| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiying Pang, Zengxin Jiang, Runwen Zhu, Chunfeng Song, Han Tang, Lu Cao, Changan Gu. Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo. Drug design, development and therapy. vol 15. 2021-09-14. PMID:34511883. |
oxidative stress-induced chondrocyte apoptosis and extracellular matrix (ecm) degradation plays an important role in the progression of osteoarthritis (oa). |
2021-09-14 |
2023-08-13 |
Not clear |
| Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhan. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414452. |
sting promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the nf-κb signaling pathway. |
2021-09-13 |
2023-08-13 |
mouse |
| Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhan. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414452. |
the influences of sting on the metabolism of the extracellular matrix (ecm), apoptosis, and senescence, were assessed in sting overexpressing and knocking-down chondrocytes. |
2021-09-13 |
2023-08-13 |
mouse |
| Yuan Liu, Wei Zhou, Fei-Fan Chen, Fei Xiao, Hai-Yang Zhu, Yun Zhou, Guan-Cheng Gu. Overexpression of LMP-1 Decreases Apoptosis in Human Nucleus Pulposus Cells via Suppressing the NF- Oxidative medicine and cellular longevity. vol 2020. 2021-09-13. PMID:33414896. |
increasing extracellular matrix (ecm) synthesis and decreasing nucleus pulposus cell (npc) apoptosis are promising strategies to recover degenerated np. |
2021-09-13 |
2023-08-13 |
human |
| Xiaobo Song, Ole K Greiner-Tollersrud, Huimin Zho. Oral Microbiota Variation: A Risk Factor for Development and Poor Prognosis of Esophageal Cancer. Digestive diseases and sciences. 2021-09-10. PMID:34505256. |
the mechanism of oral bacteria in ec progression is complex, which involves a combination of cytokines, chemokines, oncogenic signaling pathways, cell surface receptors, the degradation of extracellular matrix, and cell apoptosis. |
2021-09-10 |
2023-08-13 |
Not clear |
| Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenbin Hua, Xinghuo Wu, Yukun Zhang, Xianlin Zeng, Cao Yan. Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2021. 2021-09-09. PMID:33628392. |
mechanosensitive ion channel piezo1 activated by matrix stiffness regulates oxidative stress-induced senescence and apoptosis in human intervertebral disc degeneration. |
2021-09-09 |
2023-08-13 |
human |
| Sayeh Mottaghi, Hassan Abbaszade. The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives. Phytotherapy research : PTR. 2021-09-09. PMID:34498311. |
a variety of molecular targets and signaling pathways such as apoptosis, cell cycle, reactive oxygen species (ros), matrix metalloproteinases (mmps), epithelial-mesenchymal transition (emt), and micrornas (mirnas) as well as signal transducer and activator of transcription 3 (stat3), nf-κb, phosphatidylinositol 3-kinase (pi3k)/akt, mitogen-activated protein kinase (mapk), and hippo pathways have been found to be involved in the anticancer effects of morin. |
2021-09-09 |
2023-08-13 |
Not clear |
| Ye Zhang, Weiwei Yi, Huiqiang Xia, Haiyang Lan, Jie Chen, Zhijie Yang, Fei Han, Pan Tang, Bo Li. A20 regulates inflammation through autophagy mediated by NF-κB pathway in human nucleus pulposus cells and ameliorates disc degeneration in vivo. Biochemical and biophysical research communications. vol 549. 2021-09-08. PMID:33677390. |
intervertebral disc degeneration (idd) is closely related to loss of the extracellular matrix (ecm), apoptosis and inflammation in nucleus pulposus cells (npcs). |
2021-09-08 |
2023-08-13 |
human |
| Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qi. Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32691413. |
inhibition of mir-27a-3p protected hg-treated hk-2 cells from apoptosis, extracellular matrix accumulation, mitochondrial dysfunction, and er stress by regulating prohibitin or tmbim6. |
2021-09-07 |
2023-08-13 |
mouse |
| Mengqi Zhang, Yaping Liu, Zhikun Huan, Yan Wang, Jin X. Metformin protects chondrocytes against IL-1β induced injury by regulation of the AMPK/NF-κ B signaling pathway. Die Pharmazie. vol 75. issue 12. 2021-09-07. PMID:33303055. |
in our study, cell viability was measured using cell counting kit-8 assay, expressions of crucial factors involved in the extracellular matrix (ecm) metabolic, proinflammatory response, cell apoptosis, and nuclear factor κ b(nf-κ b) pathway were analyzed using western blot analysis and immunofluorescence staining. |
2021-09-07 |
2023-08-13 |
Not clear |
| Zhiming Lin, Jianing Miao, Tao Zhang, Ming He, Ziyuan Wang, Xinyuan Feng, Lunhao Ba. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Aging cell. vol 20. issue 2. 2021-09-06. PMID:33450132. |
