| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chien-Ming Chao, Chun-Liang Chen, Ko-Chi Niu, Cheng-Hsien Lin, Ling-Yu Tang, Lieh-Sheng Lin, Ching-Ping Chan. Hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia. International journal of medical sciences. vol 17. issue 17. 2021-08-02. PMID:33162790. |
hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia. |
2021-08-02 |
2023-08-13 |
rat |
| Lingang Xu, Nan Sun, Guangshuai Li, Linbo Li. LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway. Molecular and cellular biochemistry. vol 476. issue 3. 2021-08-02. PMID:33389493. |
besides, h19 knockdown hindered the proliferation, migration, invasion, extracellular matrix (ecm) deposition, and enhanced the apoptosis of keloid fibroblasts. |
2021-08-02 |
2023-08-13 |
Not clear |
| R J Kim, S H An, J Y Gwark, H B Par. Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts. European cells & materials. vol 41. 2021-08-02. PMID:34114203. |
expressions of hypoxia-inducible factor-1α (hif-1α) and heme oxygenase-1 (ho-1), cell viability, intracellular reactive oxygen species (ros) production, apoptosis rates as well as expressions of cleaved caspase-3, cleaved poly adp-ribose polymerase-1 (parp-1), vascular endothelial growth factors-β (vegf-β) and matrix metalloproteinase-2 (mmp-2) were evaluated. |
2021-08-02 |
2023-08-13 |
rat |
| Yu Du, Xinrui Lin, Qiang Feng, Xinyan Pan, Shuling Song, Julun Yan. Inhibition of human lung cancer cells by anti-p21Ras scFv mediated by the activatable cell-penetrating peptide. Anti-cancer drugs. 2021-08-02. PMID:34338241. |
we found that acpp-p21ras scfv could penetrate tumour cell membranes with high expression of matrix metalloproteinase-2 (mmp-2), effectively inhibit the migration and proliferation of a549 cells and h1299 cells, and promote the apoptosis of a549 cells and h1299 cells. |
2021-08-02 |
2023-08-13 |
human |
| Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming H. The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress. Aging. vol 12. issue 10. 2021-08-02. PMID:32445555. |
the results showed that sirt1 could promote bmp2-induced chondrogenic differentiation of mscs, and reduce the apoptosis and decomposition of extracellular matrix under oxidative stress. |
2021-08-02 |
2023-08-13 |
Not clear |
| Li-Wen Huang, Tzu-Ching Huang, Yu-Chen Hu, Bau-Shan Hsieh, Hsiao-Ling Cheng, Pu-Rong Chiu, Kee-Lung Chan. S-Equol Protects Chondrocytes against Sodium Nitroprusside-Caused Matrix Loss and Apoptosis through Activating PI International journal of molecular sciences. vol 22. issue 13. 2021-07-29. PMID:34209006. |
s-equol protects chondrocytes against sodium nitroprusside-caused matrix loss and apoptosis through activating pi osteoarthritis (oa) is a common chronic disease with increasing prevalence in societies with more aging populations, therefore, it is causing more concern. |
2021-07-29 |
2023-08-13 |
rat |
| Xianjun Tan, Tao Li, Shaowei Zhu, Weiying Zhong, Feng Li, Yunyan Wan. Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32495004. |
the results showed that sparc upregulated the expression of nox4 through the tgf-β1-dependent signaling pathway, leading to oxidative stress and pro-inflammatory matrix behavior and apoptosis in hbvsmcs. |
2021-07-29 |
2023-08-13 |
human |
| Julio Aguila, Shangli Cheng, Nigel Kee, Ming Cao, Menghan Wang, Qiaolin Deng, Eva Hedlun. Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-27. PMID:34305528. |
network analysis reveal gene interactions unique to each subpopulation and highlight differences in regulation of mitochondrial stability, apoptosis, neuronal survival, cytoskeleton regulation, extracellular matrix modulation as well as synapse integrity, which could explain the relative resilience of vta dopamine neurons. |
2021-07-27 |
2023-08-13 |
human |
| Pengfei Xia, Jin Liang, Di Jin, Zhanyong Ji. Reversine inhibits proliferation, invasion and migration and induces cell apoptosis in gastric cancer cells by downregulating TTK. Experimental and therapeutic medicine. vol 22. issue 3. 2021-07-27. PMID:34306198. |
rev-treated cells exhibited reduced matrix metalloproteinase (mmp)2/9 expression and increased apoptosis compared with those in control cells. |
2021-07-27 |
2023-08-13 |
human |
| Jia Xiaoshi, Li Maoquan, Wang Jiwei, Ning Jinqiu, Zhao K. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-26. PMID:33617050. |
the pathological characteristics of osteoarthritis are cartilage matrix degradation, chondrocytes apoptosis, and low-grade inflammation of the joint. |
