| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenting Yang, Lin Pan, Yiju Cheng, Xiao Wu, Songsong Huang, Juan Du, Honglan Zhu, Menglin Zhang, Yuquan Zhan. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. Scientific reports. vol 13. issue 1. 2023-06-28. PMID:37380638. |
we then assessed histopathological changes, inflammatory factors, oxidative indicators, apoptosis, epithelial-mesenchymal transition, extracellular matrix changes, and levels of phosphatidylinositol 3-kinase (pi3k)/akt/mammalian target of rapamycin (mtor) signaling pathway-related proteins in the blm-treated mice to determine the effect of ami treatment on these factors. |
2023-06-28 |
2023-08-14 |
mouse |
| Wenting Yang, Lin Pan, Yiju Cheng, Xiao Wu, Songsong Huang, Juan Du, Honglan Zhu, Menglin Zhang, Yuquan Zhan. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. Scientific reports. vol 13. issue 1. 2023-06-28. PMID:37380638. |
more specifically, ami alleviated blm-induced oxidative stress, inflammation, alveolar cell apoptosis, epithelial-mesenchymal transition, and extracellular matrix deposition by regulating the pi3k/akt/mtor signaling pathway. |
2023-06-28 |
2023-08-14 |
mouse |
| Xinyan Li, Yuanyuan Han, Guimiao Li, Yingze Zhang, Juan Wang, Chen Fen. Role of Wnt signaling pathway in joint development and cartilage degeneration. Frontiers in cell and developmental biology. vol 11. 2023-06-27. PMID:37363728. |
excessive mechanical load activates wnt pathway in chondrocytes, resulting in chondrocyte apoptosis, matrix destruction and other osteoarthritis-related changes. |
2023-06-27 |
2023-08-14 |
Not clear |
| Ramin Masoudi, Ali Mohammadi, Solmaz Morovati, Amir Ali Heidari, Mehdi Asad-Sangab. Induction of apoptosis in colorectal cancer cells by matrix protein of PPR virus as a novel anti-cancer agent. International journal of biological macromolecules. 2023-06-27. PMID:37369256. |
induction of apoptosis in colorectal cancer cells by matrix protein of ppr virus as a novel anti-cancer agent. |
2023-06-27 |
2023-08-14 |
Not clear |
| Xiaohua Zhang, Shan Shan Liu, Jingru Ma, Wei Q. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications. Pathology, research and practice. vol 248. 2023-06-25. PMID:37356220. |
furthermore, slpi interacts intricately with other cancer-promoting factors, including matrix metalloproteinase-2 (mmp-2), mmp-9, the nf-κb and akt pathways, and the p53-upregulated modulator of apoptosis (puma). |
2023-06-25 |
2023-08-14 |
Not clear |
| Guojun Yao, Ling Deng, Xinquan Long, Yufan Zhou, Xiang Zho. An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis. Aging. vol 15. 2023-06-24. PMID:37354488. |
focal adhesions (fas) allow cells to contact the extracellular matrix, helping to maintain tension and enabling signal transmission in cell migration, differentiation, and apoptosis. |
2023-06-24 |
2023-08-14 |
Not clear |
| Samar M Al-Tantawy, Salma M Eraky, Laila A Eiss. Promising renoprotective effect of gold nanoparticles and dapagliflozin in diabetic nephropathy via targeting miR-192 and miR-21. Journal of biochemical and molecular toxicology. 2023-06-23. PMID:37352119. |
aunps and dapa treatment alleviated renal fibrosis as they decreased transforming growth factorß1(tgf-ß1) as well as matrix metalloproteinase-2 (mmp-2) renal expression, decreased apoptosis through alleviating the proapoptotic gene (caspase-3) renal expression and increased the antiapoptotic gene (bcl-2) renal expression, and increased autophagy as they increased lc-3 as well as beclin-1 renal expression. |
2023-06-23 |
2023-08-14 |
rat |
| Rebeca Alvariño, Cristina Gil-Mouce, Manuel A Botana, Sandra Gegunde, Jesús González-Jartín, Mercedes R Vieytes, Amparo Alfonso, Luis M Botan. Cyclophilin B serum levels present variations across the menstrual cycle. Scientific reports. vol 13. issue 1. 2023-06-22. PMID:37349369. |
cyclophilin b is released by inflammatory cells and acts through the receptor cd147, affecting matrix metalloproteases release, whilst cyclophilin d participates in hypoxia-induced apoptosis. |
2023-06-22 |
2023-08-14 |
Not clear |
| Xiao Ouyang, Yunzhi Ding, Li Yu, Feng Xin, Xiaowei Yang, Xingyong Liu, Songming Ton. Circular RNA CircDHRS3 Aggravates IL-1β-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression. Inflammation. 2023-06-20. PMID:37340152. |
circdhrs3 silencing weakened il-1β-induced chondrocyte cartilage extracellular matrix (ecm) degradation, apoptosis, and inflammatory response. |
2023-06-20 |
2023-08-14 |
Not clear |
| Xuefeng Zhang, Zhikun Wang, Binbin Wang, Jingyi Li, Hui Yua. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-06-19. PMID:37333451. |
