| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lele Liu, Hua Zhang, Baiming Jin, Haonan Li, Xiujuan Zheng, Xuying Li, Mengyuan Li, Mingqi Li, Shijing Nian, Kewei Wan. MiR-214-3p may alleviate T-2 toxin-induced chondrocyte apoptosis and matrix degradation by regulating NF-κB signaling pathway in vitro. Toxicon : official journal of the International Society on Toxinology. 2023-02-16. PMID:36796497. |
mir-214-3p may alleviate t-2 toxin-induced chondrocyte apoptosis and matrix degradation by regulating nf-κb signaling pathway in vitro. |
2023-02-16 |
2023-08-14 |
Not clear |
| Rajiv Supra, Devendra K Agrawa. Mechanobiology of MicroRNAs in Intervertebral Disk Degeneration. Journal of spine research and surgery. vol 5. issue 1. 2023-02-13. PMID:36777190. |
the degradation of the extracellular matrix (ecm), inflammation, and apoptosis have all been investigated as critical factors involved in the pathology of degenerative disk disease. |
2023-02-13 |
2023-08-14 |
Not clear |
| Marjolein van Driel, Johannes P T M van Leeuwe. Vitamin D and Bone: A Story of Endocrine and Auto/Paracrine Action in Osteoblasts. Nutrients. vol 15. issue 3. 2023-02-11. PMID:36771187. |
vitamin d is involved in directing the osteoblasts towards proliferation or apoptosis, regulates their differentiation to bone matrix producing cells, and controls the subsequent mineralization of the bone matrix. |
2023-02-11 |
2023-08-14 |
Not clear |
| Hua Chao, Lisheng Zheng, Pojui Hsu, Jinyun He, Ridong Wu, Shuqia Xu, Ruixi Zeng, Yuan Zhou, Huisi Ma, Haibo Liu, Qing Tan. IL13RA2 downregulation in fibroblast promotes keloid fibrosis via JAK/STAT6 activation. JCI insight. 2023-02-09. PMID:36757802. |
ectopic expression of il13ra2 in keloid fibroblasts resulted in inhibition of stat6 phosphorylation, cell proliferation, migration, invasion, extracellular matrix secretion and myofibroblast marker expression, as well as an increase in apoptosis. |
2023-02-09 |
2023-08-14 |
mouse |
| Joseph C Cooley, Nomin Javkhlan, Jasmine A Wilson, Daniel G Foster, Benjamin L Edelman, Luis A Ortiz, David A Schwartz, David Wh Riches, Elizabeth F Redent. Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis. JCI insight. vol 8. issue 3. 2023-02-08. PMID:36752201. |
a hallmark feature is fibroblast resistance to apoptosis, leading to their persistence, accumulation, and excessive deposition of extracellular matrix. |
2023-02-08 |
2023-08-14 |
mouse |
| Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zha. Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. Frontiers in pharmacology. vol 14. 2023-02-06. PMID:36744257. |
sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. |
2023-02-06 |
2023-08-14 |
rat |
| Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zha. Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. Frontiers in pharmacology. vol 14. 2023-02-06. PMID:36744257. |
apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (ivdd) and can be explained by endoplasmic reticulum (er) stress. |
2023-02-06 |
2023-08-14 |
rat |
| Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zha. Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. Frontiers in pharmacology. vol 14. 2023-02-06. PMID:36744257. |
our results showed that sal003 inhibited apoptosis and extracellular matrix degradation by suppressing the endoplasmic reticulum stress pathway. |
2023-02-06 |
2023-08-14 |
rat |
| Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zha. Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. Frontiers in pharmacology. vol 14. 2023-02-06. PMID:36744257. |
the therapeutic effects of sal003 were also observed in the intervertebral disc degeneration rat model, as evidenced by improved degeneration along with decreased apoptosis and extracellular matrix degradation in intervertebral discs. |
2023-02-06 |
2023-08-14 |
rat |
| Zhongyin Zhang, Lichan Yuan, Yufeng Liu, Ruobing Wang, Yihong Zhang, Yan Yang, Hui Wei, Junqing M. Integrated cascade nanozyme remodels chondrocyte inflammatory microenvironment in temporomandibular joint osteoarthritis via inhibiting ROS-NF-κB and MAPK pathways. Advanced healthcare materials. 2023-02-04. PMID:36738173. |
notably, the inflammatory microenvironment in tmj oa is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory cytokine release, and extracellular matrix (ecm) synthesis. |
2023-02-04 |
2023-08-14 |
rat |
| Giulia Fiorentino, Andrew Smith, Giovanna Nicora, Riccardo Bellazzi, Fulvio Magni, Silvia Garagna, Maurizio Zuccott. MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis. Molecular human reproduction. 2023-02-03. PMID:36734599. |
