| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Yin, Weilu Gao, Hao Tang, Zongsheng Yi. BASP1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: A possible therapeutic approach for osteoarthritis. Experimental cell research. 2023-05-19. PMID:37207971. |
osteoarthritis(oa) is an age-related degenerative disease involving chondrocyte apoptosis and extracellular matrix(ecm) degradation.brain acid soluble protein 1(basp1) has been reported to induce apoptosis.thus, we speculated that basp1 might regulate oa progression by inducing apoptosis, which is also the purpose of this study.the cartilage of the knee joint was collected from oa patients who received the joint replacement.in oa cartilage tissue,we found basp1 expression was highly expressed, which inferred that basp1 might be involved in oa.to validate our hypothesis, destabilization of the medial meniscus (dmm) surgery-induced male c57bl/6mice and interleukin-1β (il-1β)-treated human chondrocytes were used to mimic the oa environment.basp1 knockdown in mice and chondrocytes was achieved by adenovirus carried with basp1-specific shrna.high expression of basp1 was observed in oa mice, which was also verified in il-1β-treated chondrocytes.the potential mechanism of basp1 in oa was further explored in vitro.basp1 knockdown alleviated il-1β-induced apoptosis and ecm degradation, as reflected by the decreased number of apoptotic cells and matrix metalloproteases 13 expression,and the increased collagen ii expression.our findings indicated that basp1 knockdown alleviated oa progression by inhibiting apoptosis and ecm degradation, suggesting that inhibiting basp1 may be a potentially applicable method for preventing oa. |
2023-05-19 |
2023-08-14 |
mouse |
| Qian Suo, Lidong Deng, Tingting Chen, Shengju Wu, Lin Qi, Ze Liu, Tingting He, Heng-Li Tian, Wanlu Li, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhan. Optogenetic Activation of Astrocytes Reduces Blood-Brain Barrier Disruption via IL-10 In Stroke. Aging and disease. 2023-05-17. PMID:37196130. |
we found for the first time that interleukin-10 derived from optogenetic-activated astrocytes protected blood-brain barrier integrity by decreasing the activity of matrix metallopeptidase 2 and attenuated neuronal apoptosis, which provided a novel therapeutic approach and target in the acute stage of ischemic stroke. |
2023-05-17 |
2023-08-14 |
rat |
| Valentina Preziosi, Mario Barra, Valeria Rachela Villella, Speranza Esposito, Pasquale D'Angelo, Simone Luigi Marasso, Matteo Cocuzza, Antonio Cassinese, Stefano Guid. Immuno-Sensing at Ultra-Low Concentration of TG2 Protein by Organic Electrochemical Transistors. Biosensors. vol 13. issue 4. 2023-05-16. PMID:37185523. |
its subcellular localization is crucial in determining its function, and indeed, tg2 is found in the extracellular matrix, mitochondria, recycling endosomes, plasma membrane, cytosol, and nucleus because it is associated with cell growth, differentiation, and apoptosis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Hao Hu, Junxu Yang, Yanping Zhong, Jiawei Wang, Jinhong Cai, Cuijuan Luo, Zhiqiang Jin, Ming Gao, Maolin He, Li Zhen. Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment. iScience. vol 26. issue 5. 2023-05-15. PMID:37182095. |
excessive reactive oxygen species (ros) in joints could lead to gradual degeneration of the extracellular matrix (ecm) and apoptosis of chondrocytes, contributing to the occurrence and development of osteoarthritis (oa). |
2023-05-15 |
2023-08-14 |
rat |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
apoptosis, inflammation, and the extracellular matrix (ecm) synthesis and catabolism are compromised with intervertebral disc degeneration (idd). |
2023-05-08 |
2023-08-14 |
Not clear |
| Antong Wu, Janak Lal Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhan. Human Salivary Histatin-1 Attenuates Osteoarthritis through Promoting M1/M2 Macrophage Transition. Pharmaceutics. vol 15. issue 4. 2023-04-28. PMID:37111757. |
furthermore, cell migration assay, alcian blue, safranin o staining, rt-qpcr, western blot, and fcm showed that hst1 not only attenuates m1-macrophage-cm-induced apoptosis and matrix metalloproteinase expression in chondrogenic cells, but it also restores their metabolic activity, migration, and chondrogenic differentiation. |
2023-04-28 |
2023-08-14 |
human |
| Júlia Benini Kohler, Alex Ferreira da Silva, Walleson Alves Farias, Barbara Fialho Carvalho Sampaio, Marco Aurélio Silveiro Neves, Leandro Gregorut Lima, Juliana Dias Lourenço, Alyne Riani Moreira, Alexandre Póvoa Barbosa, Iolanda de Fátima Lopes Calvo Tibério, Walcy Rosolia Teodoro, Fernanda Degobbi Tenorio Quirino Dos Santos Lope. Smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components. Scientific reports. vol 13. issue 1. 2023-04-28. PMID:37117332. |
smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components. |
2023-04-28 |
2023-08-14 |
Not clear |
