| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinjie Wu, Wei Su. Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration. Frontiers in cell and developmental biology. vol 9. 2022-01-31. PMID:35096823. |
intervertebral disc degeneration (ivdd) is the leading cause of low back pain related to degradation of cartilaginous tissues, mainly resulting from oxidative stress, cell apoptosis, and extracellular matrix degradation. |
2022-01-31 |
2023-08-13 |
Not clear |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
high hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the wnt/β-catenin pathway. |
2022-01-31 |
2023-08-13 |
human |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
appropriate hydrostatic stimulation (3 atm) enhanced the viability and proteoglycan synthesis yet inhibited the apoptosis of hnpcs, which also up-regulated extracellular matrix and collagen-ii levels, and down-regulated mmp3, wnt-3a and β-catenin levels in treated hnpcs. |
2022-01-31 |
2023-08-13 |
human |
| Zongting Shi, Jun He, Jian He, Yuan X. High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway. Bioengineered. vol 13. issue 2. 2022-01-31. PMID:35100096. |
furthermore, high hydrostatic pressure (30 atm) inhibited the viability and proteoglycan synthesis, and promoted the morphological change and apoptosis of hnpcs, which also down-regulated extracellular matrix and collagen-ii levels and up-regulated mmp3, wnt-3a and β-catenin levels. |
2022-01-31 |
2023-08-13 |
human |
| Shuo Yang, Wenbo Lia. Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069863. |
hydroxysafflor yellow a attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via ca xii. |
2022-01-24 |
2023-08-13 |
cat |
| Guoshuai Cao, Sidong Yang, Jianye Cao, Zixuan Tan, Linyu Wu, Fang Dong, Wenyuan Ding, Feng Zhan. The Role of Oxidative Stress in Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2022. 2022-01-24. PMID:35069969. |
idd is known to be associating with a complex process involving in extracellular matrix and cellular damage, and in recent years, there is increasing evidence that oxidative stress is an important activation mechanism of idd and that reactive oxygen and reactive nitrogen species regulate matrix metabolism, proinflammatory phenotype, autophagy and senescence in intervertebral disc cells, apoptosis, autophagy, and senescence. |
2022-01-24 |
2023-08-13 |
Not clear |
| Derong Xu, Xuexiao Ma, Chong Sun, Jialuo Han, Chuanli Zhou, Sunny Hei Wong, Matthew T V Chan, William K K W. Circular RNAs in Intervertebral Disc Degeneration: An Updated Review. Frontiers in molecular biosciences. vol 8. 2022-01-24. PMID:35071323. |
emerging evidence suggests that circular rnas (circrnas), a major type of regulatory non-coding rna, play critical roles in cellular processes that are pertinent to idd development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition. |
2022-01-24 |
2023-08-13 |
Not clear |
| Mi Na Kim, Jung Yeon Hong, Eun Gyul Kim, Jae Woo Lee, Soo Yeon Lee, Kyung Won Kim, Hyo Sup Shim, Chun Geun Lee, Jack A Elias, Yong Ju Lee, Myung Hyun Soh. A Novel Regulatory Role of ALCAM in the Pathogenesis of Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022-01-24. PMID:35073245. |
idiopathic pulmonary fibrosis is a chronic, progressive lung disease characterized by fibroproliferative matrix molecule accumulation, collagen deposition, and apoptosis. |
2022-01-24 |
2023-08-13 |
mouse |
| Funmilayo O Adeshakin, Adeleye O Adeshakin, Zhao Liu, Jian Cheng, Pengchao Zhang, Dehong Yan, Guizhong Zhang, Xiaochun Wa. Targeting Oxidative Phosphorylation-Proteasome Activity in Extracellular Detached Cells Promotes Anoikis and Inhibits Metastasis. Life (Basel, Switzerland). vol 12. issue 1. 2022-01-21. PMID:35054435. |
anoikis-the apoptosis of detached cells (from the extracellular matrix (ecm)) is often circumvented by metastatic cells as a result of biochemical and molecular transformations. |
2022-01-21 |
2023-08-13 |
Not clear |
| Hao Chen, Jiarui Ma, Jin Liu, Lin Dou, Tao Shen, Huiyan Zuo, Fangzhi Xu, Li Zhao, Weiqing Tang, Yong Man, Yanyan Ma, Jian Li, Xiuqing Huan. Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes. FEBS letters. 2022-01-19. PMID:35043979. |
lpc-induced rounding of cells reduced both cell-extracellular matrix (ecm) adhesion and cell-cell junctions, which promoted detachment-induced apoptosis (defined as anoikis) in hepatocytes. |
2022-01-19 |
2023-08-13 |
Not clear |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
aloin regulates matrix metabolism and apoptosis in human nucleus pulposus cells via the tak1/nf- intervertebral disc degeneration (idd) is a degenerative disease that is characterized by decreased matrix synthesis and extra degradation, nucleus pulposus cells (npcs) apoptosis, and infiltration of inflammatory factors. |
2022-01-17 |
2023-08-13 |
human |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
in our study, the upregulation of proinflammatory factors, apoptosis, and unbalanced matrix metabolism were observed in degenerative np tissues. |
2022-01-17 |
2023-08-13 |
human |
| Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Lian. Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF- Stem cells international. vol 2022. 2022-01-17. PMID:35035490. |
we found that aloin had a curative effect on extracellular matrix metabolism and apoptosis in tnf-alpha- (tnf- |
2022-01-17 |
2023-08-13 |
human |
| Dan Liu, Wei Liu, Limin Jiang, Shengjie Dong, Weihua Ma, Shijun Wang, Chao Wa. Silencing of TLR7 protects against lipopolysaccharide-induced chondrocyte apoptosis and injury by blocking the p21-mediated JAK2/STAT3 pathway. American journal of translational research. vol 13. issue 12. 2022-01-17. PMID:35035696. |
in this study, we sought to investigate the contribution of tlr7 in regulating chondrocyte apoptosis, inflammation, and degradation of the extracellula matrix (ecm), and its underlying mechanisms. |
2022-01-17 |
2023-08-13 |
Not clear |
| Huanzhi Ma, Wei Zhang, Jun Sh. Differentially Expressed Genes Reveal the Biomarkers and Molecular Mechanism of Osteonecrosis. Journal of healthcare engineering. vol 2022. 2022-01-17. PMID:35035862. |
the go enrichment showed that osteonecrosis was related with extracellular matrix, external encapsulating structure organization, skeletal system development, immune response activity, cell apoptosis, mononuclear cell differentiation, and serine/threonine kinase activity. |
2022-01-17 |
2023-08-13 |
Not clear |
| Yixuan Amy Pei, Song Chen, Ming Pe. The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair. Cellular and molecular life sciences : CMLS. vol 79. issue 1. 2022-01-14. PMID:35029764. |
this vascularization then leads to matrix breakdown, chondrocyte apoptosis, and ossification. |
2022-01-14 |
2023-08-13 |
Not clear |
| Jun Zhu, Yongchun Gu. Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway. Immunological investigations. 2022-01-11. PMID:35012421. |
circ_0020093 overexpression alleviates interleukin-1 beta-induced inflammation, apoptosis and extracellular matrix degradation in human chondrocytes by targeting the mir-181a-5p/erg pathway. |
2022-01-11 |
2023-08-13 |
human |
| Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, Guozhi Xia. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone research. vol 10. issue 1. 2022-01-11. PMID:35013104. |
this vicious cycle promotes extracellular matrix (ecm) catabolism and np cell apoptosis. |
2022-01-11 |
2023-08-13 |
mouse |
| Huichang Gao, Jin Xiao, Yingqi Wei, Hui Yang, Fen Zo. Manipulating Mesenchymal Stem Cell Differentiation on Nanopattern Constructed through Cell-Mediated Mineralization. ACS applied bio materials. vol 4. issue 7. 2022-01-10. PMID:35006735. |
the extracellular matrix microenvironment, including chemical constituents and topological structure, plays key role in regulating the cell behavior, such as adhesion, proliferation, differentiation, apoptosis, etc. |
2022-01-10 |
2023-08-13 |
mouse |
| Yu Sun, Xinnan Bao, Haiou Chen, Liping Zho. MicroRNA-128-3p suppresses interleukin-1β-stimulated cartilage degradation and chondrocyte apoptosis via targeting zinc finger E-box binding homeobox 1 in osteoarthritis. Bioengineered. vol 13. issue 1. 2022-01-06. PMID:34990303. |
mir-128-3p overexpression or zeb1 silencing attenuated extracellular matrix degradation and cell apoptosis, and increased the proliferation of il-1β-activated chon-001 cells. |
2022-01-06 |
2023-08-13 |
Not clear |