| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G-M Cao, X-Z Xuan, H-L Don. Low expression of integrin signaling pathway genes is associated with abdominal aortic aneurysm: a bioinformatic analysis by WGCNA. European review for medical and pharmacological sciences. vol 26. issue 8. 2022-05-03. PMID:35503629. |
aaa is pathologically distinguished by atherosclerotic thrombosis, immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. |
2022-05-03 |
2023-08-13 |
Not clear |
| Olesya A Puchenkova, Vladislav O Soldatov, Andrei E Belykh, OlgaYu Bushueva, Gennadii A Piavchenko, Artem A Venediktov, Nikolay K Shakhpazyan, Alexey V Deykin, Mikhail V Korokin, Mikhail V Pokrovski. Cytokines in Abdominal Aortic Aneurysm: Master Regulators With Clinical Application. Biomarker insights. vol 17. 2022-05-02. PMID:35492378. |
all the inflammatory cascades, extracellular matrix degradation and vascular smooth muscle cell apoptosis are driven by cytokines. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jingguo Xin, Yongjie Wang, Zhi Zheng, Shuo Wang, Shibo Na, Shaokun Zhan. Treatment of Intervertebral Disc Degeneration. Orthopaedic surgery. 2022-04-29. PMID:35486489. |
the pathological changes of idd are mainly composed of the senescence and apoptosis of nucleus pulposus cells (npcs), the progressive degeneration of extracellular matrix (ecm), the fibrosis of annulus fibrosus (af), and the inflammatory response. |
2022-04-29 |
2023-08-13 |
Not clear |
| Yijian Zhang, Tao Liu, Huilin Yang, Fan He, Xuesong Zh. Melatonin: A Novel Candidate for the Treatment of Osteoarthritis. Ageing research reviews. 2022-04-28. PMID:35483626. |
with regards to oa, melatonin reportedly promotes synthesis of cartilage matrix, inhibition of chondrocyte apoptosis, attenuation of inflammatory response, and suppression of matrix degradation by regulating the tgf-β, mapk, or nf-κb signaling pathways. |
2022-04-28 |
2023-08-13 |
Not clear |
| Guowen Li, Heyuan Luo, Zhiyong Ding, Haofeng Liang, Zhoupeng Lai, Shuzhen Chen, Yuliang Huan. Silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting miR-766-3p/ADAMTS5 axis. Innate immunity. vol 28. issue 2. 2022-04-28. PMID:35484121. |
silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting mir-766-3p/adamts5 axis. |
2022-04-28 |
2023-08-13 |
Not clear |
| Guowen Li, Heyuan Luo, Zhiyong Ding, Haofeng Liang, Zhoupeng Lai, Shuzhen Chen, Yuliang Huan. Silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting miR-766-3p/ADAMTS5 axis. Innate immunity. vol 28. issue 2. 2022-04-28. PMID:35484121. |
cell proliferation, apoptosis, and extracellular matrix (ecm) synthesis were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and 5-ethynyl-2-deoxyuridine assays, flow cytometry, and qrt-pcr and western blot assays. |
2022-04-28 |
2023-08-13 |
Not clear |
| Guowen Li, Heyuan Luo, Zhiyong Ding, Haofeng Liang, Zhoupeng Lai, Shuzhen Chen, Yuliang Huan. Silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting miR-766-3p/ADAMTS5 axis. Innate immunity. vol 28. issue 2. 2022-04-28. PMID:35484121. |
il-1β treatment could attenuate cell viability of primary chondrocytes and proliferating cell nuclear antigen (pcna) and collagen ii type alpha-1 (col2a1) levels, and elevate apoptosis rate and cleaved caspase-3, adamts5 and matrix metalloproteinase-13 (mmp13) levels, suggesting that il-1β induced chondrocyte apoptosis and ecm degradation. |
2022-04-28 |
2023-08-13 |
Not clear |
| Shunlun Chen, Linchuan Lei, Zemin Li, Fan Chen, Yuming Huang, Guowei Jiang, Xingyu Guo, Zhuoyang Zhao, Hui Liu, Hua Wang, Caijun Liu, Zhaomin Zheng, Jianru Wan. Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation. Experimental & molecular medicine. 2022-04-20. PMID:35440754. |
these results indicated that the expression of grem1 was positively correlated with the severity of intervertebral disc degeneration, and grem1 sirna could inhibit grem1-induced apoptosis and extracellular matrix alterations by mediating the tgf-β/smad signaling pathway. |
2022-04-20 |
2023-08-13 |
human |
| Xi Yang, Lianqin Tao, Yani Xu, Sujian Li, Weiwei Yang, Lijuan Wang, Junfei Zh. CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis. Bioengineered. vol 13. issue 4. 2022-04-20. PMID:35441564. |
circmyc promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting mir-145/ matrix metallopeptidase 2 axis. |
2022-04-20 |
2023-08-13 |
human |
| Karen Jung, Megan A Pawluk, Michael Lane, Layla Nabai, David J Granvill. Granzyme B in Epithelial Barrier Dysfunction and Related Skin Diseases. American journal of physiology. Cell physiology. 2022-04-20. PMID:35442832. |
discovered in the 1980s, granzyme b is currently recognized for its intracellular roles in immune cell-mediated targeted apoptosis as well as extracellular roles in inflammation, chronic injuries, tissue remodeling, and processing of cytokines, matrix proteins, and autoantigens. |
2022-04-20 |
2023-08-13 |
Not clear |
| Zhijun Cai, Yi Cui, Jing Wang, Xin Qi, Pengju He, Pengfei Bu, Yongqing Xu, Yang L. A narrative review of the progress in the treatment of knee osteoarthritis. Annals of translational medicine. vol 10. issue 6. 2022-04-18. PMID:35433989. |
