| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Zhengwei Xu, Hao Yang, Dingjun Ha. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration. Frontiers in endocrinology. vol 13. 2022-12-26. PMID:36568075. |
ncrnas mainly participate in the process of idd through regulating apoptosis of nucleus pulposus (np) cells, metabolism of extracellular matrix (ecm) and inflammatory response; ii). |
2022-12-26 |
2023-08-14 |
Not clear |
| Cunliang Guo, Yungang Chen, Yuhe Wang, Yanke Ha. Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review). Experimental and therapeutic medicine. vol 25. issue 1. 2022-12-26. PMID:36569433. |
the key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. |
2022-12-26 |
2023-08-14 |
Not clear |
| Jieya Luo, Yuxuan Yang, Xuan Wang, Xingyu Chang, Songbo F. Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications. Biomolecules. vol 12. issue 12. 2022-12-23. PMID:36551232. |
unlike apoptosis, pyroptosis is characterized by the rupture of the plasma membrane and the release of inflammatory mediators, accelerating the destruction of the extracellular matrix (ecm). |
2022-12-23 |
2023-08-14 |
Not clear |
| Jin Han, Donghwi Park, Ji Young Park, Seungwoo Ha. Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552552. |
increased oxidative stress in osteoarthritis (oa) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis. |
2022-12-23 |
2023-08-14 |
mouse |
| Qian Lin, Bin Gen. The Role of Hydrogen Sulfide in Plaque Stability. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552564. |
although the initiation, procession, and precise time of controlling plaque rupture are unclear, foam cell formation and apoptosis, cell death, extracellular matrix components, protease expression and activity, local inflammation, intraplaque hemorrhage, and calcification contribute to the plaque instability. |
2022-12-23 |
2023-08-14 |
Not clear |
| Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Eloisa Helena Ribeiro Olivieri, Eduardo Caetano Abilio da Silva, Alexandre Muxfeldt Ab' Saber, Teresa Yae Takagaki, Vera Luiza Capelozz. Proposing Specific Neuronal Epithelial-to-Mesenchymal Transition Genes as an Ancillary Tool for Differential Diagnosis among Pulmonary Neuroendocrine Neoplasms. Genes. vol 13. issue 12. 2022-12-23. PMID:36553576. |
functional enrichment analysis of the emt genes differentially expressed among pnens subtypes showed that they are involved in cellular proliferation, extracellular matrix degradation, regulation of cell apoptosis, oncogenesis, and tumor cell invasion. |
2022-12-23 |
2023-08-14 |
Not clear |
| Min Hu, Hui Qiu, Tao He, Minyu Zhon. Effect of miRNA-218-5p on Proliferation, Migration, Apoptosis and Inflammation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm and Extracellular Matrix Protein. Iranian journal of public health. vol 51. issue 11. 2022-12-23. PMID:36561253. |
effect of mirna-218-5p on proliferation, migration, apoptosis and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm and extracellular matrix protein. |
2022-12-23 |
2023-08-14 |
Not clear |
| Fengqi Cheng, Honghao Yang, Yunzhong Cheng, Yuzeng Liu, Yong Hai, Yangpu Zhan. The role of oxidative stress in intervertebral disc cellular senescence. Frontiers in endocrinology. vol 13. 2022-12-23. PMID:36561567. |
reactive oxygen species (ros) and reactive nitrogen species (rns) could regulate matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and aging of intervertebral disc cells. |
2022-12-23 |
2023-08-14 |
Not clear |
| Nancy Husseiny Hassan, Doaa Mohammed Yousef, Amira Ebrahim Alseme. Hesperidin protects against aluminum-induced renal injury in rats via modulating MMP-9 and apoptosis: biochemical, histological, and ultrastructural study. Environmental science and pollution research international. 2022-12-22. PMID:36547838. |
the study verified the nephroprotective effects of hesperidin on alcl3-induced renal damage and confirmed the critical role of extracellular matrix (ecm) remodeling and apoptosis inhibition. |
2022-12-22 |
2023-08-14 |
rat |
| Kevin Montagne, Katsuko S Furukawa, Yuki Taninaka, Brandon Ngao, Takashi Ushid. Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells. PloS one. vol 17. issue 12. 2022-12-20. PMID:36538560. |
osteoarthritis (oa) is the most common joint disease in older adults and is characterized by a gradual degradation of articular cartilage due to decreased cartilage matrix gene expression and increased expression of genes involved in protein degradation, apoptosis and inflammation. |
2022-12-20 |
2023-08-14 |
Not clear |
