| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Zhang, Shiqi Zhao, Xuejie Han, Yun Zhang, Xuexin Jin, Yue Yuan, Xinbo Zhao, Yingchun Luo, Yun Zhou, Yunlong Gao, Hui Yu, Danghui Sun, Wei Xu, Sen Yan, Yongtai Gong, Yue L. Lnc-C2orf63-4-1 Confers VSMC Homeostasis and Prevents Aortic Dissection Formation via STAT3 Interaction. Frontiers in cell and developmental biology. vol 9. 2021-12-23. PMID:34938738. |
besides, overexpression of lnc-c2orf63-4-1 significantly attenuated ang ii-induced apoptosis, phenotypic switching of vsmcs and degradation of extracellular matrix both |
2021-12-23 |
2023-08-13 |
Not clear |
| Zhenzhen Wang, Liyuan Ji, Yimeng Ren, Menghan Liu, Xiaoyu Ai, Cheng Yan. Preparation and Anti-tumor Study of Dextran 70,000-Selenium Nanoparticles and Poloxamer 188-Selenium Nanoparticles. AAPS PharmSciTech. vol 23. issue 1. 2021-12-21. PMID:34931279. |
t70-senps and p188-senps can aggregate in cell matrix and play an anti-tumor role to hepg2 by promoting apoptosis, increasing reactive oxygen species (ros) content and reducing mitochondrial membrane potential (mmp). |
2021-12-21 |
2023-08-13 |
Not clear |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
tert-butylhydroquinone prevents oxidative stress-mediated apoptosis and extracellular matrix degradation in rat chondrocytes. |
2021-12-20 |
2023-08-13 |
rat |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
oxidative stress-induced chondrocyte apoptosis and degradation of the extracellular matrix (ecm) play an important role in the progression of osteoarthritis (oa). |
2021-12-20 |
2023-08-13 |
rat |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
the present study aimed to determine the effectiveness of tbhq in preventing the apoptosis of chondrocytes and degradation of the extracellular matrix, induced by oxidative stress, in vitro. |
2021-12-20 |
2023-08-13 |
rat |
| Fudong Li, Xiaofei Sun, Bing Zheng, Kaiqiang Sun, Jian Zhu, Chenglong Ji, Feng Lin, Le Huan, Xi Luo, Chen Yan, Jiashun Xu, Yun Hong, Yuan Wang, Ximing Xu, Jingchuan Sun, Zheming Song, Fanqi Kong, Jiangang Sh. Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation Frontiers in cell and developmental biology. vol 9. 2021-12-20. PMID:34926442. |
based on previous studies, we hypothesized that arg2 deficiency might be conducive to the treatment of idd by inhibiting the dyshomeostasis of the extracellular matrix (ecm), and the oxidative stress and inflammatory response-induced senescence and apoptosis |
2021-12-20 |
2023-08-13 |
Not clear |
| Jialei Chen, Xi Yu, Xiang Zhan. Advances on biological functions of exosomal non-coding RNAs in osteoarthritis. Cell biochemistry and function. 2021-12-18. PMID:34921424. |
exosomal ncrnas are involved in pathological processes of osteoarthritis, such as proliferation, migration, chondrogenesis, chondrocyte differentiation induction, extracellular matrix formation, apoptosis, and inflammation. |
2021-12-18 |
2023-08-13 |
Not clear |
| Yu Dai, Can Jian, Xiaofeng Wang, Xiaoxia Da. Comprehensive expression profiles of mRNAs, lncRNAs and miRNAs in Kashin-Beck disease identified by RNA-sequencing. Molecular omics. 2021-12-16. PMID:34913457. |
kashin-beck disease (kbd) is a chronic, endemic and deforming osteochondropathy, whose basic pathological alterations include apoptosis and necrosis of chondrocytes in articular cartilage and growth plates and imbalanced extracellular matrix metabolism. |
2021-12-16 |
2023-08-13 |
Not clear |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Qinhao Shen, Yiwen Xiao, Bei Cheng, Zheyi Sun, Yu Hu, Hefeng Yang, Yingwei Lu. PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway. The international journal of biochemistry & cell biology. vol 141. 2021-12-11. PMID:34715362. |
prmt1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the akt/foxo1 signaling pathway. |
2021-12-11 |
2023-08-13 |
rat |
| Qinhao Shen, Yiwen Xiao, Bei Cheng, Zheyi Sun, Yu Hu, Hefeng Yang, Yingwei Lu. PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway. The international journal of biochemistry & cell biology. vol 141. 2021-12-11. PMID:34715362. |
temporomandibular joint osteoarthritis (tmjoa) is a chronic degenerative joint disease characterized by extracellular matrix (ecm) degradation and chondrocyte apoptosis. |
2021-12-11 |
2023-08-13 |
rat |
| Jiashu Yang, Ming Zhang, Dawei Yang, Yunfei Ma, Yuting Tang, Mengying Xing, Lingyun Li, Li Chen, Yucui Jin, Changyan M. m Experimental & molecular medicine. vol 53. issue 11. 2021-12-11. PMID:34737423. |
