| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huaming Xue, Yihui Tu, Tong Ma, Tao Wen, Tao Yang, Long Xue, Minwei Cai, Fangxing Wang, Mengying Gua. miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4. Bone. vol 123. 2020-07-20. PMID:30930294. |
overexpression of mir-93-5p promoted chondrocyte viability, suppressed chondrocyte apoptosis, and maintained the balance between anabolic and catabolic factors of the extracellular matrix in vitro. |
2020-07-20 |
2023-08-13 |
human |
| Dorothy H J Cheong, Daniel W S Tan, Fred W S Wong, Thai Tra. Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. Pharmacological research. vol 158. 2020-07-20. PMID:32405226. |
artemisinins can regulate the expression of pro-inflammatory cytokines, nuclear factor-kappa b (nf-κb), matrix metalloproteinases (mmps), vascular endothelial growth factor (vegf), promote cell cycle arrest, drive reactive oxygen species (ros) production and induce bak or bax-dependent or independent apoptosis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Jeffrey C Horowitz, Daniel J Tschumperlin, Kevin K Kim, John J Osterholzer, Natalya Subbotina, Iyabode O Ajayi, Seagal Teitz-Tennenbaum, Ammara Virk, Megan Dotson, Fei Liu, Delphine Sicard, Shijing Jia, Thomas H Sisso. Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis. Thrombosis and haemostasis. vol 119. issue 12. 2020-07-09. PMID:31705517. |
prior studies demonstrate that enhanced pa in the lung limits the severity of scarring following injury and in vitro studies indicate that pa promotes matrix degradation and fibroblast apoptosis. |
2020-07-09 |
2023-08-13 |
Not clear |
| Wenbo Chen, Yaying Sun, Xueping Gu, Yuefeng Hao, Xingwang Liu, Jinrong Lin, Jiwu Chen, Shiyi Che. Conditioned medium of mesenchymal stem cells delays osteoarthritis progression in a rat model by protecting subchondral bone, maintaining matrix homeostasis, and enhancing autophagy. Journal of tissue engineering and regenerative medicine. vol 13. issue 9. 2020-07-08. PMID:31210406. |
well-maintained subchondral bone structure, significantly more abundant cartilage matrix, notably decreased ratio of mmp-13 to timp-1, and inhibited chondrocyte apoptosis with enhanced autophagy were observed in the cm group compared with the pbs group. |
2020-07-08 |
2023-08-13 |
rat |
| Sule Ayla, Sercin Karahüseyinoglu. Cancer Stem Cells, Their Microenvironment and Anoikis. Critical reviews in oncogenesis. vol 24. issue 1. 2020-07-08. PMID:31679217. |
as a barrier to metastases, cells normally undergo apoptosis (cell death process) after they lose contact with their extracellular matrix or neighboring cells. |
2020-07-08 |
2023-08-13 |
Not clear |
| Savita Singh, Michael Torzewsk. Fibroblasts and Their Pathological Functions in the Fibrosis of Aortic Valve Sclerosis and Atherosclerosis. Biomolecules. vol 9. issue 9. 2020-07-06. PMID:31510085. |
post wound repair, these cells undergo apoptosis or become senescent; however, in the presence of unresolved inflammation and persistence signaling for myofibroblast activation, the tissue homeostasis is disturbed, leading to excessive extracellular matrix (ecm) secretion, disorganized ecm, and thickening of the affected tissue. |
2020-07-06 |
2023-08-13 |
Not clear |
| Jie Zhou, Anjing Liang, Junmin Hong, Jianchao Sun, Xiaolin Lin, Yan Peng, Xiaofei Wang, Siguo Sun, Dong Xiao, Kang Xu, Wei Y. MicroRNA-155 suppresses the catabolic effect induced by TNF-α and IL-1β by targeting C/EBPβ in rat nucleus pulposus cells. Connective tissue research. vol 60. issue 2. 2020-07-03. PMID:29852820. |
mir-155 controls apoptosis and matrix degradation in nucleus pulposus (np) cells in vitro. |
2020-07-03 |
2023-08-13 |
rat |
| Sidong Yang, Feng Zhang, Jiangtao Ma, Wenyuan Din. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing research reviews. vol 57. 2020-06-30. PMID:31669486. |
oestrogen can decrease ivd cell apoptosis in multiple ways, including the inhibition of the inflammatory cytokines il-1β and tnf-α, reducing catabolism because of inhibition of matrix metalloproteinases, upregulating integrin α |
2020-06-30 |
2023-08-13 |
Not clear |
| Shi-Kang Deng, Jian-Zhong Tang, Yan Jin, Ping-Hai Hu, Jun-Feng Wang, Xiao-Wen Zhan. Activin B signaling may promote the conversion of normal fibroblasts to scar fibroblasts. Medicine. vol 99. issue 24. 2020-06-29. PMID:32541451. |
their function were associated with activin signaling, synthesis and degradation of extracellular matrix, formation and activation of cytokine, inflammatory reaction, immunoreaction, tissue damage reaction, cell cycle, migration, apoptosis, and secretion, etc. |
2020-06-29 |
2023-08-13 |
human |
| Fangnan Ma, Guangheng Li, Yangyi Yu, Jianzhong Xu, Xuejian W. MiR-33b-3p promotes chondrocyte proliferation and inhibits chondrocyte apoptosis and cartilage ECM degradation by targeting DNMT3A in osteoarthritis. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31522815. |
