| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Qingxin, Jiang Kai, Zheng Dandan, Jin Linyu, Chen Xiuyuan, Feng Yubo, Wang Kun, Han Yingchao, Chen Hao, Song Jie, Chen Zhi, Shen Hongxin. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment. Journal of nanobiotechnology. vol 21. issue 1. 2023-09-27. PMID:37759249. |
therefore, a potential therapeutic strategy for managing ivdd involves the reestablishment of metabolic equilibrium within the extracellular matrix and the suppression of excessive myeloid cell apoptosis. |
2023-09-27 |
2023-10-07 |
Not clear |
| Weicong Zhu, Xiaohong Yang, Shaojie Liu, Yiwen Wang, Wenxu Li, Qiguang Zhong, Lihua Zhang, Jiake X. Lentivirus-based shRNA of Caspase-3 gene silencing inhibits chondrocyte apoptosis and delays the progression of surgically induced osteoarthritis. Biotechnology journal. 2023-09-26. PMID:37750185. |
excessive apoptosis of chondrocytes disrupts the dynamic balance of cell proliferation and apoptosis, with a marked reduction in chondrocytes and cartilage matrix disintegration, which represents the main pathology of oa. |
2023-09-26 |
2023-10-07 |
rat |
| Irwin H Gelma. Metastasis suppressor genes in clinical practice: are they druggable? Cancer metastasis reviews. 2023-09-25. PMID:37749308. |
msg can regulate various pathways or cell biological functions such as those controlling mitogen-activated protein kinase pathway mediators, cell-cell and cell-extracellular matrix protein adhesion, cytoskeletal architecture, g-protein-coupled receptors, apoptosis, and transcriptional complexes. |
2023-09-25 |
2023-10-07 |
Not clear |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
snd1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in il-1β-stimulated chondrocytes via pink1/becn1 pathway. |
2023-09-25 |
2023-10-07 |
mouse |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
we validated the association between snd1 and pink1 and found that pink1 reversed the inhibitory effects of snd1 silencing on il-1β-induced mitochondrial damage, inflammatory reaction, apoptosis and extracellular matrix degradation in mouse chondrocytes. |
2023-09-25 |
2023-10-07 |
mouse |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
furthermore, we found that pink1 upregulated becn1 protein expression and that becn reversed the inhibitory effects of pink1 silencing on il-1β-induced mitochondrial damage, inflammatory reaction, apoptosis and extracellular matrix degradation. |
2023-09-25 |
2023-10-07 |
mouse |
| Dengbo Yao, Ming Li, Kun Wang, Song Jin, Weike Zeng, Zhuangyao Liao, Enming Chen, Yuwei Liang, Tong Xing, Guoming Wen, Changchun Liang, Kaihui Su, Shixin Lu, Zhen Che, Yuxi Li, Lin Huan. Emodin ameliorates matrix degradation and apoptosis in nucleus pulposus cells and attenuates intervertebral disc degeneration through LRP1 in vitro and in vivo. Experimental cell research. 2023-09-23. PMID:37741491. |
emodin ameliorates matrix degradation and apoptosis in nucleus pulposus cells and attenuates intervertebral disc degeneration through lrp1 in vitro and in vivo. |
2023-09-23 |
2023-10-07 |
rat |
| Peggy Kong, Raja Elina Ahmad, Amirah Zulkifli, Shaliny Hari Rama Krishnan, Hui Yin Nam, Tunku Kamaru. The role of autophagy in mitigating osteoarthritis progression via regulation of chondrocyte apoptosis: a review. Joint bone spine. 2023-09-22. PMID:37739213. |
although the occurrence of apoptosis in osteoarthritic cartilage and its correlation with cartilage degradation is evident, the causes of chondrocyte apoptosis leading to matrix loss are still not well-understood. |
2023-09-22 |
2023-10-07 |
Not clear |
| Rasit Din. The Role of Immune Mechanisms in Abdominal Aortic Aneurysm: Could It be a Promising Therapeutic Strategy? Acta Cardiologica Sinica. vol 39. issue 5. 2023-09-18. PMID:37720407. |
apoptosis of vascular smooth muscle cells, the major cellular component of the aorta, and degeneration of the extracellular matrix, the skeleton of the aortic wall, are hallmarks of aaa pathology. |
2023-09-18 |
2023-10-07 |
Not clear |
| Haiyan Fan, Hao Tian, Fa Jin, Xin Zhang, Shixing Su, Yanchao Liu, Zhuohua Wen, Xuying He, Xifeng Li, Chuanzhi Dua. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. Redox biology. vol 67. 2023-09-17. PMID:37717465. |
reactive oxygen species (ros) are widely accepted as a pernicious factor in the progression of intracranial aneurysm (ia), which is eminently related to cell apoptosis and extracellular matrix degradation, but the mechanism remains to be elucidated. |
2023-09-17 |
2023-10-07 |
mouse |
| Haiyan Fan, Hao Tian, Fa Jin, Xin Zhang, Shixing Su, Yanchao Liu, Zhuohua Wen, Xuying He, Xifeng Li, Chuanzhi Dua. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. Redox biology. vol 67. 2023-09-17. PMID:37717465. |
however, no study has confirmed whether cypd is a detrimental mediator of cell apoptosis and extracellular matrix degradation in the setting of ia development. |
2023-09-17 |
2023-10-07 |
mouse |
