| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ge Wang, Mei-Li Wan. [Effect of metabolic reprogramming on abdominal aortic aneurysm]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 3. 2024-06-28. PMID:38939940. |
this review article focuses on the research progress regarding the effects of metabolic reprogramming of vascular smooth muscle cells (vsmcs) and macrophages on the occurrence and development of aaa, especially their roles in major pathological processes such as vsmcs apoptosis and phenotype transformation, extracellular matrix remodeling, oxidative stress, and inflammatory response. |
2024-06-28 |
2024-06-30 |
Not clear |
| Anna O Giarratana, Conor M Prendergast, Mary M Salvatore, Kathleen M Capaccion. TGF-β signaling: critical nexus of fibrogenesis and cancer. Journal of translational medicine. vol 22. issue 1. 2024-06-27. PMID:38926762. |
the transforming growth factor-beta (tgf-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. |
2024-06-27 |
2024-06-29 |
Not clear |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Attenuates Intracerebral-Hemorrhage-Induced Brain Damage by Inhibiting MMP-9/MMP-2 Expression. Biomedicines. vol 12. issue 6. 2024-06-27. PMID:38927580. |
recent studies have implicated mirnas in the pathogenesis of stroke, affecting endothelial dysfunction, neurovascular integrity, edema, apoptosis, inflammation, and extracellular matrix remodeling. |
2024-06-27 |
2024-06-29 |
human |
| Fataneh Esmaeili, Maryam Abolhasani, Hossein Zabihi-Mahmoudabadi, Shadi Sadat Seyyed Ebrahimi, Solaleh Emamgholipour, Maliheh Pakneja. Exosomes isolated from metabolically unhealthy normal weight and overweight phenotypes deteriorate the ER/PR positive breast cancer behavior. Journal of diabetes and metabolic disorders. vol 23. issue 1. 2024-06-27. PMID:38932828. |
this study aims to assess how plasma exosomes taken from women with varying obesity phenotypes impact mcf-7 cell migration, matrix metalloproteinase-2 activity, and apoptosis. |
2024-06-27 |
2024-06-29 |
Not clear |
| Justyna Totoń-Żurańska, Tomasz P Mikolajczyk, Blessy Saju, Tomasz J Guzi. Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation. Clinical science (London, England : 1979). vol 138. issue 13. 2024-06-26. PMID:38920058. |
they contribute to a dynamic interplay between cell proliferation, apoptosis, migration, inflammation, and extracellular matrix reorganisation, all critical mechanisms of vascular remodelling. |
2024-06-26 |
2024-06-29 |
Not clear |
| Xuke Wang, Qingfeng Wang, Guowang Li, Haiwei Xu, Bangxin Liu, Bing Yuan, Yingjie Zhou, Yongjin L. Identifying the protective effects of miR-874-3p/ATF3 axis in intervertebral disc degeneration by single-cell RNA sequencing and validation. Journal of cellular and molecular medicine. vol 28. issue 12. 2024-06-19. PMID:38890795. |
we previously demonstrated that silencing activation transcription factor 3 (atf3) blocked the ivdd pathological process by regulating nucleus pulposus cell (npc) ferroptosis, apoptosis, inflammation, and extracellular matrix (ecm) metabolism. |
2024-06-19 |
2024-06-21 |
rat |
| Fengying Li, Wentao Yu, Xiaoling Zhou, Jingyu Hou, Yunyi Gao, Jun Zhang, Xiangwei Ga. SIRT6 Inhibits Anoikis of Colorectal Cancer Cells by Down-Regulating NDRG1. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891773. |
anoikis, a form of apoptosis resulting from the loss of cell-extracellular matrix interaction, is a significant barrier to cancer cell metastasis. |
2024-06-19 |
2024-06-21 |
Not clear |
| Fei Xie, Bin Liu, Wen Qiao, Jing-Zhen He, Jie Cheng, Zhao-Yang Wang, Ya-Min Hou, Xu Zhang, Bo-Han Xu, Yun Zhang, Yu-Guo Chen, Ming-Xiang Zhan. Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis. Nature communications. vol 15. issue 1. 2024-06-11. PMID:38862515. |
vsmc-specific nf90/110 knockout in male mice decreases obviously ages-induced atherosclerotic calcification, along with the inhibitions of vsmc phenotypic changes to osteoblast-like cells, apoptosis, and matrix vesicle release. |
2024-06-11 |
2024-06-14 |
mouse |
| Qiwei Yang, Ali Falahati, Azad Khosh, Somayeh Vafaei, Ayman Al-Hend. Targeting Bromodomain-Containing Protein 9 in Human Uterine Fibroid Cells. Reproductive sciences (Thousand Oaks, Calif.). 2024-06-10. PMID:38858328. |
our studies demonstrated that targeted inhibition of brd9 with its potent inhibitor tp-472 inhibited the pathogenesis of uf through increased apoptosis and proliferation arrest and decreased extracellular matrix deposition in uf cells. |
2024-06-10 |
2024-06-14 |
human |
| Yumin Wang, Sihang Cheng, Joshua S Fleishman, Jichao Chen, Hailin Tang, Zhe-Sheng Chen, Wenkuan Chen, Mingchao Din. Targeting anoikis resistance as a strategy for cancer therapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 75. 2024-06-08. PMID:38850692. |
anoikis, known as matrix detachment-induced apoptosis or detachment-induced cell death, is crucial for tissue development and homeostasis. |
2024-06-08 |
2024-06-11 |
