| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruihua Jing, Conghui Hu, Tiantian Qi, Jiaqi Yue, Guangyan Wang, Ming Zhang, Chan Wen, Cheng Pei, Bo M. FILIP1L-mediated cell apoptosis, epithelial-mesenchymal transition and extracellular matrix synthesis aggravate posterior capsular opacification. Life sciences. vol 286. 2021-11-15. PMID:34666037. |
filip1l-mediated cell apoptosis, epithelial-mesenchymal transition and extracellular matrix synthesis aggravate posterior capsular opacification. |
2021-11-15 |
2023-08-13 |
rabbit |
| Kyueng-Whan Min, Dong-Hoon Kim, Yung-Kyun Noh, Byoung Kwan Son, Mi Jung Kwon, Ji-Yong Moo. Cancer-associated fibroblasts are associated with poor prognosis in solid type of lung adenocarcinoma in a machine learning analysis. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:34408230. |
in the pathway analyses, cafs were related to blood vessel remodeling, matrix organization, negative regulation of apoptosis and transforming growth factor-β signaling. |
2021-11-11 |
2023-08-13 |
Not clear |
| Hyo-Jun Kim, Jin-Haeng Lee, Sung-Yup Cho, Ju-Hong Jeon, In-Gyu Ki. Transglutaminase 2 mediates transcriptional regulation through BAF250a polyamination. Genes & genomics. vol 43. issue 4. 2021-11-10. PMID:33555506. |
transglutaminase 2 (tg2) mediates protein modifications by crosslinking or by incorporating polyamine in response to oxidative or dna-damaging stress, thereby regulating apoptosis, extracellular matrix formation, and inflammation. |
2021-11-10 |
2023-08-13 |
Not clear |
| Weiyi Qu, Tengfei Ma, Jingjing Cai, Xiaojing Zhang, Peng Zhang, Zhigang She, Feng Wan, Hongliang L. Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies. Frontiers in medicine. vol 8. 2021-11-10. PMID:34746195. |
in this review, we cover recent discoveries in new targets and molecules for antifibrotic treatment, which target pathways intertwined with the fibrogenesis process, including lipid metabolism, inflammation, cell apoptosis, oxidative stress, and extracellular matrix formation. |
2021-11-10 |
2023-08-13 |
Not clear |
| Jian Dong, Kai-Jia Zhang, Gao-Cai Li, Xing-Ren Chen, Jia-Jia Lin, Jia-Wei Li, Zhong-Yang Lv, Zhao-Zhi Deng, Jin Dai, Wangsen Cao, Qing Jian. CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy. Acta pharmacologica Sinica. 2021-11-10. PMID:34754093. |
we showed that cddo-im (20 nm) significantly alleviated tnf-α-induced apoptosis of primary human chondrocytes and extracellular matrix degradation. |
2021-11-10 |
2023-08-13 |
mouse |
| Zuo-Long Wu, Qi-Qi Xie, Tai-Cong Liu, Xing Yang, Guang-Zhi Zhang, Hai-Hong Zhan. Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs. Pathology, research and practice. vol 220. 2021-11-09. PMID:33647863. |
however, the activation of the wnt pathway after birth promotes ivd cell senescence, apoptosis, and degradation of the extracellular matrix and induces the production of inflammatory factors, thereby accelerating the ivdd process. |
2021-11-09 |
2023-08-13 |
Not clear |
| Hongwei Lu, Chao Jia, Dengying Wu, Haidong Jin, Zeng Lin, Jun Pan, Xiucui Li, Wei Wan. Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. Cell death & disease. vol 12. issue 10. 2021-11-09. PMID:34556628. |
fibroblast growth factor 21 (fgf21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the sirt1-mtor signaling pathway. |
2021-11-09 |
2023-08-13 |
Not clear |
| Hongwei Lu, Chao Jia, Dengying Wu, Haidong Jin, Zeng Lin, Jun Pan, Xiucui Li, Wei Wan. Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. Cell death & disease. vol 12. issue 10. 2021-11-09. PMID:34556628. |
in vitro, the results revealed that fgf21 administration alleviated apoptosis, senescence, and extracellular matrix (ecm) catabolism of the chondrocytes induced by tert-butyl hydroperoxide (tbhp) by mediating autophagy flux. |
2021-11-09 |
2023-08-13 |
Not clear |
| Ken-Ichi Miyazono, Tomoko Ito, Yui Fukatsu, Hikaru Wada, Akira Kurisaki, Masaru Tanokur. Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-β signaling. Science signaling. vol 13. issue 662. 2021-11-08. PMID:33323411. |
transforming growth factor-β (tgf-β) proteins regulate multiple cellular functions, including cell proliferation, apoptosis, and extracellular matrix formation. |
2021-11-08 |
2023-08-13 |
Not clear |
| Peng Xi, Cai-Lin Zhang, Shi-Yan Wu, Lei Liu, Wen-Ju Li, Yi-Mei L. CircRNA circ-IQGAP1 Knockdown Alleviates Interleukin-1β-Induced Osteoarthritis Progression via Targeting miR-671-5p/TCF4. Orthopaedic surgery. vol 13. issue 3. 2021-11-08. PMID:33675175. |
