| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica Millar, Elias Nasser, Gorav Ailawadi, Morgan Salmo. IL-1 in Abdominal Aortic Aneurysms. Journal of cellular immunology. vol 5. issue 2. 2023-07-21. PMID:37476160. |
aaas are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. |
2023-07-21 |
2023-08-14 |
Not clear |
| Xian Yang, Qingsong Jiang, Tiankuo Luan, Chao Yu, Zhibo Liu, Ting Wang, Jingyuan Wan, Jiayu Huang, Ke L. Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression. BMC musculoskeletal disorders. vol 24. issue 1. 2023-07-20. PMID:37474941. |
moreover, by inhibiting pdk1, cartilage loss is markedly accelerated in dmm-induced oa through extracellular matrix (ecm) degradation and apoptosis of chondrocytes. |
2023-07-20 |
2023-08-14 |
Not clear |
| Saurav Bhowmick, M R Preetha Rani, Shubham Singh, P M Abdul-Munee. Discovery of novel microRNAs and their pathogenic responsive target genes in mild traumatic brain injury. Experimental brain research. 2023-07-19. PMID:37466694. |
further, we filtered the differentially expressed mirnas that were linked with proinflammatory cytokines, apoptosis, matrix metalloproteinases (mmps), and tight junction and junctional adhesion molecule genes. |
2023-07-19 |
2023-08-14 |
mouse |
| Vidisha Singh, Aurelien Naldi, Sylvain Soliman, Anna Niaraki. A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint. NPJ systems biology and applications. vol 9. issue 1. 2023-07-15. PMID:37454172. |
in this paper, we present a large-scale boolean model for ra-fls that consists of five submodels focusing on apoptosis, cell proliferation, matrix degradation, bone erosion and inflammation. |
2023-07-15 |
2023-08-14 |
Not clear |
| Yifan Su, Zirou Liao, Xinran Liang, Jing Hua, Dawei Zhang, Dexuan Hu, Qian Yu, Yikun Xi. Ent-kaurane-type Diterpenes Induce ROS-mediated Mitochondrial Dysfunction and Apoptosis by Suppress the Homologous Recombination DNA Repair in Triple-negative Breast Cancer Cells. Chemistry & biodiversity. 2023-07-14. PMID:37448115. |
furthermore, this research reveals that the mechanism between mitochondria dysfunction and dna damage is deserved to be investigated for elucidating the dynamic signal transduction between the nucleus and the cellular matrix during apoptosis. |
2023-07-14 |
2023-08-14 |
human |
| Anjali Murmu, Purusottam Banjare, Balaji Wamanrao Matore, Partha Pratim Roy, Jagadish Sing. 1,3,4-Oxadiazole: An Emerging Scaffold to Inhibit the Thymidine Phosphorylase as an Anticancer Agent. Current medicinal chemistry. 2023-07-13. PMID:37438902. |
tp overexpression is highly associated with angiogenic factors such as vascular endothelial growth factor (vegf), interleukins (ils), matrix metalloproteases (mmps), etc., which accelerate tumorigenesis, invasion, metastasis, immune response evasion, and resistant to apoptosis. |
2023-07-13 |
2023-08-14 |
human |
| Axiang He, Yaru Liu, Renbo Zhang, Yanjie Mao, Wanjun Li. CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation. Heliyon. vol 9. issue 6. 2023-07-13. PMID:37441407. |
circsfmbt2-oa alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing nf-κb/nlrp3 inflammasome activation. |
2023-07-13 |
2023-08-14 |
Not clear |
| Fang Huang, Enjing Zhang, Yan Lei, Qiong Yan, Chengbin Xu. Tripterine inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting ROS/JNK signaling. Journal of burn care & research : official publication of the American Burn Association. 2023-07-12. PMID:37436955. |
cell viability, proliferation, migration, apoptosis and extracellular matrix (ecm) deposition were determined by cck-8, edu, wound healing, transwell, flow cytometry, western blotting and rt-qpcr assays. |
2023-07-12 |
2023-08-14 |
mouse |
| Jiaxin Shi, Bo Peng, Xiang Zhou, Chenghao Wang, Ran Xu, Tong Lu, Xiaoyan Chang, Zhiping Shen, Kaiyu Wang, Chengyu Xu, Linyou Zhan. An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration. Journal of cancer research and clinical oncology. 2023-07-08. PMID:37421452. |
anoikis is a particular type of programmed apoptosis brought on by the separation of cell-cell or extracellular matrix (ecm). |
2023-07-08 |
2023-08-14 |
Not clear |
| Zhang Juan, Mu Xing-Tong, Zhang Xu, Li Chang-Y. Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis. Journal of dental sciences. vol 18. issue 3. 2023-07-05. PMID:37404608. |
in this narrative review, we summarized the main pathological changes of tmj oa, including inflammatory responses, degeneration of extracellular matrix (ecm), abnormal cell biological behaviors (apoptosis, autophagy, and differentiation) in tmj tissue, and aberrant angiogenesis. |
