| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Qiang Wu, Wei Wang, Yue-Hong Zhen. [Role of Vascular Aging in the Pathogenesis of Abdominal Aortic Aneurysm and Potential Therapeutic Targets]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 6. 2022-01-04. PMID:34980338. |
abdominal aortic aneurysm(aaa)is a common aortic degenerative disease in the elderly,and its incidence is gradually increasing with the aging of the population.there are no specific drugs available to delay the expansion of aaa.once the aneurysm ruptures,the mortality will exceed 90%,which seriously threatens the life of patients.given the high incidence of aaa in the elderly,this review discusses the role of vascular aging in the pathogenesis of aaa,involving chronic inflammation,oxidative stress,mitochondrial dysfunction,protein homeostasis imbalance,increased apoptosis and necrosis,extracellular matrix remodeling,nutritional sensing disorders,epigenetic changes,and increased pro-aging factors.meanwhile,several potential aging-related drug targets of aaa are listed.this review provides new ideas for basic and translational medical research of aaa. |
2022-01-04 |
2023-08-13 |
Not clear |
| Jeongeun Hyun, Hae-Won Ki. Leveraging cellular mechano-responsiveness for cancer therapy. Trends in molecular medicine. 2022-01-02. PMID:34973934. |
these include targeting mechanosensitive machineries in cancer cells to induce apoptosis, intervening matrix stiffening incurred by cancer-associated fibroblasts (cafs) in both primary and metastatic tumor sites, and modulating matrix mechanics to improve immune cell therapeutic efficacy. |
2022-01-02 |
2023-08-13 |
Not clear |
| Jing Feng, Jinping Zhou, Lin Zhao, Xinpeng Wang, Danyu Ma, Baoqing Xu, Feilai Xie, Xingfeng Qi, Gang Chen, Hu Zhao, Junxin W. Fam20C Overexpression Predicts Poor Outcomes and is a Diagnostic Biomarker in Lower-Grade Glioma. Frontiers in genetics. vol 12. 2021-12-31. PMID:34970298. |
gene set enrichment analysis also revealed the potential signaling pathways associated with fam20c gene expression in lgg; these pathways were mainly enriched in extracellular matrix receptor interactions, cell adhesion, cell apoptosis, notch signaling, cell cycle, etc. |
2021-12-31 |
2023-08-13 |
Not clear |
| Xiaoliang Bai, Yong Lian, Changqing Hu, Shuai Yang, Bo Pei, Mingyan Yao, Xiaojuan Zhu, Lin Shang, Zhihong L. Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling. Journal of applied toxicology : JAT. 2021-12-29. PMID:34964128. |
treatment with n-acetylcysteine (nac) reversed hg-induced cell apoptosis and extracellular matrix (ecm) degradation. |
2021-12-29 |
2023-08-13 |
human |
| Jinquan Hu, Qiang Yan, Hanran Jiang, Chen Xu, Yu Chen, Wen Yua. A decrease in IL-33 regulates matrix degradation and apoptosis in intervertebral disc degeneration via HIF-1alpha. American journal of translational research. vol 13. issue 11. 2021-12-27. PMID:34956487. |
a decrease in il-33 regulates matrix degradation and apoptosis in intervertebral disc degeneration via hif-1alpha. |
2021-12-27 |
2023-08-13 |
Not clear |
| Zhen Wang, Jianxiong Shen, Erwei Feng, Yang Jia. AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration. Frontiers in molecular biosciences. vol 8. 2021-12-27. PMID:34957218. |
degenerative discs display a series of characteristic pathological changes, including cell apoptosis, senescence, remodeling of extracellular matrix, oxidative stress and inflammatory local microenvironment. |
2021-12-27 |
2023-08-13 |
Not clear |
| Mikhail A Novikov, Eugeniy A Titov, Larisa M Sosedova, Viktor S Rukavishnikov, Vera A Vokina, Oleg L Lakhma. Comparative Assessment of Silver Nanocomposites' Biological Effects on the Natural and Synthetic Matrix. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948053. |
we found that the effect of the nanocomposite on the arabinogalactan matrix causes a disturbance in the nervous tissue structure, an increase in the area of mitochondria, a disturbance of the structure of nerve cells, and activation of the process of apoptosis. |
2021-12-24 |
2023-08-13 |
rat |
| Yonggan Ji, Hongli Fan, Mengmeng Yang, Changcai Bai, Wen Yang, Zhisheng Wan. Synergistic effect of baculovirus-mediated endostatin and angiostatin combined with gemcitabine in hepatocellular carcinoma. Biological & pharmaceutical bulletin. 2021-12-23. PMID:34937830. |
the results showed that the combined group significantly inhibited (p<0.05 or p<0.01 or p<0.001) the growth of tumor weight and volume, reduced the expression of ki67 (cell proliferation marker), cd31 (angiogenic marker) and matrix metalloproteinase 9 (mmp-9, tumor invasion and metastasis marker) and increased the apoptosis of tumor cells compared with the monotherapy and control groups, respectively. |
2021-12-23 |
2023-08-13 |
mouse |