| Zhangfu Li, Honghao Yang, Yong Hai, Yunzhong Chen. Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration. Mediators of inflammation. vol 2023. 2023-04-27. PMID:37101594. |
it is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ecm), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. |
2023-04-27 |
2023-08-14 |
Not clear |
| Xueying Shao, Yuanjun Zhang, Yuan Li. Cyclic stretch-regulated wound healing. Biophysical journal. 2023-04-26. PMID:37098651. |
specifically, a great diversity of cellular responses (1-4) have been reported, including 1) re-alignment of cells, associated with the remodeling of cellular stress fibers and focal adhesions; 2) altered cell proliferation or apoptosis; 3) migration of cells driven by stretch-triggered formation of lamellipodia; 4) secretion of extracellular matrix (ecm) proteins that are critical for tissue remodeling; 5) activation of mitogen-activated protein kinase (mapk), nuclear factor-kappa b (nf-kb) and wnt signaling pathways; and 6) upregulation of genes involved in cell adhesion and inflammation. |
2023-04-26 |
2023-08-14 |
Not clear |
| Yuanmin Li, Lingyun Tao, Yawei Xu, Rong Gu. Taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating TLR4/NF-κB axis. International immunopharmacology. vol 119. 2023-04-25. PMID:37098322. |
taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating tlr4/nf-κb axis. |
2023-04-25 |
2023-08-14 |
human |
| Jicheng Han, Zongjian Luo, Yifei Wang, Yantao Lian. LncRNA ZFAS1 protects chondrocytes from IL-1β-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-04-25. PMID:37098630. |
lncrna zfas1 protects chondrocytes from il-1β-induced apoptosis and extracellular matrix degradation via regulating mir-7-5p/flrt2 axis. |
2023-04-25 |
2023-08-14 |
Not clear |
| Hulin Wang, Junjie Zhao, Jin Wan. Role of circular RNAs in osteoarthritis: update on pathogenesis and therapeutics. Molecular genetics and genomics : MGG. 2023-04-22. PMID:37086279. |
and they are closely associated with various pathological progressions in oa, such as extracellular matrix degradation, chondrocyte apoptosis, and inflammation. |
2023-04-22 |
2023-08-14 |
Not clear |
| Chao Song, Yan Zhou, Kang Cheng, Fei Liu, Weiye Cai, Daqian Zhou, Rui Chen, Houyin Shi, Zhijiang Fu, Jingwen Chen, Zongchao Li. Cellular senescence - Molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-21. PMID:37084562. |
the pathophysiology of ivdd has been linked to numerous variables, including oxidative stress, apoptosis, matrix metalloproteinases, and inflammatory factors. |
2023-04-21 |
2023-08-14 |
human |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
microrna-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting rorα in nucleus pulposus cells. |
2023-04-16 |
2023-08-14 |
mouse |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
in vitro studies using western blotting (wb) and immunofluorescence (if) confirmed that the mir-155 mimic could alleviate cholesterol-induced matrix degradation, apoptosis and pyroptosis in np. |
2023-04-16 |
2023-08-14 |
mouse |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
in this study, we demonstrated that mir-155 could target rorα and that inhibition of rorα could prevent cholesterol-induced matrix degradation, apoptosis, and pyroptosis in np, indicating the protective effect of mir-155 in cholesterol-induced idd by targeting rorα. |
2023-04-16 |
2023-08-14 |
mouse |
| Yan Zhang, Xinghua Lv, Feng Chen, Qian Fan, Yongqiang Liu, Zhanhai Wan, Janvier Nibaruta, Jipeng Lv, Xuena Han, Lin Wu, Hao Wang, Yufang Len. Role of microRNAs in programmed cell death in renal diseases: A review. Medicine. vol 102. issue 15. 2023-04-14. PMID:37058073. |
micrornas (mirnas) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. |
2023-04-14 |
2023-08-14 |
Not clear |
| Jing-Yu Qu, Hua-Tao Xie, Yu-Ting Xiao, Ying-Ying Zhang, Zhi-Xin Hu, Jia-Song Wang, Ming-Chang Zhang, Han X. The inhibition of p38 MAPK blocked inflammation to restore the functions of rat meibomian gland epithelial cells. Experimental eye research. 2023-04-14. PMID:37059216. |
cell proliferation, keratinization, lipid accumulation, and matrix metalloproteinases 9 (mmp9) expression were evaluated by mtt assay, polymerase chain reaction (pcr), immunofluorescence staining, apoptosis assay, lipid staining, and western blot analyses. |
2023-04-14 |
2023-08-14 |
mouse |
| Sonali Karnik, Hessam Noori-Dokht, Taylor Williams, Amin Joukar, Stephen B Trippel, Uma Sankar, Diane R Wagne. Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047494. |
sirt1 enzymatic activity decreased as early as 5 min following the mechanical overload, and remained suppressed for at least 24 h. the chondrocyte injury response, including apoptosis, oxidative stress, secretion of inflammatory mediators, and alterations in cartilage matrix expression, was prevented with pharmacological activation of sirt1 in a dose-dependent manner. |
2023-04-13 |
2023-08-14 |
cattle |