| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandra Z Crawford, Jie Zhang, Akilesh Gokul, Charles N J McGhee, Sue E Ormond. The Enigma of Environmental Factors in Keratoconus. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). vol 9. issue 6. 2021-08-10. PMID:33284230. |
the first 4 factors can induce ocular surface inflammation, matrix metalloproteinase release, and keratocyte apoptosis, consistent with the postulated etiology of keratoconus. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yan Zhou, David Lagare. Methods for Studying Myofibroblast Apoptotic Pathways. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028739. |
evasion of apoptosis by myofibroblasts is a hallmark of fibrotic diseases, ultimately leading to persistent myofibroblast activation, extracellular matrix (ecm) deposition, and remodeling. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yan Zhou, David Lagare. Methods for Studying Myofibroblast Apoptotic Pathways. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028739. |
we have recently discovered that in the process of fibroblast-to-myofibroblast transdifferentiation driven by matrix stiffness, the "mitochondrial priming" (readiness to undergo apoptosis) is dramatically increased in stiffness-activated myofibroblasts. |
2021-08-10 |
2023-08-13 |
Not clear |
| Volha I Summerhill, Vasily N Sukhorukov, Ali H Eid, Ludmila V Nedosugova, Igor A Sobenin, Alexander N Orekho. Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations. Biomolecular concepts. vol 12. issue 1. 2021-08-09. PMID:34115932. |
the pathogenesis of aaa involves several biological processes, including aortic mural inflammation, oxidative stress, vascular smooth muscle cell apoptosis, elastin depletion, and degradation of the extracellular matrix. |
2021-08-09 |
2023-08-13 |
Not clear |
| Roman Pawla. Vitamin B12 status is a risk factor for bone fractures among vegans. Medical hypotheses. vol 153. 2021-08-09. PMID:34116377. |
the detrimental impact of inadequate b12 status on bone tissue is both direct, via the impairment of the insulin-like growth hormone 1 and taurine synthesis, and indirect, induced through its hyperhomocysteinemic effect, via at least the following mechanisms: 1) reducing bone mineral content and density by accumulating in the extracellular matrix, 2) reducing osteoblasts and increasing osteoclasts function, 3) reducing blood flow to bone tissue, 4) inducing apoptosis via the reactive oxygen-species-mediated mitochondrial pathway, and 5) obstructing the formation of collagen cross-links, impeding lyslyl oxidase, and hampering insolubility of fibrils. |
2021-08-09 |
2023-08-13 |
Not clear |
| Takeshi Uemura, Takehiro Suzuki, Kenta Ko, Mizuho Nakamura, Naoshi Dohmae, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarash. Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction. Cytoskeleton (Hoboken, N.J.). vol 77. issue 10. 2021-08-04. PMID:33070462. |
these findings indicate that a dysfunction of the cytoskeleton by acrolein is strongly involved in the tissue damage during brain infarction, together with the apoptosis caused by glyceraldehyde-3-phosphate dehydrogenase and protein degradation by matrix metalloproteinase-9. |
2021-08-04 |
2023-08-13 |
mouse |
| Anastasiya Muntyanu, Michelle Le, Zainab Ridha, Elizabeth O'Brien, Ivan V Litvinov, Philippe Lefrançois, Elena Netchiporou. Novel role of long non-coding RNAs in autoimmune cutaneous disease. Journal of cell communication and signaling. 2021-08-04. PMID:34346026. |
in ssc, negative regulator of ifn response (nrir) was thought to modulate interferon (ifn) response in monocytes, anti-sense gene to x-inactivation specific transcript (tsix) to regulate increased collagen stability, hox transcript antisense rna (hotair) to increase numbers of myofibroblasts, otud6b-anti-sense rna 1 to decrease fibroblast apoptosis, ncrna00201 to regulate pathways in ssc pathogenesis and carcinogenesis, h19x potentiating tgf-β-driven extracellular matrix production, and finally psmb8-as1 potentiates ifn response. |
2021-08-04 |
2023-08-13 |
Not clear |
| Olivier Schussler, Juan C Chachques, Marco Alifano, Yves Lecarpentie. Key Roles of RGD-Recognizing Integrins During Cardiac Development, on Cardiac Cells, and After Myocardial Infarction. Journal of cardiovascular translational research. 2021-08-03. PMID:34342855. |
cardiac cells interact with the extracellular matrix (ecm) proteins through integrin mechanoreceptors that control many cellular events such as cell survival, apoptosis, differentiation, migration, and proliferation. |
2021-08-03 |
2023-08-13 |
Not clear |
| Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming H. The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress. Aging. vol 12. issue 10. 2021-08-02. PMID:32445555. |
the results showed that sirt1 could promote bmp2-induced chondrogenic differentiation of mscs, and reduce the apoptosis and decomposition of extracellular matrix under oxidative stress. |
2021-08-02 |
2023-08-13 |
Not clear |