mir-33b-3p overexpression or dnmt3a knockdown inhibited extracellular matrix (ecm) degradation and cell apoptosis and promoted cell proliferation in il-1β-induced chondrocytes. |
2020-06-29 |
2023-08-13 |
Not clear |
| Yao Li, Yaosen Wu, Kaixia Jiang, Wen Han, Jing Zhang, Lin Xie, Yanlong Liu, Jian Xiao, Xiangyang Wan. Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis. Oxidative medicine and cellular longevity. vol 2019. 2020-06-25. PMID:31885823. |
osteoarthritis (oa) is an age-related degenerative disease with complicated pathology involving chondrocyte apoptosis and extracellular matrix (ecm) degradation. |
2020-06-25 |
2023-08-13 |
mouse |
| Xue-Lin Zeng, Lu Sun, Hua-Qing Zheng, Guan-Lei Wang, Yan-Hua Du, Xiao-Fei Lv, Ming-Ming Ma, Yong-Yuan Gua. Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition. Journal of molecular and cellular cardiology. vol 134. 2020-06-24. PMID:31301303. |
cerebrovascular remodeling is the leading factor for stroke and characterized by increased extracellular matrix deposition, migration and proliferation of vascular smooth muscle cells, and inhibition of their apoptosis. |
2020-06-24 |
2023-08-13 |
Not clear |
| Xinghuo Wu, Zhiwei Liao, Kun Wang, Wenbin Hua, Xianzhe Liu, Yu Song, Yukun Zhang, Shuhua Yang, Cao Yan. Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc. Experimental & molecular medicine. vol 51. issue 9. 2020-06-22. PMID:31554783. |
intervertebral disc degeneration (idd) is characterized by excessive apoptosis of nucleus pulposus (np) cells and hyperactive extracellular matrix (ecm) catabolism. |
2020-06-22 |
2023-08-13 |
human |
| Po-Ting Wu, Wei-Ren Su, Chia-Lung Li, Jeng-Long Hsieh, Ching-Hou Ma, Chao-Liang Wu, Li-Chieh Kuo, I-Ming Jou, Shih-Yao Che. Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy. The Journal of biological chemistry. vol 294. issue 52. 2020-06-22. PMID:31732563. |
inhibition of cd44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy. |
2020-06-22 |
2023-08-13 |
human |
| Po-Ting Wu, Wei-Ren Su, Chia-Lung Li, Jeng-Long Hsieh, Ching-Hou Ma, Chao-Liang Wu, Li-Chieh Kuo, I-Ming Jou, Shih-Yao Che. Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy. The Journal of biological chemistry. vol 294. issue 52. 2020-06-22. PMID:31732563. |
our data imply that cd44 may play a role in tendinopathy via regulating apoptosis, inflammation, and extracellular matrix homeostasis. |
2020-06-22 |
2023-08-13 |
human |
| Su-Ya Wang, Jiang-Wei Sang, Wei Ding, Ting-Wu Qin, Lin Bai, Jie Zhang, Jing-Cong Lu. The cytoptrotection of small intestinal submucosa-derived gel in HL-1 cells during hypoxia/reoxygenation-induced injury. Journal of tissue engineering and regenerative medicine. vol 13. issue 8. 2020-06-19. PMID:31062928. |
sis gel and sis matrix as coating substrates markedly improved cell viability, preventing cell apoptosis compared with uncoated plates, with sis gel yielding the best cytoprotective effects. |
2020-06-19 |
2023-08-13 |
Not clear |
| Nan Wang, Ruizhen Li, Min Xu. Potential regulatory network in the PSG10P/miR-19a-3p/IL1RAP pathway is possibly involved in preeclampsia pathogenesis. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-06-18. PMID:30370628. |
in vivo experiments showed that il1rap promoted the expression of caspase-3, a key apoptosis enzyme, but inhibited mmp9, which is responsible for degrading the extracellular matrix, suggesting a significant role of il1rap in cell proliferation, migration, and invasion. |
2020-06-18 |
2023-08-13 |
mouse |
| Guoqing Li, Wei Tan, Yuxuan Fang, Xia Wu, Wei Zhou, Chunwang Zhang, Yu Zhang, Yanqing Liu, Guangzheng Jiu, Dan Li. circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking. Aging. vol 11. issue 10. 2020-06-17. PMID:31141496. |
in contrast, mir-498 down-regulation affected circfads2 silencing, promoting extracellular matrix (ecm) degradation and apoptosis. |
2020-06-17 |
2023-08-13 |
rat |
| Yongqi Li, Weicheng Wang, Lei Li, Raouf A Khali. MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm. Life sciences. vol 253. 2020-06-15. PMID:32283055. |
the occurrence and development of aaa involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. |
2020-06-15 |
2023-08-13 |
Not clear |
| Madhura Patankar, Taneli Mattila, Juha P Väyrynen, Kai Klintrup, Jyrki Mäkelä, Anne Tuomisto, Pentti Nieminen, Markus J Mäkinen, Tuomo J Karttune. Putative anoikis-resistant subpopulations in colorectal carcinoma: a marker of adverse prognosis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 128. issue 5. 2020-06-12. PMID:32202676. |
anoikis is a form of apoptosis induced when a cell loses contact with the extracellular matrix (ecm). |
2020-06-12 |
2023-08-13 |
Not clear |