functional assays showed that ectopic expression of ac008, aqp1, and ankh significantly decreased chondrocyte viability and promoted chondrocyte apoptosis and extracellular matrix (ecm) degradation, whereas knockdown of ac008, aqp1, and ankh resulted in the opposite effects. |
2021-12-11 |
2023-08-13 |
Not clear |
| Guangming Ren, Liming Xu, Jingzhuang Zhao, Yizhi Shao, Tongyan Lu, Qiya Zhan. Comparative transcriptome analysis of long non coding RNA (lncRNA) in RTG-2 cells infected by infectious hematopoietic necrosis virus. Fish & shellfish immunology. vol 120. 2021-12-11. PMID:34890776. |
further analysis found that some de-lncrnas might participate in the regulation of extracellular matrix metabolism, apoptosis, lipid synthesis, autophagy, and immune responses referring to the functions of their target genes. |
2021-12-11 |
2023-08-13 |
Not clear |
| Paloma Ruiz-Blázquez, Valeria Pistorio, María Fernández-Fernández, Anna Mole. The multifaceted role of cathepsins in liver disease. Journal of hepatology. vol 75. issue 5. 2021-12-10. PMID:34242696. |
they can operate alone or as part of signalling cascades and regulatory circuits, playing important roles in apoptosis, extracellular matrix remodelling, hepatic stellate cell activation, autophagy and metastasis, contributing to the initiation, development and progression of liver disease. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sarah J Richardson, Alberto Puglies. 100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story. The Journal of endocrinology. vol 252. issue 2. 2021-12-10. PMID:34755679. |
additionally, there are changes affecting extracellular matrix components, evidence of viral infections, inflammation, and er stress, which could contribute to beta-cell dysfunction and the stimulation of apoptosis and autoimmunity. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sadia Perveen, Daniela Rossin, Emanuela Vitale, Rachele Rosso, Roberto Vanni, Caterina Cristallini, Raffaella Rastaldo, Claudia Giachin. Therapeutic Acellular Scaffolds for Limiting Left Ventricular Remodelling-Current Status and Future Directions. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884856. |
following mi, the hypoxic microenvironment triggers apoptosis, disrupts the extracellular matrix and forms a non-functional scar that leads towards adverse left ventricular (lv) remodelling. |
2021-12-10 |
2023-08-13 |
Not clear |
| Xiaohe Li, Hailong Li, Shanshan Zhang, Ruotong Zhang, Jinhe Li, Yiying Wei, Cheng Yang, Fubo Zhang, Honggang Zho. Protective effect of Idelalisib on carbon tetrachloride-induced liver fibrosis via microRNA-124-3P/phosphatidylinositol-3-hydroxykinase signalling pathway. Journal of cellular and molecular medicine. vol 25. issue 24. 2021-12-07. PMID:34747105. |
inhibition of pi3k/akt signalling pathway can reduce the deposition of extracellular matrix, inhibit the proliferation of hepatic stellate cells (hscs), and promote its apoptosis to achieve the purpose of therapy. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuai Huang, Kai Luo, Li Jiang, Xu-Dong Zhang, Ying-Hao Lv, Ren-Feng L. PCBP1 regulates the transcription and alternative splicing of metastasis‑related genes and pathways in hepatocellular carcinoma. Scientific reports. vol 11. issue 1. 2021-12-07. PMID:34857818. |
we obtained and analysed pcbp1-knockdown rna-seq data and eclip-seq data of pcbp1 in hepg2 cells and found that pcbp1 widely regulates the alternative splicing and expression of genes enriched in cancer-related pathways, including extracellular matrix, cell adhesion, small molecule metabolic process and apoptosis. |
2021-12-07 |
2023-08-13 |
human |
| Manipa Saha, Neha Deshpande, Abhinav Dubey, Debnath Pal, Hanudatta S Atreya, Annapoorni Rangaraja. Sustained AMPK Activation and Proline Metabolism Play Critical Roles in the Survival of Matrix-Deprived Transformed Cells. Frontiers in cell and developmental biology. vol 9. 2021-12-07. PMID:34869367. |
attachment to the matrix is critical for the survival of adherent cells, whereas detachment triggers death by apoptosis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Qian Wang, Zhaoyang Chen, Xiaoping Peng, Zeqi Zheng, Aiping Le, Junjie Guo, Leilei Ma, Hongtao Shi, Kang Yao, Shuning Zhang, Zhenzhong Zheng, Jianbing Zh. Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages. Frontiers in cardiovascular medicine. vol 8. 2021-12-07. PMID:34869700. |
improved outcomes in neu1 cko mice subjected to bapn treatment were associated with the ameliorated vascular inflammation, lowered apoptosis, decreased reactive oxygen species production, mitigated extracellular matrix degradation, and improved m2 macrophage polarization. |
2021-12-07 |
2023-08-13 |
mouse |