2023-07-05 |
2023-08-14 |
Not clear |
| Y-W He, Q-P Fan, A-L Hua, Q Li. Identification of hub anoikis-associated genes and risk signature in cutaneous melanoma. European review for medical and pharmacological sciences. vol 27. issue 12. 2023-07-04. PMID:37401304. |
anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ecm). |
2023-07-04 |
2023-08-14 |
human |
| Zhiqiang He, Yufan Gu, Huan Yang, Qian Fu, Maofang Zhao, Yuhan Xie, Yi Liu, Wenlong D. Identification and verification of a novel anoikis-related gene signature with prognostic significance in clear cell renal cell carcinoma. Journal of cancer research and clinical oncology. 2023-07-04. PMID:37402968. |
the loss of extracellular matrix (ecm) stimulates cell apoptosis, known as anoikis. |
2023-07-04 |
2023-08-14 |
Not clear |
| Hongyi Jiang, Jiachen Yu, Zijian Yan, Zhongnan Lin, Minghao Lin, Yiwen Mao, Zechao Hong, Jian Lin, Xinghe Xue, Xiaoyun Pa. Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis. International immunopharmacology. vol 122. 2023-07-03. PMID:37399606. |
osteoarthritis (oa) is a widely prevalent degenerative disease marked by extracellular matrix (ecm) degradation, inflammation, and apoptosis. |
2023-07-03 |
2023-08-14 |
Not clear |
| Y Wang, Z Liu, G Ma, Y Xu, Y L. Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats. Tissue & cell. vol 83. 2023-07-03. PMID:37399641. |
these results suggest that mouth breathing leads to subchondral bone resorption, cartilage layer thinning, and cartilage matrix destruction, inducing chondrocyte apoptosis via both the extrinsic and mitochondrial apoptosis pathways. |
2023-07-03 |
2023-08-14 |
rat |
| Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jian. The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes. International immunopharmacology. vol 122. 2023-07-01. PMID:37392568. |
in oa chondrocytes, loc727924 knockdown boosted cell viability, suppressed cell apoptosis, reactive oxygen species (ros) accumulation, increased aggrecan and collagen ii, decreased matrix metallopeptidase (mmp)-3/13 and adam metallopeptidase with thrombospondin type 1 motif (adamts)-4/5 levels, and reduced the levels of tumor necrosis factor alpha (tnf-α), interleukin 1 beta (il-1β), and interleukin 6 (il-6). |
2023-07-01 |
2023-08-14 |
mouse |
| Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jian. The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes. International immunopharmacology. vol 122. 2023-07-01. PMID:37392568. |
in conclusion, the p65-loc727924-mir-26a/kpna3-p65 regulatory loop modulates oa chondrocyte apoptosis, ros accumulation, extracellular matrix (ecm) deposition, and inflammatory response in vitro and oa development in vivo, being one of the mechanisms mediating vip ameliorating oa. |
2023-07-01 |
2023-08-14 |
mouse |
| Wei Wei, Hongjie Mu, Qiaoyi Cui, Peng Yu, Tong Liu, Tao Wang, Lin Shen. CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-κB signaling. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-07-01. PMID:37393232. |
circtbx5 knockdown modulates the mir-558/myd88 axis to alleviate il-1β-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the nf-κb signaling. |
2023-07-01 |
2023-08-14 |
Not clear |
| Cheng Chi, Xifeng Liang, Tianyu Cui, Xiao Gao, Ruixia Liu, Chenghong Yi. SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis. Biomolecules & biomedicine. 2023-06-30. PMID:37389959. |
conversely, downregulation of snon inhibited hsc apoptosis, increased collagen iii and timp-1 levels, and decreased matrix metalloproteinase 13 (mmp-13) expression. |
2023-06-30 |
2023-08-14 |
rat |
| Jin Zhang, Xuesong Li, Yi Lu, Guowen Wang, Ying M. Anoikis-Related Gene Signature for Prognostication of Pancreatic Adenocarcinoma: A Multi-Omics Exploration and Verification Study. Cancers. vol 15. issue 12. 2023-06-28. PMID:37370756. |
anoikis, a form of apoptosis that occurs due to detachment of cells from the extracellular matrix, has been linked to the development of cancer in several studies. |
2023-06-28 |
2023-08-14 |
Not clear |
| Sen Ma, Dejun Ji, Xiaolong Wang, Yuxin Yang, Yinghua Shi, Yulin Che. Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats. Cells. vol 12. issue 12. 2023-06-28. PMID:37371115. |
hair fiber growth is determined by the spatiotemporally controlled proliferation, differentiation, and apoptosis of hair matrix cells (hmcs) inside the hair follicle (hf); however, dermal papilla cells (dpcs), the cell population surrounded by hmcs, manipulate the above processes via intercellular crosstalk with hmcs. |
2023-06-28 |
2023-08-14 |
Not clear |