| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Wang, Z Liu, G Ma, Y Xu, Y L. Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats. Tissue & cell. vol 83. 2023-07-03. PMID:37399641. |
these results suggest that mouth breathing leads to subchondral bone resorption, cartilage layer thinning, and cartilage matrix destruction, inducing chondrocyte apoptosis via both the extrinsic and mitochondrial apoptosis pathways. |
2023-07-03 |
2023-08-14 |
rat |
| Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jian. The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes. International immunopharmacology. vol 122. 2023-07-01. PMID:37392568. |
in oa chondrocytes, loc727924 knockdown boosted cell viability, suppressed cell apoptosis, reactive oxygen species (ros) accumulation, increased aggrecan and collagen ii, decreased matrix metallopeptidase (mmp)-3/13 and adam metallopeptidase with thrombospondin type 1 motif (adamts)-4/5 levels, and reduced the levels of tumor necrosis factor alpha (tnf-α), interleukin 1 beta (il-1β), and interleukin 6 (il-6). |
2023-07-01 |
2023-08-14 |
mouse |
| Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jian. The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes. International immunopharmacology. vol 122. 2023-07-01. PMID:37392568. |
in conclusion, the p65-loc727924-mir-26a/kpna3-p65 regulatory loop modulates oa chondrocyte apoptosis, ros accumulation, extracellular matrix (ecm) deposition, and inflammatory response in vitro and oa development in vivo, being one of the mechanisms mediating vip ameliorating oa. |
2023-07-01 |
2023-08-14 |
mouse |
| Wei Wei, Hongjie Mu, Qiaoyi Cui, Peng Yu, Tong Liu, Tao Wang, Lin Shen. CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-07-01. PMID:37393232. |
circtbx5 knockdown modulates the mir-558/myd88 axis to alleviate il-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the nf-κb signaling. |
2023-07-01 |
2023-08-14 |
Not clear |
| Cheng Chi, Xifeng Liang, Tianyu Cui, Xiao Gao, Ruixia Liu, Chenghong Yi. SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis. Biomolecules & biomedicine. 2023-06-30. PMID:37389959. |
conversely, downregulation of snon inhibited hsc apoptosis, increased collagen iii and timp-1 levels, and decreased matrix metalloproteinase 13 (mmp-13) expression. |
2023-06-30 |
2023-08-14 |
rat |
| Jin Zhang, Xuesong Li, Yi Lu, Guowen Wang, Ying M. Anoikis-Related Gene Signature for Prognostication of Pancreatic Adenocarcinoma: A Multi-Omics Exploration and Verification Study. Cancers. vol 15. issue 12. 2023-06-28. PMID:37370756. |
anoikis, a form of apoptosis that occurs due to detachment of cells from the extracellular matrix, has been linked to the development of cancer in several studies. |
2023-06-28 |
2023-08-14 |
Not clear |
| Sen Ma, Dejun Ji, Xiaolong Wang, Yuxin Yang, Yinghua Shi, Yulin Che. Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats. Cells. vol 12. issue 12. 2023-06-28. PMID:37371115. |
hair fiber growth is determined by the spatiotemporally controlled proliferation, differentiation, and apoptosis of hair matrix cells (hmcs) inside the hair follicle (hf); however, dermal papilla cells (dpcs), the cell population surrounded by hmcs, manipulate the above processes via intercellular crosstalk with hmcs. |
2023-06-28 |
2023-08-14 |
Not clear |
| Wenting Yang, Lin Pan, Yiju Cheng, Xiao Wu, Songsong Huang, Juan Du, Honglan Zhu, Menglin Zhang, Yuquan Zhan. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. Scientific reports. vol 13. issue 1. 2023-06-28. PMID:37380638. |
we then assessed histopathological changes, inflammatory factors, oxidative indicators, apoptosis, epithelial-mesenchymal transition, extracellular matrix changes, and levels of phosphatidylinositol 3-kinase (pi3k)/akt/mammalian target of rapamycin (mtor) signaling pathway-related proteins in the blm-treated mice to determine the effect of ami treatment on these factors. |
2023-06-28 |
2023-08-14 |
mouse |
| Wenting Yang, Lin Pan, Yiju Cheng, Xiao Wu, Songsong Huang, Juan Du, Honglan Zhu, Menglin Zhang, Yuquan Zhan. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. Scientific reports. vol 13. issue 1. 2023-06-28. PMID:37380638. |
more specifically, ami alleviated blm-induced oxidative stress, inflammation, alveolar cell apoptosis, epithelial-mesenchymal transition, and extracellular matrix deposition by regulating the pi3k/akt/mtor signaling pathway. |
2023-06-28 |
2023-08-14 |
mouse |
| Xinyan Li, Yuanyuan Han, Guimiao Li, Yingze Zhang, Juan Wang, Chen Fen. Role of Wnt signaling pathway in joint development and cartilage degeneration. Frontiers in cell and developmental biology. vol 11. 2023-06-27. PMID:37363728. |
excessive mechanical load activates wnt pathway in chondrocytes, resulting in chondrocyte apoptosis, matrix destruction and other osteoarthritis-related changes. |
