| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Ran, Hai-Yang Liao, Zhi-Qiang Wang, Chao-Yang Gong, Kai-Sheng Zhou, Hai-Hong Zhan. Mechanisms and functions of long noncoding RNAs in intervertebral disc degeneration. Pathology, research and practice. vol 235. 2022-06-02. PMID:35653923. |
these changes are closely related to cell proliferation, apoptosis, senescence, autophagy, inflammation, and extracellular matrix (ecm) remodeling. |
2022-06-02 |
2023-08-14 |
Not clear |
| Waheed-Ul-Rahman Ahmed, Sam Kleeman, Michael Ng, Wei Wang, Adam Auton, Regent Lee, Ashok Handa, Krina T Zondervan, Akira Wiberg, Dominic Furnis. Genome-wide association analysis and replication in 810,625 individuals with varicose veins. Nature communications. vol 13. issue 1. 2022-06-02. PMID:35654884. |
pathway analysis identified enrichment in extracellular matrix biology, inflammation, (lymph)angiogenesis, vascular smooth muscle cell migration, and apoptosis. |
2022-06-02 |
2023-08-14 |
Not clear |
| Xuancheng Zhang, Ang Li, Kang Han, He Zhang, Xiaoqiao Huangfu, Jinghuan Huang, Jia Jiang, Jinzhong Zha. Anti-inflammatory and Tendon-Protective Effects of Adipose Stem Cell-Derived Exosomes with Concomitant Use of Glucocorticoids. Stem cells international. vol 2022. 2022-06-01. PMID:35646125. |
in vitro cytoprotective analysis showed that asc-exos overrode gc-induced detrimental effects on tenocytes by significantly improving gc-suppressed cellular proliferation, migration, and transcription of tenocytic matrix molecules and degradative enzyme inhibitors and significantly decreasing gc-induced cell senescence, apoptosis, and transcription of ros and tenocytic degradative enzymes. |
2022-06-01 |
2023-08-13 |
Not clear |
| Ming Zhao, Darren Finlay, Robert Liddington, Kristiina Vuor. SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK. Autophagy reports. vol 1. issue 1. 2022-06-01. PMID:35647611. |
cell detachment from the extracellular matrix (ecm) typically promotes cell death via a form of apoptosis known as anoikis. |
2022-06-01 |
2023-08-13 |
Not clear |
| Peng Luo, Qishan Huang, Suo Chen, Yinghui Wang, Haicheng Do. Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway. International immunopharmacology. vol 108. 2022-05-27. PMID:35623293. |
osteoarthritis has become the fourth cause of disability in the world and its occurrence and development are caused by apoptosis and extracellular matrix (ecm) degradation of chondrocytes. |
2022-05-27 |
2023-08-13 |
mouse |
| Su'an Tang, Yumei Cao, Zhaopeng Cai, Xiaoyu Nie, Jianzhao Ruan, Zuoqing Zhou, Guangfeng Ruan, Zhaohua Zhu, Weiyu Han, Changhai Din. The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1. Science signaling. vol 15. issue 735. 2022-05-24. PMID:35609127. |
knockdown of pila inhibited tnf-induced nf-κb signaling, extracellular matrix catabolism, and apoptosis in chondrocytes, whereas ectopic expression of pila promoted nf-κb signaling and matrix degradation. |
2022-05-24 |
2023-08-13 |
mouse |
| Fabiao Hu, Changping Deng, Yiwen Zhou, Yuping Liu, Tong Zhang, Peiwen Zhang, Zhangting Zhao, Hui Miao, Wenyun Zheng, Wenliang Zhang, Meiyan Wang, Xingyuan M. Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy. Bioengineering & translational medicine. vol 7. issue 2. 2022-05-23. PMID:35600646. |
fts (fth1-matrix metalloproteinase-2-tmsm)/ym155 nc synthesis was easily scaled up, and these ncs could sequentially release tmsm protein through matrix metalloproteinase-2 and promote ym155 to enter the nucleus via transferrin receptor 1 (tfr1) binding, which increased the cytotoxicity and apoptosis of capan-2 and a549 cells compared to that with individual drugs. |
2022-05-23 |
2023-08-13 |
mouse |
| Binte Zehra, Ayaz Ahmed, Ajmal Khan, Afshan Shams, Reaz Uddin, Sidra Rafi, Taseer Ahmed Khan, Umar Farooq, Syed Abid Al. Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2022-05-23. PMID:35604429. |
sesquiterpene from polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in nci-h460 cells. |
2022-05-23 |
2023-08-13 |
Not clear |
| Dan Li, Dongdong Luo, Hu Su, Hailin Zhao, Biao Pen. Syringic acid suppressed proliferation, invasion, and migration via inhibition of matrix metalloproteinases expression on glioblastoma cells by promoting apoptosis. Current pharmaceutical biotechnology. 2022-05-16. PMID:35570553. |
syringic acid suppressed proliferation, invasion, and migration via inhibition of matrix metalloproteinases expression on glioblastoma cells by promoting apoptosis. |
2022-05-16 |
2023-08-13 |
human |
| Massimiliano Marvasi, Monica Monici, Desirée Pantalone, Duccio Cavalier. Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions. Frontiers in bioengineering and biotechnology. vol 10. 2022-05-16. PMID:35573226. |
