| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryo Inoue, Taro Yasuma, Valeria Fridman D'Alessandro, Masaaki Toda, Toshiyuki Ito, Atsushi Tomaru, Corina N D'Alessandro-Gabazza, Tatsuki Tsuruga, Tomohito Okano, Atsuro Takeshita, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Esteban C Gabazz. Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047672. |
active matrix metalloproteinase-2 significantly decreased bleomycin-induced apoptosis in alveolar epithelial cells. |
2023-04-13 |
2023-08-14 |
mouse |
| Ryo Inoue, Taro Yasuma, Valeria Fridman D'Alessandro, Masaaki Toda, Toshiyuki Ito, Atsushi Tomaru, Corina N D'Alessandro-Gabazza, Tatsuki Tsuruga, Tomohito Okano, Atsuro Takeshita, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Esteban C Gabazz. Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047672. |
matrix metalloproteinase-2 appears to protect against pulmonary fibrosis by inhibiting apoptosis of lung epithelial cells. |
2023-04-13 |
2023-08-14 |
mouse |
| Shijie Chen, Quan Zhuang, Pinghuang Li, Jin Zeng, Yi Peng, Zhiyu Ding, Hongqing Cao, Ruping Zheng, Weiguo Wan. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells. Cell and tissue research. 2023-04-13. PMID:37052702. |
excessive apoptosis of intervertebral disc cells, namely nucleus pulposus (np) cells, results in decreased cell density and extracellular matrix (ecm) catabolism, hence leading to intervertebral disc degeneration (ivdd). |
2023-04-13 |
2023-08-14 |
human |
| Soichiro Saito, Shuji Mizumoto, Tsukasa Yonekura, Rina Yamashita, Kenta Nakano, Tadashi Okubo, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuich. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. PloS one. vol 18. issue 4. 2023-04-13. PMID:37053259. |
proliferation, apoptosis and differentiation were not affected in the chondrocytes of slc35a3-/-mice, suggesting that the chondrodysplasia phenotypes were mainly caused by the abnormal extracellular matrix quality. |
2023-04-13 |
2023-08-14 |
mouse |
| Xin-An Zhang, Hui Kon. Mechanism of HIFs in osteoarthritis. Frontiers in immunology. vol 14. 2023-04-06. PMID:37020556. |
for example, hif-1α can maintain the stability of the articular cartilage matrix, hif-2α is able to cause chondrocyte apoptosis and intensify in-flammatory response, and hif-3α may be the target gene of hif-1α and hif-2α, thereby playing a negative regulatory role. |
2023-04-06 |
2023-08-14 |
Not clear |
| Xin-An Zhang, Hui Kon. Mechanism of HIFs in osteoarthritis. Frontiers in immunology. vol 14. 2023-04-06. PMID:37020556. |
this review examines the mechanism of hifs in cartilage extracellular matrix degradation, apoptosis, inflammatory reaction, autophagy and then further expounds on the roles of hifs in oa, consequently providing theoretical support for the pathogenesis of oa and a new target for oa treatment. |
2023-04-06 |
2023-08-14 |
Not clear |
| Fengmei Li, Yan Wang, Wenqun Li, Junyong Wu, Shengnan Li, Xiongbin Hu, Tiantian Tang, Xinyi Li. Enhanced protection against hypoxia/reoxygenation-induced apoptosis in H9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium. Journal of liposome research. 2023-04-05. PMID:37017315. |
enhanced protection against hypoxia/reoxygenation-induced apoptosis in h9c2 cells by puerarin-loaded liposomes modified with matrix metalloproteinases-targeting peptide and triphenylphosphonium. |
2023-04-05 |
2023-08-14 |
Not clear |
| Hugo Marchal-Chaud, Romain Rieger, Van Than Mai, Edwin-Joffrey Courtial, Mélanie Ottenio, Catherine Bonnefont-Rebeix, Karine Bruyère, Caroline Bouloche. Contactless mechanical stimulation of tissue engineered constructs: Development and validation of an air-pulse device. Biomaterials advances. vol 149. 2023-04-05. PMID:37018914. |
mechanotransduction is the process through which mechanical stimulation triggers proliferation, apoptosis, and extracellular matrix synthesis, among other cell activities. |
2023-04-05 |
2023-08-14 |
Not clear |
| Minghao Qu, Mingjue Chen, Weiyuan Gong, Shaochuan Huo, Qinnan Yan, Qing Yao, Yumei Lai, Di Chen, Xiaohao Wu, Guozhi Xia. Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice. Aging and disease. vol 14. issue 2. 2023-04-03. PMID:37008048. |
pip5k1c loss promotes extracellular matrix (ecm) degradation, chondrocyte hypertrophy and apoptosis, and inhibits chondrocyte proliferation in the articular cartilage of aged mice. |
2023-04-03 |
2023-08-14 |
mouse |
| Aiting Liu, Pei Luo, Hui Huan. New insight of complement system in the process of vascular calcification. Journal of cellular and molecular medicine. 2023-04-01. PMID:37002701. |
we also describe the complex network of complement system and vascular smooth muscle cells osteogenic transdifferentiation, systemic inflammation, endoplasmic reticulum stress, extracellular matrix remodelling, oxidative stress, apoptosis in vascular calcification. |
