| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhangfu Li, Honghao Yang, Yong Hai, Yunzhong Chen. Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration. Mediators of inflammation. vol 2023. 2023-04-27. PMID:37101594. |
it is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ecm), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. |
2023-04-27 |
2023-08-14 |
Not clear |
| Xueying Shao, Yuanjun Zhang, Yuan Li. Cyclic stretch-regulated wound healing. Biophysical journal. 2023-04-26. PMID:37098651. |
specifically, a great diversity of cellular responses (1-4) have been reported, including 1) re-alignment of cells, associated with the remodeling of cellular stress fibers and focal adhesions; 2) altered cell proliferation or apoptosis; 3) migration of cells driven by stretch-triggered formation of lamellipodia; 4) secretion of extracellular matrix (ecm) proteins that are critical for tissue remodeling; 5) activation of mitogen-activated protein kinase (mapk), nuclear factor-kappa b (nf-kb) and wnt signaling pathways; and 6) upregulation of genes involved in cell adhesion and inflammation. |
2023-04-26 |
2023-08-14 |
Not clear |
| Yuanmin Li, Lingyun Tao, Yawei Xu, Rong Gu. Taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating TLR4/NF-κB axis. International immunopharmacology. vol 119. 2023-04-25. PMID:37098322. |
taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating tlr4/nf-κb axis. |
2023-04-25 |
2023-08-14 |
human |
| Jicheng Han, Zongjian Luo, Yifei Wang, Yantao Lian. LncRNA ZFAS1 protects chondrocytes from IL-1β-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis. Journal of orthopaedic surgery and research. vol 18. issue 1. 2023-04-25. PMID:37098630. |
lncrna zfas1 protects chondrocytes from il-1β-induced apoptosis and extracellular matrix degradation via regulating mir-7-5p/flrt2 axis. |
2023-04-25 |
2023-08-14 |
Not clear |
| Hulin Wang, Junjie Zhao, Jin Wan. Role of circular RNAs in osteoarthritis: update on pathogenesis and therapeutics. Molecular genetics and genomics : MGG. 2023-04-22. PMID:37086279. |
and they are closely associated with various pathological progressions in oa, such as extracellular matrix degradation, chondrocyte apoptosis, and inflammation. |
2023-04-22 |
2023-08-14 |
Not clear |
| Chao Song, Yan Zhou, Kang Cheng, Fei Liu, Weiye Cai, Daqian Zhou, Rui Chen, Houyin Shi, Zhijiang Fu, Jingwen Chen, Zongchao Li. Cellular senescence - Molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-04-21. PMID:37084562. |
the pathophysiology of ivdd has been linked to numerous variables, including oxidative stress, apoptosis, matrix metalloproteinases, and inflammatory factors. |
2023-04-21 |
2023-08-14 |
human |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
microrna-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting rorα in nucleus pulposus cells. |
2023-04-16 |
2023-08-14 |
mouse |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
in vitro studies using western blotting (wb) and immunofluorescence (if) confirmed that the mir-155 mimic could alleviate cholesterol-induced matrix degradation, apoptosis and pyroptosis in np. |
2023-04-16 |
2023-08-14 |
mouse |
| Tianyu Qin, Jiansen Yan, Shuangxing Li, Xiaolin Lin, Jiajun Wu, Zhengqi Huang, Chao Zhang, Yangyang Zhang, Zhihuai Deng, Dong Xiao, Song Jin, Yin Xiao, Kang Xu, Wei Y. MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells. Cellular signalling. 2023-04-16. PMID:37062437. |
in this study, we demonstrated that mir-155 could target rorα and that inhibition of rorα could prevent cholesterol-induced matrix degradation, apoptosis, and pyroptosis in np, indicating the protective effect of mir-155 in cholesterol-induced idd by targeting rorα. |
2023-04-16 |
2023-08-14 |
mouse |
| Yan Zhang, Xinghua Lv, Feng Chen, Qian Fan, Yongqiang Liu, Zhanhai Wan, Janvier Nibaruta, Jipeng Lv, Xuena Han, Lin Wu, Hao Wang, Yufang Len. Role of microRNAs in programmed cell death in renal diseases: A review. Medicine. vol 102. issue 15. 2023-04-14. PMID:37058073. |
micrornas (mirnas) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. |
2023-04-14 |
2023-08-14 |
Not clear |
| Jing-Yu Qu, Hua-Tao Xie, Yu-Ting Xiao, Ying-Ying Zhang, Zhi-Xin Hu, Jia-Song Wang, Ming-Chang Zhang, Han X. The inhibition of p38 MAPK blocked inflammation to restore the functions of rat meibomian gland epithelial cells. Experimental eye research. 2023-04-14. PMID:37059216. |
