| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A Fornal, Billy C Wang, Ryan C Martin, Elsa A Olson, Ammar L Ujjainwala, David M Pinson, Jeffrey D Klopfenstein, Krishna Kumar Veeravall. Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration. Frontiers in neuroscience. vol 16. 2022-10-21. PMID:36267234. |
we recently showed that the post-ischemic induction of matrix metalloproteinase-12 (mmp-12) in the brain degrades tight junction proteins, increases mmp-9 and tnfα expression, and contributes to the blood-brain barrier (bbb) disruption, apoptosis, demyelination, and infarct volume development. |
2022-10-21 |
2023-08-14 |
rat |
| Yuying Ge, Yuying Chen, Chijiao Guo, Huan Luo, Fangda Fu, Weifeng Ji, Chengliang Wu, Hongfeng Rua. Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications. Journal of inflammation research. vol 15. 2022-10-20. PMID:36263145. |
in this review, we summarize the characteristics of pyroptosis and emphasize the effects of ivd cell pyroptosis on the pathological progression of ivdd, including secretion of cytokines, nucleus pulposus cell apoptosis and autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory and sympathetic fiber neoinnervation, and infiltrating lymphatic vessels. |
2022-10-20 |
2023-08-14 |
Not clear |
| Jing Wang, Zhijie Luo, Lizhu Lin, Xinbing Sui, Lili Yu, Cong Xu, Ruonan Zhang, Ziming Zhao, Qianru Zhu, Bo An, Qiao Wang, Bi Chen, Elaine Lai-Han Leung, Qibiao W. Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies. Cancers. vol 14. issue 19. 2022-10-14. PMID:36230714. |
anoikis is a mechanism of apoptosis that combats tumor metastasis; it inhibits the escape of tumor cells from the native extracellular matrix to other organs. |
2022-10-14 |
2023-08-14 |
Not clear |
| Karolina L Stepien, Karolina Bajdak-Rusinek, Agnieszka Fus-Kujawa, Wacław Kuczmik, Katarzyna Gawro. Role of Extracellular Matrix and Inflammation in Abdominal Aortic Aneurysm. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232377. |
inflammation, apoptosis of smooth muscle cells, and degradation of the extracellular matrix in the aaa wall are believed to be the major molecular processes underlying aaa formation. |
2022-10-14 |
2023-08-14 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
the nobly increased expression of matrix metallopeptidase 13 (mmp13) and type x collagen (col10a1) as runx2 downstream genes contributed to the hypertrophic differentiation of chondrocytes, and the efficiently upregulated level of matrix metallopeptidase 9 (mmp9) may trigger chondrocyte apoptosis with mps treatments. |
2022-10-14 |
2023-08-14 |
Not clear |
| Xin Zhao, Benchi Xu, Wei Duan, Le Chang, Rui Tan, Zhen Sun, Zhengxu Y. Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function. International journal of medical sciences. vol 19. issue 11. 2022-10-14. PMID:36237988. |
the major contributor of lbp is intervertebral disc degeneration (idd), which is caused by a spectrum of homeostasis alteration, including the apoptosis of nucleus pulposus (np) and annulus fibrosus (af) cells, degradation of extracellular matrix (ecm), calcification of cartilaginous endplates (cep) and so on. |
2022-10-14 |
2023-08-14 |
Not clear |
| Shengbin Shuai, Qianqian Cai, Yunxia O. Circular RNA circ_0008365 regulates SOX9 by targeting miR-338-3p to inhibit IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-10-14. PMID:36242088. |
circular rna circ_0008365 regulates sox9 by targeting mir-338-3p to inhibit il-1β-induced chondrocyte apoptosis and extracellular matrix degradation. |
2022-10-14 |
2023-08-14 |
Not clear |
| Jing Yan, Lun-Gang Wu, Ming Zhang, Tao Fang, Wei Pan, Jia-Li Zhao, Quan Zho. miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2. Oxidative medicine and cellular longevity. vol 2022. 2022-10-10. PMID:36211818. |
intervertebral disc degeneration (idd) development is regulated by mirna, including inflammatory reactions, cell apoptosis, and degradation of extracellular matrix. |
2022-10-10 |
2023-08-14 |
human |
| Haiqi Zhou, Sha Wu, Huixian Ling, Changjie Zhang, Ying Kon. Primary Cilia: A Cellular Regulator of Articular Cartilage Degeneration. Stem cells international. vol 2022. 2022-10-04. PMID:36193252. |
the main pathological characteristic of oa is cartilage degeneration, which is caused by chondrocyte apoptosis, cartilage matrix degradation, and inflammatory factor destruction. |
2022-10-04 |
2023-08-14 |
Not clear |
| Stephanie J Florczyk, Nathan A Hotaling, Mylene Simon, Joe Chalfoun, Allison L Horenberg, Nicholas J Schaub, Dongbo Wang, Piotr M Szczypiński, Veronica L DeFelice, Peter Bajcsy, Carl G Simo. Measuring dimensionality of cell-scaffold contacts of primary human bone marrow stromal cells cultured on electrospun fiber scaffolds. Journal of biomedical materials research. Part A. 2022-10-04. PMID:36194510. |
sites of cell adhesion to the extracellular matrix (ecm) initiate intracellular signaling that directs cell functions such as proliferation, differentiation, and apoptosis. |
2022-10-04 |