2023-04-01 |
2023-08-14 |
Not clear |
| Maryam E Mashaly, Hams M Kotb, Amany Abdin, Sabiha E Hedy. Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand-foot syndrome induced by capecitabine in rats. Canadian journal of physiology and pharmacology. 2023-03-31. PMID:37001149. |
to enhance the tolerability of capecitabine, this work evaluated the incorporation of quercetin into topical collagen matrix formula to target thymidine phosphorylase enzyme, oxidative stress, and apoptosis underlying hfs. |
2023-03-31 |
2023-08-14 |
rat |
| Kai Sun, Zhou Guo, Jinming Zhang, Liangcai Hou, Shuang Liang, Fan Lu, Genchun Wang, Jingting Xu, Xiong Zhang, Fengjing Guo, Wentao Zh. Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy. Cell death discovery. vol 9. issue 1. 2023-03-31. PMID:37002200. |
we demonstrated that tnf-α-related oa-like phenotypes including inflammation response, extracellular matrix degradation, apoptosis, and necroptosis in chondrocytes were inhibited by tradd deficiency. |
2023-03-31 |
2023-08-14 |
mouse |
| Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhan. Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging. PloS one. vol 18. issue 3. 2023-03-30. PMID:36996033. |
meanwhile, the des and ator groups were similar in plaque stability, with smaller plaque size, areas of macrophages, higher smooth muscle cell content, and decreased apoptosis and matrix metalloproteinase (mmp) activities relative to the control group. |
2023-03-30 |
2023-08-14 |
rabbit |
| Yi Li, Qin Pan, Mingxia Cheng, Zhengyuan W. Identification and validation of anoikis-associated gene SNCG as a prognostic biomarker in gastric cancer. Aging. vol 15. 2023-03-30. PMID:36996495. |
anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ecm). |
2023-03-30 |
2023-08-14 |
Not clear |
| Mei Li Ng, Xu Ang, Kwan Yi Yap, Jun Jie Ng, Eugene Chen Howe Goh, Benjamin Bing Jie Khoo, Arthur Mark Richards, Chester Lee Dru. Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979896. |
os is both initiated by, and triggers inflammation, cardiomyocyte apoptosis, matrix remodeling, myocardial fibrosis, and neurohumoral activation. |
2023-03-29 |
2023-08-14 |
Not clear |
| María Sánchez-Aguilar, Luz Ibarra-Lara, Agustina Cano-Martínez, Elizabeth Soria-Castro, Vicente Castrejón-Téllez, Natalia Pavón, Citlalli Osorio-Yáñez, Eulises Díaz-Díaz, María Esther Rubio-Ruí. PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982395. |
the pathophysiology of injury by ischemia/reperfusion (i/r) is highly complex and the inflammatory condition plays an important role by increasing matrix remodeling and cardiac apoptosis. |
2023-03-29 |
2023-08-14 |
rat |
| Yanlin Tan, Xiaobin Wang, Yi Zhang, Zhehao Dai, Jing Li, Chuning Dong, Xingwang Yao, Chang Lu, Fei Che. FOXO3-Activated circFGFBP1 Inhibits Extracellular Matrix Degradation and Nucleus Pulposus Cell Death via miR-9-5p/BMP2 Axis in Intervertebral Disc Degeneration In Vivo and In Vitro. Pharmaceuticals (Basel, Switzerland). vol 16. issue 3. 2023-03-29. PMID:36986573. |
circfgfbp1 upregulation inhibited apoptosis and extracellular matrix (ecm) degradation and promoted proliferation in il-1β-stimulated np cells. |
2023-03-29 |
2023-08-14 |
rat |
| Guanyu Jiang, Chenghu Song, Xiaokun Wang, Yongrui Xu, Huixing Li, Zhao He, Ying Cai, Mingfeng Zheng, Wenjun Ma. The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma. Heliyon. vol 9. issue 3. 2023-03-27. PMID:36967927. |
anoikis serves as programmed apoptosis initiated by the detachment of cells from the extracel-lular matrix. |
2023-03-27 |
2023-08-14 |
Not clear |
| Noah A Stueven, DeannaLee M Beauvais, Rong Hu, Randall J Kimple, Alan C Rapraege. Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN Cancer research communications. vol 3. issue 1. 2023-03-27. PMID:36968227. |
inhibiting igf1r-mediated survival signaling in head and neck cancer with the peptidomimetic sstn previous studies have shown that the type i igfr (igf1r) suppresses apoptosis when it is autoactivated by coupling its extracellular domain to a matrix adhesion receptor complex consisting of syndecan-1 (sdc1) and αvβ3 or αvβ5 integrin. |
2023-03-27 |
2023-08-14 |
Not clear |
| Ramana Vaka, Sandrine Parent, Yousef Risha, Saad Khan, David Courtman, Duncan J Stewart, Darryl R Davi. Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways. Molecular therapy. Nucleic acids. vol 32. 2023-03-27. PMID:36969553. |
evs from bm-mscs were implicated in apoptosis, cell-cycle progression, collagen formation, heme pigment synthesis, and smooth muscle differentiation, while hdc and uc-msc evs were found to regulate complement activation, endopeptidase activity, and matrix metallopeptidases. |
2023-03-27 |
2023-08-14 |
Not clear |