| Yong-Hua Yang, Xiao-Peng Gu, Hong Hu, Bin Hu, Xiang-Lian Wan, Zhi-Ping Gu, Shao-Jin Zhon. Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration. Journal of orthopaedic surgery and research. vol 17. issue 1. 2022-12-20. PMID:36539815. |
ginsenoside rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the yap1/taz pathway in rats with intervertebral disc degeneration. |
2022-12-20 |
2023-08-14 |
rat |
| Wanzhen Xu, Manfeng Wang, Yang Bai, Yong Chen, Xiaoshan Ma, Zhiqing Yang, Liyan Zhao, Yunqian L. The role of microfibrillar-associated protein 2 in cancer. Frontiers in oncology. vol 12. 2022-12-19. PMID:36530974. |
recent studies have shown that mfap2, an effective prognostic molecule for various tumors, is associated with tumor occurrence and development and may be involved in remodeling the extracellular matrix and regulating proliferation, apoptosis, invasion, tumor cell metastasis, and tumor angiogenesis. |
2022-12-19 |
2023-08-14 |
Not clear |
| Xiao-Tao Wu, Yong-Xiang Wang, Xin-Min Feng, Min Feng, Hui-Hui Su. Update on the roles of macrophages in the degeneration and repair process of intervertebral discs. Joint bone spine. 2022-12-18. PMID:36529418. |
the process of ivd degeneration involves a complex of pathologic changes on both extracellular matrix degradation and resident cell apoptosis. |
2022-12-18 |
2023-08-14 |
Not clear |
| Yanrong Sun, E Liu, Yanhong Pei, Qinhan Yao, Haowen Ma, Yakun Mu, Yingjie Wang, Yan Zhang, Xiaomei Yang, Xing Wang, Jiajia Xue, Jiliang Zhai, Roxana O Carare, Lihua Qin, Junhao Ya. The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage. Acta neuropathologica communications. vol 10. issue 1. 2022-12-18. PMID:36529767. |
after sah, there was significant impairment in the ipad system: marked expansion of perivascular spaces, and isf clearance rate was significantly decreased, associated with the apoptosis of endothelial cells, activation of astrocytes, over-expression of matrix metalloproteinase 9 and loss of collagen type iv. |
2022-12-18 |
2023-08-14 |
rat |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Rui Ran, Yi Wu, Hai-Hong Zhan. Acid-Sensing Ion Channels: Implications For Intervertebral Disc Degeneration. Current pharmaceutical biotechnology. 2022-12-12. PMID:36503387. |
matrix acidity potentially negatively affects gene expression, activity, proliferation, and apoptosis of ivd cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Teng Ma, Xiangpeng Wang, Wenjing Qu, Lingsen Yang, Cheng Jing, Bingrui Zhu, Yongkui Zhang, Wenpeng Xi. Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway. Molecules (Basel, Switzerland). vol 27. issue 23. 2022-12-11. PMID:36500713. |
we found that osthole inhibited il-1β-induced apoptosis and cartilage matrix degeneration by activating autophagy in rat chondrocytes. |
2022-12-11 |
2023-08-14 |
rat |
| Samantha B Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V Brown, Jared B Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P Vostrejs, Kia Z Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R Donahue, Caius G Radu, Cynthia Clendenin, James G Christensen, Robert H Vonderheide, Ben Z Stange. Efficacy of a small molecule inhibitor of KrasG12D in immunocompetent models of pancreatic cancer. Cancer discovery. 2022-12-06. PMID:36472553. |
concomitant with tumor cell apoptosis and proliferative arrest, drug treatment led to marked shifts in the tumor microenvironment (tme), including changes in fibroblasts, matrix, and macrophages. |
2022-12-06 |
2023-08-14 |
Not clear |
| Yue-Liang Yue, Meng-Yu Zhang, Jian-Yu Liu, Li-Jun Fang, Yi-Qing Q. The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies. Therapeutic advances in respiratory disease. vol 16. 2022-12-05. PMID:36468453. |
this review focused on the six steps of autophagy, as well as the interplay between autophagy and other seven pulmonary fibrosis related mechanisms, which include extracellular matrix deposition, myofibroblast differentiation, epithelial-mesenchymal transition, pulmonary epithelial cell dysfunction, apoptosis, tgf-β1 pathway, and the renin-angiotensin system. |
2022-12-05 |
2023-08-14 |
Not clear |
| Yue Li, Bin Shen, Cunxian Lv, Xinyi Zhu, Qiqige Naren, Dong Xu, He Chen, Fengmiao W. Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression. International immunopharmacology. vol 114. 2022-12-02. PMID:36459925. |
osteoarthritis (oa) is a common age-related degenerative disease involving various pathological processes, among which apoptosis in chondrocyte and extracellular matrix (ecm) degradation are the main pathologies. |
2022-12-02 |
2023-08-14 |
mouse |