| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingchen Meng, En Xie, Heng Sun, Huan Wang, Jiaying Li, Zhao Liu, Kexin Li, Jie Hu, Qianglong Chen, Chaoyong Liu, Bin Li, Fengxuan Ha. High-Strength Smart Microneedles with "Offensive and Defensive" Effects for Intervertebral Disc Repair. Advanced materials (Deerfield Beach, Fla.). 2023-09-08. PMID:37681640. |
in vitro experiments demonstrated that the synergistic treatment of photothermal therapy and anti-inflammation effectively reduced inflammation, inhibited cell apoptosis, and promoted the synthesis of the extracellular matrix (ecm). |
2023-09-08 |
2023-10-07 |
rat |
| Xingli Zhang, Jing Shi, Peng Yuan, Tengfei Li, Zhiguo Cao, Wei Zo. Differential developmental and proinflammatory responses of zebrafish embryo to repetitive exposure of biodigested polyamide and polystyrene microplastics. Journal of hazardous materials. vol 460. 2023-09-08. PMID:37683353. |
relative to the pristine form, the bioaccumulation of digested ps elevated and the musculoskeletal deformity and mortality of juvenile zebrafish were obviously enhanced, but these changes were unobservable for pa. lipopolysaccharide-triggered inflammation and apoptosis via toll-like receptor signaling pathways and reduction of extracellular matrix secretions driven by oxidative stress contributed to the aggravated inhibitory effects of digested ps on larval development. |
2023-09-08 |
2023-10-07 |
zebrafish |
| Rajnish Kumar, Devansh M Sinha, Brenden R Lankau, Nishant R Sinha, Ratnakar Tripathi, Suneel Gupta, Rajiv R Moha. Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools. Experimental eye research. 2023-09-08. PMID:37683796. |
pathway enrichment was performed for the genes associated with cellular apoptosis, death, adhesion, migration, differentiation, proliferation, extracellular matrix, and tumor necrosis factor production. |
2023-09-08 |
2023-10-07 |
rabbit |
| Jingtao Wu, Heng Yu, Yangcan Jin, Jingquan Wang, Liwen Zhou, Teng Cheng, Zhao Zhang, Binghao Lin, Jiansen Miao, Zhongke Li. Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model. Chinese medicine. vol 18. issue 1. 2023-09-07. PMID:37679844. |
osteoarthritis (oa), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ecm) and the apoptosis of chondrocytes. |
2023-09-07 |
2023-10-07 |
mouse |
| Gisela Soledad Gualdoni, Camila Barril, Patricia Verónica Jacobo, Liliana Nazareth Pacheco Rodríguez, Elisa Cebra. Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis-vascularization of normal and experimental pathological mouse placenta related to maternal alcohol exposure. Frontiers in cell and developmental biology. vol 11. 2023-09-06. PMID:37670932. |
prior to the initiation of invasion and endothelial replacement by trophoblasts, interactions between decidual stromal cells and maternal leukocytes, such as uterine natural killer cells and macrophages, play crucial roles in the processes of early maternal vascularization, such as proliferation, apoptosis, migration, differentiation, and matrix and vessel remodeling. |
2023-09-06 |
2023-10-07 |
mouse |
| Zhifang Tang, Hanzhen Feng, Xusheng Chen, Shuiyan Shao, Chuan L. SNORC knockdown alleviates inflammation, autophagy defect and matrix degradation of chondrocytes in osteoarthritis development. Molecular and cellular biochemistry. 2023-09-02. PMID:37659033. |
in a word, snorc knockdown alleviates inflammation, matrix degradation, autophagy defect and excessive apoptosis of chondrocytes during oa development via suppressing the pi3k and jnk signaling pathway. |
2023-09-02 |
2023-09-07 |
rat |
| Jun Yi, Qingluo Zhou, Jishang Huang, Shuo Niu, Guanglin Ji, Tiansheng Zhen. Lipid metabolism disorder promotes the development of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-31. PMID:37651799. |
lipid metabolism disorder contributes to extracellular matrix (ecm) degradation, cell apoptosis, and cartilage calcification in the intervertebral discs (ivds) by activating inflammatory responses, endoplasmic reticulum (er) stress, and oxidative stress and inhibiting autophagy. |
2023-08-31 |
2023-09-07 |
human |
| Yingjie Li, Cankun Wang, Anjun Ma, Abdul Qawee Rani, Mingjue Luo, Jenny Li, Xuefeng Liu, Qin M. Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single-cell transcriptomic analysis. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645794. |
these hpv-positive cells, compared to hpv-negative, showed different gene expressions related to the extracellular matrix, cell adhesion, proliferation, and apoptosis. |
2023-08-30 |
2023-09-07 |
human |
| Kanna Xu, Haoran Wang, Zhongqing W. Genkwanin suppresses mitochondrial dysfunction to alleviate IL-1β-elicited inflammation, apoptosis, and degradation of extracellular matrix in chondrocytes through upregulating DUSP1. The Chinese journal of physiology. vol 66. issue 4. 2023-08-28. PMID:37635488. |
