| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexi Surette, Byong Hoon Yoo, Tallal Younis, Kara Matheson, Tarek Rameh, Jaime Snowdon, Gillian Bethune, Kirill V Rose. Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. Breast cancer research and treatment. vol 187. issue 3. 2021-06-23. PMID:33728523. |
we found previously that erbb2 blocks breast tumor cell anoikis, apoptosis induced by cell detachment from the extracellular matrix, by downregulating the pro-apoptotic protein irf6 and upregulating the anti-apoptotic protein epidermal growth factor receptor (egfr) in the cells and, thus, promotes their three-dimensional growth. |
2021-06-23 |
2023-08-13 |
Not clear |
| Guangxuan Zeng, Gang Deng, Shiliang Xiao, Fei L. Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes. Immunological investigations. 2021-06-23. PMID:34160339. |
fibroblast-like synoviocytes-derived exosomal pcgem1 accelerates il-1β-induced apoptosis and cartilage matrix degradation by mir-142-5p/runx2 in chondrocytes. |
2021-06-23 |
2023-08-13 |
Not clear |
| Ximiao Chen, Chongan Huang, Haiqiu Sun, Haofeng Hong, Jie Jin, Chaoyong Bei, Zhongqiu Lu, Xiaolei Zhan. Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice. Food & function. vol 12. issue 5. 2021-06-22. PMID:33543180. |
the effects of puerarin on apoptosis, extracellular matrix (ecm) metabolism, and inflammation-related factors were assessed; also, the nuclear factor-κb (nf-κb) signaling pathway and nrf2/ho-1 (nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1) axis were evaluated to elucidate the working mechanism of puerarin. |
2021-06-22 |
2023-08-13 |
mouse |
| Soumya Ganguly, Saikat Dewanjee, Ramkrishna Sen, Dipankar Chattopadhyay, Shantanu Ganguly, Raghuvir Gaonkar, Mita Chatterjee Debnat. Apigenin-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma. Colloids and surfaces. B, Biointerfaces. vol 204. 2021-06-22. PMID:33915380. |
in in vivo studies, api-gal-nps exhibited a better protective effect against den-induced hcc in rats evidenced by the significant reduction of nodule formation, downregulation of matrix metalloproteinases (mmp-2 and mmp-9), and induction of apoptosis in the liver than api and api-nps. |
2021-06-22 |
2023-08-13 |
rat |
| Jinhua Luo, Haoyuan You, Jianhua Zhan, Guanghua Guo, Xing Cheng, Guoyu Zhen. Long non-coding RNA TPT1-AS1 alleviates cell injury and promotes the production of extracellular matrix by targeting the microRNA-324-5p/CDK16 axis in human dermal fibroblasts after thermal injury. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-22. PMID:34149889. |
cell viability, cell cycle distribution, cell apoptosis rate and extracellular matrix (ecm) synthesis were assessed with a series of |
2021-06-22 |
2023-08-13 |
human |
| Deyu Zuo, Botao Tan, Gongwei Jia, Dandong Wu, Lehua Yu, Lang Ji. A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway. American journal of translational research. vol 13. issue 5. 2021-06-22. PMID:34149994. |
reactive oxidative stress (ros) related apoptosis in chondrocytes and extracellular matrix (ecm) degradation play crucial roles in the process of osteoarthritis. |
2021-06-22 |
2023-08-13 |
Not clear |
| Deyu Zuo, Botao Tan, Gongwei Jia, Dandong Wu, Lehua Yu, Lang Ji. A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway. American journal of translational research. vol 13. issue 5. 2021-06-22. PMID:34149994. |
the pbnps/lipus combination treatment reduced cellular ros, apoptosis, and matrix metalloproteinases (mmps), as a consequence, alleviated articular cartilage damage in koa. |
2021-06-22 |
2023-08-13 |
Not clear |
| Lulu Wang, Zheng Liu, Dongni Huang, Yuxin Ran, Hanwen Zhang, Jie He, Nanlin Yin, Hongbo Q. IL-37 Exerts Anti-Inflammatory Effects in Fetal Membranes of Spontaneous Preterm Birth via the NF- Mediators of inflammation. vol 2020. 2021-06-21. PMID:32733162. |
however, the inflammatory imbalance at the maternal-fetal interface promotes excessive secretion of inflammatory factors and induces apoptosis and degradation of the extracellular matrix (ecm), which can subsequently lead to preterm birth. |
2021-06-21 |
2023-08-13 |
human |
| Marc Clément, Fabien Lareyre, Alexia Loste, Aurélie Sannier, Fanny Burel-Vandenbos, Nicolas Massiot, Joseph Carboni, Elixène Jean-Baptiste, Giuseppina Caligiuri, Antonino Nicoletti, Juliette Raffor. Vascular Remodeling and Immune Cell Infiltration in Splenic Artery Aneurysms. Angiology. vol 72. issue 6. 2021-06-21. PMID:32851875. |
splenic artery aneurysms were characterized by a profound vascular remodeling with a dramatic loss of vsmcs, elastin degradation, adventitial fibrosis associated with enhanced apoptosis, and increased matrix metalloproteinase 9 expression. |
2021-06-21 |
2023-08-13 |
Not clear |