there is evidence that inflammatory factors, abnormal chondrocyte apoptosis, and extracellular matrix degradation are closely associated with the occurrence and development of oa. |
2022-04-18 |
2023-08-13 |
Not clear |
| Erika P New, Nihan Semerci, Asli Ozmen, Xiaofang Guo, Venkata A Jonnalagadda, Joung Woul Kim, Matthew L Anderson, Ozlem Guzeloglu-Kayisli, Anthony N Imudia, Charles J Lockwood, Umit A Kayisl. FKBP51 Contributes to Uterine Leiomyoma Pathogenesis by Inducing Cell Proliferation and Extracellular Matrix Deposition. Reproductive sciences (Thousand Oaks, Calif.). 2022-04-15. PMID:35426036. |
control (scramble) vs. fkbp5 sirna-transfected leiomyoma cell cultures were assessed for proliferation, apoptosis, and mrna levels of genes involved in cell survival and extracellular matrix (ecm) formation. |
2022-04-15 |
2023-08-13 |
human |
| Yao Hai, Cao Zhidong, Wu Wenya. Human umbilical cord mesenchymal stromal cells promotes the proliferation and osteogenic differentiation of autologous bone marrow stem cells by secreting exosomes. Bioengineered. vol 13. issue 4. 2022-04-12. PMID:35412945. |
the results indicated that humscs could increase the proliferation of abmscs, reduce apoptosis, and promote matrix metabolism. |
2022-04-12 |
2023-08-13 |
human |
| Liang Qi, Min Wang, Jinlong He, Bin Jia, Jing Ren, Shicheng Zhen. E3 ubiquitin ligase ITCH improves LPS-induced chondrocyte injury by mediating JAG1 ubiquitination in osteoarthritis. Chemico-biological interactions. 2022-04-06. PMID:35385713. |
overexpressing itch or silencing jag1 promoted proliferation, and restrained apoptosis, inflammation and extracellular matrix (ecm) degradation in lps-stimulated chondrocytes. |
2022-04-06 |
2023-08-13 |
mouse |
| Chao Gao, Xiaolei Lin, Fan Fan, Xin Liu, Huijuan Wan, Ting Yuan, Xinrong Zhao, Yi Lu. Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts. BMC ophthalmology. vol 22. issue 1. 2022-04-05. PMID:35379202. |
transforming growth factor (tgf) is a cytokine that acts on the proliferation, migration, differentiation, and apoptosis of cells and the accumulation of extracellular matrix components. |
2022-04-05 |
2023-08-13 |
Not clear |
| Ok Joo Sul, Jin Hyoung Kim, Taehoon Lee, Kwang Won Seo, Hee Jeong Cha, Byungsuk Kwon, Jong-Joon Ahn, You Sook Cho, Yeon-Mok Oh, Yangjin Jegal, Seung Won R. GSPE Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice via Ameliorating Epithelial Apoptosis through Inhibition of Oxidative Stress. Oxidative medicine and cellular longevity. vol 2022. 2022-03-31. PMID:35355866. |
idiopathic pulmonary fibrosis (ipf) is a chronic, progressive interstitial lung disease of unknown cause which leads to alveolar epithelial cell apoptosis followed by basement membrane disruption and accumulation of extracellular matrix, destroying the lung architecture. |
2022-03-31 |
2023-08-13 |
mouse |
| Siam-Yee Lee, Pooi-Fong Wong, Juliana Jamal, Margaret M Roebuc. Naturally-derived endoplasmic reticulum stress inhibitors for osteoarthritis? European journal of pharmacology. 2022-03-30. PMID:35351442. |
chondrocytes have limited proliferative capacity and their apoptosis eventually leads to extracellular matrix loss and cartilage degeneration. |
2022-03-30 |
2023-08-13 |
Not clear |
| Fangyuan Chen, Jingyue Deng, Lishi Luo, Ying Zhu, Yuying Dong, Yuanting Yang, Rijia Zhang, Jian Chen, Qing Zho. Crosslinked Decellularized Porcine Pericardium as a Substrate for Conjunctival Reconstruction. Stem cells international. vol 2022. 2022-03-28. PMID:35342430. |
in vitro dpp showed lower apoptosis, highly desirable, well preservation of extracellular matrix components, and favorable macro-microstructure, which was confirmed by histology, immunofluorescence, electron microscopy, collagen and dna quantification, and cytotoxicity assay, compared to the native porcine pericardium (npp). |
2022-03-28 |
2023-08-13 |
human |
| Bessi Qorri, Reza Bayat Mokhtari, William W Harless, Myron R Szewczu. Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression. Cancers. vol 14. issue 6. 2022-03-25. PMID:35326525. |
to assess the key survival pathways critical for pancreatic cancer progression, we used the alamarblue cytotoxicity assay to determine the cell viability and combination index for the drug combinations, flow cytometric analysis of annexin v apoptosis assay to detect apoptotic and necrotic cells, fluorometric qcm™ chemotaxis migration assay to assess cellular migration, fluorometric extracellular matrix (ecm) cell adhesion array kit to assess the expression of the ecm proteins, scratch wound assay using the 96-well woundmaker™, and the methylcellulose clonogenic assay to assess clonogenic potential. |
2022-03-25 |
2023-08-13 |
human |
| Bessi Qorri, Reza Bayat Mokhtari, William W Harless, Myron R Szewczu. Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression. Cancers. vol 14. issue 6. 2022-03-25. PMID:35326525. |
the combination of asa and op with gem significantly upended miapaca-2 and panc-1 pancreatic cancer cell viability, clonogenic potential, expression of critical extracellular matrix proteins, migration, and promoted apoptosis. |
2022-03-25 |
2023-08-13 |
human |