| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
ectopic mir27a expression inhibited apoptosis, suppressed the inflammatory response and attenuated the catabolism of the extracellular matrix by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
at the same time, mir27a is up-regulated by tnf-α via the p38 signalling pathway, which ameliorates inflammation, apoptosis and matrix degradation by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J Wilson, Juan J Marugan, Alexander I Agoulni. Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction. Frontiers in physiology. vol 12. 2021-10-15. PMID:34305630. |
in the present study, we tested the hypothesis that ml290, a small molecule agonist of the human relaxin receptor (rxfp1), is able to target the kidney to remodel the extracellular matrix and reduce apoptosis induced by unilateral ureteral obstruction (uuo). |
2021-10-15 |
2023-08-13 |
mouse |
| Hua Jiang, Abu Moro, Jiaqi Wang, Dihua Meng, Xinli Zhan, Qingjun We. MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration. Experimental & molecular medicine. vol 53. issue 9. 2021-10-15. PMID:34531509. |
our functional studies showed that mir-338-3p significantly influenced the expression of extracellular matrix synthesis genes, as well as the proliferation and apoptosis of np cells. |
2021-10-15 |
2023-08-13 |
mouse |
| Jiapeng Bao, Changjian Lin, Xing Zhou, Diana Ma, Lujie Ge, Kai Xu, Safwat Adel Abdo Moqbel, Yuzhe He, Chiyuan Ma, Jisheng Ran, Lidong W. circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3. Oxidative medicine and cellular longevity. vol 2021. 2021-10-15. PMID:34646424. |
while overexpression of circfam160a2 decreased the production of extracellular matrix (ecm) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of mir-505-3p could reverse the protective effect of circfam160a2 on the oa phenotype both in vitro and in vivo. |
2021-10-15 |
2023-08-13 |
human |
| William H Miller, Danny W Scot. Follicular Dysplasia of the Portuguese Water Dog. Veterinary dermatology. vol 6. issue 2. 2021-10-14. PMID:34644864. |
unique histopathologic findings included prominent apoptosis of keratinocytes in the inner and outer root sheath, and dissolution of the hair matrix of anagen hair follicles. |
2021-10-14 |
2023-08-13 |
dog |
| Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xi. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-13. PMID:34536759. |
furthermore, the mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) signaling pathway is closely related to various pathological processes in idd, and the activation of the mapk/erk pathway promotes the degradation of the ivd extracellular matrix, cell aging, apoptosis, and inflammatory responses. |
2021-10-13 |
2023-08-13 |
Not clear |
| Chi-Yung Chai, I-Chun Tai, Rui Zhou, Junlong Song, Chaoying Zhang, Shengrong Su. MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β. Biology open. vol 9. issue 12. 2021-10-12. PMID:33355167. |
in this paper, we firstly disclosed that mir-9-5p hampered extracellular matrix deposition and proliferation, and induced apoptosis by targeting pparβ in hs fibroblasts. |
2021-10-12 |
2023-08-13 |
human |
| Feng Lv, Longbiao Yang, Jianxiu Wang, Zhixiang Chen, Qizhao Sun, Peiguo Zhang, Chentong Guan, Yanbin Li. Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway. Neurochemical research. vol 46. issue 6. 2021-10-12. PMID:33713325. |
intervertebral disc degeneration (idd) is accompanied by nucleus pulposus (np) cell apoptosis, inflammation, and extracellular matrix degradation. |
2021-10-12 |
2023-08-13 |
human |
| Ling Dong, Bo Don. miR-489-3p overexpression inhibits lipopolysaccharide-induced nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via targeting Toll-like receptor 4. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630677. |
mir-489-3p overexpression inhibits lipopolysaccharide-induced nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via targeting toll-like receptor 4. |
2021-10-12 |
2023-08-13 |
human |
| Ning Gao, Yuzhen Zhang, Lei Lei, Li Li, Ping Cao, Xuan Zhao, Lin Lin, Rui X. Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 43. issue 11. 2021-10-11. PMID:32439914. |
