| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zha. Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats. Frontiers in pharmacology. vol 14. 2023-02-06. PMID:36744257. |
the therapeutic effects of sal003 were also observed in the intervertebral disc degeneration rat model, as evidenced by improved degeneration along with decreased apoptosis and extracellular matrix degradation in intervertebral discs. |
2023-02-06 |
2023-08-14 |
rat |
| Zhongyin Zhang, Lichan Yuan, Yufeng Liu, Ruobing Wang, Yihong Zhang, Yan Yang, Hui Wei, Junqing M. Integrated cascade nanozyme remodels chondrocyte inflammatory microenvironment in temporomandibular joint osteoarthritis via inhibiting ROS-NF-κB and MAPK pathways. Advanced healthcare materials. 2023-02-04. PMID:36738173. |
notably, the inflammatory microenvironment in tmj oa is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory cytokine release, and extracellular matrix (ecm) synthesis. |
2023-02-04 |
2023-08-14 |
rat |
| Giulia Fiorentino, Andrew Smith, Giovanna Nicora, Riccardo Bellazzi, Fulvio Magni, Silvia Garagna, Maurizio Zuccott. MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis. Molecular human reproduction. 2023-02-03. PMID:36734599. |
enrichment analysis highlighted significant kegg and reactome pathways, with apoptosis, developmental biology, pi3k-akt, epigenetic regulation of gene expression, and extracellular matrix organisation being well represented. |
2023-02-03 |
2023-08-14 |
mouse |
| Jiang-Nan Ye, Cheng-Guo Su, Yu-Qing Jiang, Yan Zhou, Wen-Xi Sun, Xiao-Xia Zheng, Jin-Tao Miao, Xiang-Yue Li, Jun Zh. Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis: A systematic evaluation and meta-analysis. Frontiers in neuroscience. vol 16. 2023-01-30. PMID:36711149. |
acupuncture modulates cytokines to attenuate cartilage extracellular matrix degradation and apoptosis, key to the pathogenesis of koa, but the mechanisms are complex. |
2023-01-30 |
2023-08-14 |
Not clear |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Jishang Huang, Qingluo Zhou, Qun Ren, Liliang Luo, Guanglin Ji, Tiansheng Zhen. Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration. Frontiers in endocrinology. vol 13. 2023-01-30. PMID:36714579. |
although the pathological development of idd is far from being fully elucidated, many studies have been shown that er stress (ers) is involved in idd development and regulates various processes, such as inflammation, cellular senescence and apoptosis, excessive mechanical loading, metabolic disturbances, oxidative stress, calcium homeostasis imbalance, and extracellular matrix (ecm) dysregulation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yitian Zhang, Xiaoli Li, Wei Liu, Guanglei Hu, Hanjiang Gu, Xiao Cui, Dewu Zhang, Weihui Zeng, Yumin Xi. TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts. European journal of cell biology. vol 102. issue 2. 2023-01-29. PMID:36709605. |
overabundance of the extracellular matrix resulting from hyperproliferation of keloid fibroblasts (kfs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. |
2023-01-29 |
2023-08-14 |
Not clear |
| Xiao Wang, Xiaoping Huang, Pingzhang Gao, Yanxuan Ren, Xiaokun Li, Yong Dia. Kallistatin attenuates inflammatory response in rheumatoid arthritis via the NF-κB signaling pathway. European journal of pharmacology. 2023-01-23. PMID:36690053. |
our results showed that kallistatin mitigated il-1β-mediated chondrocyte apoptosis and inhibited the synthesis of ecm-degrading generation, like matrix metalloproteinase (mmp)-3/13 and a disintegrin and metalloproteinase with thrombospondin motifs (adamts)-4/5, in il-1β-mediated chondrocytes. |
2023-01-23 |
2023-08-14 |
mouse |
| Nicola Di-Iacovo, Stefania Pieroni, Danilo Piobbico, Marilena Castelli, Damiano Scopetti, Simona Ferracchiato, Maria Agnese Della-Fazia, Giuseppe Servill. Liver Regeneration and Immunity: A Tale to Tell. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674692. |
achieving the correct liver/body weight ratio is ensured by several pathways as extracellular matrix signalling, apoptosis through caspase-3 activation, and molecules including transforming growth factor-beta, and cyclic adenosine monophosphate. |
2023-01-21 |
2023-08-14 |
Not clear |
| Huamin Zhang, Yutong Zhou, Dada Wen, Jie Wan. Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36675315. |
myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions, especially fibrosis; they synthesize and secrete a large amount of extracellular matrix (ecm), such as α-sma and collagen, which leads to the distortion of organ parenchyma structure, an imbalance in collagen deposition and degradation, and the replacement of parenchymal cells by fibrous connective tissues. |