| Chenhao Yao, Shu Dai, Cheng Wang, Ke Fu, Rui Wu, Xingtao Zhao, Yuxin Yao, Yunxia L. Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-15. PMID:37713990. |
the results indicate that luteolin improves liver lesions through various mechanisms, including inhibiting inflammatory factors, reducing oxidative stress, regulating lipid balance, slowing down excessive aggregation of extracellular matrix, inducing apoptosis and autophagy of liver cancer cells. |
2023-09-15 |
2023-10-07 |
Not clear |
| Zhiwen Luo, Renwen Wan, Shan Liu, Xinting Feng, Zhen Peng, Qing Wang, Shiyi Chen, Xiliang Shan. Mechanisms of exercise in the treatment of lung cancer - a mini-review. Frontiers in immunology. vol 14. 2023-09-11. PMID:37691942. |
this review will analyze the biological basis of exercise's anticancer effects on lung cancer, with a focus on aspects such as the tumor microenvironment, matrix regulation, apoptosis and angiogenesis. |
2023-09-11 |
2023-10-07 |
Not clear |
| Qingchen Meng, En Xie, Heng Sun, Huan Wang, Jiaying Li, Zhao Liu, Kexin Li, Jie Hu, Qianglong Chen, Chaoyong Liu, Bin Li, Fengxuan Ha. High-Strength Smart Microneedles with "Offensive and Defensive" Effects for Intervertebral Disc Repair. Advanced materials (Deerfield Beach, Fla.). 2023-09-08. PMID:37681640. |
in vitro experiments demonstrated that the synergistic treatment of photothermal therapy and anti-inflammation effectively reduced inflammation, inhibited cell apoptosis, and promoted the synthesis of the extracellular matrix (ecm). |
2023-09-08 |
2023-10-07 |
rat |
| Xingli Zhang, Jing Shi, Peng Yuan, Tengfei Li, Zhiguo Cao, Wei Zo. Differential developmental and proinflammatory responses of zebrafish embryo to repetitive exposure of biodigested polyamide and polystyrene microplastics. Journal of hazardous materials. vol 460. 2023-09-08. PMID:37683353. |
relative to the pristine form, the bioaccumulation of digested ps elevated and the musculoskeletal deformity and mortality of juvenile zebrafish were obviously enhanced, but these changes were unobservable for pa. lipopolysaccharide-triggered inflammation and apoptosis via toll-like receptor signaling pathways and reduction of extracellular matrix secretions driven by oxidative stress contributed to the aggravated inhibitory effects of digested ps on larval development. |
2023-09-08 |
2023-10-07 |
zebrafish |
| Rajnish Kumar, Devansh M Sinha, Brenden R Lankau, Nishant R Sinha, Ratnakar Tripathi, Suneel Gupta, Rajiv R Moha. Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools. Experimental eye research. 2023-09-08. PMID:37683796. |
pathway enrichment was performed for the genes associated with cellular apoptosis, death, adhesion, migration, differentiation, proliferation, extracellular matrix, and tumor necrosis factor production. |
2023-09-08 |
2023-10-07 |
rabbit |
| Jingtao Wu, Heng Yu, Yangcan Jin, Jingquan Wang, Liwen Zhou, Teng Cheng, Zhao Zhang, Binghao Lin, Jiansen Miao, Zhongke Li. Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model. Chinese medicine. vol 18. issue 1. 2023-09-07. PMID:37679844. |
osteoarthritis (oa), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ecm) and the apoptosis of chondrocytes. |
2023-09-07 |
2023-10-07 |
mouse |
| Gisela Soledad Gualdoni, Camila Barril, Patricia Verónica Jacobo, Liliana Nazareth Pacheco Rodríguez, Elisa Cebra. Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis-vascularization of normal and experimental pathological mouse placenta related to maternal alcohol exposure. Frontiers in cell and developmental biology. vol 11. 2023-09-06. PMID:37670932. |
prior to the initiation of invasion and endothelial replacement by trophoblasts, interactions between decidual stromal cells and maternal leukocytes, such as uterine natural killer cells and macrophages, play crucial roles in the processes of early maternal vascularization, such as proliferation, apoptosis, migration, differentiation, and matrix and vessel remodeling. |
2023-09-06 |
2023-10-07 |
mouse |
| Zhifang Tang, Hanzhen Feng, Xusheng Chen, Shuiyan Shao, Chuan L. SNORC knockdown alleviates inflammation, autophagy defect and matrix degradation of chondrocytes in osteoarthritis development. Molecular and cellular biochemistry. 2023-09-02. PMID:37659033. |
in a word, snorc knockdown alleviates inflammation, matrix degradation, autophagy defect and excessive apoptosis of chondrocytes during oa development via suppressing the pi3k and jnk signaling pathway. |
2023-09-02 |
2023-09-07 |
rat |
| Jun Yi, Qingluo Zhou, Jishang Huang, Shuo Niu, Guanglin Ji, Tiansheng Zhen. Lipid metabolism disorder promotes the development of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-31. PMID:37651799. |
lipid metabolism disorder contributes to extracellular matrix (ecm) degradation, cell apoptosis, and cartilage calcification in the intervertebral discs (ivds) by activating inflammatory responses, endoplasmic reticulum (er) stress, and oxidative stress and inhibiting autophagy. |
2023-08-31 |
2023-09-07 |
human |