |
| H Allison, L M O'Sullivan, L M McNamar. Temporal changes in cortical microporosity during estrogen deficiency associated with perilacunar resorption and osteocyte apoptosis: A pilot study. Bone reports. vol 16. 2022-06-06. PMID:35663377. |
we propose that microporosity changes arise due to processes driven by distinct populations of osteocytes, which are either actively resorbing their matrix or have undergone apoptosis and are infilling lacunae by micropetrosis. |
2022-06-06 |
2023-08-14 |
rat |
| Zhiquan Li, Yingchun Wang, Yaoping Wu, Yanwu Liu, Yinan Zhao, Xiaochao Chen, Mo Li, Rui Zha. Role of BLACAT1 in IL-1β-induced human articular chondrocyte apoptosis and extracellular matrix degradation via the miR-149-5p/HMGCR axis. Protein and peptide letters. 2022-06-03. PMID:35657039. |
role of blacat1 in il-1β-induced human articular chondrocyte apoptosis and extracellular matrix degradation via the mir-149-5p/hmgcr axis. |
2022-06-03 |
2023-08-14 |
human |
| Rachana Vaidya, Spencer P Lake, Jennifer A Zeller. Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking. Journal of diabetes science and technology. 2022-06-02. PMID:35652696. |
in addition to dysfunction of the extracellular matrix, tendon cells such as tenocytes and tendon stem/progenitor cells show significant abnormalities in proliferation, apoptosis, and remodeling capacity in the presence of hyperglycemia and advanced glycation end-products, thus contributing to the disruption of tendon homeostasis and healing. |
2022-06-02 |
2023-08-14 |
Not clear |
| Rui Ran, Hai-Yang Liao, Zhi-Qiang Wang, Chao-Yang Gong, Kai-Sheng Zhou, Hai-Hong Zhan. Mechanisms and functions of long noncoding RNAs in intervertebral disc degeneration. Pathology, research and practice. vol 235. 2022-06-02. PMID:35653923. |
these changes are closely related to cell proliferation, apoptosis, senescence, autophagy, inflammation, and extracellular matrix (ecm) remodeling. |
2022-06-02 |
2023-08-14 |
Not clear |
| Waheed-Ul-Rahman Ahmed, Sam Kleeman, Michael Ng, Wei Wang, Adam Auton, Regent Lee, Ashok Handa, Krina T Zondervan, Akira Wiberg, Dominic Furnis. Genome-wide association analysis and replication in 810,625 individuals with varicose veins. Nature communications. vol 13. issue 1. 2022-06-02. PMID:35654884. |
pathway analysis identified enrichment in extracellular matrix biology, inflammation, (lymph)angiogenesis, vascular smooth muscle cell migration, and apoptosis. |
2022-06-02 |
2023-08-14 |
Not clear |
| Xuancheng Zhang, Ang Li, Kang Han, He Zhang, Xiaoqiao Huangfu, Jinghuan Huang, Jia Jiang, Jinzhong Zha. Anti-inflammatory and Tendon-Protective Effects of Adipose Stem Cell-Derived Exosomes with Concomitant Use of Glucocorticoids. Stem cells international. vol 2022. 2022-06-01. PMID:35646125. |
in vitro cytoprotective analysis showed that asc-exos overrode gc-induced detrimental effects on tenocytes by significantly improving gc-suppressed cellular proliferation, migration, and transcription of tenocytic matrix molecules and degradative enzyme inhibitors and significantly decreasing gc-induced cell senescence, apoptosis, and transcription of ros and tenocytic degradative enzymes. |
2022-06-01 |
2023-08-13 |
Not clear |
| Ming Zhao, Darren Finlay, Robert Liddington, Kristiina Vuor. SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK. Autophagy reports. vol 1. issue 1. 2022-06-01. PMID:35647611. |
cell detachment from the extracellular matrix (ecm) typically promotes cell death via a form of apoptosis known as anoikis. |
2022-06-01 |
2023-08-13 |
Not clear |
| Peng Luo, Qishan Huang, Suo Chen, Yinghui Wang, Haicheng Do. Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway. International immunopharmacology. vol 108. 2022-05-27. PMID:35623293. |
osteoarthritis has become the fourth cause of disability in the world and its occurrence and development are caused by apoptosis and extracellular matrix (ecm) degradation of chondrocytes. |
2022-05-27 |
2023-08-13 |
mouse |
| Su'an Tang, Yumei Cao, Zhaopeng Cai, Xiaoyu Nie, Jianzhao Ruan, Zuoqing Zhou, Guangfeng Ruan, Zhaohua Zhu, Weiyu Han, Changhai Din. The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1. Science signaling. vol 15. issue 735. 2022-05-24. PMID:35609127. |
knockdown of pila inhibited tnf-induced nf-κb signaling, extracellular matrix catabolism, and apoptosis in chondrocytes, whereas ectopic expression of pila promoted nf-κb signaling and matrix degradation. |
2022-05-24 |
2023-08-13 |
mouse |
| Fabiao Hu, Changping Deng, Yiwen Zhou, Yuping Liu, Tong Zhang, Peiwen Zhang, Zhangting Zhao, Hui Miao, Wenyun Zheng, Wenliang Zhang, Meiyan Wang, Xingyuan M. Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy. Bioengineering & translational medicine. vol 7. issue 2. 2022-05-23. PMID:35600646. |
fts (fth1-matrix metalloproteinase-2-tmsm)/ym155 nc synthesis was easily scaled up, and these ncs could sequentially release tmsm protein through matrix metalloproteinase-2 and promote ym155 to enter the nucleus via transferrin receptor 1 (tfr1) binding, which increased the cytotoxicity and apoptosis of capan-2 and a549 cells compared to that with individual drugs. |
2022-05-23 |
2023-08-13 |
mouse |
| Binte Zehra, Ayaz Ahmed, Ajmal Khan, Afshan Shams, Reaz Uddin, Sidra Rafi, Taseer Ahmed Khan, Umar Farooq, Syed Abid Al. Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2022-05-23. PMID:35604429. |
sesquiterpene from polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in nci-h460 cells. |
2022-05-23 |
2023-08-13 |
Not clear |