genkwanin suppresses mitochondrial dysfunction to alleviate il-1β-elicited inflammation, apoptosis, and degradation of extracellular matrix in chondrocytes through upregulating dusp1. |
2023-08-28 |
2023-09-07 |
Not clear |
| Yuelong Zhang, Huangming Zhuang, Xunshan Ren, Fuze Jiang, Panghu Zho. Therapeutic effects of different intervention forms of human umbilical cord mesenchymal stem cells in the treatment of osteoarthritis. Frontiers in cell and developmental biology. vol 11. 2023-08-28. PMID:37635870. |
huc-mscs secret extracellular vesicles and participates in oa treatment by transmitting bioactive molecules related to migration, proliferation, apoptosis, inflammatory reaction, extracellular matrix synthesis and cartilage repair. |
2023-08-28 |
2023-09-07 |
human |
| Yingjie Li, Cankun Wang, Anjun Ma, Abdul Qawee Rani, Mingjue Luo, Jenny Li, Xuefeng Liu, Qin M. Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single-cell transcriptomic analysis. Journal of medical virology. vol 95. issue 8. 2023-08-28. PMID:37638381. |
these hpv-positive cells, compared to hpv-negative, showed different gene expressions related to the extracellular matrix, cell adhesion, proliferation, and apoptosis. |
2023-08-28 |
2023-09-07 |
human |
| Fan Zhang, Liang Liu, Hui Wang, Liaobin Che. Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-08-26. PMID:37633638. |
fetal knee joints were harvested on gd18 to analyze cartilage morphology, chondrocyte proliferation and apoptosis, and matrix content, synthesis and degradation. |
2023-08-26 |
2023-09-07 |
mouse |
| Fan Zhang, Liang Liu, Hui Wang, Liaobin Che. Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-08-26. PMID:37633638. |
results showed that 400 mg/kg∙d acetaminophen exposure during gd10-12 decreased chondrocyte numbers, safranin o staining, proliferation and matrix synthesis, without elevating matrix degradation and apoptosis. |
2023-08-26 |
2023-09-07 |
mouse |
| Liyun Zhang, Wei Li, Xin Liu, Junhong Guo, Xueping Wu, Jiantao Wan. Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway. Experimental eye research. 2023-08-24. PMID:37619828. |
niclosamide also induced apoptosis and counteracted tgf-β1-induced cytoskeletal changes and extracellular matrix accumulation. |
2023-08-24 |
2023-09-07 |
human |
| Tianyou Kan, Zhaoyang Ran, Lin Sun, Xu Jiang, Lingli Hou, Yiqi Yang, Zhuoxuan Jia, Wenjie Zhang, Liao Wang, Mengning Yan, Kai Xi. Cell-free fat extract-loaded microneedles attenuate inflammation-induced apoptosis and mitochondrial damage in tendinopathy. Materials today. Bio. vol 22. 2023-08-21. PMID:37600349. |
we found that ceffe-loaded mns (ceffe-mns) had good biosafety and inhibited lipopolysaccharide (lps)-induced apoptosis and matrix degradation in achilles tendon cells of rats. |
2023-08-21 |
2023-09-07 |
rat |
| Jiaqi Chen, Jianan Shao, Yaoyao Wang, Kangxiang Wu, Mingyuan Huan. OPA1, a molecular regulator of dilated cardiomyopathy. Journal of cellular and molecular medicine. 2023-08-21. PMID:37603376. |
opa1 regulates apoptosis by regulating the release of cytochrome c from the mitochondrial matrix through cjs (crisp linkages, located in the inner mitochondrial membrane) and unbalances mitochondrial fusion and fission by affecting mitochondrial inner membrane (im) fusion. |
2023-08-21 |
2023-09-07 |
Not clear |
| Lu Zhang, Junsheng Gao, Zhentao Li, Jun Liu, Chong Zhang, Jie Liu, Hui Dong, Wei Me. Astragaloside IV relieves IL-1β-induced human nucleus pulposus cells degeneration through modulating PI3K/Akt signaling pathway. Medicine. vol 102. issue 33. 2023-08-21. PMID:37603510. |
intervertebral disc degeneration (idd) is a multifactorial disease that is associated with nucleus pulposus (np) apoptosis and extracellular matrix (ecm) degeneration and inflammation. |
2023-08-21 |
2023-09-07 |
human |
| Jin Xu, Xiaocheng Zhi, Yunhui Zhang, Ren Din. Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis. Open life sciences. vol 18. issue 1. 2023-08-17. PMID:37589005. |
tanshinone iia alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis. |
2023-08-17 |
2023-09-07 |
Not clear |
| Lian Ren, Shi-Gao Cheng, Peng-Cheng Kang, Teng-Fei Li, Xun Li, Jiong-Zhe Xiao, Dong Jian. Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation. The Kaohsiung journal of medical sciences. 2023-08-14. PMID:37578083. |
silencing of lasp1 promoted chondrocyte proliferation and expression of collagen ii and aggrecan and inhibited chondrocyte apoptosis, inflammatory factors, and matrix metalloprotein expression. |
2023-08-14 |
2023-08-16 |
mouse |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |