| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruijie Liu, Qi Wang, Xiaoping Zhan. Identification of prognostic coagulation-related signatures in clear cell renal cell carcinoma through integrated multi-omics analysis and machine learning. Computers in biology and medicine. vol 168. 2023-12-07. PMID:38061153. |
it's also demonstrated that the specific expression patterns of coagulation signature genes driven by cnv and methylation were closely correlated with pathways including apoptosis, immune infiltration, angiogenesis, and the construction of extracellular matrix. |
2023-12-07 |
2023-12-17 |
Not clear |
| Dongxu Lin, Changcheng Luo, Pengyu Wei, An Zhang, Mengyang Zhang, Xiaoliang Wu, Bolang Deng, Zhipeng Li, Kai Cui, Zhong Che. YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-05. PMID:38050650. |
yap1 silencing suppresses cell survival by decreasing cell proliferation and increasing apoptosis, and alleviates fibrosis by reversing epithelial-mesenchymal transition (emt) and extracellular matrix (ecm) deposition in prostatic bph-1 and wpmy-1 cells. |
2023-12-05 |
2023-12-10 |
human |
| Xiaochen Su, Menghao Teng, Yingang Zhang, Wenchen J. Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/ Biomedical materials (Bristol, England). vol 19. issue 1. 2023-12-04. PMID:38044745. |
decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through wnt/ spinal cord injury (sci) causes tissue destruction and neuronal apoptosis, which impede neural function recovery. |
2023-12-04 |
2023-12-10 |
Not clear |
| Daimin Wei, Yaxin Su, Peter C K Leung, Yan Li, Zi-Jiang Che. Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy. Human reproduction update. 2023-12-01. PMID:38037193. |
bone morphogenetic proteins (bmps), a subset of the transforming growth factor-β (tgf-β) superfamily, are multifunctional cytokines that regulate diverse cellular activities, such as differentiation, proliferation, apoptosis, and extracellular matrix synthesis, are now understood as integral to multiple reproductive processes in women. |
2023-12-01 |
2023-12-10 |
human |
| Yi-Bei Song, Wen-Guang Bao, Deng-He Liu, Li-Qiang Wei, Shu-Ting Yang, Xue-Jing Miao, Chun-Yu Lin, Hong-Jun Li, Dong Lan, Hui-Min H. Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2. Medicine. vol 102. issue 46. 2023-11-27. PMID:37986328. |
go and kegg pathway analyses of gxylt2 co-expressed genes in stad suggested that gxylt2 possibly plays a role in epithelial-mesenchymal transition, extracellular matrix production and degradation, angiogenesis, apoptosis, as well as in tumor inflammation, such as cytokine production and t cell activation. |
2023-11-27 |
2023-11-28 |
Not clear |
| Chao Jiang, Youjun Liu, Weigong Zhao, Yimin Yang, Zhiwei Ren, Xiaohui Wang, Dingjun Hao, Heng Du, Si Yi. microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3. Journal of cellular and molecular medicine. 2023-11-27. PMID:38009813. |
microrna-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting efna3. |
2023-11-27 |
2023-11-29 |
rat |
| Dengbo Yao, Enming Chen, Yuxi Li, Kun Wang, Zhuangyao Liao, Ming Li, Lin Huan. The role of endoplasmic reticulum stress, mitochondrial dysfunction and their crosstalk in intervertebral disc degeneration. Cellular signalling. 2023-11-25. PMID:38007189. |
while the underlying mechanisms of ivdd remain incompletely understood, it has been confirmed that apoptosis and extracellular matrix (ecm) degradation caused by many factors such as inflammation, oxidative stress, calcium (ca |
2023-11-25 |
2023-11-28 |
Not clear |
| Peng Cheng, Hang-Zhi Wei, Hai-Wei Chen, Zhi-Qiang Wang, Peng Mao, Hai-Hong Zhan. DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway. Journal of cellular and molecular medicine. 2023-11-21. PMID:37986543. |
cellularly, dnmt3a inhibition significantly inhibited il-1β-induced apoptosis and extracellular matrix (ecm) degradation in rat np cells. |
2023-11-21 |
2023-11-29 |
rat |
| Yuan Liu, Chuankun Zhou, Jianye Tan, Tianlong Wu, Chongzhi Pan, Jiahao Liu, Xigao Chen. Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway. Chemical biology & drug design. 2023-11-20. PMID:37984927. |
subsequently, the investigation was conducted afterward according to the following indicators: cell viability, apoptosis, inflammation, and extracellular matrix (ecm) degradation. |
2023-11-20 |
2023-11-29 |
mouse |
| Yingjie Hao, Guangduo Zhu, Lei Yu, Zhinan Ren, Weiwei Zhou, Panke Zhang, Xu Lia. FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration. The American journal of pathology. 2023-11-19. PMID:37981220. |
conclusively, the transcription factor foxo3 may decrease mir-615-3p binding to col2a1 and upregulate col2a1 expression by activating hottip transcription, which in turn inhibits np cell apoptosis and promotes its proliferation, to prevent the degradation of intervertebral disc matrix, maintain the normal physiological function of intervertebral disc, thereby preventing the occurrence and development of ivdd. |