increased extracellular matrix of the glomerulus and an increased glomerular sclerosis index, podocyte foot process effacement and fusion, as well as increased podocyte apoptosis, were observed in the hhcy group compared with the control group; these effects were associated with increased expression of nox2 and nox4 and decreased nephrin expression in renal tissue from shrs with hhcy. |
2021-10-11 |
2023-08-13 |
rat |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the brd7-pi3k-yap1 signaling axis. |
2021-10-11 |
2023-08-13 |
human |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
in addition, pi3k inhibition augmented matrix degradation, enhanced apoptosis, and reduced yap1 expression, whereas yap1 overexpression promoted matrix synthesis, suppressed apoptosis and promoted pi3k expression. |
2021-10-11 |
2023-08-13 |
human |
| Shuangxing Li, Zhengqi Huang, Yuanxin Zhu, Jiansen Yan, Jun Li, Jiancong Chen, Jie Zhou, Yangyang Zhang, Weijian Chen, Kang Xu, Wei Y. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34038745. |
in summary, our results demonstrate that brd7 can regulate matrix metabolism and apoptosis in human np cells through the brd7-pi3k-yap1 signaling axis. |
2021-10-11 |
2023-08-13 |
human |
| Xipeng Wang, Xiaoping Zhang, Tao Qiu, Yang Yang, Qingle Li, Xiaoming Zhan. Dexamethasone reduces the formation of thoracic aortic aneurysm and dissection in a murine model. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34118251. |
dex reduced infiltration of macrophages and neutrophils, apoptosis of vascular smooth muscle cells (vsmcs), expression of metalloproteinase 2/9, and extracellular matrix degradation in bapn-treated taad mice. |
2021-10-11 |
2023-08-13 |
mouse |
| Chetan, Uthirapathy Vijayalakshm. A systematic review of the interaction and effects generated by antimicrobial metallic substituents in bone tissue engineering. Metallomics : integrated biometal science. vol 12. issue 10. 2021-10-08. PMID:32744267. |
although most of these elements interact with genetic material, resulting in denaturation to produce apoptosis of pathogenic cells, some create adverse effects in the cellular matrix, which interfere with normal cellular metabolism and inhibit cellular activity, reducing the further growth and formation of bacterial colonies. |
2021-10-08 |
2023-08-13 |
human |
| Yan Zhou, Jianghua Ming, Ming Deng, Yaming Li, Bochun Li, Jia Li, Yonggang Ma, Zhonghui Chen, Guirong Wang, Shiqing Li. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. Journal of molecular medicine (Berlin, Germany). vol 98. issue 10. 2021-10-08. PMID:32860098. |
herein, we aim to assess the chondroprotective effect and underlying mechanisms of a novel chemically modified curcumin, cmc2.24, in modulating extracellular matrix (ecm) homeostasis and inhibiting chondrocyte apoptosis. |
2021-10-08 |
2023-08-13 |
rat |
| Yan Zhou, Jianghua Ming, Ming Deng, Yaming Li, Bochun Li, Jia Li, Yonggang Ma, Zhonghui Chen, Guirong Wang, Shiqing Li. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. Journal of molecular medicine (Berlin, Germany). vol 98. issue 10. 2021-10-08. PMID:32860098. |
results from in vivo studies demonstrated that the intra-articular administration of cmc2.24 ameliorated osteoarthritic cartilage destruction by promoting collagen 2a1 production and inhibited cartilage degradation and apoptosis by suppressing hypoxia-inducible factor-2a (hif-2α), matrix metalloproteinase-3, runt-related transcription factor 2, cleaved caspase-3, and vascular endothelial growth factor and the phosphorylation of iκbα and nf-κb p65. |
2021-10-08 |
2023-08-13 |
rat |
| Jingbo Zhou, Shu Zhang, Xinyi Sun, Yan Lou, Jinjing Bao, Jiangyi Y. Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. Journal of pharmacological sciences. vol 146. issue 1. 2021-10-06. PMID:33858650. |
western blot analysis was conducted for detection of extracellular matrix accumulation, inflammatory response and cell apoptosis. |
2021-10-06 |
2023-08-13 |
mouse |
| Bei Zhao, Jun Xie, Xiyuan Zhou, Lixia Zhang, Xiankui Cheng, Chenglin Lian. YAP activation in melanoma contributes to anoikis resistance and metastasis. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 8. 2021-10-05. PMID:33307801. |
anoikis resistance is a hallmark feature of metastatic melanoma to escape apoptosis when cells lose contact with adjacent cells or extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |