| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaowei Lin, Tao Jiang, Wei Zheng, Jiayuan Zhang, Anan Li, Chao Lu, Wengang Li. N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression. Cell communication and signaling : CCS. vol 21. issue 1. 2023-08-10. PMID:37563688. |
functional studies have demonstrated that wtap knockdown enhances proliferation ability, suppresses apoptosis, and reduces extracellular matrix (ecm) degradation in an lps-induced oa chondrocyte injury model and ameliorates cartilage damage in a destabilizing the medial meniscus (dmm)-induced oa mice model. |
2023-08-10 |
2023-08-16 |
mouse |
| Aika Yamawaki-Ogata, Masato Mutsuga, Yuji Narit. A review of current status of cell-based therapies for aortic aneurysms. Inflammation and regeneration. vol 43. issue 1. 2023-08-06. PMID:37544997. |
the aneurysmal wall is a complex inflammatory environment characterized by endothelial dysfunction, macrophage activation, vascular smooth muscle cell (vsmc) apoptosis, and the production of proinflammatory molecules and matrix metalloproteases (mmps) secreted by infiltrated inflammatory cells such as macrophages, t and b cells, dendritic cells, neutrophils, mast cells, and natural killer cells. |
2023-08-06 |
2023-08-14 |
Not clear |
| Takahiro Suzuki, Fernanda Scala Dinelli, Dana-Lee Demetrius, Jennifer Gherardini, Jose Rodriguez-Feliz, Gorana Epstein-Kuka, Jérémy Chéret, Ralf Pau. IL-15 prolongs anagen, stimulates proliferation and suppresses apoptosis in the hair matrix of human scalp hair follicles. The Journal of investigative dermatology. 2023-08-05. PMID:37543243. |
il-15 prolongs anagen, stimulates proliferation and suppresses apoptosis in the hair matrix of human scalp hair follicles. |
2023-08-05 |
2023-08-14 |
human |
| Shanbo Qin, Peng Tan, Junjie Xie, Yongfeng Zhou, Junning Zha. A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective. Chinese medicine. vol 18. issue 1. 2023-08-03. PMID:37537605. |
the anti-fibrotic mechanisms of these traditional chinese medicine studies can be roughly categorized into 5 main aspects, including inhibition of epithelial-mesenchymal transition, anti-inflammatory and antioxidant effects, improvement of extracellular matrix deposition, mediation of apoptosis and autophagy, and inhibition of endoplasmic reticulum stress. |
2023-08-03 |
2023-08-14 |
human |
| Kadirvel Devi, Thukani Sathanantham Shanmugaraja. Therapeutic Potential of Plant Metabolites in Bone Apoptosis: A Review. Current drug targets. 2023-08-01. PMID:37526458. |
osteoblast apoptosis is governed by the factors like b cell lymphoma 2 (bcl-2) family proteins, extracellular signal-regulated kinase (erk), mitogen-activated protein kinases (mapk), phosphoinositide-3-kinase/ protein kinase b (pi3-k/akt), janus kinase 2 (jak2), bone morphogenetic protein (bmp), and bone matrix protein. |
2023-08-01 |
2023-08-14 |
Not clear |
| Francesca Veronesi, Viviana Costa, Daniele Bellavia, Valentina Basoli, Gianluca Giavares. Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation. Cells. vol 12. issue 14. 2023-07-29. PMID:37508486. |
osteoarthritis (oa) is a joint disorder characterized by progressive degeneration of cartilage extracellular matrix (ecm), chondrocyte hypertrophy and apoptosis and inflammation. |
2023-07-29 |
2023-08-14 |
Not clear |
| Liujie Zheng, Yunfeng Yao, Dasheng Luo, Zhiwei Han, Xin Zhang, Nanyu Pang, Mingyang Ding, Houlong Ye, Keyan Zhu, Wenkai Y. Iron regulates chondrocyte phenotype in haemophilic cartilage through the PTEN/PI3 K/AKT/FOXO1 pathway. Hematology (Amsterdam, Netherlands). vol 28. issue 1. 2023-07-26. PMID:37493406. |
this change was caused by iron's effect on chondrocyte expression of fgf23 and sox9, in addition to iron-induced chondrocyte apoptosis and cartilage extracellular matrix degradation. |
2023-07-26 |
2023-08-14 |
Not clear |
| Jessica Millar, Elias Nasser, Gorav Ailawadi, Morgan Salmo. IL-1 in Abdominal Aortic Aneurysms. Journal of cellular immunology. vol 5. issue 2. 2023-07-21. PMID:37476160. |
aaas are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. |
2023-07-21 |
2023-08-14 |
Not clear |
| Xian Yang, Qingsong Jiang, Tiankuo Luan, Chao Yu, Zhibo Liu, Ting Wang, Jingyuan Wan, Jiayu Huang, Ke L. Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression. BMC musculoskeletal disorders. vol 24. issue 1. 2023-07-20. PMID:37474941. |
moreover, by inhibiting pdk1, cartilage loss is markedly accelerated in dmm-induced oa through extracellular matrix (ecm) degradation and apoptosis of chondrocytes. |
2023-07-20 |
2023-08-14 |
Not clear |
| Saurav Bhowmick, M R Preetha Rani, Shubham Singh, P M Abdul-Munee. Discovery of novel microRNAs and their pathogenic responsive target genes in mild traumatic brain injury. Experimental brain research. 2023-07-19. PMID:37466694. |