microgravity and possible physical factors associated with space affect alterations in fibroblast, matrix formation, dysregulation in apoptosis and inflammation. |
2022-05-16 |
2023-08-13 |
human |
| Chao-Peng He, Cheng Chen, Xin-Chen Jiang, Hui Li, Li-Xin Zhu, Ping-Xiao Wang, Tao Xia. The role of AGEs in pathogenesis of cartilage destruction in osteoarthritis. Bone & joint research. vol 11. issue 5. 2022-05-13. PMID:35549515. |
in recent years, it has been found that ages are involved in a variety of pathological processes of oa, including extracellular matrix degradation, chondrocyte apoptosis, and autophagy. |
2022-05-13 |
2023-08-13 |
Not clear |
| Lixia Gao, Xiaoyun Wang, Jian Xiong, Yan M. Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1β via circPDE4D/miR-4306/SOX9 cascade. Immunopharmacology and immunotoxicology. 2022-05-13. PMID:35549803. |
circular rna from phosphodiesterase 4d can attenuate chondrocyte apoptosis and matrix degradation under oa milieu induced by il-1β via circpde4d/mir-4306/sox9 cascade. |
2022-05-13 |
2023-08-13 |
human |
| Edward Hurley, Junyan Tao, Silvia S Liu, Yekaterina Krutsenko, Satdarshan P Mong. HSF1 Signaling Inhibits Apoptosis in Hepatoblastoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554956. |
recent work has shown that hsf1 controls a suite of genes in cancer related to apoptosis, cell cycle signaling, dna repair, energy metabolism and extracellular matrix formation. |
2022-05-13 |
2023-08-13 |
mouse |
| Faihaa Ahmed, Shaymaa Abousaad, Ayman Abouzeid, Elimelda Onger. Meprin β mediates Osteopontin-Signaling in IR-Induced Acute Kidney Injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555103. |
opn mediates cell signaling pathways involved in apoptosis and extracellular matrix metabolism. |
2022-05-13 |
2023-08-13 |
mouse |
| Vasileios Kapralos, Jannis Böcker, Kirstin Vach, Markus Altenburger, Susanne Proksch, Lamprini Karygiann. On the biocompatibility of endodontic sealers. Swiss dental journal. vol 132. issue 9. 2022-05-10. PMID:35536041. |
while all sealers influenced the cell morphology and the expression of genes associated with apoptosis (casp3), proliferation (histone h3), and inflammation (interleukin-6 and matrix metalloproteinases 1 and 3), mainly ah plus® and apexit® yielded a regular actin cytoskeleton and beneficial gene expression patterns. |
2022-05-10 |
2023-08-13 |
human |
| Minglei Qian, Yuanxin Shi, Wei L. LINC00707 knockdown inhibits IL-1β-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the miR-330-5p/FSHR axis. Immunopharmacology and immunotoxicology. 2022-05-10. PMID:35536095. |
linc00707 knockdown inhibits il-1β-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the mir-330-5p/fshr axis. |
2022-05-10 |
2023-08-13 |
Not clear |
| Jialing Xiao, Yali Li, Gang Cheng, Guochao X. Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-05-09. PMID:35529473. |
cell viability, apoptosis, mrna, and protein expression of relevant genes involved in extracellular matrix (ecm) degradation, apoptosis, and wnt/β-catenin signaling were examined. |
2022-05-09 |
2023-08-13 |
rabbit |
| Kai Sun, Li-Guo Zhu, Xu Wei, He Yin, Jia-Wen Zhan, Xun-Lu Yin, Tao Ha. [Research progress in mechanism of Chinese herbal compounds and monomers in delaying lumbar intervertebral disc degeneration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531687. |
the main molecular mechanisms by which herbal compound and monomeric components delay of lumbar intervertebral disc degeneration include improving the intervertebral disc microenvironment, promoting the synthesis of aggregated proteoglycans and type Ⅱ collagen in the intervertebral disc, reducing the degradation of the extracellular matrix, and inhibiting apoptosis in the nucleus pulposus cells, etc. |
2022-05-09 |
2023-08-13 |
Not clear |
| Chaofan Zhang, Yunzhi Lin, Chun Hoi Yan, Wenming Zhan. Adipokine Signaling Pathways in Osteoarthritis. Frontiers in bioengineering and biotechnology. vol 10. 2022-05-06. PMID:35519618. |
increasing evidence show that various adipokines may significantly affect the development or clinical course of oa by regulating the pro/anti-inflammatory and anabolic/catabolic balance, matrix remodeling, chondrocyte apoptosis and autophagy, and subchondral bone sclerosis. |
2022-05-06 |
2023-08-13 |
Not clear |
| I Yilmaz, N Karaarsla. Examining the effects of HMG-CoA reductase inhibitors on anabolic and catabolic signaling pathway proteins associated with degenerative disc disease. European review for medical and pharmacological sciences. vol 26. issue 8. 2022-05-03. PMID:35503599. |
additionally, nuclear factor kappa b (nf-κb) is reported to be suppressed in statin-administered nucleus pulposus (np) cells for the prevention of interleukin (il) -1 beta (il-1β)-induced apoptosis and extracellular matrix (ecm) degradation. |
2022-05-03 |
2023-08-13 |
human |