| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Funmilayo O Adeshakin, Adeleye O Adeshakin, Zhao Liu, Jian Cheng, Pengchao Zhang, Dehong Yan, Guizhong Zhang, Xiaochun Wa. Targeting Oxidative Phosphorylation-Proteasome Activity in Extracellular Detached Cells Promotes Anoikis and Inhibits Metastasis. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054435. |
anoikis-the apoptosis of detached cells (from the extracellular matrix (ecm)) is often circumvented by metastatic cells as a result of biochemical and molecular transformations. |
2022-01-21 |
2023-08-13 |
Not clear |
| Hao Chen, Jiarui Ma, Jin Liu, Lin Dou, Tao Shen, Huiyan Zuo, Fangzhi Xu, Li Zhao, Weiqing Tang, Yong Man, Yanyan Ma, Jian Li, Xiuqing Huan. Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes. FEBS letters. 2022-01-19. PMID:35043979. |
lpc-induced rounding of cells reduced both cell-extracellular matrix (ecm) adhesion and cell-cell junctions, which promoted detachment-induced apoptosis (defined as anoikis) in hepatocytes. |
2022-01-19 |
2023-08-13 |
Not clear |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
aloin regulates matrix metabolism and apoptosis in human nucleus pulposus cells via the tak1/nf- intervertebral disc degeneration (idd) is a degenerative disease that is characterized by decreased matrix synthesis and extra degradation, nucleus pulposus cells (npcs) apoptosis, and infiltration of inflammatory factors. |
2022-01-17 |
2023-08-13 |
human |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
in our study, the upregulation of proinflammatory factors, apoptosis, and unbalanced matrix metabolism were observed in degenerative np tissues. |
2022-01-17 |
2023-08-13 |
human |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
we found that aloin had a curative effect on extracellular matrix metabolism and apoptosis in tnf-alpha- (tnf- |
2022-01-17 |
2023-08-13 |
human |
| Dan Liu, Wei Liu, Limin Jiang, Shengjie Dong, Weihua Ma, Shijun Wang, Chao Wa. Silencing of TLR7 protects against lipopolysaccharide-induced chondrocyte apoptosis and injury by blocking the p21-mediated JAK2/STAT3 pathway. American journal of translational research. vol 13. issue 12. 2022-01-17. PMID:35035696. |
in this study, we sought to investigate the contribution of tlr7 in regulating chondrocyte apoptosis, inflammation, and degradation of the extracellula matrix (ecm), and its underlying mechanisms. |
2022-01-17 |
2023-08-13 |
Not clear |
| Huanzhi Ma, Wei Zhang, Jun Sh. Differentially Expressed Genes Reveal the Biomarkers and Molecular Mechanism of Osteonecrosis. Journal of healthcare engineering. vol 2022. 2022-01-17. PMID:35035862. |
the go enrichment showed that osteonecrosis was related with extracellular matrix, external encapsulating structure organization, skeletal system development, immune response activity, cell apoptosis, mononuclear cell differentiation, and serine/threonine kinase activity. |
2022-01-17 |
2023-08-13 |
Not clear |
| Yixuan Amy Pei, Song Chen, Ming Pe. The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair. Cellular and molecular life sciences : CMLS. vol 79. issue 1. 2022-01-14. PMID:35029764. |
this vascularization then leads to matrix breakdown, chondrocyte apoptosis, and ossification. |
2022-01-14 |
2023-08-13 |
Not clear |
| Jun Zhu, Yongchun Gu. Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway. Immunological investigations. 2022-01-11. PMID:35012421. |
circ_0020093 overexpression alleviates interleukin-1 beta-induced inflammation, apoptosis and extracellular matrix degradation in human chondrocytes by targeting the mir-181a-5p/erg pathway. |
2022-01-11 |
2023-08-13 |
human |
| Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, Guozhi Xia. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone research. vol 10. issue 1. 2022-01-11. PMID:35013104. |
this vicious cycle promotes extracellular matrix (ecm) catabolism and np cell apoptosis. |
2022-01-11 |
2023-08-13 |
mouse |
| Huichang Gao, Jin Xiao, Yingqi Wei, Hui Yang, Fen Zo. Manipulating Mesenchymal Stem Cell Differentiation on Nanopattern Constructed through Cell-Mediated Mineralization. ACS applied bio materials. vol 4. issue 7. 2022-01-10. PMID:35006735. |
the extracellular matrix microenvironment, including chemical constituents and topological structure, plays key role in regulating the cell behavior, such as adhesion, proliferation, differentiation, apoptosis, etc. |
2022-01-10 |
2023-08-13 |
mouse |
| Yu Sun, Xinnan Bao, Haiou Chen, Liping Zho. MicroRNA-128-3p suppresses interleukin-1β-stimulated cartilage degradation and chondrocyte apoptosis via targeting zinc finger E-box binding homeobox 1 in osteoarthritis. Bioengineered. vol 13. issue 1. 2022-01-06. PMID:34990303. |
mir-128-3p overexpression or zeb1 silencing attenuated extracellular matrix degradation and cell apoptosis, and increased the proliferation of il-1β-activated chon-001 cells. |
