| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiqi Zhou, Sha Wu, Huixian Ling, Changjie Zhang, Ying Kon. Primary Cilia: A Cellular Regulator of Articular Cartilage Degeneration. Stem cells international. vol 2022. 2022-10-04. PMID:36193252. |
the main pathological characteristic of oa is cartilage degeneration, which is caused by chondrocyte apoptosis, cartilage matrix degradation, and inflammatory factor destruction. |
2022-10-04 |
2023-08-14 |
Not clear |
| Stephanie J Florczyk, Nathan A Hotaling, Mylene Simon, Joe Chalfoun, Allison L Horenberg, Nicholas J Schaub, Dongbo Wang, Piotr M Szczypiński, Veronica L DeFelice, Peter Bajcsy, Carl G Simo. Measuring dimensionality of cell-scaffold contacts of primary human bone marrow stromal cells cultured on electrospun fiber scaffolds. Journal of biomedical materials research. Part A. 2022-10-04. PMID:36194510. |
sites of cell adhesion to the extracellular matrix (ecm) initiate intracellular signaling that directs cell functions such as proliferation, differentiation, and apoptosis. |
2022-10-04 |
2023-08-14 |
human |
| Ligang Qian, Bo Yu, Taoping Chen, Kang Chen, Zheng Ma, Yunfei Wang, Bo Su. Circ_0022383 alleviates IL-1β-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by miR-3619-5p/SIRT1 axis. International immunopharmacology. vol 112. 2022-10-04. PMID:36194985. |
circ_0022383 alleviates il-1β-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by mir-3619-5p/sirt1 axis. |
2022-10-04 |
2023-08-14 |
Not clear |
| Sunlong Li, Chongan Huang, Jian Xiao, Yuhao Wu, Zengjie Zhang, Yifei Zhou, Naifeng Tian, Yaosen Wu, Xiangyang Wang, Xiaolei Zhan. The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186138. |
apoptosis, senescence, and extracellular matrix metabolism were found to be regulated by these cytokines in ivdd. |
2022-10-03 |
2023-08-14 |
Not clear |
| Dorian Yarih Garcia-Ortega, Sara Aileen Cabrera-Nieto, Haydee Sarai Caro-Sánchez, Marlid Cruz-Ramo. An overview of resistance to chemotherapy in osteosarcoma and future perspectives. Cancer drug resistance (Alhambra, Calif.). vol 5. issue 3. 2022-09-30. PMID:36176756. |
molecular and cellular mechanisms associated with resistance to chemotherapy include dna repair and cell-cycle alterations, enhanced drug efflux, increased detoxification, resistance to apoptosis, autophagy, tumor extracellular matrix, and angiogenesis. |
2022-09-30 |
2023-08-14 |
Not clear |
| Nicholas J MacKnight, Bradford A Dimos, Kelsey M Beavers, Erinn M Muller, Marilyn E Brandt, Laura D Mydlar. Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles. Science advances. vol 8. issue 39. 2022-09-30. PMID:36179017. |
whether or not a coral developed a lesion was mediated by plasticity in genes involved in extracellular matrix maintenance, autophagy, and apoptosis, while resistant coral species had constitutively higher expression of intracellular protein trafficking. |
2022-09-30 |
2023-08-14 |
Not clear |
| Yan He, Shengpeng Zhang, Wu Bao, Yi Xue, Bin Yin, Xialin Cheng, Zexin Zhang, Chiyu Ji. An improved explants culture method: sustainable isolation of keloid fibroblasts with primary characteristics. Journal of cosmetic dermatology. 2022-09-28. PMID:36170348. |
meanwhile, the purity, proliferation, apoptosis, migration, invasion, extracellular matrix (ecm) synthesis, and some fibrosis and inflammation-related proteins of kfs obtained from the first, fifth and tenth explants cultures were detected. |
2022-09-28 |
2023-08-14 |
Not clear |
| Mukti Chowkwale, Merry L Lindsey, Jeffrey J Saucerma. Intercellular model predicts mechanisms of inflammation-fibrosis coupling after myocardial infarction. The Journal of physiology. 2022-09-28. PMID:35862254. |
resolution of inflammation was driven by degradation of il-1β, matrix metalloproteinase 9, and transforming growth factor β (tgf-β), as well as apoptosis of neutrophils. |
2022-09-28 |
2023-08-16 |
Not clear |
| Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Pen. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164862. |
furthermore, mediating the activation of janus kinase 2(jak2)/stat3/suppressor of cytokine signaling 3(socs3) signaling pathway and phosphoinositide 3-kinase(pi3 k)/protein kinase b(akt)/glycogen synthase kinase-3β(gsk3β) signaling pathway and regulating the release of matrix metalloproteinase(mmp) inhibitor/mmp are main ways that c. tinctorius inhibits neuronal apoptosis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xu. Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160436. |
the research results and deficiencies of exosomes and exosomal micrornas in the regulation of apoptosis, extracellular matrix homeostasis, inflammatory response, oxidative stress, and angiogenesis in intervertebral disc degeneration are primarily investigated. |
2022-09-26 |
2023-08-14 |
Not clear |
| Ji Zhang, Haoran Jiang, Min Li, Lixiang Din. Knockdown of triggering receptor expressed on myeloid cells 1 (TREM1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells. Experimental and therapeutic medicine. vol 24. issue 4. 2022-09-26. PMID:36160910. |
