| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Su, Sheng-Yong Su, Pu Yang, Yan-Jun Guo, Jing L. [Progress of research on mechanisms of acupuncture and moxibustion in the treatment of rheumatoid arthritis]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 5. 2023-05-29. PMID:37247865. |
), 4) regulating related signaling pathways (suppressing nuclear factor-kb/vascular endothelial growth factor, janus tyrosine kinase-signal transducer and activator of transcription, transient receptor potential vanilloid and canonical wnt/β-catenin pathways), and activating cholinergic anti-inflammatory pathway, 5) regulating histocyte energy metabolism (improving amino acid supply and reducing negative nitrogen balance to improve immune regulation function), 6) maintaining the balance of bone cells and articular cartilage (by regulating the balance between synthesis and degradation of articular cartilage matrix, and the balance of bone cells and osteoclasts), 7) up-regulating energy metabolism gene (atp50, atp6v1b2) expression and regulating biological rhythm gene (clock, per2, rev-erb) expression, 8) regulating mirnas-mediated chondrocyte apoptosis. |
2023-05-29 |
2023-08-14 |
Not clear |
| Argen Mamazhakypov, Abdirashit Maripov, Akpay S Sarybaev, Ralph Theo Schermuly, Akylbek Sydyko. Osteopontin in Pulmonary Hypertension. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37239056. |
osteopontin modulates a plethora of cellular processes within the pulmonary vasculature, including cell proliferation, migration, apoptosis, extracellular matrix synthesis, and inflammation via binding to various receptors such as integrins and cd44. |
2023-05-27 |
2023-08-14 |
Not clear |
| Maria Teresa Rocchetti, Francesco Bellanti, Mariia Zadorozhna, Daniela Fiocco, Domenica Mangier. Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240168. |
thus, the purpose of this review consists in highlighting the relevant mechanisms by which luteolin inhibits tumor progression in metastasis, i.e., affecting epithelial-mesenchymal transition (emt), repressing angiogenesis and lysis of extracellular matrix (ecm), as well as inducing apoptosis. |
2023-05-27 |
2023-08-14 |
human |
| b' Krist\\xc3\\xbdna Sl\\xc3\\xa1mov\\xc3\\xa1, Jakub \\xc4\\x8cerven\\xc3\\xbd, Zuzana M\\xc3\\xa9sz\\xc3\\xa1ros, Tereza Friede, David Vrbata, Vladim\\xc3\\xadr K\\xc5\\x99en, Pavla Bojarov\\xc3\\xa. Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly. Molecules (Basel, Switzerland). vol 28. issue 10. 2023-05-27. PMID:37241779.' |
galectins are carbohydrate-binding lectins that modulate the proliferation, apoptosis, adhesion, or migration of cells by cross-linking glycans on cell membranes or extracellular matrix components. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yuan Yue, Jia-Qi Yang, Sheng-Yu Lu, Jun Ge, Hong-Yun Nie, Kai-Ge Liu, Fei Liu, Hao Li, Hong-Feng Yan, Tao Zhang, Pei-Ming Sun, Hong-Wei Sun, Jian-Wu Yang, Jin-Lian Zhou, Yan Cu. Simulated microgravity altered the proliferation, apoptosis, and extracellular matrix formation of L929 fibroblasts and the transforming growth factor-β1/Smad3 signaling pathway. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). vol 29. issue 5. 2023-05-26. PMID:37231921. |
simulated microgravity altered the proliferation, apoptosis, and extracellular matrix formation of l929 fibroblasts and the transforming growth factor-β1/smad3 signaling pathway. |
2023-05-26 |
2023-08-14 |
Not clear |
| Wenzhao Li, Cheng Tao, Minzhi Mao, Kewei Zh. The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis. Acta biochimica et biophysica Sinica. 2023-05-26. PMID:37232576. |
the nrf2/hmgb1/nf-κb axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis. |
2023-05-26 |
2023-08-14 |
Not clear |
| Ye Tian, Xinxi Li, Chao Bai, Zhenwei Yang, Lei Zhang, Jun Luo, Wenbin Zhan. lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm. Mediators of inflammation. vol 2023. 2023-05-25. PMID:37228901. |
lncrna mir503hg targets mir-191-5p/plcd1 axis and negatively modulates apoptosis, extracellular matrix disruption, and inflammation in abdominal aortic aneurysm. |
2023-05-25 |
2023-08-14 |
Not clear |
| Ye Tian, Xinxi Li, Chao Bai, Zhenwei Yang, Lei Zhang, Jun Luo, Wenbin Zhan. lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm. Mediators of inflammation. vol 2023. 2023-05-25. PMID:37228901. |
as the most prevalent subtype of aortic aneurysm, abdominal aortic aneurysm (aaa) features the apoptosis, extracellular matrix (ecm) disruption, and inflammation response of vascular smooth muscle cells (vsmcs). |
2023-05-25 |
2023-08-14 |
Not clear |
| Zhuang Li, Jun L. CircRNAs in osteoarthritis: research status and prospect. Frontiers in genetics. vol 14. 2023-05-25. PMID:37229197. |
many studies have found that circrnas play an essential role in the progression of oa, including extracellular matrix metabolism, autophagy, apoptosis, the proliferation of chondrocytes, inflammation, oxidative stress, cartilage development, and chondrogenic differentiation. |
2023-05-25 |
2023-08-14 |
Not clear |
| Haoran Wang, Zhongqing Wu, Kanna X. CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. Experimental and therapeutic medicine. vol 25. issue 6. 2023-05-25. PMID:37229323. |
cklf1 interference alleviates il‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via ccr5. |
2023-05-25 |
2023-08-14 |
human |
| Bo Xiong, Lihua Chen, Yue Huang, Guanyu Lu, Cai Chen, Jiao Nong, Haida Pa. ZBTB16 eases lipopolysaccharide‑elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing GRK2 transcription. Experimental and therapeutic medicine. vol 25. issue 6. 2023-05-19. PMID:37206562. |