2023-11-19 |
2023-11-29 |
mouse |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
therapeutic potential of ginsenoside compound k in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. |
2023-11-18 |
2023-11-20 |
Not clear |
| Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jun. Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy. Tissue & cell. vol 86. 2023-11-18. PMID:37979397. |
despite efforts to improve diabetes management, there is a lack of research on therapeutic agents targeting the core features of tendinopathy, namely, tenocyte apoptosis and extracellular matrix (ecm) damage. |
2023-11-18 |
2023-11-20 |
Not clear |
| Mathilde Padrona, Manon Maroquenne, Hanane El-Hafci, Lucille Rossiaud, Hervé Petite, Esther Potie. Glucose depletion decreases cell viability without triggering degeneratIVE changes in a physiological nucleus pulposus explant model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023-11-17. PMID:37975418. |
the effects of glucose depletion were evaluated on np cell viability, apoptosis, phenotype, metabolism, senescence, extracellular matrix anabolism and catabolism, and inflammatory mediator production using fluorescent staining, rt-qpcr, (immuno)histology, elisa, biochemical, and enzymatic assays. |
2023-11-17 |
2023-11-20 |
cattle |
| Rajalakshmi Sabanayagam, Sneha Krishnamoorthy, Mohan Anbuselvam, Bharathi Muruganantham, Sridhar Muthusam. A comparative analysis of phyto-components on EGFR binding, viability, and migration in HPV positive ME180 and HPV negative C33A cervical cancer cells. Medical oncology (Northwood, London, England). vol 40. issue 12. 2023-11-14. PMID:37964051. |
it was then validated by cell viability, mitochondrial membrane potential, apoptosis, migration, and matrix metalloproteinase (mmp-2) in human papilloma virus (hpv) positive and hpv negative cc cells using top nine phyto-components based on computational screening. |
2023-11-14 |
2023-11-20 |
human |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
analysis was performed using the mtt assay to assess cell viability, flow cytometry to measure the apoptosis level, sa-β-gal staining to observe cellular senescence, and western blot to assess protein levels of trpv1, p16, p53, p21, matrix metalloproteinase (mmp)-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Yinglei Jiang, Ying Wang, Zhengyan Wang, Yinzhen Zhang, Yulong Hou, Xukai Wan. Anoikis-related genes signature development for clear cell renal cell carcinoma prognosis and tumor microenvironment. Scientific reports. vol 13. issue 1. 2023-11-03. PMID:37919386. |
anoikis is a specific type of programmed cell death in which solid tumor cells or normal epithelial cells that do not have metastatic properties lose adhesion to the extracellular matrix or undergo inappropriate cell adhesion-induced apoptosis. |
2023-11-03 |
2023-11-08 |
Not clear |
| Cheng Zeng, Jing Liu, Xialei Zheng, Xinqun Hu, Yuhu H. Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension. Respiratory research. vol 24. issue 1. 2023-11-02. PMID:37915044. |
the mechanisms involved in this process include inflammation, vascular matrix remodeling, endothelial cell apoptosis and proliferation, vasoconstriction, vascular smooth muscle cell proliferation and hypertrophy. |
2023-11-02 |
2023-11-08 |
Not clear |
| Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Li. Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1. Phytotherapy research : PTR. 2023-11-02. PMID:37918392. |
qrt-pcr, western blot, immunofluorescence, and tunel staining were used to detect apoptosis, ers, extracellular matrix (ecm), and sirt1-related pathways. |
2023-11-02 |
2023-11-08 |
rat |
| Irina V Kholodenko, Roman V Kholodenko, Konstantin N Yarygi. The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894893. |
the analysis of the hepatocyte-msc interaction showed that mscs carry out chaperone-like functions, including the synthesis of the supportive extracellular matrix proteins; prevention of apoptosis, pyroptosis, and ferroptosis; support of regeneration; elimination of lipotoxicity and er stress; promotion of antioxidant effects; and donation of mitochondria. |
2023-10-30 |
2023-11-08 |
Not clear |
| Deeptarup Biswas, Ankit Halder, Abhilash Barpanda, Susmita Ghosh, Aparna Chauhan, Lipika Bhat, Sridhar Epari, Prakash Shetty, Aliasgar Moiyadi, Graham Roy Ball, Sanjeeva Srivastav. Integrated Meta-Omics Analysis Unveils the Pathways Modulating Tumorigenesis and Proliferation in High-Grade Meningioma. Cells. vol 12. issue 20. 2023-10-27. PMID:37887327. |
the in silico pathway analysis indicated the roles of extracellular matrix organization (emo) and integrin binding cascades in regulating the apoptosis, angiogenesis, and proliferation responsible for the pathobiology. |
2023-10-27 |
2023-11-08 |
Not clear |