2022-01-06 |
2023-08-13 |
Not clear |
| Jian-Qiang Wu, Wei Wang, Yue-Hong Zhen. [Role of Vascular Aging in the Pathogenesis of Abdominal Aortic Aneurysm and Potential Therapeutic Targets]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 6. 2022-01-04. PMID:34980338. |
abdominal aortic aneurysm(aaa)is a common aortic degenerative disease in the elderly,and its incidence is gradually increasing with the aging of the population.there are no specific drugs available to delay the expansion of aaa.once the aneurysm ruptures,the mortality will exceed 90%,which seriously threatens the life of patients.given the high incidence of aaa in the elderly,this review discusses the role of vascular aging in the pathogenesis of aaa,involving chronic inflammation,oxidative stress,mitochondrial dysfunction,protein homeostasis imbalance,increased apoptosis and necrosis,extracellular matrix remodeling,nutritional sensing disorders,epigenetic changes,and increased pro-aging factors.meanwhile,several potential aging-related drug targets of aaa are listed.this review provides new ideas for basic and translational medical research of aaa. |
2022-01-04 |
2023-08-13 |
Not clear |
| Jeongeun Hyun, Hae-Won Ki. Leveraging cellular mechano-responsiveness for cancer therapy. Trends in molecular medicine. 2022-01-02. PMID:34973934. |
these include targeting mechanosensitive machineries in cancer cells to induce apoptosis, intervening matrix stiffening incurred by cancer-associated fibroblasts (cafs) in both primary and metastatic tumor sites, and modulating matrix mechanics to improve immune cell therapeutic efficacy. |
2022-01-02 |
2023-08-13 |
Not clear |
| Jing Feng, Jinping Zhou, Lin Zhao, Xinpeng Wang, Danyu Ma, Baoqing Xu, Feilai Xie, Xingfeng Qi, Gang Chen, Hu Zhao, Junxin W. Fam20C Overexpression Predicts Poor Outcomes and is a Diagnostic Biomarker in Lower-Grade Glioma. Frontiers in genetics. vol 12. 2021-12-31. PMID:34970298. |
gene set enrichment analysis also revealed the potential signaling pathways associated with fam20c gene expression in lgg; these pathways were mainly enriched in extracellular matrix receptor interactions, cell adhesion, cell apoptosis, notch signaling, cell cycle, etc. |
2021-12-31 |
2023-08-13 |
Not clear |
| Xiaoliang Bai, Yong Lian, Changqing Hu, Shuai Yang, Bo Pei, Mingyan Yao, Xiaojuan Zhu, Lin Shang, Zhihong L. Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling. Journal of applied toxicology : JAT. 2021-12-29. PMID:34964128. |
treatment with n-acetylcysteine (nac) reversed hg-induced cell apoptosis and extracellular matrix (ecm) degradation. |
2021-12-29 |
2023-08-13 |
human |
| Jinquan Hu, Qiang Yan, Hanran Jiang, Chen Xu, Yu Chen, Wen Yua. A decrease in IL-33 regulates matrix degradation and apoptosis in intervertebral disc degeneration via HIF-1alpha. American journal of translational research. vol 13. issue 11. 2021-12-27. PMID:34956487. |
a decrease in il-33 regulates matrix degradation and apoptosis in intervertebral disc degeneration via hif-1alpha. |
2021-12-27 |
2023-08-13 |
Not clear |
| Zhen Wang, Jianxiong Shen, Erwei Feng, Yang Jia. AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration. Frontiers in molecular biosciences. vol 8. 2021-12-27. PMID:34957218. |
degenerative discs display a series of characteristic pathological changes, including cell apoptosis, senescence, remodeling of extracellular matrix, oxidative stress and inflammatory local microenvironment. |
2021-12-27 |
2023-08-13 |
Not clear |
| Mikhail A Novikov, Eugeniy A Titov, Larisa M Sosedova, Viktor S Rukavishnikov, Vera A Vokina, Oleg L Lakhma. Comparative Assessment of Silver Nanocomposites' Biological Effects on the Natural and Synthetic Matrix. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948053. |
we found that the effect of the nanocomposite on the arabinogalactan matrix causes a disturbance in the nervous tissue structure, an increase in the area of mitochondria, a disturbance of the structure of nerve cells, and activation of the process of apoptosis. |
2021-12-24 |
2023-08-13 |
rat |
| Yonggan Ji, Hongli Fan, Mengmeng Yang, Changcai Bai, Wen Yang, Zhisheng Wan. Synergistic effect of baculovirus-mediated endostatin and angiostatin combined with gemcitabine in hepatocellular carcinoma. Biological & pharmaceutical bulletin. 2021-12-23. PMID:34937830. |
the results showed that the combined group significantly inhibited (p<0.05 or p<0.01 or p<0.001) the growth of tumor weight and volume, reduced the expression of ki67 (cell proliferation marker), cd31 (angiogenic marker) and matrix metalloproteinase 9 (mmp-9, tumor invasion and metastasis marker) and increased the apoptosis of tumor cells compared with the monotherapy and control groups, respectively. |
2021-12-23 |
2023-08-13 |
mouse |