to explore the function of circular rna iq motif-containing gtpase-activating protein 1 (circ-iqgap1) in interleukin (il)-1β-induced osteoarthritis (oa) model and to explore whether circ-iqgap1 can modulate microrna-671-5p (mir-671-5p) and transcription factor 4 (tcf4) to regulate chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ying-Ying Zhang, Rui-Zhi Tan, Ying Yu, Yang-Yang Niu, Chen Y. LncRNA GAS5 protects against TGF-β-induced renal fibrosis via the Smad3/miRNA-142-5p axis. American journal of physiology. Renal physiology. vol 321. issue 4. 2021-11-08. PMID:34486400. |
taken together, our results uncovered a lncrna/mirna competing endogenous rna network-based mechanism that modulates extracellular matrix formation and cell apoptosis via the smad3 pathway. |
2021-11-08 |
2023-08-13 |
mouse |
| Gaofeng Zhang, Yuanmei Liao, Hanshi Yang, Jian Tao, Lin Ma, Xiaohua Zu. Irigenin reduces the expression of caspase-3 and matrix metalloproteinases, thus suppressing apoptosis and extracellular matrix degradation in TNF-α-stimulated nucleus pulposus cells. Chemico-biological interactions. vol 349. 2021-11-08. PMID:34600870. |
irigenin reduces the expression of caspase-3 and matrix metalloproteinases, thus suppressing apoptosis and extracellular matrix degradation in tnf-α-stimulated nucleus pulposus cells. |
2021-11-08 |
2023-08-13 |
Not clear |
| Caining Wen, Limei Xu, Xiao Xu, Daping Wang, Yujie Liang, Li Dua. Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment. Arthritis research & therapy. vol 23. issue 1. 2021-11-08. PMID:34717735. |
igf-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yoon Young Kim, Jun-Won Yun, Sung Woo Kim, Hoon Kim, Byeong-Cheol Kang, Seung-Yup K. Synergistic Promoting Effects of X-Linked Inhibitor of Apoptosis Protein and Matrix on the In Vitro Follicular Maturation of Marmoset Follicles. Tissue engineering and regenerative medicine. 2021-11-06. PMID:34741748. |
synergistic promoting effects of x-linked inhibitor of apoptosis protein and matrix on the in vitro follicular maturation of marmoset follicles. |
2021-11-06 |
2023-08-13 |
mouse |
| Yoon Young Kim, Jun-Won Yun, Sung Woo Kim, Hoon Kim, Byeong-Cheol Kang, Seung-Yup K. Synergistic Promoting Effects of X-Linked Inhibitor of Apoptosis Protein and Matrix on the In Vitro Follicular Maturation of Marmoset Follicles. Tissue engineering and regenerative medicine. 2021-11-06. PMID:34741748. |
in this study, we attempted to establish a 3d matrix (matrtigel)-based ivfm condition for marmoset ovarian follicles in combination with anti-apoptotic factor, x-linked inhibitor of apoptosis protein (xiap). |
2021-11-06 |
2023-08-13 |
mouse |
| Yuan Li, Zhiming Wang, Xiuwen Wu, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jianan Re. Intestinal mucosa-derived DNA methylation signatures in the penetrating intestinal mucosal lesions of Crohn's disease. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:33963246. |
differential dna methylation sites were participated in the positive regulation of apoptosis and the positive regulation of il-8 production and were enriched in signaling pathways related to inflammatory bowel disease and extracellular matrix receptor interaction signaling pathways. |
2021-11-02 |
2023-08-13 |
Not clear |
| Yuan Li, Zhiming Wang, Xiuwen Wu, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jianan Re. Intestinal mucosa-derived DNA methylation signatures in the penetrating intestinal mucosal lesions of Crohn's disease. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:33963246. |
apoptosis, interleukin-8 production and abnormal extracellular matrix might be involved in the mechanism of penetrating intestinal mucosal lesions in crohn's disease. |
2021-11-02 |
2023-08-13 |
Not clear |
| Yi-Li Zheng, Ge Song, Jia-Bao Guo, Xuan Su, Yu-Meng Chen, Zheng Yang, Pei-Jie Chen, Xue-Qiang Wan. Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases. Frontiers in cell and developmental biology. vol 9. 2021-10-30. PMID:34708047. |
long non-coding rnas (lncrnas) and circular rnas (circrnas) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. |
2021-10-30 |
2023-08-13 |
Not clear |
| Huajie Mao, Bin Han, Hao Li, Yiqing Tao, Weigang W. FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway. Molecular medicine reports. vol 24. issue 6. 2021-10-26. PMID:34651666. |
fabp4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in il-1β-induced chondrocytes by activating pparγ to regulate the nf-κb signaling pathway. |
2021-10-26 |
2023-08-13 |
Not clear |
| Huajie Mao, Bin Han, Hao Li, Yiqing Tao, Weigang W. FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway. Molecular medicine reports. vol 24. issue 6. 2021-10-26. PMID:34651666. |
in conclusion, fabp4 knockdown suppressed the inflammation, oxidative stress, apoptosis and extracellular matrix degradation of il‑1β‑induced chondrocytes by activating pparγ to inhibit the nf‑κb signaling pathway. |
2021-10-26 |
2023-08-13 |
Not clear |