zbtb16 eases lipopolysaccharide‑elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing grk2 transcription. |
2023-05-19 |
2023-08-14 |
human |
| Li Yin, Weilu Gao, Hao Tang, Zongsheng Yi. BASP1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: A possible therapeutic approach for osteoarthritis. Experimental cell research. 2023-05-19. PMID:37207971. |
basp1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: a possible therapeutic approach for osteoarthritis. |
2023-05-19 |
2023-08-14 |
mouse |
| Li Yin, Weilu Gao, Hao Tang, Zongsheng Yi. BASP1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: A possible therapeutic approach for osteoarthritis. Experimental cell research. 2023-05-19. PMID:37207971. |
osteoarthritis(oa) is an age-related degenerative disease involving chondrocyte apoptosis and extracellular matrix(ecm) degradation.brain acid soluble protein 1(basp1) has been reported to induce apoptosis.thus, we speculated that basp1 might regulate oa progression by inducing apoptosis, which is also the purpose of this study.the cartilage of the knee joint was collected from oa patients who received the joint replacement.in oa cartilage tissue,we found basp1 expression was highly expressed, which inferred that basp1 might be involved in oa.to validate our hypothesis, destabilization of the medial meniscus (dmm) surgery-induced male c57bl/6mice and interleukin-1β (il-1β)-treated human chondrocytes were used to mimic the oa environment.basp1 knockdown in mice and chondrocytes was achieved by adenovirus carried with basp1-specific shrna.high expression of basp1 was observed in oa mice, which was also verified in il-1β-treated chondrocytes.the potential mechanism of basp1 in oa was further explored in vitro.basp1 knockdown alleviated il-1β-induced apoptosis and ecm degradation, as reflected by the decreased number of apoptotic cells and matrix metalloproteases 13 expression,and the increased collagen ii expression.our findings indicated that basp1 knockdown alleviated oa progression by inhibiting apoptosis and ecm degradation, suggesting that inhibiting basp1 may be a potentially applicable method for preventing oa. |
2023-05-19 |
2023-08-14 |
mouse |
| Qian Suo, Lidong Deng, Tingting Chen, Shengju Wu, Lin Qi, Ze Liu, Tingting He, Heng-Li Tian, Wanlu Li, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhan. Optogenetic Activation of Astrocytes Reduces Blood-Brain Barrier Disruption via IL-10 In Stroke. Aging and disease. 2023-05-17. PMID:37196130. |
we found for the first time that interleukin-10 derived from optogenetic-activated astrocytes protected blood-brain barrier integrity by decreasing the activity of matrix metallopeptidase 2 and attenuated neuronal apoptosis, which provided a novel therapeutic approach and target in the acute stage of ischemic stroke. |
2023-05-17 |
2023-08-14 |
rat |
| Valentina Preziosi, Mario Barra, Valeria Rachela Villella, Speranza Esposito, Pasquale D'Angelo, Simone Luigi Marasso, Matteo Cocuzza, Antonio Cassinese, Stefano Guid. Immuno-Sensing at Ultra-Low Concentration of TG2 Protein by Organic Electrochemical Transistors. Biosensors. vol 13. issue 4. 2023-05-16. PMID:37185523. |
its subcellular localization is crucial in determining its function, and indeed, tg2 is found in the extracellular matrix, mitochondria, recycling endosomes, plasma membrane, cytosol, and nucleus because it is associated with cell growth, differentiation, and apoptosis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Hao Hu, Junxu Yang, Yanping Zhong, Jiawei Wang, Jinhong Cai, Cuijuan Luo, Zhiqiang Jin, Ming Gao, Maolin He, Li Zhen. Polydopamine-Pd nanozymes as potent ROS scavengers in combination with near-infrared irradiation for osteoarthritis treatment. iScience. vol 26. issue 5. 2023-05-15. PMID:37182095. |
excessive reactive oxygen species (ros) in joints could lead to gradual degeneration of the extracellular matrix (ecm) and apoptosis of chondrocytes, contributing to the occurrence and development of osteoarthritis (oa). |
2023-05-15 |
2023-08-14 |
rat |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
apoptosis, inflammation, and the extracellular matrix (ecm) synthesis and catabolism are compromised with intervertebral disc degeneration (idd). |
2023-05-08 |
2023-08-14 |
Not clear |
| Antong Wu, Janak Lal Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhan. Human Salivary Histatin-1 Attenuates Osteoarthritis through Promoting M1/M2 Macrophage Transition. Pharmaceutics. vol 15. issue 4. 2023-04-28. PMID:37111757. |
furthermore, cell migration assay, alcian blue, safranin o staining, rt-qpcr, western blot, and fcm showed that hst1 not only attenuates m1-macrophage-cm-induced apoptosis and matrix metalloproteinase expression in chondrogenic cells, but it also restores their metabolic activity, migration, and chondrogenic differentiation. |
2023-04-28 |
2023-08-14 |
human |
| Júlia Benini Kohler, Alex Ferreira da Silva, Walleson Alves Farias, Barbara Fialho Carvalho Sampaio, Marco Aurélio Silveiro Neves, Leandro Gregorut Lima, Juliana Dias Lourenço, Alyne Riani Moreira, Alexandre Póvoa Barbosa, Iolanda de Fátima Lopes Calvo Tibério, Walcy Rosolia Teodoro, Fernanda Degobbi Tenorio Quirino Dos Santos Lope. Smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components. Scientific reports. vol 13. issue 1. 2023-04-28. PMID:37117332. |
smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components. |
2023-04-28 |
2023-08-14 |
Not clear |