| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Cheng, Hang-Zhi Wei, Hai-Wei Chen, Zhi-Qiang Wang, Peng Mao, Hai-Hong Zhan. DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway. Journal of cellular and molecular medicine. 2023-11-21. PMID:37986543. |
cellularly, dnmt3a inhibition significantly inhibited il-1β-induced apoptosis and extracellular matrix (ecm) degradation in rat np cells. |
2023-11-21 |
2023-11-29 |
rat |
| Yuan Liu, Chuankun Zhou, Jianye Tan, Tianlong Wu, Chongzhi Pan, Jiahao Liu, Xigao Chen. Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway. Chemical biology & drug design. 2023-11-20. PMID:37984927. |
subsequently, the investigation was conducted afterward according to the following indicators: cell viability, apoptosis, inflammation, and extracellular matrix (ecm) degradation. |
2023-11-20 |
2023-11-29 |
mouse |
| Yingjie Hao, Guangduo Zhu, Lei Yu, Zhinan Ren, Weiwei Zhou, Panke Zhang, Xu Lia. FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration. The American journal of pathology. 2023-11-19. PMID:37981220. |
conclusively, the transcription factor foxo3 may decrease mir-615-3p binding to col2a1 and upregulate col2a1 expression by activating hottip transcription, which in turn inhibits np cell apoptosis and promotes its proliferation, to prevent the degradation of intervertebral disc matrix, maintain the normal physiological function of intervertebral disc, thereby preventing the occurrence and development of ivdd. |
2023-11-19 |
2023-11-29 |
mouse |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
therapeutic potential of ginsenoside compound k in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. |
2023-11-18 |
2023-11-20 |
Not clear |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
despite efforts to improve diabetes management, there is a lack of research on therapeutic agents targeting the core features of tendinopathy, namely, tenocyte apoptosis and extracellular matrix (ecm) damage. |
2023-11-18 |
2023-11-20 |
Not clear |
| Mathilde Padrona, Manon Maroquenne, Hanane El-Hafci, Lucille Rossiaud, Hervé Petite, Esther Potie. Glucose depletion decreases cell viability without triggering degeneratIVE changes in a physiological nucleus pulposus explant model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023-11-17. PMID:37975418. |
the effects of glucose depletion were evaluated on np cell viability, apoptosis, phenotype, metabolism, senescence, extracellular matrix anabolism and catabolism, and inflammatory mediator production using fluorescent staining, rt-qpcr, (immuno)histology, elisa, biochemical, and enzymatic assays. |
2023-11-17 |
2023-11-20 |
cattle |
| Rajalakshmi Sabanayagam, Sneha Krishnamoorthy, Mohan Anbuselvam, Bharathi Muruganantham, Sridhar Muthusam. A comparative analysis of phyto-components on EGFR binding, viability, and migration in HPV positive ME180 and HPV negative C33A cervical cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 12. 2023-11-14. PMID:37964051. |
it was then validated by cell viability, mitochondrial membrane potential, apoptosis, migration, and matrix metalloproteinase (mmp-2) in human papilloma virus (hpv) positive and hpv negative cc cells using top nine phyto-components based on computational screening. |
2023-11-14 |
2023-11-20 |
human |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
analysis was performed using the mtt assay to assess cell viability, flow cytometry to measure the apoptosis level, sa-β-gal staining to observe cellular senescence, and western blot to assess protein levels of trpv1, p16, p53, p21, matrix metalloproteinase (mmp)-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Yinglei Jiang, Ying Wang, Zhengyan Wang, Yinzhen Zhang, Yulong Hou, Xukai Wan. Anoikis-related genes signature development for clear cell renal cell carcinoma prognosis and tumor microenvironment. Scientific reports. vol 13. issue 1. 2023-11-03. PMID:37919386. |
anoikis is a specific type of programmed cell death in which solid tumor cells or normal epithelial cells that do not have metastatic properties lose adhesion to the extracellular matrix or undergo inappropriate cell adhesion-induced apoptosis. |
2023-11-03 |
2023-11-08 |
Not clear |
| Cheng Zeng, Jing Liu, Xialei Zheng, Xinqun Hu, Yuhu H. Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension. Respiratory research. vol 24. issue 1. 2023-11-02. PMID:37915044. |
the mechanisms involved in this process include inflammation, vascular matrix remodeling, endothelial cell apoptosis and proliferation, vasoconstriction, vascular smooth muscle cell proliferation and hypertrophy. |
2023-11-02 |
2023-11-08 |
Not clear |
| Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Li. Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1. Phytotherapy research : PTR. 2023-11-02. PMID:37918392. |