| Song Zhang, Shiqi Zhao, Xuejie Han, Yun Zhang, Xuexin Jin, Yue Yuan, Xinbo Zhao, Yingchun Luo, Yun Zhou, Yunlong Gao, Hui Yu, Danghui Sun, Wei Xu, Sen Yan, Yongtai Gong, Yue L. Lnc-C2orf63-4-1 Confers VSMC Homeostasis and Prevents Aortic Dissection Formation via STAT3 Interaction. Frontiers in cell and developmental biology. vol 9. 2021-12-23. PMID:34938738. |
besides, overexpression of lnc-c2orf63-4-1 significantly attenuated ang ii-induced apoptosis, phenotypic switching of vsmcs and degradation of extracellular matrix both |
2021-12-23 |
2023-08-13 |
Not clear |
| Zhenzhen Wang, Liyuan Ji, Yimeng Ren, Menghan Liu, Xiaoyu Ai, Cheng Yan. Preparation and Anti-tumor Study of Dextran 70,000-Selenium Nanoparticles and Poloxamer 188-Selenium Nanoparticles. AAPS PharmSciTech. vol 23. issue 1. 2021-12-21. PMID:34931279. |
t70-senps and p188-senps can aggregate in cell matrix and play an anti-tumor role to hepg2 by promoting apoptosis, increasing reactive oxygen species (ros) content and reducing mitochondrial membrane potential (mmp). |
2021-12-21 |
2023-08-13 |
Not clear |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
tert-butylhydroquinone prevents oxidative stress-mediated apoptosis and extracellular matrix degradation in rat chondrocytes. |
2021-12-20 |
2023-08-13 |
rat |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
oxidative stress-induced chondrocyte apoptosis and degradation of the extracellular matrix (ecm) play an important role in the progression of osteoarthritis (oa). |
2021-12-20 |
2023-08-13 |
rat |
| Bo Yang, Haisheng Huang, Qisong He, Wei Lu, Lu Zheng, Li Cu. Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-20. PMID:34925524. |
the present study aimed to determine the effectiveness of tbhq in preventing the apoptosis of chondrocytes and degradation of the extracellular matrix, induced by oxidative stress, in vitro. |
2021-12-20 |
2023-08-13 |
rat |
| Fudong Li, Xiaofei Sun, Bing Zheng, Kaiqiang Sun, Jian Zhu, Chenglong Ji, Feng Lin, Le Huan, Xi Luo, Chen Yan, Jiashun Xu, Yun Hong, Yuan Wang, Ximing Xu, Jingchuan Sun, Zheming Song, Fanqi Kong, Jiangang Sh. Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation Frontiers in cell and developmental biology. vol 9. 2021-12-20. PMID:34926442. |
based on previous studies, we hypothesized that arg2 deficiency might be conducive to the treatment of idd by inhibiting the dyshomeostasis of the extracellular matrix (ecm), and the oxidative stress and inflammatory response-induced senescence and apoptosis |
2021-12-20 |
2023-08-13 |
Not clear |
| Jialei Chen, Xi Yu, Xiang Zhan. Advances on biological functions of exosomal non-coding RNAs in osteoarthritis. Cell biochemistry and function. 2021-12-18. PMID:34921424. |
exosomal ncrnas are involved in pathological processes of osteoarthritis, such as proliferation, migration, chondrogenesis, chondrocyte differentiation induction, extracellular matrix formation, apoptosis, and inflammation. |
2021-12-18 |
2023-08-13 |
Not clear |
| Yu Dai, Can Jian, Xiaofeng Wang, Xiaoxia Da. Comprehensive expression profiles of mRNAs, lncRNAs and miRNAs in Kashin-Beck disease identified by RNA-sequencing. Molecular omics. 2021-12-16. PMID:34913457. |
kashin-beck disease (kbd) is a chronic, endemic and deforming osteochondropathy, whose basic pathological alterations include apoptosis and necrosis of chondrocytes in articular cartilage and growth plates and imbalanced extracellular matrix metabolism. |
2021-12-16 |
2023-08-13 |
Not clear |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Qinhao Shen, Yiwen Xiao, Bei Cheng, Zheyi Sun, Yu Hu, Hefeng Yang, Yingwei Lu. PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway. The international journal of biochemistry & cell biology. vol 141. 2021-12-11. PMID:34715362. |
prmt1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the akt/foxo1 signaling pathway. |
2021-12-11 |
2023-08-13 |
rat |
| Qinhao Shen, Yiwen Xiao, Bei Cheng, Zheyi Sun, Yu Hu, Hefeng Yang, Yingwei Lu. PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway. The international journal of biochemistry & cell biology. vol 141. 2021-12-11. PMID:34715362. |
temporomandibular joint osteoarthritis (tmjoa) is a chronic degenerative joint disease characterized by extracellular matrix (ecm) degradation and chondrocyte apoptosis. |
2021-12-11 |
2023-08-13 |
rat |
| Jiashu Yang, Ming Zhang, Dawei Yang, Yunfei Ma, Yuting Tang, Mengying Xing, Lingyun Li, Li Chen, Yucui Jin, Changyan M. m Experimental & molecular medicine. vol 53. issue 11. 2021-12-11. PMID:34737423. |
functional assays showed that ectopic expression of ac008, aqp1, and ankh significantly decreased chondrocyte viability and promoted chondrocyte apoptosis and extracellular matrix (ecm) degradation, whereas knockdown of ac008, aqp1, and ankh resulted in the opposite effects. |
2021-12-11 |
2023-08-13 |
Not clear |