| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
the modulating effects of matrix stiffness on spreading and apoptosis of tumor cells have been well recognized. |
2023-10-03 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
while the cell spreading increased and the apoptosis decreased with the matrix stiffness, such modulating effect of matrix on cell spreading exhibited different time evolvement behaviors as a function of stiffness, which likely led to surprisingly similar apoptosis rates for the 30 kpa and 250 kpa samples. |
2023-10-03 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
matrix stiffness mediated the spreading and apoptosis of mg-63 cells by regulating cell adhesion to matrix and in particular cytoskeletal organization, which was dependent on ras, rap1 and pi3k-akt signaling pathways and finally led to the apoptosis of cancer cells dominated by endoplasmic reticulum stress pathway. |
2023-10-03 |
2023-10-07 |
Not clear |
| Zélie Dirand, Marion Tissot, Brice Chatelain, Céline Viennet, Gwenaël Roli. Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research? Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760792. |
as major parameters for fibrogenesis assessment, we evaluated apoptosis, myofibroblast differentiation and response to tgf-β1, extracellular matrix (ecm) synthesis, and ecm-related genes regulation in kfs spheroids. |
2023-09-28 |
2023-10-07 |
Not clear |
| Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Fen. Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance. Materials today. Bio. vol 23. 2023-09-28. PMID:37766899. |
in this study, the protective effect of gold nanoparticles (aunps) on the cartilage of children was realized by counteracting chondrocyte apoptosis and extracellular matrix (ecm) degradation in a young mouse model of lipopolysaccharide (lps)-induced growth plate (gp) cartilage damage. |
2023-09-28 |
2023-10-07 |
mouse |
| Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakan. Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis. Scientific reports. vol 13. issue 1. 2023-09-28. PMID:37770630. |
conversely, magnesium supplementation mitigated extracellular matrix calcification and phenotypic transdifferentiation and apoptosis caused by calcifying conditions in cultured met5a cells and mefs. |
2023-09-28 |
2023-10-07 |
mouse |
| Yuting Tang, Yang Liu, Xiaoshu Zhu, Yanlin Chen, Xinluan Jiang, Siyang Ding, Que Zheng, Ming Zhang, Jiashu Yang, Yunfei Ma, Mengying Xing, Zongyu Zhang, Huimin Ding, Yucui Jin, Changyan M. ALKBH5-mediated m iScience. vol 26. issue 10. 2023-09-27. PMID:37752950. |
overexpression of hs3st3b1-it1 significantly increased chondrocyte viability, inhibited chondrocyte apoptosis, and upregulated extracellular matrix (ecm) proteins, whereas hs3st3b1-it1 knockdown had the opposite effects. |
2023-09-27 |
2023-10-07 |
Not clear |
| Song Qingxin, Jiang Kai, Zheng Dandan, Jin Linyu, Chen Xiuyuan, Feng Yubo, Wang Kun, Han Yingchao, Chen Hao, Song Jie, Chen Zhi, Shen Hongxin. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment. Journal of nanobiotechnology. vol 21. issue 1. 2023-09-27. PMID:37759249. |
the pathogenesis of intervertebral disc degeneration (ivdd) is attributed to metabolic dysregulation within the extracellular matrix and heightened apoptosis of nucleus pulposus cells (npc). |
2023-09-27 |
2023-10-07 |
Not clear |
| Song Qingxin, Jiang Kai, Zheng Dandan, Jin Linyu, Chen Xiuyuan, Feng Yubo, Wang Kun, Han Yingchao, Chen Hao, Song Jie, Chen Zhi, Shen Hongxin. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment. Journal of nanobiotechnology. vol 21. issue 1. 2023-09-27. PMID:37759249. |
therefore, a potential therapeutic strategy for managing ivdd involves the reestablishment of metabolic equilibrium within the extracellular matrix and the suppression of excessive myeloid cell apoptosis. |
2023-09-27 |
2023-10-07 |
Not clear |
| Weicong Zhu, Xiaohong Yang, Shaojie Liu, Yiwen Wang, Wenxu Li, Qiguang Zhong, Lihua Zhang, Jiake X. Lentivirus-based shRNA of Caspase-3 gene silencing inhibits chondrocyte apoptosis and delays the progression of surgically induced osteoarthritis. Biotechnology journal. 2023-09-26. PMID:37750185. |
excessive apoptosis of chondrocytes disrupts the dynamic balance of cell proliferation and apoptosis, with a marked reduction in chondrocytes and cartilage matrix disintegration, which represents the main pathology of oa. |
