| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Zheng, Kaiyuan Yang, Tong Chen, Songwei Lv, Liangliang Wang, Jianchao Gui, Chao X. Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137. Autoimmunity. vol 56. issue 1. 2023-10-18. PMID:37849308. |
in conclusion, inhibition of lncrna snhg14 attenuates chondrocyte inflammatory response, apoptosis and extracellular matrix degradation by targeting mir-137 in lps induced chondrocytes. |
2023-10-18 |
2023-11-08 |
human |
| Saeedeh Keyvani-Ghamsari, Maryam Rahimi, Khatereh Khorsand. An update on the potential mechanism of gallic acid as an antibacterial and anticancer agent. Food science & nutrition. vol 11. issue 10. 2023-10-12. PMID:37823155. |
also, ga inhibits cancer cell growth by targeting different signaling pathways in apoptosis, increasing reactive oxygen species (ros) production, targeting the cell cycle, and inhibiting oncogenes and matrix metalloproteinases (mmps) expression. |
2023-10-12 |
2023-10-15 |
Not clear |
| Yan Liu, Yi-Hui Shao, Jun-Meng Zhang, Ying Wang, Mei Zhou, Hui-Qin Li, Cong-Cong Zhang, Pei-Jie Yu, Shi-Juan Gao, Xue-Rui Wang, Li-Xin Jia, Chun-Mei Piao, Jie Du, Yu-Lin L. Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-12. PMID:37828006. |
additionally, card9 ko suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase (mmp) expression. |
2023-10-12 |
2023-10-15 |
mouse |
| Yuan Gao, Qinghua Huang, Yuling Qin, Xianhui Bao, You Pan, Jianlan Mo, Shipeng Nin. A prognostic model related to necrotizing apoptosis of breast cancer based on biorthogonal constrained depth semi-supervised nonnegative matrix decomposition and single-cell sequencing analysis. American journal of cancer research. vol 13. issue 9. 2023-10-11. PMID:37818066. |
a prognostic model related to necrotizing apoptosis of breast cancer based on biorthogonal constrained depth semi-supervised nonnegative matrix decomposition and single-cell sequencing analysis. |
2023-10-11 |
2023-10-15 |
Not clear |
| Hao-Wei Xu, Xin-Yue Fang, Xiao-Wei Liu, Shu-Bao Zhang, Yu-Yang Yi, Sheng-Jie Chang, Hao Chen, Shan-Jin Wan. α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway. American journal of physiology. Cell physiology. vol 325. issue 4. 2023-10-10. PMID:37661920. |
α-kg supplementation significantly attenuated senescence, apoptosis, and matrix metalloproteinase-13 (mmp-13) protein expression, and it increased the synthesis of aggrecan and collagen ii in il-1β-treated npcs. |
2023-10-10 |
2023-10-15 |
rat |
| Hongtao Li, Hongyu Pan, Changming Xiao, Hanyue Li, Longhai Long, Xiaoqiang Wang, Shengyu Luo, Kexin Lyu, Yixuan Chen, Li Jiang, Jingwei Lu, Huarui Shen, Sen L. IL-1β-mediated inflammatory responses in intervertebral disc degeneration: Mechanisms, signaling pathways, and therapeutic potential. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809657. |
current studies have found that il-1β is mainly involved in idd by affecting the metabolism of the extracellular matrix and regulating cell death (rcd), such as apoptosis, pyroptosis, and ferroptosis (a new form of rcd). |
2023-10-09 |
2023-10-15 |
Not clear |
| Wen Li, Xing-Hua Li, Yang Gao, Cheng-Jie Xiong, Zhong-Zhi Tan. Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis. Orthopaedic surgery. 2023-10-07. PMID:37803912. |
dysregulated phenotypes of nucleus pulposus (np) cells and oa chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of idd and oa. |
2023-10-07 |
2023-10-15 |
Not clear |
| Georgia Atkinson, Rosaria Bianco, Karina Di Gregoli, Jason L Johnso. The contribution of matrix metalloproteinases and their inhibitors to the development, progression, and rupture of abdominal aortic aneurysms. Frontiers in cardiovascular medicine. vol 10. 2023-10-06. PMID:37799778. |
matrix metalloproteinases (mmps) and their regulation by tissue inhibitors metalloproteinases (timps) can orchestrate not only ecm remodelling, but also moderate the proliferation, migration, and apoptosis of resident aortic cells, alongside the recruitment and subsequent behaviour of inflammatory cells. |
2023-10-06 |
2023-10-07 |
human |
| Wen-Peng Xie, Teng Ma, Yan-Chen Liang, Xiang-Peng Wang, Rong-Xiu Bi, Wei-Guo Wang, Yong-Kui Zhan. [Cangxi Tongbi Capsules promote chondrocyte autophagy by regulating circRNA＿0008365/miR-1271/p38 MAPK pathway to inhibit development of knee osteoarthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802826. |
the chondrocytes treated with il-1β showed down-regulated expression of circrna＿0008365, up-regulated expression of mir-1271 and p38 mapk, lowered autophagy level, increased apoptosis rate, and accelerated catabolism of extracellular matrix. |
2023-10-06 |
2023-10-15 |
rat |