2023-08-14 |
human |
| Ligang Qian, Bo Yu, Taoping Chen, Kang Chen, Zheng Ma, Yunfei Wang, Bo Su. Circ_0022383 alleviates IL-1β-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by miR-3619-5p/SIRT1 axis. International immunopharmacology. vol 112. 2022-10-04. PMID:36194985. |
circ_0022383 alleviates il-1β-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by mir-3619-5p/sirt1 axis. |
2022-10-04 |
2023-08-14 |
Not clear |
| Sunlong Li, Chongan Huang, Jian Xiao, Yuhao Wu, Zengjie Zhang, Yifei Zhou, Naifeng Tian, Yaosen Wu, Xiangyang Wang, Xiaolei Zhan. The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186138. |
apoptosis, senescence, and extracellular matrix metabolism were found to be regulated by these cytokines in ivdd. |
2022-10-03 |
2023-08-14 |
Not clear |
| Dorian Yarih Garcia-Ortega, Sara Aileen Cabrera-Nieto, Haydee Sarai Caro-Sánchez, Marlid Cruz-Ramo. An overview of resistance to chemotherapy in osteosarcoma and future perspectives. Cancer drug resistance (Alhambra, Calif.). vol 5. issue 3. 2022-09-30. PMID:36176756. |
molecular and cellular mechanisms associated with resistance to chemotherapy include dna repair and cell-cycle alterations, enhanced drug efflux, increased detoxification, resistance to apoptosis, autophagy, tumor extracellular matrix, and angiogenesis. |
2022-09-30 |
2023-08-14 |
Not clear |
| Nicholas J MacKnight, Bradford A Dimos, Kelsey M Beavers, Erinn M Muller, Marilyn E Brandt, Laura D Mydlar. Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles. Science advances. vol 8. issue 39. 2022-09-30. PMID:36179017. |
whether or not a coral developed a lesion was mediated by plasticity in genes involved in extracellular matrix maintenance, autophagy, and apoptosis, while resistant coral species had constitutively higher expression of intracellular protein trafficking. |
2022-09-30 |
2023-08-14 |
Not clear |
| Yan He, Shengpeng Zhang, Wu Bao, Yi Xue, Bin Yin, Xialin Cheng, Zexin Zhang, Chiyu Ji. An improved explants culture method: sustainable isolation of keloid fibroblasts with primary characteristics. Journal of cosmetic dermatology. 2022-09-28. PMID:36170348. |
meanwhile, the purity, proliferation, apoptosis, migration, invasion, extracellular matrix (ecm) synthesis, and some fibrosis and inflammation-related proteins of kfs obtained from the first, fifth and tenth explants cultures were detected. |
2022-09-28 |
2023-08-14 |
Not clear |
| Mukti Chowkwale, Merry L Lindsey, Jeffrey J Saucerma. Intercellular model predicts mechanisms of inflammation-fibrosis coupling after myocardial infarction. The Journal of physiology. 2022-09-28. PMID:35862254. |
resolution of inflammation was driven by degradation of il-1β, matrix metalloproteinase 9, and transforming growth factor β (tgf-β), as well as apoptosis of neutrophils. |
2022-09-28 |
2023-08-16 |
Not clear |
| Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Pen. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164862. |
furthermore, mediating the activation of janus kinase 2(jak2)/stat3/suppressor of cytokine signaling 3(socs3) signaling pathway and phosphoinositide 3-kinase(pi3 k)/protein kinase b(akt)/glycogen synthase kinase-3β(gsk3β) signaling pathway and regulating the release of matrix metalloproteinase(mmp) inhibitor/mmp are main ways that c. tinctorius inhibits neuronal apoptosis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xu. Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160436. |
the research results and deficiencies of exosomes and exosomal micrornas in the regulation of apoptosis, extracellular matrix homeostasis, inflammatory response, oxidative stress, and angiogenesis in intervertebral disc degeneration are primarily investigated. |
2022-09-26 |
2023-08-14 |
Not clear |
| Ji Zhang, Haoran Jiang, Min Li, Lixiang Din. Knockdown of triggering receptor expressed on myeloid cells 1 (TREM1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160910. |
knockdown of triggering receptor expressed on myeloid cells 1 (trem1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells. |
2022-09-26 |
2023-08-14 |
human |
| Yuan Li, Yuan Xu, Bo Chen, Zhi-Fang Xu, Shen-Jun Wang, Yu-Xin Fang, Yang-Yang Liu, Ze-Lin Chen, Yong-Ming Guo, Yi Gu. [Progress of researches on acupuncture-moxibustion treatment of cartilage damage of osteoarthritis]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 9. 2022-09-24. PMID:36153460. |
in this paper, we reviewed the mechanisms of acupuncture and moxibustion underlying relieving cartilage damage from three aspects: 1) promoting chondrocyte homeostasis by inhibiting apoptosis and improving cellular autophagy, 2) regulating extracellular matrix (ecm) metabolism (inhibiting decomposition and promoting synthesis) by suppressing the release of inflammatory factors and the activity of proteolytic enzymes, and 3) improving oa microenvironment by reducing the number of macrophagocyte 1 (m1) and increasing the ratio of m2/m1 in the local inflammatory locus. |
2022-09-24 |
2023-08-14 |
Not clear |