further, we filtered the differentially expressed mirnas that were linked with proinflammatory cytokines, apoptosis, matrix metalloproteinases (mmps), and tight junction and junctional adhesion molecule genes. |
2023-07-19 |
2023-08-14 |
mouse |
| Vidisha Singh, Aurelien Naldi, Sylvain Soliman, Anna Niaraki. A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint. NPJ systems biology and applications. vol 9. issue 1. 2023-07-15. PMID:37454172. |
in this paper, we present a large-scale boolean model for ra-fls that consists of five submodels focusing on apoptosis, cell proliferation, matrix degradation, bone erosion and inflammation. |
2023-07-15 |
2023-08-14 |
Not clear |
| Yifan Su, Zirou Liao, Xinran Liang, Jing Hua, Dawei Zhang, Dexuan Hu, Qian Yu, Yikun Xi. Ent-kaurane-type Diterpenes Induce ROS-mediated Mitochondrial Dysfunction and Apoptosis by Suppress the Homologous Recombination DNA Repair in Triple-negative Breast Cancer Cells. Chemistry & biodiversity. 2023-07-14. PMID:37448115. |
furthermore, this research reveals that the mechanism between mitochondria dysfunction and dna damage is deserved to be investigated for elucidating the dynamic signal transduction between the nucleus and the cellular matrix during apoptosis. |
2023-07-14 |
2023-08-14 |
human |
| Anjali Murmu, Purusottam Banjare, Balaji Wamanrao Matore, Partha Pratim Roy, Jagadish Sing. 1,3,4-Oxadiazole: An Emerging Scaffold to Inhibit the Thymidine Phosphorylase as an Anticancer Agent. Current medicinal chemistry. 2023-07-13. PMID:37438902. |
tp overexpression is highly associated with angiogenic factors such as vascular endothelial growth factor (vegf), interleukins (ils), matrix metalloproteases (mmps), etc., which accelerate tumorigenesis, invasion, metastasis, immune response evasion, and resistant to apoptosis. |
2023-07-13 |
2023-08-14 |
human |
| Axiang He, Yaru Liu, Renbo Zhang, Yanjie Mao, Wanjun Li. CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation. Heliyon. vol 9. issue 6. 2023-07-13. PMID:37441407. |
circsfmbt2-oa alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing nf-κb/nlrp3 inflammasome activation. |
2023-07-13 |
2023-08-14 |
Not clear |
| Fang Huang, Enjing Zhang, Yan Lei, Qiong Yan, Chengbin Xu. Tripterine inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting ROS/JNK signaling. Journal of burn care & research : official publication of the American Burn Association. 2023-07-12. PMID:37436955. |
cell viability, proliferation, migration, apoptosis and extracellular matrix (ecm) deposition were determined by cck-8, edu, wound healing, transwell, flow cytometry, western blotting and rt-qpcr assays. |
2023-07-12 |
2023-08-14 |
mouse |
| Jiaxin Shi, Bo Peng, Xiang Zhou, Chenghao Wang, Ran Xu, Tong Lu, Xiaoyan Chang, Zhiping Shen, Kaiyu Wang, Chengyu Xu, Linyou Zhan. An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration. Journal of cancer research and clinical oncology. 2023-07-08. PMID:37421452. |
anoikis is a particular type of programmed apoptosis brought on by the separation of cell-cell or extracellular matrix (ecm). |
2023-07-08 |
2023-08-14 |
Not clear |
| Zhang Juan, Mu Xing-Tong, Zhang Xu, Li Chang-Y. Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis. Journal of dental sciences. vol 18. issue 3. 2023-07-05. PMID:37404608. |
in this narrative review, we summarized the main pathological changes of tmj oa, including inflammatory responses, degeneration of extracellular matrix (ecm), abnormal cell biological behaviors (apoptosis, autophagy, and differentiation) in tmj tissue, and aberrant angiogenesis. |
2023-07-05 |
2023-08-14 |
Not clear |
| Y-W He, Q-P Fan, A-L Hua, Q Li. Identification of hub anoikis-associated genes and risk signature in cutaneous melanoma. European review for medical and pharmacological sciences. vol 27. issue 12. 2023-07-04. PMID:37401304. |
anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ecm). |
2023-07-04 |
2023-08-14 |
human |
| Zhiqiang He, Yufan Gu, Huan Yang, Qian Fu, Maofang Zhao, Yuhan Xie, Yi Liu, Wenlong D. Identification and verification of a novel anoikis-related gene signature with prognostic significance in clear cell renal cell carcinoma. Journal of cancer research and clinical oncology. 2023-07-04. PMID:37402968. |
the loss of extracellular matrix (ecm) stimulates cell apoptosis, known as anoikis. |
2023-07-04 |
2023-08-14 |
Not clear |
| Hongyi Jiang, Jiachen Yu, Zijian Yan, Zhongnan Lin, Minghao Lin, Yiwen Mao, Zechao Hong, Jian Lin, Xinghe Xue, Xiaoyun Pa. Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis. International immunopharmacology. vol 122. 2023-07-03. PMID:37399606. |
osteoarthritis (oa) is a widely prevalent degenerative disease marked by extracellular matrix (ecm) degradation, inflammation, and apoptosis. |
2023-07-03 |
2023-08-14 |
Not clear |