| Wen-Peng Xie, Teng Ma, Yan-Chen Liang, Xiang-Peng Wang, Rong-Xiu Bi, Wei-Guo Wang, Yong-Kui Zhan. [Cangxi Tongbi Capsules promote chondrocyte autophagy by regulating circRNA＿0008365/miR-1271/p38 MAPK pathway to inhibit development of knee osteoarthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802826. |
the intervention with cangxi tongbi capsules up-regulated the expression of circrna＿0008365, down-regulated the expression of mir-1271 and p38 mapk, increased the autophagy level, decreased the apoptosis rate, and weakened the catabolism of extracellular matrix. |
2023-10-06 |
2023-10-15 |
rat |
| Yunfei Qu, Ning Zhang, Yu Zha. Resveratrol Inhibits Abdominal Aortic Aneurysm Progression by Reducing Extracellular Matrix Degradation, Apoptosis, Autophagy, and Inflammation of Vascular Smooth Muscle Cells via Upregulation of HMOX1. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 2023-10-04. PMID:37789605. |
resveratrol inhibits abdominal aortic aneurysm progression by reducing extracellular matrix degradation, apoptosis, autophagy, and inflammation of vascular smooth muscle cells via upregulation of hmox1. |
2023-10-04 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
matrix stiffness regulated endoplasmic reticulum stress-mediated apoptosis of osteosarcoma cell through ras signal cascades. |
2023-10-03 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
the modulating effects of matrix stiffness on spreading and apoptosis of tumor cells have been well recognized. |
2023-10-03 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
while the cell spreading increased and the apoptosis decreased with the matrix stiffness, such modulating effect of matrix on cell spreading exhibited different time evolvement behaviors as a function of stiffness, which likely led to surprisingly similar apoptosis rates for the 30 kpa and 250 kpa samples. |
2023-10-03 |
2023-10-07 |
Not clear |
| Huan Deng, Xuedong Shu, Yao Wang, Junwei Zhang, Yue Yin, Fang Wu, Jing H. Matrix Stiffness Regulated Endoplasmic Reticulum Stress-mediated Apoptosis of Osteosarcoma Cell through Ras Signal Cascades. Cell biochemistry and biophysics. 2023-10-03. PMID:37789235. |
matrix stiffness mediated the spreading and apoptosis of mg-63 cells by regulating cell adhesion to matrix and in particular cytoskeletal organization, which was dependent on ras, rap1 and pi3k-akt signaling pathways and finally led to the apoptosis of cancer cells dominated by endoplasmic reticulum stress pathway. |
2023-10-03 |
2023-10-07 |
Not clear |
| Zélie Dirand, Marion Tissot, Brice Chatelain, Céline Viennet, Gwenaël Roli. Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research? Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760792. |
as major parameters for fibrogenesis assessment, we evaluated apoptosis, myofibroblast differentiation and response to tgf-β1, extracellular matrix (ecm) synthesis, and ecm-related genes regulation in kfs spheroids. |
2023-09-28 |
2023-10-07 |
Not clear |
| Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Fen. Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance. Materials today. Bio. vol 23. 2023-09-28. PMID:37766899. |
in this study, the protective effect of gold nanoparticles (aunps) on the cartilage of children was realized by counteracting chondrocyte apoptosis and extracellular matrix (ecm) degradation in a young mouse model of lipopolysaccharide (lps)-induced growth plate (gp) cartilage damage. |
2023-09-28 |
2023-10-07 |
mouse |
| Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakan. Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis. Scientific reports. vol 13. issue 1. 2023-09-28. PMID:37770630. |
conversely, magnesium supplementation mitigated extracellular matrix calcification and phenotypic transdifferentiation and apoptosis caused by calcifying conditions in cultured met5a cells and mefs. |
2023-09-28 |
2023-10-07 |
mouse |
| Yuting Tang, Yang Liu, Xiaoshu Zhu, Yanlin Chen, Xinluan Jiang, Siyang Ding, Que Zheng, Ming Zhang, Jiashu Yang, Yunfei Ma, Mengying Xing, Zongyu Zhang, Huimin Ding, Yucui Jin, Changyan M. ALKBH5-mediated m iScience. vol 26. issue 10. 2023-09-27. PMID:37752950. |
overexpression of hs3st3b1-it1 significantly increased chondrocyte viability, inhibited chondrocyte apoptosis, and upregulated extracellular matrix (ecm) proteins, whereas hs3st3b1-it1 knockdown had the opposite effects. |
2023-09-27 |
2023-10-07 |
Not clear |
| Song Qingxin, Jiang Kai, Zheng Dandan, Jin Linyu, Chen Xiuyuan, Feng Yubo, Wang Kun, Han Yingchao, Chen Hao, Song Jie, Chen Zhi, Shen Hongxin. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment. Journal of nanobiotechnology. vol 21. issue 1. 2023-09-27. PMID:37759249. |
the pathogenesis of intervertebral disc degeneration (ivdd) is attributed to metabolic dysregulation within the extracellular matrix and heightened apoptosis of nucleus pulposus cells (npc). |
2023-09-27 |
2023-10-07 |
Not clear |