| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minghao Qu, Mingjue Chen, Weiyuan Gong, Shaochuan Huo, Qinnan Yan, Qing Yao, Yumei Lai, Di Chen, Xiaohao Wu, Guozhi Xia. Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice. Aging and disease. vol 14. issue 2. 2023-04-03. PMID:37008048. |
pip5k1c loss promotes extracellular matrix (ecm) degradation, chondrocyte hypertrophy and apoptosis, and inhibits chondrocyte proliferation in the articular cartilage of aged mice. |
2023-04-03 |
2023-08-14 |
mouse |
| Aiting Liu, Pei Luo, Hui Huan. New insight of complement system in the process of vascular calcification. Journal of cellular and molecular medicine. 2023-04-01. PMID:37002701. |
we also describe the complex network of complement system and vascular smooth muscle cells osteogenic transdifferentiation, systemic inflammation, endoplasmic reticulum stress, extracellular matrix remodelling, oxidative stress, apoptosis in vascular calcification. |
2023-04-01 |
2023-08-14 |
Not clear |
| Maryam E Mashaly, Hams M Kotb, Amany Abdin, Sabiha E Hedy. Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand-foot syndrome induced by capecitabine in rats. Canadian journal of physiology and pharmacology. 2023-03-31. PMID:37001149. |
to enhance the tolerability of capecitabine, this work evaluated the incorporation of quercetin into topical collagen matrix formula to target thymidine phosphorylase enzyme, oxidative stress, and apoptosis underlying hfs. |
2023-03-31 |
2023-08-14 |
rat |
| Kai Sun, Zhou Guo, Jinming Zhang, Liangcai Hou, Shuang Liang, Fan Lu, Genchun Wang, Jingting Xu, Xiong Zhang, Fengjing Guo, Wentao Zh. Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy. Cell death discovery. vol 9. issue 1. 2023-03-31. PMID:37002200. |
we demonstrated that tnf-α-related oa-like phenotypes including inflammation response, extracellular matrix degradation, apoptosis, and necroptosis in chondrocytes were inhibited by tradd deficiency. |
2023-03-31 |
2023-08-14 |
mouse |
| Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhan. Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging. PloS one. vol 18. issue 3. 2023-03-30. PMID:36996033. |
meanwhile, the des and ator groups were similar in plaque stability, with smaller plaque size, areas of macrophages, higher smooth muscle cell content, and decreased apoptosis and matrix metalloproteinase (mmp) activities relative to the control group. |
2023-03-30 |
2023-08-14 |
rabbit |
| Yi Li, Qin Pan, Mingxia Cheng, Zhengyuan W. Identification and validation of anoikis-associated gene SNCG as a prognostic biomarker in gastric cancer. Aging. vol 15. 2023-03-30. PMID:36996495. |
anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ecm). |
2023-03-30 |
2023-08-14 |
Not clear |
| Mei Li Ng, Xu Ang, Kwan Yi Yap, Jun Jie Ng, Eugene Chen Howe Goh, Benjamin Bing Jie Khoo, Arthur Mark Richards, Chester Lee Dru. Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979896. |
os is both initiated by, and triggers inflammation, cardiomyocyte apoptosis, matrix remodeling, myocardial fibrosis, and neurohumoral activation. |
2023-03-29 |
2023-08-14 |
Not clear |
| María Sánchez-Aguilar, Luz Ibarra-Lara, Agustina Cano-Martínez, Elizabeth Soria-Castro, Vicente Castrejón-Téllez, Natalia Pavón, Citlalli Osorio-Yáñez, Eulises Díaz-Díaz, María Esther Rubio-Ruí. PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982395. |
the pathophysiology of injury by ischemia/reperfusion (i/r) is highly complex and the inflammatory condition plays an important role by increasing matrix remodeling and cardiac apoptosis. |
2023-03-29 |
2023-08-14 |
rat |
| Yanlin Tan, Xiaobin Wang, Yi Zhang, Zhehao Dai, Jing Li, Chuning Dong, Xingwang Yao, Chang Lu, Fei Che. FOXO3-Activated circFGFBP1 Inhibits Extracellular Matrix Degradation and Nucleus Pulposus Cell Death via miR-9-5p/BMP2 Axis in Intervertebral Disc Degeneration In Vivo and In Vitro. Pharmaceuticals (Basel, Switzerland). vol 16. issue 3. 2023-03-29. PMID:36986573. |
circfgfbp1 upregulation inhibited apoptosis and extracellular matrix (ecm) degradation and promoted proliferation in il-1β-stimulated np cells. |
2023-03-29 |
2023-08-14 |
rat |
| Guanyu Jiang, Chenghu Song, Xiaokun Wang, Yongrui Xu, Huixing Li, Zhao He, Ying Cai, Mingfeng Zheng, Wenjun Ma. The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma. Heliyon. vol 9. issue 3. 2023-03-27. PMID:36967927. |
anoikis serves as programmed apoptosis initiated by the detachment of cells from the extracel-lular matrix. |
2023-03-27 |
2023-08-14 |
Not clear |