2023-06-27 |
2023-08-14 |
Not clear |
| Ramin Masoudi, Ali Mohammadi, Solmaz Morovati, Amir Ali Heidari, Mehdi Asad-Sangab. Induction of apoptosis in colorectal cancer cells by matrix protein of PPR virus as a novel anti-cancer agent. International journal of biological macromolecules. 2023-06-27. PMID:37369256. |
induction of apoptosis in colorectal cancer cells by matrix protein of ppr virus as a novel anti-cancer agent. |
2023-06-27 |
2023-08-14 |
Not clear |
| Xiaohua Zhang, Shan Shan Liu, Jingru Ma, Wei Q. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications. Pathology, research and practice. vol 248. 2023-06-25. PMID:37356220. |
furthermore, slpi interacts intricately with other cancer-promoting factors, including matrix metalloproteinase-2 (mmp-2), mmp-9, the nf-κb and akt pathways, and the p53-upregulated modulator of apoptosis (puma). |
2023-06-25 |
2023-08-14 |
Not clear |
| Guojun Yao, Ling Deng, Xinquan Long, Yufan Zhou, Xiang Zho. An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis. Aging. vol 15. 2023-06-24. PMID:37354488. |
focal adhesions (fas) allow cells to contact the extracellular matrix, helping to maintain tension and enabling signal transmission in cell migration, differentiation, and apoptosis. |
2023-06-24 |
2023-08-14 |
Not clear |
| Samar M Al-Tantawy, Salma M Eraky, Laila A Eiss. Promising renoprotective effect of gold nanoparticles and dapagliflozin in diabetic nephropathy via targeting miR-192 and miR-21. Journal of biochemical and molecular toxicology. 2023-06-23. PMID:37352119. |
aunps and dapa treatment alleviated renal fibrosis as they decreased transforming growth factorß1(tgf-ß1) as well as matrix metalloproteinase-2 (mmp-2) renal expression, decreased apoptosis through alleviating the proapoptotic gene (caspase-3) renal expression and increased the antiapoptotic gene (bcl-2) renal expression, and increased autophagy as they increased lc-3 as well as beclin-1 renal expression. |
2023-06-23 |
2023-08-14 |
rat |
| Rebeca Alvariño, Cristina Gil-Mouce, Manuel A Botana, Sandra Gegunde, Jesús González-Jartín, Mercedes R Vieytes, Amparo Alfonso, Luis M Botan. Cyclophilin B serum levels present variations across the menstrual cycle. Scientific reports. vol 13. issue 1. 2023-06-22. PMID:37349369. |
cyclophilin b is released by inflammatory cells and acts through the receptor cd147, affecting matrix metalloproteases release, whilst cyclophilin d participates in hypoxia-induced apoptosis. |
2023-06-22 |
2023-08-14 |
Not clear |
| Xiao Ouyang, Yunzhi Ding, Li Yu, Feng Xin, Xiaowei Yang, Xingyong Liu, Songming Ton. Circular RNA CircDHRS3 Aggravates IL-1β-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression. Inflammation. 2023-06-20. PMID:37340152. |
circdhrs3 silencing weakened il-1β-induced chondrocyte cartilage extracellular matrix (ecm) degradation, apoptosis, and inflammatory response. |
2023-06-20 |
2023-08-14 |
Not clear |
| Xuefeng Zhang, Zhikun Wang, Binbin Wang, Jingyi Li, Hui Yua. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333451. |
after the expression of oip5-as1 or mir-338-3p in interleukin (il)-1β-stimulated primary chondrocytes and chon-001 cells was manipulated, cell viability, proliferation, apoptosis rate, apoptosis-related protein (cleaved caspase-9, bax) expressions, extracellular matrix (ecm) (matrix metalloproteinase (mmp)-3, mmp-13, aggrecan, and collagen ii), pi3k/akt pathway, and mrna expressions of inflammatory factors (il-6 and il-8), oip5-as1, and mir-338-3p were determined by cell counting kit-8, edu, flow cytometry, western blot, and quantitative reverse transcription-polymerase chain reaction. |
2023-06-19 |
2023-08-14 |
Not clear |
| Hao Jiang, Zuoxiang Dong, Xiaomin Xia, Xue L. Cathepsins in oral diseases: mechanisms and therapeutic implications. Frontiers in immunology. vol 14. 2023-06-19. PMID:37334378. |
cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. |
2023-06-19 |
2023-08-14 |
human |
| Zhenyu Wu, Zhouxin Yang, Luying Liu, Yong Xia. Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling. Frontiers in pharmacology. vol 14. 2023-06-16. PMID:37324450. |
oxidative stress contributes to inflammatory responses, extracellular matrix (ecm) degradation, and chondrocyte apoptosis and promotes the pathogenesis of oa. |
2023-06-16 |
2023-08-14 |
Not clear |
| Daqian Zhou, Chao Song, Yongliang Mei, Kang Cheng, Fei Liu, Weiye Cai, Silong Gao, Zhenlong Wang, Zongchao Li. A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-06-15. PMID:37322524. |
at present, we found that its mechanism of action mainly involves regulation of inflammatory factors, reduction of apoptosis and pyroptosis of npcs, inhibition of extracellular matrix degradation, improvement of intestinal flora, etc. |
2023-06-15 |
2023-08-14 |
Not clear |