2023-09-26 |
2023-10-07 |
rat |
| Irwin H Gelma. Metastasis suppressor genes in clinical practice: are they druggable? Cancer metastasis reviews. 2023-09-25. PMID:37749308. |
msg can regulate various pathways or cell biological functions such as those controlling mitogen-activated protein kinase pathway mediators, cell-cell and cell-extracellular matrix protein adhesion, cytoskeletal architecture, g-protein-coupled receptors, apoptosis, and transcriptional complexes. |
2023-09-25 |
2023-10-07 |
Not clear |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
snd1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in il-1β-stimulated chondrocytes via pink1/becn1 pathway. |
2023-09-25 |
2023-10-07 |
mouse |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
we validated the association between snd1 and pink1 and found that pink1 reversed the inhibitory effects of snd1 silencing on il-1β-induced mitochondrial damage, inflammatory reaction, apoptosis and extracellular matrix degradation in mouse chondrocytes. |
2023-09-25 |
2023-10-07 |
mouse |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
furthermore, we found that pink1 upregulated becn1 protein expression and that becn reversed the inhibitory effects of pink1 silencing on il-1β-induced mitochondrial damage, inflammatory reaction, apoptosis and extracellular matrix degradation. |
2023-09-25 |
2023-10-07 |
mouse |
| Dengbo Yao, Ming Li, Kun Wang, Song Jin, Weike Zeng, Zhuangyao Liao, Enming Chen, Yuwei Liang, Tong Xing, Guoming Wen, Changchun Liang, Kaihui Su, Shixin Lu, Zhen Che, Yuxi Li, Lin Huan. Emodin ameliorates matrix degradation and apoptosis in nucleus pulposus cells and attenuates intervertebral disc degeneration through LRP1 in vitro and in vivo. Experimental cell research. 2023-09-23. PMID:37741491. |
emodin ameliorates matrix degradation and apoptosis in nucleus pulposus cells and attenuates intervertebral disc degeneration through lrp1 in vitro and in vivo. |
2023-09-23 |
2023-10-07 |
rat |
| Peggy Kong, Raja Elina Ahmad, Amirah Zulkifli, Shaliny Hari Rama Krishnan, Hui Yin Nam, Tunku Kamaru. The role of autophagy in mitigating osteoarthritis progression via regulation of chondrocyte apoptosis: a review. Joint bone spine. 2023-09-22. PMID:37739213. |
although the occurrence of apoptosis in osteoarthritic cartilage and its correlation with cartilage degradation is evident, the causes of chondrocyte apoptosis leading to matrix loss are still not well-understood. |
2023-09-22 |
2023-10-07 |
Not clear |
| Rasit Din. The Role of Immune Mechanisms in Abdominal Aortic Aneurysm: Could It be a Promising Therapeutic Strategy? Acta Cardiologica Sinica. vol 39. issue 5. 2023-09-18. PMID:37720407. |
apoptosis of vascular smooth muscle cells, the major cellular component of the aorta, and degeneration of the extracellular matrix, the skeleton of the aortic wall, are hallmarks of aaa pathology. |
2023-09-18 |
2023-10-07 |
Not clear |
| Haiyan Fan, Hao Tian, Fa Jin, Xin Zhang, Shixing Su, Yanchao Liu, Zhuohua Wen, Xuying He, Xifeng Li, Chuanzhi Dua. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. Redox biology. vol 67. 2023-09-17. PMID:37717465. |
reactive oxygen species (ros) are widely accepted as a pernicious factor in the progression of intracranial aneurysm (ia), which is eminently related to cell apoptosis and extracellular matrix degradation, but the mechanism remains to be elucidated. |
2023-09-17 |
2023-10-07 |
mouse |
| Haiyan Fan, Hao Tian, Fa Jin, Xin Zhang, Shixing Su, Yanchao Liu, Zhuohua Wen, Xuying He, Xifeng Li, Chuanzhi Dua. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. Redox biology. vol 67. 2023-09-17. PMID:37717465. |
however, no study has confirmed whether cypd is a detrimental mediator of cell apoptosis and extracellular matrix degradation in the setting of ia development. |
2023-09-17 |
2023-10-07 |
mouse |
| Chenhao Yao, Shu Dai, Cheng Wang, Ke Fu, Rui Wu, Xingtao Zhao, Yuxin Yao, Yunxia L. Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-15. PMID:37713990. |
the results indicate that luteolin improves liver lesions through various mechanisms, including inhibiting inflammatory factors, reducing oxidative stress, regulating lipid balance, slowing down excessive aggregation of extracellular matrix, inducing apoptosis and autophagy of liver cancer cells. |
2023-09-15 |
2023-10-07 |
Not clear |