| Wenchao Zhang, Lin Qi, Ruiqi Chen, Jieyu He, Zhongyue Liu, Wanchun Wang, Chao Tu, Zhihong L. Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications. Arthritis research & therapy. vol 23. issue 1. 2021-06-21. PMID:33436088. |
more importantly, circrnas have been demonstrated to interplay with components in oa microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. |
2021-06-21 |
2023-08-13 |
Not clear |
| Fei Xue, Jianmin Yang, Jing Cheng, Wenhai Sui, Cheng Cheng, Hongxuan Li, Meng Zhang, Jie Zhang, Xingli Xu, Jing Ma, Lin Lu, Jinfeng Xu, Meng Zhang, Yun Zhang, Cheng Zhan. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. British journal of pharmacology. vol 177. issue 8. 2021-06-21. PMID:31658493. |
to test the hypothesis that angiotensin-(1-7) [ang-(1-7)] may attenuate abdominal aortic aneurysm (aaa) via inhibiting vascular inflammation, extracellular matrix degradation, and smooth muscle cell (smc) apoptosis, an animal model of aaa was established by angiotensin ii (ang ii) infusion to apolipoprotein e-knockout (apoe |
2021-06-21 |
2023-08-13 |
mouse |
| Elisabetta Chiaradia, Marco Pepe, Paola Sassi, Ronny Mohren, Pier Luigi Orvietani, Marco Paolantoni, Alessia Tognoloni, Monica Sforna, Maxime Eveque, Niki Tombolesi, Berta Cillero-Pasto. Comparative label-free proteomic analysis of equine osteochondrotic chondrocytes. Journal of proteomics. vol 228. 2021-06-18. PMID:32768606. |
in particular, we identified proteins involved in extracellular matrix degradation and organization, vitamin metabolism, osteoblast differentiation, apoptosis, protein folding and localization, signalling and gene expression modulation and lysosomal activities. |
2021-06-18 |
2023-08-13 |
Not clear |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| Lei Luo, Fanshu Xu, Huilan Peng, Yonghuang Luo, Xiaohe Tian, Giuseppe Battaglia, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Lu. Stimuli-responsive polymeric prodrug-based nanomedicine delivering nifuroxazide and doxorubicin against primary breast cancer and pulmonary metastasis. Journal of controlled release : official journal of the Controlled Release Society. vol 318. 2021-06-17. PMID:31838206. |
meanwhile, histological immunofluorescence and immunohistochemical analyses revealed a high level of apoptosis, suppressed expression of matrix metalloproteinases and reduction in mdscs infiltration, and all these contributed to inhibit pulmonary metastasis. |
2021-06-17 |
2023-08-13 |
mouse |
| Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong B. Long noncoding RNA H19 acts as a miR-29b sponge to promote wound healing in diabetic foot ulcer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 1. 2021-06-15. PMID:33174326. |
silencing of lncrna h19 led to inhibited proliferation, migration, and enhanced apoptosis of fibroblasts, accompanied by downregulated fbn1 but upregulated mir-29b, which diminished the expression of tgf-β1, smad3, fn, and col-1 and reduced extracellular matrix accumulation. |
2021-06-15 |
2023-08-13 |
mouse |
| Q Liu, H Yang, M Zhang, J Zhang, L Lu, S Yu, Y Wu, M Wan. Initiation and progression of dental-stimulated temporomandibular joints osteoarthritis. Osteoarthritis and cartilage. vol 29. issue 5. 2021-06-14. PMID:33422706. |
in the case of insufficient restoration of the matrix, the cells in the deep zone flow into the ones undergoing autophagy, apoptosis, and terminal differentiation while the cells in the superficial zone are promoted to differentiate to supply the loss of the deep zone cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Kenneth P Hough, Miranda L Curtiss, Trevor J Blain, Rui-Ming Liu, Jennifer Trevor, Jessy S Deshane, Victor J Thannicka. Airway Remodeling in Asthma. Frontiers in medicine. vol 7. 2021-06-11. PMID:32509793. |
airway remodeling in asthma constitutes cellular and extracellular matrix changes in the large and small airways, epithelial cell apoptosis, airway smooth muscle cell proliferation, and fibroblast activation. |
2021-06-11 |
2023-08-13 |
Not clear |
| Ren Wu, Fan Zhang, Yuzhong Cai, Zeling Long, Zhixi Duan, Dengke Wu, Yu Zhou, Qiyuan Wan. Circ_0134111 knockdown relieves IL-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network. International immunopharmacology. vol 95. 2021-06-10. PMID:33684877. |
circ_0134111 knockdown relieves il-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-mir-515-5p-socs1 network. |
2021-06-10 |
2023-08-13 |
human |
| Ren Wu, Fan Zhang, Yuzhong Cai, Zeling Long, Zhixi Duan, Dengke Wu, Yu Zhou, Qiyuan Wan. Circ_0134111 knockdown relieves IL-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network. International immunopharmacology. vol 95. 2021-06-10. PMID:33684877. |
osteoarthritis (oa) is characterized by chondrocyte injury and dysfunction, such as excessive apoptosis, inflammatory response and extracellular matrix (ecm) degradation. |
2021-06-10 |
2023-08-13 |
human |