after the expression of oip5-as1 or mir-338-3p in interleukin (il)-1β-stimulated primary chondrocytes and chon-001 cells was manipulated, cell viability, proliferation, apoptosis rate, apoptosis-related protein (cleaved caspase-9, bax) expressions, extracellular matrix (ecm) (matrix metalloproteinase (mmp)-3, mmp-13, aggrecan, and collagen ii), pi3k/akt pathway, and mrna expressions of inflammatory factors (il-6 and il-8), oip5-as1, and mir-338-3p were determined by cell counting kit-8, edu, flow cytometry, western blot, and quantitative reverse transcription-polymerase chain reaction. |
2023-06-19 |
2023-08-14 |
Not clear |
| Hao Jiang, Zuoxiang Dong, Xiaomin Xia, Xue L. Cathepsins in oral diseases: mechanisms and therapeutic implications. Frontiers in immunology. vol 14. 2023-06-19. PMID:37334378. |
cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. |
2023-06-19 |
2023-08-14 |
human |
| Zhenyu Wu, Zhouxin Yang, Luying Liu, Yong Xia. Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling. Frontiers in pharmacology. vol 14. 2023-06-16. PMID:37324450. |
oxidative stress contributes to inflammatory responses, extracellular matrix (ecm) degradation, and chondrocyte apoptosis and promotes the pathogenesis of oa. |
2023-06-16 |
2023-08-14 |
Not clear |
| Daqian Zhou, Chao Song, Yongliang Mei, Kang Cheng, Fei Liu, Weiye Cai, Silong Gao, Zhenlong Wang, Zongchao Li. A review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-06-15. PMID:37322524. |
at present, we found that its mechanism of action mainly involves regulation of inflammatory factors, reduction of apoptosis and pyroptosis of npcs, inhibition of extracellular matrix degradation, improvement of intestinal flora, etc. |
2023-06-15 |
2023-08-14 |
Not clear |
| Jun Gu, Xiaoyang Zhou, Lin Xi. Significance of Oxidative Stress in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration. Biochemical genetics. 2023-06-14. PMID:37314550. |
intervertebral disc degeneration (ivdd) is a common illness of aging, and its pathophysiological process is mainly manifested by cell aging and apoptosis, an imbalance in the production and catabolism of extracellular matrix, and an inflammatory response. |
2023-06-14 |
2023-08-14 |
Not clear |
| Ilaria Bernabei, Uwe Hansen, Driss Ehirchiou, Jürgen Brinckmann, Veronique Chobaz, Nathalie Busso, Sonia Nas. CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298730. |
cd11b deficiency favors cartilage calcification via increased matrix vesicles, apoptosis, and lysyl oxidase activity. |
2023-06-11 |
2023-08-14 |
mouse |
| Ilaria Bernabei, Uwe Hansen, Driss Ehirchiou, Jürgen Brinckmann, Veronique Chobaz, Nathalie Busso, Sonia Nas. CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298730. |
mechanistically, we found more calcification-competent matrix vesicles and more apoptosis in both cartilage and chondrocytes isolated from cd11b-deficient mice. |
2023-06-11 |
2023-08-14 |
mouse |
| Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qi. ANGPTL8 Deletion Attenuates Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. Clinical science (London, England : 1979). 2023-06-09. PMID:37294581. |
knockout of angptl8 significantly reduced angii-induced aaa formation, elastin breaks, aortic inflammatory cytokines, matrix metalloproteinase expression, and smooth muscle cell apoptosis in apoe-/- mice. |
2023-06-09 |
2023-08-14 |
mouse |
| Ritesh Urade, Wen-Tsan Chang, Ching-Chung Ko, Ruei-Nian Li, Hui-Min Yang, Hsuan-Yu Chen, Lin-Ya Huang, Meng-Yang Chang, Chang-Yi Wu, Chien-Chih Chi. A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy. Life sciences. 2023-06-09. PMID:37295712. |
along with elevated ros generation and apoptosis, msdf also caused anoikis and cell death by causing cells to lose contact with their extracellular matrix. |
2023-06-09 |
2023-08-14 |
human |
| Xiaokun Zhao, Jinghong Yuan, Jingyu Jia, Jian Zhang, Jiahao Liu, Qi Chen, Tao Li, Zhiwen Wu, Hui Wu, Xinxin Miao, Tianlong Wu, Bin Li, Xigao Chen. Role of non‑coding RNAs in cartilage endplate (Review). Experimental and therapeutic medicine. vol 26. issue 1. 2023-06-05. PMID:37273754. |
in addition, a summary of the current knowledge regarding the deregulation of ncrnas in idd in relation to their actions on cep cell functions, including cell proliferation, apoptosis and extracellular matrix synthesis/degradation is presented. |
2023-06-05 |
2023-08-14 |
Not clear |
| Yuting Tang, Fangling Hong, Siyang Ding, Jiashu Yang, Ming Zhang, Yunfei Ma, Que Zheng, Dawei Yang, Yucui Jin, Changyan M. METTL3-mediated m Cell reports. vol 42. issue 6. 2023-06-04. PMID:37270777. |
overexpression of igfbp7-ot significantly inhibits chondrocyte viability, promotes chondrocyte apoptosis, and reduces extracellular matrix components, whereas igfbp7-ot knockdown has the opposite effects. |
2023-06-04 |
2023-08-14 |
Not clear |