| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Song, Yuan-Jing Ren, Lu-Lu Liu, Ya-Ying Zhao, Qi-Fu Li, Hai-Bo Yan. Curcumin induced the cell death of immortalized human keratinocytes (HaCaT) through caspase-independent and caspase-dependent pathways. Food & function. vol 12. issue 18. 2021-09-21. PMID:34351351. |
we identified 16 differentially expressed nuclear matrix (nm) proteins, including apoptosis inducing factor (aif) and caspase 3, by 2-de and maldi-tof/tof mass spectrometry. |
2021-09-21 |
2023-08-13 |
human |
| Brandon M Fox, Kirsten B Dorschel, Michael T Lawton, John E Waneb. Pathophysiology of Vascular Stenosis and Remodeling in Moyamoya Disease. Frontiers in neurology. vol 12. 2021-09-21. PMID:34539540. |
several molecular pathways have been implicated in the pathophysiology of stenosis in mmd with functions in cellular proliferation and migration, extracellular matrix remodeling, apoptosis, and vascular inflammation. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhenzhu Jiang, Jing Yin, Guangyao Peng, Xiaoping Lon. Circ_0074027 contributes to the progression of non-small cell lung cancer via microRNA-362-3p/clathrin heavy chain axis. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932275. |
western blot assay was utilized to measure the levels of clathrin heavy chain (cltc), cyclin d1, bcl2-associated x, apoptosis regulator bax (bax), vimentin and matrix metallopeptidase 9. |
2021-09-20 |
2023-08-13 |
human |
| Tao Li, Ting Guo, Houqin Liu, Hongtao Jiang, Yi Wan. Platelet‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway. Oncology reports. vol 45. issue 1. 2021-09-20. PMID:33416116. |
anoikis resistance is an important mechanism by which metastatic cells avoid apoptosis when detaching from adjacent cells or the extracellular matrix. |
2021-09-20 |
2023-08-13 |
human |
| Shuwen Zhang, Weidong Liang, Yakefu Abulizi, Tao Xu, Rui Cao, Chuanhui Xun, Jian Zhang, Weibin Shen. Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy. BioMed research international. vol 2021. 2021-09-20. PMID:34055990. |
oxidative stress is a major pathogenic factor of aging that results in the apoptosis of nucleus pulposus cells (npcs) and extracellular matrix (ecm) degradation. |
2021-09-20 |
2023-08-13 |
Not clear |
| Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhan. Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes. Clinical science (London, England : 1979). vol 135. issue 4. 2021-09-17. PMID:33491733. |
further analysis indicated that bbr activated trxr1, suppressed its downstream jnk signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase (mmp) 9 (mmp9) and up-regulated transforming growth factor-β1 (tgf-β1) and tissue inhibitors of mmp 1 (timp1), resulting in accelerated wound healing. |
2021-09-17 |
2023-08-13 |
rat |
| Batara Sirait, Budi Wiweko, Ahmad Aulia Jusuf, Dein Iftitah, R Muhara. Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review. Frontiers in cell and developmental biology. vol 9. 2021-09-17. PMID:34527670. |
the biomarkers were reviewed according to the respective oocyte maturation events namely: nuclear maturation, apoptosis, and extracellular matrix remodeling, and steroid metabolism. |
2021-09-17 |
2023-08-13 |
Not clear |
| Zhiying Pang, Zengxin Jiang, Runwen Zhu, Chunfeng Song, Han Tang, Lu Cao, Changan Gu. Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo. Drug design, development and therapy. vol 15. 2021-09-14. PMID:34511883. |
bardoxolone-methyl prevents oxidative stress-mediated apoptosis and extracellular matrix degradation in vitro and alleviates osteoarthritis in vivo. |
2021-09-14 |
2023-08-13 |
Not clear |
| Zhiying Pang, Zengxin Jiang, Runwen Zhu, Chunfeng Song, Han Tang, Lu Cao, Changan Gu. Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo. Drug design, development and therapy. vol 15. 2021-09-14. PMID:34511883. |
oxidative stress-induced chondrocyte apoptosis and extracellular matrix (ecm) degradation plays an important role in the progression of osteoarthritis (oa). |
2021-09-14 |
2023-08-13 |
Not clear |
| Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhan. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414452. |
sting promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the nf-κb signaling pathway. |
2021-09-13 |
2023-08-13 |
mouse |
| Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhan. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway. Cell death & disease. vol 12. issue 1. 2021-09-13. PMID:33414452. |
the influences of sting on the metabolism of the extracellular matrix (ecm), apoptosis, and senescence, were assessed in sting overexpressing and knocking-down chondrocytes. |
2021-09-13 |
2023-08-13 |
mouse |
| Yuan Liu, Wei Zhou, Fei-Fan Chen, Fei Xiao, Hai-Yang Zhu, Yun Zhou, Guan-Cheng Gu. Overexpression of LMP-1 Decreases Apoptosis in Human Nucleus Pulposus Cells via Suppressing the NF- Oxidative medicine and cellular longevity. vol 2020. 2021-09-13. PMID:33414896. |
increasing extracellular matrix (ecm) synthesis and decreasing nucleus pulposus cell (npc) apoptosis are promising strategies to recover degenerated np. |
2021-09-13 |
2023-08-13 |
human |
| Xiaobo Song, Ole K Greiner-Tollersrud, Huimin Zho. Oral Microbiota Variation: A Risk Factor for Development and Poor Prognosis of Esophageal Cancer. Digestive diseases and sciences. 2021-09-10. PMID:34505256. |
the mechanism of oral bacteria in ec progression is complex, which involves a combination of cytokines, chemokines, oncogenic signaling pathways, cell surface receptors, the degradation of extracellular matrix, and cell apoptosis. |
2021-09-10 |
2023-08-13 |
Not clear |
| Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenbin Hua, Xinghuo Wu, Yukun Zhang, Xianlin Zeng, Cao Yan. Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2021. 2021-09-09. PMID:33628392. |
mechanosensitive ion channel piezo1 activated by matrix stiffness regulates oxidative stress-induced senescence and apoptosis in human intervertebral disc degeneration. |
2021-09-09 |
2023-08-13 |
human |
| Sayeh Mottaghi, Hassan Abbaszade. The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives. Phytotherapy research : PTR. 2021-09-09. PMID:34498311. |
a variety of molecular targets and signaling pathways such as apoptosis, cell cycle, reactive oxygen species (ros), matrix metalloproteinases (mmps), epithelial-mesenchymal transition (emt), and micrornas (mirnas) as well as signal transducer and activator of transcription 3 (stat3), nf-κb, phosphatidylinositol 3-kinase (pi3k)/akt, mitogen-activated protein kinase (mapk), and hippo pathways have been found to be involved in the anticancer effects of morin. |
2021-09-09 |
2023-08-13 |
Not clear |
| Ye Zhang, Weiwei Yi, Huiqiang Xia, Haiyang Lan, Jie Chen, Zhijie Yang, Fei Han, Pan Tang, Bo Li. A20 regulates inflammation through autophagy mediated by NF-κB pathway in human nucleus pulposus cells and ameliorates disc degeneration in vivo. Biochemical and biophysical research communications. vol 549. 2021-09-08. PMID:33677390. |
intervertebral disc degeneration (idd) is closely related to loss of the extracellular matrix (ecm), apoptosis and inflammation in nucleus pulposus cells (npcs). |
2021-09-08 |
2023-08-13 |
human |
| Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qi. Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32691413. |
inhibition of mir-27a-3p protected hg-treated hk-2 cells from apoptosis, extracellular matrix accumulation, mitochondrial dysfunction, and er stress by regulating prohibitin or tmbim6. |
2021-09-07 |
2023-08-13 |
mouse |
| Mengqi Zhang, Yaping Liu, Zhikun Huan, Yan Wang, Jin X. Metformin protects chondrocytes against IL-1β induced injury by regulation of the AMPK/NF-κ B signaling pathway. Die Pharmazie. vol 75. issue 12. 2021-09-07. PMID:33303055. |
in our study, cell viability was measured using cell counting kit-8 assay, expressions of crucial factors involved in the extracellular matrix (ecm) metabolic, proinflammatory response, cell apoptosis, and nuclear factor κ b(nf-κ b) pathway were analyzed using western blot analysis and immunofluorescence staining. |
2021-09-07 |
2023-08-13 |
Not clear |
| Zhiming Lin, Jianing Miao, Tao Zhang, Ming He, Ziyuan Wang, Xinyuan Feng, Lunhao Ba. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Aging cell. vol 20. issue 2. 2021-09-06. PMID:33450132. |
overall, our findings reveal that the junb-fbxo21-erk axis regulates oa apoptosis and cartilage matrix metabolism by inhibiting autophagy. |
2021-09-06 |
2023-08-13 |
rat |
| Tsunehiko Ikeda, Kimitoshi Nakamura, Takaki Sato, Teruyo Kida, Hidehiro Ok. Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33572210. |
anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). |
2021-09-06 |
2023-08-13 |
Not clear |