| Noah A Stueven, DeannaLee M Beauvais, Rong Hu, Randall J Kimple, Alan C Rapraege. Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN Cancer research communications. vol 3. issue 1. 2023-03-27. PMID:36968227. |
inhibiting igf1r-mediated survival signaling in head and neck cancer with the peptidomimetic sstn previous studies have shown that the type i igfr (igf1r) suppresses apoptosis when it is autoactivated by coupling its extracellular domain to a matrix adhesion receptor complex consisting of syndecan-1 (sdc1) and αvβ3 or αvβ5 integrin. |
2023-03-27 |
2023-08-14 |
Not clear |
| Ramana Vaka, Sandrine Parent, Yousef Risha, Saad Khan, David Courtman, Duncan J Stewart, Darryl R Davi. Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways. Molecular therapy. Nucleic acids. vol 32. 2023-03-27. PMID:36969553. |
evs from bm-mscs were implicated in apoptosis, cell-cycle progression, collagen formation, heme pigment synthesis, and smooth muscle differentiation, while hdc and uc-msc evs were found to regulate complement activation, endopeptidase activity, and matrix metallopeptidases. |
2023-03-27 |
2023-08-14 |
Not clear |
| Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhan. Nanomaterial-based Reactive Oxygen Species Scavengers for Osteoarthritis Therapy. Acta biomaterialia. 2023-03-26. PMID:36967052. |
recent studies on osteoarthritis (oa) have suggested that ros plays a crucial role in its development and progression, serving as key mediators in the degradation of the extracellular matrix, mitochondrial dysfunction, chondrocyte apoptosis, and oa progression. |
2023-03-26 |
2023-08-14 |
Not clear |
| Dong Chen, Xin Jiang, Haibo Zo. hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration. Journal of orthopaedic translation. vol 39. 2023-03-23. PMID:36950198. |
intervertebral disc degeneration (idd) is a complex chronic disease involving nucleus pulposus cells (npcs) senescence, apoptosis, autophagy and extracellular matrix (ecm) degradation. |
2023-03-23 |
2023-08-14 |
human |
| Shing-Hsien Chou, Hung-Chen Lin, Shao-Wei Chen, Yu-Ting Tai, Shih-Ming Jung, Fu-Hsiang Ko, Jong-Hwei Su Pang, Pao-Hsien Ch. Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-23. PMID:36958389. |
cd also induced the apoptosis of cardiomyocytes and increased the expression levels of matrix metalloproteinase (mmp)-2 and mmp-14 in cardiac tissues. |
2023-03-23 |
2023-08-14 |
mouse |
| Kun Wang, Dengbo Yao, Yuxi Li, Ming Li, Weike Zeng, Zhuangyao Liao, Engming Chen, Shixin Lu, Kaihui Su, Zhen Che, Yuwei Liang, Peng Wang, Lin Huan. TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo. Arthritis research & therapy. vol 25. issue 1. 2023-03-22. PMID:36945021. |
inflammation, apoptosis and extracellular matrix (ecm) degradation contribute to disc degeneration in nucleus pulposus cells (npcs). |
2023-03-22 |
2023-08-14 |
Not clear |
| Hao Yu, Yun Teng, Jun Ge, Ming Yang, Haifeng Xie, Tianyi Wu, Qi Yan, Mengting Jia, Qing Zhu, Yanping Shen, Lianxue Zhang, Jun Zo. Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells. Journal of nanobiotechnology. vol 21. issue 1. 2023-03-21. PMID:36941611. |
excessive reactive oxygen species (ros) in nucleus pulposus cells (npcs) promote extracellular matrix (ecm) degradation and cellular inflammatory responses by activating a variety of cellular pathways, ultimately inducing cell apoptosis and leading to the development of low back pain. |
2023-03-21 |
2023-08-14 |
rat |
| J Bai, T Liu, M Ren, X Wan. Neobavaisoflavone improves medial collateral ligament-induced osteoarthritis through repressing the nuclear factor -κB/hypoxia-inducible factor-2α axis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 73. issue 5. 2023-03-21. PMID:36942811. |
as indicated by the results, nbif mitigated cartilage matrix degradation and chondrocyte apoptosis in the oa rat model. |
2023-03-21 |
2023-08-14 |
rat |
| Liang Liu, Wanying Zhang, Tanghao Liu, Yangfan Tan, Cheng Chen, Jun Zhao, Huan Geng, Chi M. The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress. Redox biology. vol 62. 2023-03-16. PMID:36924682. |
chondrocyte proliferation and apoptosis, synthesis and degradation of extracellular matrix, and inflammation mediators were analyzed. |
2023-03-16 |
2023-08-14 |
human |
| Shane T Killarney, Rachel Washart, Ryan S Soderquist, Jacob P Hoj, Jamie Lebhar, Kevin H Lin, Kris C Woo. Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. Nature communications. vol 14. issue 1. 2023-03-15. PMID:36918588. |
during apoptosis, mitochondrial outer membrane permeabilization (momp) enables certain mitochondrial matrix macromolecules to escape into the cytosol. |
2023-03-15 |
2023-08-14 |
Not clear |