| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi-Cong Tao, Ji-Yan Huang, Yuan Gao, Zi-Xiang Li, Zhan-Ying Wei, Helen Dawes, Shang-Chun Gu. Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioactive materials. vol 6. issue 12. 2021-05-26. PMID:34027234. |
osteoarthritis (oa), characterized by chondrocyte apoptosis and disturbance of the balance between catabolism and anabolism of the extracellular matrix (ecm), is the most common age-related degenerative joint disease worldwide. |
2021-05-26 |
2023-08-13 |
Not clear |
| Abeer M Hegazy, Nan Chen, Hanzuo Lin, Sarath Babu V, Feng Li, Youcheng Yang, Zhendong Qin, Fei Shi, Jun Li, Li Li. Induction of apoptosis in SSN-1cells by Snakehead Fish Vesiculovirus (SHVV) via Matrix protein dependent intrinsic pathway. Fish & shellfish immunology. vol 113. 2021-05-25. PMID:33757800. |
induction of apoptosis in ssn-1cells by snakehead fish vesiculovirus (shvv) via matrix protein dependent intrinsic pathway. |
2021-05-25 |
2023-08-13 |
Not clear |
| Ali Raza Jahejo, Wen Xia Tia. Cellular, molecular and genetical overview of avian tibial dyschondroplasia. Research in veterinary science. vol 135. 2021-05-24. PMID:33066991. |
the failure of angiogenesis attributed improper nutrients supply to the chondrocytes; ultimately, bone development stopped, poor calcification of cartilage matrix, and apoptosis of chondrocytes occurred. |
2021-05-24 |
2023-08-13 |
chicken |
| Júlia Chaumel, Merlind Schotte, Joseph J Bizzarro, Paul Zaslansky, Peter Fratzl, Daniel Baum, Mason N Dea. Co-aligned chondrocytes: Zonal morphological variation and structured arrangement of cell lacunae in tessellated cartilage. Bone. vol 134. 2021-05-17. PMID:32058019. |
during this process, cartilage cells (chondrocytes) mineralize the extracellular matrix and undergo apoptosis, giving way to bone cells (osteocytes). |
2021-05-17 |
2023-08-13 |
Not clear |
| Talita Pizza Anunciato Casarini, Luiza Abrahão Frank, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterre. Dermatological applications of the flavonoid phloretin. European journal of pharmacology. vol 889. 2021-05-14. PMID:32971088. |
phloretin has been shown to inhibit elastase and matrix metalloproteinase-1 activity, to reduce cellular tyrosinase activity and melanin content, and induce apoptosis in b16 mouse melanoma 4a5 cells. |
2021-05-14 |
2023-08-13 |
mouse |
| Shan-Shan Wang, Chen Wang, Han Che. MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33089928. |
in the last decade, a variety of micrornas have been identified as key regulators for the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition in vascular smooth muscle cells during vascular calcification. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chuchu Lin, Xuan Yang, Huatian Li, Yiqing Zou, Imran Shair Mohammad, Hehui Rong, Yiqin Rao, Jia Song, Sharon S Y Leung, Haiyan H. Self-assembled nanomedicine combining a berberine derivative and doxorubicin for enhanced antitumor and antimetastatic efficacy via mitochondrial pathways. Nanoscale. vol 13. issue 13. 2021-05-14. PMID:33885540. |
driven by delocalized lipophilic cations, nanodrugs could escape from lysosomes and reach mitochondria to induce a cascade reaction and finally cell apoptosis, as well as suppressing matrix metalloprotease (mmp)-2 and -9 activities and finally cell migration and invasion. |
2021-05-14 |
2023-08-13 |
mouse |
| Masaaki Ito, Takashi Yurube, Yutaro Kanda, Yuji Kakiuchi, Yoshiki Takeoka, Toru Takada, Ryosuke Kuroda, Kenichiro Kakutan. Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism. International journal of molecular sciences. vol 22. issue 8. 2021-05-12. PMID:33921398. |
inhibition of autophagy at different stages by atg5 knockdown and chloroquine supplementation enhances consistent human disc cellular apoptosis and senescence induction rather than extracellular matrix catabolism. |
2021-05-12 |
2023-08-13 |
human |
| Regan J Hayward, James W Marsh, Michael S Humphrys, Wilhelmina M Huston, Garry S A Myer. Chromatin accessibility dynamics of Chlamydia-infected epithelial cells. Epigenetics & chromatin. vol 13. issue 1. 2021-05-10. PMID:33109274. |
these regions and motifs were linked to genomic features and genes associated with immune responses, re-direction of host cell nutrients, intracellular signalling, cell-cell adhesion, extracellular matrix, metabolism and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Masanari Umemura, Masatoshi Narikawa, Ryo Tanaka, Hiroko Nemoto, Rina Nakakaji, Akane Nagasako, Yoshihiro Ishikaw. [Doxorubicin directly induced fibrotic change of cardiac fibroblasts]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 156. issue 3. 2021-05-10. PMID:33952842. |
dox also increased the mrna and protein expression of matrix metalloproteinase (mmp)-1 in less than 0.1 μm which did not induce cell apoptosis of hcfs cells via pi3k/akt pathway in hcfs. |
2021-05-10 |
2023-08-13 |
mouse |
| Junwei Yan, Xuejiao Yang, Xuefei Jiao, Xian Yang, Mingjin Guo, Yunqing Chen, Lu Zhan, Wenshi Che. Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K-Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31680442. |
previous studies found that some pathways were related to glaucoma, such as extracellular matrix (ecm)-receptor interaction, phosphatidylinositol 3-kinase (pi3k)-protein kinase b (akt) and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Vadivel Dinesh Babu, Anandasadagopan Suresh Kumar, Ganapasam Sudhandira. Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis. Drug and chemical toxicology. 2021-05-07. PMID:32924642. |
a consequent disturbance of fibroblast proliferation and apoptosis results in subsequent release of pro-inflammatory and pro-fibrotic mediators coupled with accumulation of extracellular matrix within the interstitium. |
2021-05-07 |
2023-08-13 |
rat |
| Daniele Vergara, William H Catherino, Giuseppe Trojano, Andrea Tinell. Vitamin D: Mechanism of Action and Biological Effects in Uterine Fibroids. Nutrients. vol 13. issue 2. 2021-05-06. PMID:33670322. |
in vitro studies proved vitamin d efficacy in inhibiting ufs growth by targeting pathways involved in the regulation of various biological processes, including proliferation, extracellular matrix (ecm) remodeling, dna repair, signaling and apoptosis. |
2021-05-06 |
2023-08-13 |
Not clear |
| Hao Zhang, Fang Liang, Junmin Yue, Peng Liu, Junyong Wang, Zhaoyang Wang, Hongxing Li, Duo Cheng, Jie Du, Kai Zhang, Peng D. MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626928. |
further results from the cell counting kit‑8, cell death detection elisa plus kit, transwell assay, rt‑qpcr and western blotting assays revealed that the mir‑137 mimic prevented cell proliferation, facilitated apoptosis and repressed cell migration, invasiveness, and expression of n‑cadherin, vimentin and matrix metalloproteinase 2; the mir‑137 inhibitor exerted the opposite effects. |
2021-05-05 |
2023-08-13 |
Not clear |
| Wei Liu, Xifeng Xiong, Weiguang Chen, Xiaojian Li, Xing Hua, Zhihe Liu, Zhi Zhan. High expression of FUSE binding protein 1 in breast cancer stimulates cell proliferation and diminishes drug sensitivity. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626933. |
furthermore, the knockdown of fbp1 decreased cell migration and metastasis by downregulating matrix metalloproteinase 2 expression, and enhanced the sensitivity of tnbc cells to cisplatin by inducing apoptosis. |
2021-05-05 |
2023-08-13 |
human |
| Rakhee K Ramakrishnan, Khuloud Bajbouj, Saba Al Heialy, Bassam Mahboub, Abdul Wahid Ansari, Ibrahim Y Hachim, Surendra Rawat, Laila Salameh, Mahmood Y Hachim, Ronald Olivenstein, Rabih Halwani, Rifat Hamoudi, Qutayba Hami. IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts. Frontiers in immunology. vol 11. 2021-05-05. PMID:32670268. |
the accumulation of fibroblasts, their synthesis of extracellular matrix (ecm) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. |
2021-05-05 |
2023-08-13 |
human |
| Z-L Han, H-Q Wang, T-S Zhang, Y-X He, H Zho. Up-regulation of exosomal miR-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting TIMP-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation. European review for medical and pharmacological sciences. vol 24. issue 15. 2021-05-04. PMID:32767336. |
up-regulation of exosomal mir-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting timp-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation. |
2021-05-04 |
2023-08-13 |
Not clear |
| Hannah J Yu, Charles C Wykof. Investigational Agents in Development for the Treatment of Geographic Atrophy Secondary to Age-Related Macular Degeneration. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 35. issue 3. 2021-05-03. PMID:33893984. |
several other biochemical pathways have also been implicated in ga development and progression, such as mitochondrial components, mediators of apoptosis and molecules involved in extracellular matrix remodeling, many of which are also being investigated for their potential value as therapeutic targets for ga treatment. |
2021-05-03 |
2023-08-13 |
human |
| Mingqi Sun, Junli Yang, Dianming Jiang, Guoyu Ba. Overexpression of hsa_circ_0094742 inhibits IL-1β-induced decline in CHON-001 cell viability by targeting microRNA-127-5p. Histology and histopathology. vol 36. issue 2. 2021-04-29. PMID:33665792. |
furthermore, il-1β-induced alterations in aggrecan, matrix metallopeptidase 13, x-linked inhibitor of apoptosis protein (xiap), bax and active caspase 3 were reversed by hsa_circ_0094742 oe. |
2021-04-29 |
2023-08-13 |
human |
| Sabrina L Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbau. Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32417168. |
olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. |
2021-04-28 |
2023-08-13 |
rat |