knockdown of triggering receptor expressed on myeloid cells 1 (trem1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells. |
2022-09-26 |
2023-08-14 |
human |
| Yuan Li, Yuan Xu, Bo Chen, Zhi-Fang Xu, Shen-Jun Wang, Yu-Xin Fang, Yang-Yang Liu, Ze-Lin Chen, Yong-Ming Guo, Yi Gu. [Progress of researches on acupuncture-moxibustion treatment of cartilage damage of osteoarthritis]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 9. 2022-09-24. PMID:36153460. |
in this paper, we reviewed the mechanisms of acupuncture and moxibustion underlying relieving cartilage damage from three aspects: 1) promoting chondrocyte homeostasis by inhibiting apoptosis and improving cellular autophagy, 2) regulating extracellular matrix (ecm) metabolism (inhibiting decomposition and promoting synthesis) by suppressing the release of inflammatory factors and the activity of proteolytic enzymes, and 3) improving oa microenvironment by reducing the number of macrophagocyte 1 (m1) and increasing the ratio of m2/m1 in the local inflammatory locus. |
2022-09-24 |
2023-08-14 |
Not clear |
| Nele Wagener, Wolfgang Lehmann, Lukas Weiser, Katharina Jäckle, Pietro Di Fazio, Arndt F Schilling, Kai O Böke. Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142172. |
in bone formation assays, all three cognitive enhancers caused a significant decrease in the mineralized matrix and an early slight reduction of cell viability without triggering apoptosis or necrosis. |
2022-09-23 |
2023-08-14 |
human |
| Nada Oršolić, Maja Jazvinšćak Jembre. Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142391. |
anticancer activity of propolis and its compounds relies on various mechanisms: cell-cycle arrest and attenuation of cancer cells proliferation, reduction in the number of cancer stem cells, induction of apoptosis, modulation of oncogene signaling pathways, inhibition of matrix metalloproteinases, prevention of metastasis, anti-angiogenesis, anti-inflammatory effects accompanied by the modulation of the tumor microenvironment (by modifying macrophage activation and polarization), epigenetic regulation, antiviral and bactericidal activities, modulation of gut microbiota, and attenuation of chemotherapy-induced deleterious side effects. |
2022-09-23 |
2023-08-14 |
Not clear |
| Yeyang Wang, Xiaoyu Zheng, Dixin Luo, Wangyang Xu, Xiaozhong Zho. MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8. BMC musculoskeletal disorders. vol 23. issue 1. 2022-09-20. PMID:36127685. |
mir-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting fzd8. |
2022-09-20 |
2023-08-14 |
Not clear |
| Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan, Hengfeng Yua. Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis. Journal of nanobiotechnology. vol 20. issue 1. 2022-09-19. PMID:36123746. |
further bioinformatics analysis revealed that msn-ol suppressed clusters of genes associated with extracellular matrix organization, cell apoptosis and cellular response to oxidative stress. |
2022-09-19 |
2023-08-14 |
Not clear |
| Eduardo Cremonese Filippi-Chiela, Jose Eduardo Vargas, Mardja Manssur Bueno E Silva, Marcos Paulo Thomé, Guido Len. Vincristine promotes differential levels of apoptosis, mitotic catastrophe, and senescence depending on the genetic background of glioblastoma cells. Toxicology in vitro : an international journal published in association with BIBRA. 2022-09-18. PMID:36116745. |
a correlation matrix based on experimental cell analysis reported strong negative correlations between cell number, nuclear irregularities, senescence, or apoptosis, depending on the cells' genetic makeup and treatment regimen. |
2022-09-18 |
2023-08-14 |
Not clear |
| Yi Li, Fulei Li, Zongzong Sun, Juan L. A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2022-09-16. PMID:36112261. |
recent studies have also documented that tpt1-as1 modulates numerous biological processes through multiple mechanisms, including cell proliferation, apoptosis, autophagy, invasion, migration, radiosensitivity, chemosensitivity, stemness, and extracellular matrix (ecm) synthesis. |
2022-09-16 |
2023-08-14 |
human |
| Kaiqiang Sun, Jialin Jiang, Yuan Wang, Xiaofei Sun, Jian Zhu, Ximing Xu, Jingchuan Sun, Jiangang Sh. The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration. Ageing research reviews. 2022-09-16. PMID:36113765. |
abnormal apoptosis, senescence, and pyroptosis of ivd cells, extracellular matrix (ecm) degradation, and infiltration of immune cells are the major molecular alternations during ivdd. |
2022-09-16 |
2023-08-14 |
Not clear |
| Po-Yen Ko, Che-Chia Hsu, Shih-Yao Chen, Li-Chieh Kuo, Wei-Ren Su, I-Ming Jou, Fong-Chin Su, Po-Ting W. Cross-Linked Hyaluronate and Corticosteroid Combination Ameliorate the Rat Experimental Tendinopathy through Anti-Senescent and -Apoptotic Effects. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077161. |
cell viability, inflammatory cytokines, tendon-related proliferation markers, matrix metalloproteinases (mmps), senescent markers, and apoptosis were examined. |
2022-09-09 |
2023-08-14 |
human |