enrichment analysis highlighted significant kegg and reactome pathways, with apoptosis, developmental biology, pi3k-akt, epigenetic regulation of gene expression, and extracellular matrix organisation being well represented. |
2023-02-03 |
2023-08-14 |
mouse |
| Jiang-Nan Ye, Cheng-Guo Su, Yu-Qing Jiang, Yan Zhou, Wen-Xi Sun, Xiao-Xia Zheng, Jin-Tao Miao, Xiang-Yue Li, Jun Zh. Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis: A systematic evaluation and meta-analysis. Frontiers in neuroscience. vol 16. 2023-01-30. PMID:36711149. |
acupuncture modulates cytokines to attenuate cartilage extracellular matrix degradation and apoptosis, key to the pathogenesis of koa, but the mechanisms are complex. |
2023-01-30 |
2023-08-14 |
Not clear |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Jishang Huang, Qingluo Zhou, Qun Ren, Liliang Luo, Guanglin Ji, Tiansheng Zhen. Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration. Frontiers in endocrinology. vol 13. 2023-01-30. PMID:36714579. |
although the pathological development of idd is far from being fully elucidated, many studies have been shown that er stress (ers) is involved in idd development and regulates various processes, such as inflammation, cellular senescence and apoptosis, excessive mechanical loading, metabolic disturbances, oxidative stress, calcium homeostasis imbalance, and extracellular matrix (ecm) dysregulation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yitian Zhang, Xiaoli Li, Wei Liu, Guanglei Hu, Hanjiang Gu, Xiao Cui, Dewu Zhang, Weihui Zeng, Yumin Xi. TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts. European journal of cell biology. vol 102. issue 2. 2023-01-29. PMID:36709605. |
overabundance of the extracellular matrix resulting from hyperproliferation of keloid fibroblasts (kfs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. |
2023-01-29 |
2023-08-14 |
Not clear |
| Xiao Wang, Xiaoping Huang, Pingzhang Gao, Yanxuan Ren, Xiaokun Li, Yong Dia. Kallistatin attenuates inflammatory response in rheumatoid arthritis via the NF-κB signaling pathway. European journal of pharmacology. 2023-01-23. PMID:36690053. |
our results showed that kallistatin mitigated il-1β-mediated chondrocyte apoptosis and inhibited the synthesis of ecm-degrading generation, like matrix metalloproteinase (mmp)-3/13 and a disintegrin and metalloproteinase with thrombospondin motifs (adamts)-4/5, in il-1β-mediated chondrocytes. |
2023-01-23 |
2023-08-14 |
mouse |
| Nicola Di-Iacovo, Stefania Pieroni, Danilo Piobbico, Marilena Castelli, Damiano Scopetti, Simona Ferracchiato, Maria Agnese Della-Fazia, Giuseppe Servill. Liver Regeneration and Immunity: A Tale to Tell. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674692. |
achieving the correct liver/body weight ratio is ensured by several pathways as extracellular matrix signalling, apoptosis through caspase-3 activation, and molecules including transforming growth factor-beta, and cyclic adenosine monophosphate. |
2023-01-21 |
2023-08-14 |
Not clear |
| Huamin Zhang, Yutong Zhou, Dada Wen, Jie Wan. Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36675315. |
myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions, especially fibrosis; they synthesize and secrete a large amount of extracellular matrix (ecm), such as α-sma and collagen, which leads to the distortion of organ parenchyma structure, an imbalance in collagen deposition and degradation, and the replacement of parenchymal cells by fibrous connective tissues. |
2023-01-21 |
2023-08-14 |
Not clear |
| Mohammad Reza Aslani, Nasim Abdollahi, Somaieh Matin, Anahita Zakeri, Hassan Ghobad. Effect of Crocin of Crocus sativus L. on Serum Inflammatory Markers (IL-6 and TNF-α) in COPD patients: A Randomized, Double-Blind, Placebo-Controlled Trial. The British journal of nutrition. 2023-01-11. PMID:36628554. |
different factors, such as inflammation, oxidative stress, extracellular matrix degradation and apoptosis affect the pathophysiology of chronic obstructive pulmonary disease (copd), as a progressive disease characterized by permanent airflow limitation. |
2023-01-11 |
2023-08-14 |
Not clear |
| Tingwen Cai, Hantao Ye, Hongyi Jiang, Chihao Lin, Chao Lou, Weidan Wang, Zijian Yan, Xinghe Xue, Xiaoyun Pan, Jian Li. Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo. International immunopharmacology. vol 115. 2023-01-11. PMID:36630751. |
on the basis of western blot, we have observed the protein expressions of cartilage matrix metabolism, inflammatory factors, and apoptosis of chondrocytes. |
2023-01-11 |
2023-08-14 |
mouse |