2023-01-21 |
2023-08-14 |
Not clear |
| Mohammad Reza Aslani, Nasim Abdollahi, Somaieh Matin, Anahita Zakeri, Hassan Ghobad. Effect of Crocin of Crocus sativus L. on Serum Inflammatory Markers (IL-6 and TNF-α) in COPD patients: A Randomized, Double-Blind, Placebo-Controlled Trial. The British journal of nutrition. 2023-01-11. PMID:36628554. |
different factors, such as inflammation, oxidative stress, extracellular matrix degradation and apoptosis affect the pathophysiology of chronic obstructive pulmonary disease (copd), as a progressive disease characterized by permanent airflow limitation. |
2023-01-11 |
2023-08-14 |
Not clear |
| Tingwen Cai, Hantao Ye, Hongyi Jiang, Chihao Lin, Chao Lou, Weidan Wang, Zijian Yan, Xinghe Xue, Xiaoyun Pan, Jian Li. Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo. International immunopharmacology. vol 115. 2023-01-11. PMID:36630751. |
on the basis of western blot, we have observed the protein expressions of cartilage matrix metabolism, inflammatory factors, and apoptosis of chondrocytes. |
2023-01-11 |
2023-08-14 |
mouse |
| Tingwen Cai, Hantao Ye, Hongyi Jiang, Chihao Lin, Chao Lou, Weidan Wang, Zijian Yan, Xinghe Xue, Xiaoyun Pan, Jian Li. Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo. International immunopharmacology. vol 115. 2023-01-11. PMID:36630751. |
the results show that svs slows extracellular matrix degradation and chondrocyte apoptosis. |
2023-01-11 |
2023-08-14 |
mouse |
| Xiaoliang Bai, Mingyan Yao, Xiaojuan Zhu, Yong Lian, Mingyuan Zhan. Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells. Immunopharmacology and immunotoxicology. 2023-01-09. PMID:36617937. |
baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells. |
2023-01-09 |
2023-08-14 |
human |
| Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yan. Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer. International journal of environmental research and public health. vol 20. issue 1. 2023-01-08. PMID:36612628. |
the tissue inhibitors of metalloproteinases-3 (timp3) are not only endogenous regulators of matrix metalloproteinases (mmps), but also induce apoptosis and inhibit endothelial cell migration and angiogenesis. |
2023-01-08 |
2023-08-14 |
Not clear |
| Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding, Hui Zen. Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review. Arthritis research & therapy. vol 25. issue 1. 2023-01-07. PMID:36609338. |
in vitro studies (n = 11) concluded that pth (1-34) was important for chondrocytes via increasing the proliferation and matrix synthesis but preventing apoptosis or hypertrophy. |
2023-01-07 |
2023-08-14 |
Not clear |
| Chao Song, Weiye Cai, Fei Liu, Kang Cheng, Daru Guo, Zongchao Li. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR spine. vol 5. issue 4. 2023-01-05. PMID:36601372. |
numerous factors, such as inflammatory factors, oxidative stress, apoptosis, matrix metalloproteinases, are linked to ivdd pathogenesis. |
2023-01-05 |
2023-08-14 |
Not clear |
| Hirofumi Nagao, Ashok Kumar Jayavelu, Weikang Cai, Hui Pan, Jonathan M Dreyfuss, Thiago M Batista, Bruna B Brandão, Matthias Mann, C Ronald Kah. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature communications. vol 14. issue 1. 2023-01-04. PMID:36599833. |
these lyk-i actions of the ir are linked to changes in phosphorylation of a network of proteins involved in the regulation of extracellular matrix organization, cell cycle, atm signaling and cellular senescence; and result in upregulation of expression of multiple extracellular matrix-related genes and proteins, down-regulation of immune/interferon-related genes and proteins, and increased sensitivity to apoptosis. |
2023-01-04 |
2023-08-14 |
Not clear |
| Fu Zhang, Songjuan Wang, Manman Gao, Baoliang Li, Zhongyuan He, Tao Tang, Zhengya Zhu, Shaoyu Liu, Zhiyu Zho. Hyaluronic acid ameliorates intervertebral disc degeneration Frontiers in bioengineering and biotechnology. vol 10. 2023-01-02. PMID:36588938. |
mitophagy, mitochondrial function, apoptosis, senescence and extracellular matrix (ecm) degradation were measured. |
2023-01-02 |
2023-08-14 |
cattle |
| Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li, Bin She. The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets. Arthritis research & therapy. vol 24. issue 1. 2022-12-30. PMID:36585687. |
mounting studies have revealed that disruption of extracellular matrix (ecm) homeostasis, aberrant chondrocyte metabolism, an increase in the number of senescent chondrocytes and abnormal activation of cell death such as chondrocyte apoptosis and autophagy, are the crucial steps in oa development. |
2022-12-30 |
2023-08-14 |
Not clear |