overall, our findings reveal that the junb-fbxo21-erk axis regulates oa apoptosis and cartilage matrix metabolism by inhibiting autophagy. |
2021-09-06 |
2023-08-13 |
rat |
| Tsunehiko Ikeda, Kimitoshi Nakamura, Takaki Sato, Teruyo Kida, Hidehiro Ok. Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33572210. |
anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). |
2021-09-06 |
2023-08-13 |
Not clear |
| Kevin Sunderland, Jingfeng Jiang, Feng Zha. Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review. Journal of cellular physiology. 2021-09-06. PMID:34486114. |
disturbed flow is associated with altered cellular morphology, upregulated expression of proteins modulating inflammation, decreased regulation of vascular permeability, degraded extracellular matrix, and heightened cellular apoptosis. |
2021-09-06 |
2023-08-13 |
Not clear |
| Christian R D'Andrea, Ausilah Alfraihat, Anita Singh, Jason B Anari, Patrick J Cahill, Thomas Schaer, Brian D Snyder, Dawn Elliott, Sriram Balasubramania. Part 2. Review and meta-analysis of studies on modulation of longitudinal bone growth and growth plate activity: A micro-scale perspective. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 5. 2021-09-03. PMID:33458882. |
gene and protein expressions related to matrix synthesis and degradation, as well as regulation of chondrocyte apoptosis were shown to exhibit magnitude-, frequency-, and duration-dependent responses to loading regimen. |
2021-09-03 |
2023-08-13 |
Not clear |
| Zhineng Fan, Shuan Liu, Houqing Zho. LncRNA H19 Regulates Proliferation, Apoptosis and ECM Degradation of Aortic Smooth Muscle Cells Via miR-1-3p/ADAM10 Axis in Thoracic Aortic Aneurysm. Biochemical genetics. 2021-09-03. PMID:34478010. |
h19 was increased in taa aorta tissues and serum and vascular smooth muscle cell (vsmc), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ecm) degradation of vsmc. |
2021-09-03 |
2023-08-13 |
Not clear |
| Tomonori Itsuji, Hitoshi Tonomura, Hidenobu Ishibashi, Yasuo Mikami, Masateru Nagae, Ryota Takatori, Takashi Tanida, Ken-Ichi Matsuda, Masaki Tanaka, Toshikazu Kub. Hepatocyte growth factor regulates HIF-1α-induced nucleus pulposus cell proliferation through MAPK-, PI3K/Akt-, and STAT3-mediated signaling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 6. 2021-09-02. PMID:32242977. |
we previously reported that hepatocyte growth factor (hgf) promotes cell proliferation and suppresses apoptosis, inflammation, and matrix degradation in nucleus pulposus (np) cells. |
2021-09-02 |
2023-08-13 |
Not clear |
| Mingli Feng, Lin Jing, Jingbo Cheng, Shuai An, Jiang Huang, Qi Ya. Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b. Molecular and cellular biochemistry. vol 476. issue 10. 2021-09-01. PMID:34046827. |
circ_0020093 ameliorates il-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating spry1 via targeting mir-23b. |
2021-09-01 |
2023-08-13 |
human |
| Jun-Ichi Takino, Takuma Sato, Kentaro Nagamine, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hor. Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products. Biological & pharmaceutical bulletin. vol 44. issue 1. 2021-08-31. PMID:33390537. |
these results suggested that the suppression of apoptosis in activated lx-2 cells by tgf-β1 and tage co-treatment is related to an increase in the production of the extracellular matrix such as collagen i. |
2021-08-31 |
2023-08-13 |
Not clear |
| Ali Mohammadi, Behzad Mansoori, Pascal H G Duijf, Elham Safarzadeh, Leila Tebbi, Souzan Najafi, Behrooz Shokouhi, Grith L Sorensen, Uffe Holmskov, Behzad Baradara. Restoration of miR-330 expression suppresses lung cancer cell viability, proliferation, and migration. Journal of cellular physiology. vol 236. issue 1. 2021-08-27. PMID:32583462. |
these findings are substantiated by increased mrna and protein expression of markers for apoptosis via the intrinsic pathway, such as caspase 9, and decreased mrna and protein expression of markers for cell migration, such as vimentin, c-x-c chemokine receptor type 4, and matrix metalloproteinase 9. |
2021-08-27 |
2023-08-13 |
Not clear |
| Zhilin Cao, Wenguang Liu, Xiaoyi Qu, Haiyong Bi, Xiujiang Sun, Qian Yu, Gong Chen. miR-296-5p inhibits IL-1β-induced apoptosis and cartilage degradation in human chondrocytes by directly targeting TGF-β1/CTGF/p38MAPK pathway. Cell cycle (Georgetown, Tex.). vol 19. issue 12. 2021-08-26. PMID:32378978. |
osteoarthritis (oa) is characterized by apoptosis of chondrocytes and an imbalance of extracellular matrix (ecm) synthesis and catabolism. |
2021-08-26 |
2023-08-13 |
human |