| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Yiming Wang, Aoyuan Fan, Liangyu Lu, Zhangyi Pan, Min Ma, Shulin Luo, Zheng Liu, Liqing Yang, Junfeng Cai, Feng Yi. Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis. Biochemical pharmacology. 2022-11-12. PMID:36370754. |
osteoarthritis (oa) is characterized by cartilage matrix degeneration and chondrocyte apoptosis. |
2022-11-12 |
2023-08-14 |
rat |
| Yiming Wang, Aoyuan Fan, Liangyu Lu, Zhangyi Pan, Min Ma, Shulin Luo, Zheng Liu, Liqing Yang, Junfeng Cai, Feng Yi. Exosome modification to better alleviates endoplasmic reticulum stress induced chondrocyte apoptosis and osteoarthritis. Biochemical pharmacology. 2022-11-12. PMID:36370754. |
administration of exogenous mir-486-5p could inhibit the er stress, alleviate chondrocytes apoptosis and promote matrix regeneration. |
2022-11-12 |
2023-08-14 |
rat |
| Lei Ye, Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Mohammad Rizwan Khan, Rosa Busquets, Zhao-Jun We. Isorhamnetin Induces Apoptosis and Suppresses Metastasis of Human Endometrial Carcinoma Ishikawa Cells via Endoplasmic Reticulum Stress Promotion and Matrix Metalloproteinase-2/9 Inhibition In Vitro and In Vivo. Foods (Basel, Switzerland). vol 11. issue 21. 2022-11-11. PMID:36360027. |
isorhamnetin induces apoptosis and suppresses metastasis of human endometrial carcinoma ishikawa cells via endoplasmic reticulum stress promotion and matrix metalloproteinase-2/9 inhibition in vitro and in vivo. |
2022-11-11 |
2023-08-14 |
human |
| Yuh-Fung Chen, Kuo-Jen Wu, Lian-Ru Siao, Huei-Yann Tsa. Trilinolein, a Natural Triacylglycerol, Protects Cerebral Ischemia through Inhibition of Neuronal Apoptosis and Ameliorates Intimal Hyperplasia via Attenuation of Migration and Modulation of Matrix Metalloproteinase-2 and RAS/MEK/ERK Signaling Pathway in VSMCs. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361610. |
trilinolein, a natural triacylglycerol, protects cerebral ischemia through inhibition of neuronal apoptosis and ameliorates intimal hyperplasia via attenuation of migration and modulation of matrix metalloproteinase-2 and ras/mek/erk signaling pathway in vsmcs. |
2022-11-11 |
2023-08-14 |
Not clear |
| Zhenglin Zhu, Shengqiang Gao, Cheng Chen, Wei Xu, Pengcheng Xiao, Zhiyu Chen, Chengcheng Du, Bowen Chen, Yan Gao, Chunli Wang, Junyi Liao, Wei Huan. The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway. Experimental & molecular medicine. 2022-11-10. PMID:36357568. |
inflammatory factors, cartilage matrix degeneration markers, and cell proliferation and apoptosis markers were detected at the mrna and protein levels. |
2022-11-10 |
2023-08-14 |
rat |
| Zhenglin Zhu, Shengqiang Gao, Cheng Chen, Wei Xu, Pengcheng Xiao, Zhiyu Chen, Chengcheng Du, Bowen Chen, Yan Gao, Chunli Wang, Junyi Liao, Wei Huan. The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway. Experimental & molecular medicine. 2022-11-10. PMID:36357568. |
we found that sa rescued tnf-α-induced degeneration of the cartilage matrix, inhibition of chondrocyte proliferation, and promotion of chondrocyte apoptosis. |
2022-11-10 |
2023-08-14 |
rat |
| b' Hamza Malik Okuyan, Ziya Yurtal, \\xc4\\xb0hsan Karabo\\xc4\\x9fa, Filiz Ka\\xc3\\xa7maz, Ayd\\xc4\\xb1ner Kalac\\xc4\\xb. Ebselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis. Biological trace element research. 2022-11-10. PMID:36357655.' |
osteoarthritis (oa) is a prevalent articular disease mainly characterized by extracellular matrix degradation, apoptosis, and inflammation, which lead to cartilage destruction and abnormal bone metabolism. |
2022-11-10 |
2023-08-14 |
rat |
| Muhammad Imran, Mahwish Aslam, Suliman A Alsagaby, Farhan Saeed, Ishtiaque Ahmad, Muhamamd Afzaal, Muhammad Umair Arshad, Mohamed A Abdelgawad, Ahmed H El-Ghorab, Ahmed Khames, Mohammad Ali Shariati, Arslan Ahmad, Muzamal Hussain, Ali Imran, Saiful Isla. Therapeutic application of carvacrol: A comprehensive review. Food science & nutrition. vol 10. issue 11. 2022-11-09. PMID:36348778. |
carvacrol has the anticancer ability against malignant cells via decreasing the expressions of matrix metalloprotease 2 and 9, inducing apoptosis, enhancing the expression of pro-apoptotic proteins, disrupting mitochondrial membrane, suppressing extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signal transduction, and also decreasing the phosphoinositide 3-kinase/protein kinase b. |
2022-11-09 |
2023-08-14 |
Not clear |
| Chen Zhao, Xiaodong Li, Guantong Sun, Pengcheng Liu, Keyu Kong, Xuzhuo Chen, Fei Yang, Xiaoqing Wan. CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy. Cell death & disease. vol 13. issue 11. 2022-11-07. PMID:36344492. |
decreased expression of circfoxo3 in oa cartilage tissues was directly associated with excessive apoptosis and imbalance between anabolic and catabolic factors of the extracellular matrix (ecm). |
2022-11-07 |
2023-08-14 |