qrt-pcr, western blot, immunofluorescence, and tunel staining were used to detect apoptosis, ers, extracellular matrix (ecm), and sirt1-related pathways. |
2023-11-02 |
2023-11-08 |
rat |
| Irina V Kholodenko, Roman V Kholodenko, Konstantin N Yarygi. The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894893. |
the analysis of the hepatocyte-msc interaction showed that mscs carry out chaperone-like functions, including the synthesis of the supportive extracellular matrix proteins; prevention of apoptosis, pyroptosis, and ferroptosis; support of regeneration; elimination of lipotoxicity and er stress; promotion of antioxidant effects; and donation of mitochondria. |
2023-10-30 |
2023-11-08 |
Not clear |
| Deeptarup Biswas, Ankit Halder, Abhilash Barpanda, Susmita Ghosh, Aparna Chauhan, Lipika Bhat, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, Sanjeeva Srivastav. Integrated Meta-Omics Analysis Unveils the Pathways Modulating Tumorigenesis and Proliferation in High-Grade Meningioma. Cells. vol 12. issue 20. 2023-10-27. PMID:37887327. |
the in silico pathway analysis indicated the roles of extracellular matrix organization (emo) and integrin binding cascades in regulating the apoptosis, angiogenesis, and proliferation responsible for the pathobiology. |
2023-10-27 |
2023-11-08 |
Not clear |
| Wenjun Wang, Jianshuang Li, Qinghua Zho. The biological function of cytoplasm-translocated ENDOG (endonuclease G). Autophagy. 2023-10-27. PMID:37889084. |
collectively, endog will be released from the mitochondrial intermembrane space, and translocated to the mitochondrial matrix, cytoplasm, and nucleus during different stress stimulation, where it digests dna or interacts with crucial proteins to regulate different biological functions, including apoptosis, autophagy, mitophagy, and lipid synthesis. |
2023-10-27 |
2023-11-08 |
Not clear |
| Albert Armoo, Tanner Diemer, Abigail Donkor, Jerrod Fedorchik, Severine Van Slambrouck, Rachel Willand-Charnley, Brian A Logu. Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide. ACS bio & med chem Au. vol 3. issue 5. 2023-10-26. PMID:37876493. |
cell viability, relative loss of extracellular matrix adhesions, and apoptosis caused by cees were measured via mtt, cell-matrix adhesion (cma), and apoptosis protein marker assays, respectively. |
2023-10-26 |
2023-11-08 |
human |
| Xin Jin, Hainan Xu, Qing Hu, Yitong Yin, Meiying Qin, Zhijun Xi. Early growth response 2, a novel target of pelvic organ prolapse, is highly expressed in anterior vaginal wall tissues with pelvic organ prolapse. Histochemistry and cell biology. 2023-10-24. PMID:37874337. |
overall, our study illustrated that egr2 was highly expressed in pop tissues, and knockdown of egr2 alleviated apoptosis and reduced matrix degradation in pop fibroblasts. |
2023-10-24 |
2023-11-08 |
Not clear |
| Nan Meng, Lingwei Mao, Qinyi Jiang, Jishan Yuan, Linjuan Liu, Lei Wan. PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1β-exposed chondrocytes via suppressing GRP78 expression. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-10-20. PMID:37853395. |
plxnc1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of il-1β-exposed chondrocytes via suppressing grp78 expression. |
2023-10-20 |
2023-11-08 |
human |
| Yanhui Ge, Zhan Wang, Xuelu Chen, Wen Wang, Zhenying Liu, Hongwen Sun, Lianying Zhan. Comparative Toxicological Effects of PFOS and its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms. Environmental toxicology and chemistry. 2023-10-20. PMID:37861387. |
compared to pfos, f-53b exhibited a weaker disruption of lipid metabolism, comparable potency for toxicity to the immune response, and a stronger potency in the extracellular matrix (ecm) destruction along with apoptosis and ferroptosis induction. |
2023-10-20 |
2023-11-08 |
cat |
| Dong Zheng, Kaiyuan Yang, Tong Chen, Songwei Lv, Liangliang Wang, Jianchao Gui, Chao X. Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137. Autoimmunity. vol 56. issue 1. 2023-10-18. PMID:37849308. |
to measure the expression of the lncrnas snhg14 and mir-137, cell survival, inflammatory response, chondrocyte apoptosis, and extracellular matrix (ecm) levels, we subjected human chondrocytes to a variety of lipopolysaccharide (lps) concentrations. |
2023-10-18 |
2023-11-08 |
human |
| Dong Zheng, Kaiyuan Yang, Tong Chen, Songwei Lv, Liangliang Wang, Jianchao Gui, Chao X. Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137. Autoimmunity. vol 56. issue 1. 2023-10-18. PMID:37849308. |
the results showed that chondrocyte viability was significantly inhibited with lps treatment and chondrocyte inflammatory response, apoptosis and extracellular matrix degradation were significantly increased. |
2023-10-18 |
2023-11-08 |
human |