Not clear |
| Yumin Wang, Joshua S Fleishman, Jinhua Wang, Jichao Chen, Lianmei Zhao, Mingchao Din. Pharmacologically inducing anoikis offers novel therapeutic opportunities in hepatocellular carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 176. 2024-06-06. PMID:38843588. |
anoikis is a matrix detachment-induced apoptosis, also known as detachment-induced cell death, and mechanistically prevents tumor cells from escaping their native extracellular matrix to metastasize to new organs. |
2024-06-06 |
2024-06-10 |
Not clear |
| Hantao Ye, Tingwen Cai, Yang Shen, Lin Zhao, Haojie Zhang, Jianxin Yang, Feida Li, Jiaoxiang Chen, Xiaolong Shu. MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-κB signalling pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-06. PMID:38842136. |
western blot, elisa and if were used to analyse the expression of inflammation, extracellular matrix (ecm) degradation, apoptosis and mitophagy-associated proteins. |
2024-06-06 |
2024-06-08 |
Not clear |
| Tian Mao, Junchi Fa. Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway. Biochemical genetics. 2024-06-06. PMID:38842745. |
the roles of myricetin in cell apoptosis, extracellular matrix (ecm) degradation, autophagy repression, and the jak2/stat3 pathway activation were examined by cell counting kit-8, flow cytometry, western blotting, real-time quantitative polymerase chain reaction, and immunofluorescence staining. |
2024-06-06 |
2024-06-08 |
rat |
| Xuejian Dan, Xiaochuan Gu, Ying Zi, Jiahui Xu, Chenggang Wang, Chen Li, Xiao Hu, Zhourui Wu, Yan Yu, Bin M. ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration. Biochimica et biophysica acta. Molecular cell research. 2024-06-05. PMID:38838859. |
arrb1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration. |
2024-06-05 |
2024-06-08 |
Not clear |
| Lars F H Theyse, Emilia M Mazu. Osteoarthritis, adipokines and the translational research potential in small animal patients. Frontiers in veterinary science. vol 11. 2024-06-04. PMID:38831954. |
in the early stages, oa is characterized by damage to the extracellular matrix (ecm) and apoptosis and depletion of chondrocytes. |
2024-06-04 |
2024-06-06 |
human |
| Yi Ting Lee, Mohd Heikal Mohd Yunus, Muhammad Dain Yazid, Azizah Ugusma. Unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic intervention. Frontiers in cell and developmental biology. vol 12. 2024-06-03. PMID:38827524. |
the apoptosis of chondrocytes is believed to play an important role in oa progression due to poor chondrocytes self-repair abilities to maintain the extracellular matrix (ecm). |
2024-06-03 |
2024-06-05 |
Not clear |
| Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Ji. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. eLife. vol 13. 2024-05-31. PMID:38819423. |
aberrant methylation and expression of tnxb promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via akt signaling. |
2024-05-31 |
2024-06-02 |
mouse |
| Tess Grett Mathes, Mahsa Monirizad, Menekse Ermis, Natan Roberto de Barros, Marco Rodriguez, Heinz-Bernhard Kraatz, Vadim Jucaud, Ali Khademhosseini, Natashya Falcon. Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype. Acta biomaterialia. 2024-05-27. PMID:38801867. |
our results demonstrated higher levels of neuroinflammation and apoptosis markers when npcs were cultured in the amyloid-like matrix compared to a natural brain matrix. |
2024-05-27 |
2024-06-01 |
Not clear |
| Martina Tosi, Irene Coloretti, Marianna Meschiari, Sara De Biasi, Massimo Girardis, Stefano Busan. The Interplay between Antibiotics and the Host Immune Response in Sepsis: From Basic Mechanisms to Clinical Considerations: A Comprehensive Narrative Review. Antibiotics (Basel, Switzerland). vol 13. issue 5. 2024-05-26. PMID:38786135. |
from pre-clinical studies, antibiotics exhibit various immunomodulatory effects, including the regulation of pro-inflammatory cytokine production, interaction with toll-like receptors, modulation of the p38/pmk-1 pathway, inhibition of matrix metalloproteinases, blockade of nitric oxide synthase, and regulation of caspase-induced apoptosis. |
2024-05-26 |
2024-05-27 |
Not clear |
| Xue-Shi DI, Jiang Chen, Xin-Ru Wang, Jun-Jie Liang, Chong-Yang Zhang, Ting Pan, Yan Meng, Jia-Jia Zhang, Zhi-Wei Feng, Wen-Ting Sun, Peng Ba. Progress of researches on mechanisms of acupuncture therapy in the treatment of lumbar disc herniation. Zhen ci yan jiu = Acupuncture research. vol 49. issue 5. 2024-05-19. PMID:38764125. |
in the present paper, we summarize the progress of researches on the mechanisms of acupuncture underlying improvement of symptoms of ldh in recent 10 years from 1) delaying the intervertibral disc degeneration (by down-regulating the expressions of matrix metalloproteinase ［mmp］-3 and mmp-4, up-regulating the expressions of diosaccharides and polyglycoprotein, inhibiting apoptosis and promoting mitochondrial autophagy of nucleus pulposus cells, etc. |
2024-05-19 |
2024-05-27 |
Not clear |