| Chien-Ming Chao, Chun-Liang Chen, Ko-Chi Niu, Cheng-Hsien Lin, Ling-Yu Tang, Lieh-Sheng Lin, Ching-Ping Chan. Hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia. International journal of medical sciences. vol 17. issue 17. 2021-08-02. PMID:33162790. |
hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia. |
2021-08-02 |
2023-08-13 |
rat |
| Lingang Xu, Nan Sun, Guangshuai Li, Linbo Li. LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway. Molecular and cellular biochemistry. vol 476. issue 3. 2021-08-02. PMID:33389493. |
besides, h19 knockdown hindered the proliferation, migration, invasion, extracellular matrix (ecm) deposition, and enhanced the apoptosis of keloid fibroblasts. |
2021-08-02 |
2023-08-13 |
Not clear |
| R J Kim, S H An, J Y Gwark, H B Par. Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts. European cells & materials. vol 41. 2021-08-02. PMID:34114203. |
expressions of hypoxia-inducible factor-1α (hif-1α) and heme oxygenase-1 (ho-1), cell viability, intracellular reactive oxygen species (ros) production, apoptosis rates as well as expressions of cleaved caspase-3, cleaved poly adp-ribose polymerase-1 (parp-1), vascular endothelial growth factors-β (vegf-β) and matrix metalloproteinase-2 (mmp-2) were evaluated. |
2021-08-02 |
2023-08-13 |
rat |
| Yu Du, Xinrui Lin, Qiang Feng, Xinyan Pan, Shuling Song, Julun Yan. Inhibition of human lung cancer cells by anti-p21Ras scFv mediated by the activatable cell-penetrating peptide. Anti-cancer drugs. 2021-08-02. PMID:34338241. |
we found that acpp-p21ras scfv could penetrate tumour cell membranes with high expression of matrix metalloproteinase-2 (mmp-2), effectively inhibit the migration and proliferation of a549 cells and h1299 cells, and promote the apoptosis of a549 cells and h1299 cells. |
2021-08-02 |
2023-08-13 |
human |
| Xianjun Tan, Tao Li, Shaowei Zhu, Weiying Zhong, Feng Li, Yunyan Wan. Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32495004. |
the results showed that sparc upregulated the expression of nox4 through the tgf-β1-dependent signaling pathway, leading to oxidative stress and pro-inflammatory matrix behavior and apoptosis in hbvsmcs. |
2021-07-29 |
2023-08-13 |
human |
| Li-Wen Huang, Tzu-Ching Huang, Yu-Chen Hu, Bau-Shan Hsieh, Hsiao-Ling Cheng, Pu-Rong Chiu, Kee-Lung Chan. S-Equol Protects Chondrocytes against Sodium Nitroprusside-Caused Matrix Loss and Apoptosis through Activating PI International journal of molecular sciences. vol 22. issue 13. 2021-07-29. PMID:34209006. |
s-equol protects chondrocytes against sodium nitroprusside-caused matrix loss and apoptosis through activating pi osteoarthritis (oa) is a common chronic disease with increasing prevalence in societies with more aging populations, therefore, it is causing more concern. |
2021-07-29 |
2023-08-13 |
rat |
| Julio Aguila, Shangli Cheng, Nigel Kee, Ming Cao, Menghan Wang, Qiaolin Deng, Eva Hedlun. Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-27. PMID:34305528. |
network analysis reveal gene interactions unique to each subpopulation and highlight differences in regulation of mitochondrial stability, apoptosis, neuronal survival, cytoskeleton regulation, extracellular matrix modulation as well as synapse integrity, which could explain the relative resilience of vta dopamine neurons. |
2021-07-27 |
2023-08-13 |
human |
| Pengfei Xia, Jin Liang, Di Jin, Zhanyong Ji. Reversine inhibits proliferation, invasion and migration and induces cell apoptosis in gastric cancer cells by downregulating TTK. Experimental and therapeutic medicine. vol 22. issue 3. 2021-07-27. PMID:34306198. |
rev-treated cells exhibited reduced matrix metalloproteinase (mmp)2/9 expression and increased apoptosis compared with those in control cells. |
2021-07-27 |
2023-08-13 |
human |
| Jia Xiaoshi, Li Maoquan, Wang Jiwei, Ning Jinqiu, Zhao K. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-26. PMID:33617050. |
the pathological characteristics of osteoarthritis are cartilage matrix degradation, chondrocytes apoptosis, and low-grade inflammation of the joint. |
2021-07-26 |
2023-08-13 |
Not clear |
| Jian Li, Mingting Liu, Xianrang Li, Hui Shi, Shui Su. Long noncoding RNA ZFAS1 suppresses chondrocytes apoptosis via miR-302d-3p/SMAD2 in osteoarthritis. Bioscience, biotechnology, and biochemistry. vol 85. issue 4. 2021-07-26. PMID:33686420. |
long noncoding rna zinc finger antisense 1 (zfas1) is downregulated and tightly associated with proliferation, migration, apoptosis, and matrix synthesis of chondrocyte in oa. |
2021-07-26 |
2023-08-13 |
Not clear |
| Michele Andreucci, Michele Provenzano, Teresa Faga, Ashour Michael, Gemma Patella, Pasquale Mastroroberto, Giuseppe Filiberto Serraino, Umberto Marcello Bracale, Nicola Ielapi, Raffaele Serr. Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases. Biomolecules. vol 11. issue 2. 2021-07-23. PMID:33573220. |
metalloproteinases (mps) are proteolytic enzymes involved in extracellular matrix deposition, regulation of cellular signals of inflammation, proliferation, and apoptosis. |
2021-07-23 |
2023-08-13 |
human |