2021-07-26 |
2023-08-13 |
Not clear |
| Jian Li, Mingting Liu, Xianrang Li, Hui Shi, Shui Su. Long noncoding RNA ZFAS1 suppresses chondrocytes apoptosis via miR-302d-3p/SMAD2 in osteoarthritis. Bioscience, biotechnology, and biochemistry. vol 85. issue 4. 2021-07-26. PMID:33686420. |
long noncoding rna zinc finger antisense 1 (zfas1) is downregulated and tightly associated with proliferation, migration, apoptosis, and matrix synthesis of chondrocyte in oa. |
2021-07-26 |
2023-08-13 |
Not clear |
| Michele Andreucci, Michele Provenzano, Teresa Faga, Ashour Michael, Gemma Patella, Pasquale Mastroroberto, Giuseppe Filiberto Serraino, Umberto Marcello Bracale, Nicola Ielapi, Raffaele Serr. Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases. Biomolecules. vol 11. issue 2. 2021-07-23. PMID:33573220. |
metalloproteinases (mps) are proteolytic enzymes involved in extracellular matrix deposition, regulation of cellular signals of inflammation, proliferation, and apoptosis. |
2021-07-23 |
2023-08-13 |
human |
| Pengcheng Dou, Yu He, Bo Yu, Juan Dua. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging. vol 13. issue 5. 2021-07-22. PMID:33177241. |
moreover, the pthlh upregulation induced by mir-29b methylation led to the enhancement of chondrocyte growth and suppression of their apoptosis and extracellular matrix degradation, which was achieved by the upregulation cyclin-dependent kinase 4 (cdk4) expression. |
2021-07-22 |
2023-08-13 |
mouse |
| Qian Qian Yang, Luzhong Zhang, Fei Ju, You Lang Zho. Sustained-Release Hydrogel-Based Rhynchophylline Delivery System Improved Injured Tendon Repair. Colloids and surfaces. B, Biointerfaces. vol 205. 2021-07-20. PMID:34087778. |
but for adhesion tissues, rhy promoted the apoptosis and accelerated the degradation of extracellular matrix. |
2021-07-20 |
2023-08-13 |
Not clear |
| Francesca Velotti, Ilaria Barchetta, Flavia Agata Cimini, Maria Gisella Cavall. Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis. Frontiers in immunology. vol 11. 2021-07-16. PMID:33262766. |
granzyme b in inflammatory diseases: apoptosis, inflammation, extracellular matrix remodeling, epithelial-to-mesenchymal transition and fibrosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wan. circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. International journal of molecular medicine. vol 47. issue 5. 2021-07-16. PMID:33649815. |
finally, the biological functions of fxr1, mir‑503‑3p, and mir‑503‑5p in keloid‑derived fibroblast proliferation, apoptosis and extracellular matrix accumulation were confirmed. |
2021-07-16 |
2023-08-13 |
Not clear |
| Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wan. circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. International journal of molecular medicine. vol 47. issue 5. 2021-07-16. PMID:33649815. |
knockdown of fxr1, mir‑503‑3p and mir‑503‑5p also inhibited proliferation and extracellular matrix accumulation in keloid‑derived fibroblasts and increased levels of cell apoptosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Zhirong Wang, Kai Yan, Gaoran Ge, Di Zhang, Jiaxiang Bai, Xiaobin Guo, Jing Zhou, Tianpeng Xu, Menglei Xu, Xiao Long, Yuefeng Hao, Dechun Gen. Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33099657. |
exosomes derived from mir-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. |
2021-07-15 |
2023-08-13 |
mouse |
| Zhirong Wang, Kai Yan, Gaoran Ge, Di Zhang, Jiaxiang Bai, Xiaobin Guo, Jing Zhou, Tianpeng Xu, Menglei Xu, Xiao Long, Yuefeng Hao, Dechun Gen. Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33099657. |
cck-8, transwell, and western blot analyses were used to detect proliferation, migration, extracellular matrix (ecm) secretion, and apoptosis of osteoarthritic chondrocytes. |
2021-07-15 |
2023-08-13 |
mouse |
| Flavia Agata Cimini, Ilaria Barchetta, Valentina Ceccarelli, Caterina Chiappetta, Alberto Di Biasio, Laura Bertoccini, Federica Sentinelli, Frida Leonetti, Gianfranco Silecchia, Claudio Di Cristofano, Marco Giorgio Baroni, Francesca Velotti, Maria Gisella Cavall. Granzyme B Expression in Visceral Adipose Tissue Associates With Local Inflammation and Glyco-Metabolic Alterations in Obesity. Frontiers in immunology. vol 11. 2021-07-15. PMID:33312176. |
granzyme b (grb) is a serine protease produced by immune and non-immune cells, able to promote multiple processes, like apoptosis, inflammation, extracellular matrix remodeling and fibrosis. |
2021-07-15 |
2023-08-13 |
human |