cell proliferation, keratinization, lipid accumulation, and matrix metalloproteinases 9 (mmp9) expression were evaluated by mtt assay, polymerase chain reaction (pcr), immunofluorescence staining, apoptosis assay, lipid staining, and western blot analyses. |
2023-04-14 |
2023-08-14 |
mouse |
| Sonali Karnik, Hessam Noori-Dokht, Taylor Williams, Amin Joukar, Stephen B Trippel, Uma Sankar, Diane R Wagne. Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047494. |
sirt1 enzymatic activity decreased as early as 5 min following the mechanical overload, and remained suppressed for at least 24 h. the chondrocyte injury response, including apoptosis, oxidative stress, secretion of inflammatory mediators, and alterations in cartilage matrix expression, was prevented with pharmacological activation of sirt1 in a dose-dependent manner. |
2023-04-13 |
2023-08-14 |
cattle |
| Ryo Inoue, Taro Yasuma, Valeria Fridman D'Alessandro, Masaaki Toda, Toshiyuki Ito, Atsushi Tomaru, Corina N D'Alessandro-Gabazza, Tatsuki Tsuruga, Tomohito Okano, Atsuro Takeshita, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Esteban C Gabazz. Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047672. |
active matrix metalloproteinase-2 significantly decreased bleomycin-induced apoptosis in alveolar epithelial cells. |
2023-04-13 |
2023-08-14 |
mouse |
| Ryo Inoue, Taro Yasuma, Valeria Fridman D'Alessandro, Masaaki Toda, Toshiyuki Ito, Atsushi Tomaru, Corina N D'Alessandro-Gabazza, Tatsuki Tsuruga, Tomohito Okano, Atsuro Takeshita, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Esteban C Gabazz. Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047672. |
matrix metalloproteinase-2 appears to protect against pulmonary fibrosis by inhibiting apoptosis of lung epithelial cells. |
2023-04-13 |
2023-08-14 |
mouse |
| Shijie Chen, Quan Zhuang, Pinghuang Li, Jin Zeng, Yi Peng, Zhiyu Ding, Hongqing Cao, Ruping Zheng, Weiguo Wan. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells. Cell and tissue research. 2023-04-13. PMID:37052702. |
excessive apoptosis of intervertebral disc cells, namely nucleus pulposus (np) cells, results in decreased cell density and extracellular matrix (ecm) catabolism, hence leading to intervertebral disc degeneration (ivdd). |
2023-04-13 |
2023-08-14 |
human |
| Soichiro Saito, Shuji Mizumoto, Tsukasa Yonekura, Rina Yamashita, Kenta Nakano, Tadashi Okubo, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuich. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. PloS one. vol 18. issue 4. 2023-04-13. PMID:37053259. |
proliferation, apoptosis and differentiation were not affected in the chondrocytes of slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality. |
2023-04-13 |
2023-08-14 |
mouse |
| Xin-An Zhang, Hui Kon. Mechanism of HIFs in osteoarthritis. Frontiers in immunology. vol 14. 2023-04-06. PMID:37020556. |
for example, hif-1α can maintain the stability of the articular cartilage matrix, hif-2α is able to cause chondrocyte apoptosis and intensify in-flammatory response, and hif-3α may be the target gene of hif-1α and hif-2α, thereby playing a negative regulatory role. |
2023-04-06 |
2023-08-14 |
Not clear |
| Xin-An Zhang, Hui Kon. Mechanism of HIFs in osteoarthritis. Frontiers in immunology. vol 14. 2023-04-06. PMID:37020556. |
this review examines the mechanism of hifs in cartilage extracellular matrix degradation, apoptosis, inflammatory reaction, autophagy and then further expounds on the roles of hifs in oa, consequently providing theoretical support for the pathogenesis of oa and a new target for oa treatment. |
2023-04-06 |
2023-08-14 |
Not clear |
| Fengmei Li, Yan Wang, Wenqun Li, Junyong Wu, Shengnan Li, Xiongbin Hu, Tiantian Tang, Xinyi Li. Enhanced protection against hypoxia/reoxygenation-induced apoptosis in H9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium. Journal of liposome research. 2023-04-05. PMID:37017315. |
enhanced protection against hypoxia/reoxygenation-induced apoptosis in h9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium. |
2023-04-05 |
2023-08-14 |
Not clear |
| Hugo Marchal-Chaud, Romain Rieger, Van Than Mai, Edwin-Joffrey Courtial, Mélanie Ottenio, Catherine Bonnefont-Rebeix, Karine Bruyère, Caroline Bouloche. Contactless mechanical stimulation of tissue engineered constructs: Development and validation of an air-pulse device. Biomaterials advances. vol 149. 2023-04-05. PMID:37018914. |
mechanotransduction is the process through which mechanical stimulation triggers proliferation, apoptosis, and extracellular matrix synthesis, among other cell activities. |
2023-04-05 |
2023-08-14 |
Not clear |