mouse |
| Xiaoshan Tang, Manqing Sun, Qian Shen, Jia Rao, Xue Yang, Ye Fang, Tianchao Xiang, Shanshan Xue, Lei Sun, Hong X. Protective role of endorepellin in renal developmental programming. Frontiers in cell and developmental biology. vol 10. 2022-11-04. PMID:36330336. |
the differentially expressed protein perlecan, which we previously identified using proteomics, is an important extracellular matrix glycoprotein, and its domain v (endorepellin) can inhibit apoptosis through a paracrine form. |
2022-11-04 |
2023-08-14 |
mouse |
| Xingyu Zhang, Yanling You, Yaying Sun, Xiang Guo, Han Lin, Ming Zong, Jianlin Sh. Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene. Materials today. Bio. vol 17. 2022-11-03. PMID:36325424. |
as one of the most common representations of articular cartilage damage, osteoarthritis (oa) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. |
2022-11-03 |
2023-08-14 |
Not clear |
| Zheli Niu, Guangwei Ren, Lijing Huang, Liqin M. Circ_0008529 Contributes to Renal Tubular Cell Dysfunction in High Glucose Stress via miR-185-5p/SMAD2 Pathway in Diabetic Nephropathy. Biochemical genetics. 2022-11-01. PMID:36316592. |
under hg treatment, cell viability and cell cycle process were suppressed, while apoptosis, inflammation and extracellular matrix accumulation were enhanced. |
2022-11-01 |
2023-08-14 |
Not clear |
| Dihua Meng, Weiyou Chen, Cheng Pan, Kunxue Yang, Yewen Guan, Jiaqi Wang, Abu Moro, Qingjun Wei, Hua Jian. Exploration of microRNA-106b-5p as a therapeutic target in intervertebral disc degeneration: a preclinical study. Apoptosis : an international journal on programmed cell death. 2022-10-29. PMID:36308623. |
overexpression of mir-106b-5p in np cells decreased cell growth, induced apoptosis, hindered extracellular matrix formation, and increased the expression of matrix-degrading enzymes through the sirt2/mapk/erk signaling pathway. |
2022-10-29 |
2023-08-14 |
human |
| Kevin K W Kuan, Douglas A Gibson, Lucy H R Whitaker, Andrew W Horn. Menstruation Dysregulation and Endometriosis Development. Frontiers in reproductive health. vol 3. 2022-10-28. PMID:36304032. |
this review summarizes literature that has explored how dysregulation of menstruation can contribute to the pathogenesis of endometriosis such as dysregulation of inflammatory mediators, aberrant endometrial matrix metalloproteinase expression, hypoxic stress, and reduced apoptosis. |
2022-10-28 |
2023-08-14 |
Not clear |
| Marina S Hernandes, Qian Xu, Kathy K Griendlin. Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290688. |
nox-derived ros have been implicated in mediating matrix metalloprotease (mmp) activation, downregulation of junctional complexes between adjacent brain endothelial cells and brain endothelial cell apoptosis, leading to brain microvascular endothelial barrier dysfunction and consequently, increases in bbb permeability. |
2022-10-27 |
2023-08-14 |
Not clear |
| Wei Ding, Ying Liu, Zhe Su, Qi Li, Jianxun Wang, Yufang Ga. Emerging Role of Non-Coding RNAs in Aortic Dissection. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291545. |
the pathogenesis of ad mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of vascular smooth muscle cells (vsmcs); however, its detailed mechanisms are still not fully elucidated. |
2022-10-27 |
2023-08-14 |
Not clear |
| Aitor Benedicto, Beatriz Arteta, Andrea Duranti, Daniel Alonso-Alconad. The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297277. |
we used the synthetic cannabinoid urb447, a known cb2 agonist and cb1 antagonist drug, and studied prometastatic ability of mouse b16 melanoma and mca38 crc cells, by means of proliferation, apoptosis, cell cycle, migration and matrix degradation in vitro upon urb447 treatment. |
2022-10-27 |
2023-08-14 |
mouse |
| Bingqian Wei, Yingjing Zhao, Weihang Li, Shilei Zhang, Ming Yan, Zebing Hu, Bo Ga. Innovative immune mechanisms and antioxidative therapies of intervertebral disc degeneration. Frontiers in bioengineering and biotechnology. vol 10. 2022-10-27. PMID:36299288. |
idd processes are caused by series of pathological processes, including oxidative stress, matrix decomposition, inflammatory reaction, apoptosis, abnormal proliferation, cell senescence, autophagy as well as sepsis process, among which the oxidative stress and inflammatory response are considered as key link in idd. |
2022-10-27 |
2023-08-14 |
Not clear |
| Maryam Nurzadeh, Seyedeh Mojgan Ghalandarpoor-Attar, Seyedeh Noushin Ghalandarpoor-Attar, Maryam Rabie. The Role of Interferon (IFN)-γ in Extravillous Trophoblast Cell (EVT) Invasion and Preeclampsia Progression. Reproductive sciences (Thousand Oaks, Calif.). 2022-10-26. PMID:36289172. |
recent studies have shown that ifn-γ can inhibit evt invasion via a mechanism dependent on an increase in evt apoptosis and a decrease in matrix metalloproteinases (mmps). |
2022-10-26 |
2023-08-14 |
human |