| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
in addition, the effects of mir-4262 on cell viability, cell apoptosis, cell autophagy and matrix synthesis were inhibited by sirt1 (p<0.05). |
2020-10-01 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
the present study revealed that the upregulation of mir-4262 may promote the occurrence and development of oa in rats by regulating cell viability, cell apoptosis, cell autophagy, and matrix synthesis. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Zhao, Yuping Yang, Lingling Song, Tianyi Kang, Ting Du, Yujiao Wu, Meimei Xiong, Li Luo, Jianlin Long, Ke Men, Lan Zhang, Xiaoxin Chen, Meijuan Huang, Maling Go. A Vesicular Stomatitis Virus-Inspired DNA Nanocomplex for Ovarian Cancer Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 5. issue 3. 2020-09-30. PMID:29593949. |
this dna nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)-poly (d,l-lactide) (mpeg-pla) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (vsvmp) that plays a critical role in the vsv-induced apoptosis of cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Guowei Shang, Yang Mi, Yingwu Mei, Guanghui Wang, Yadong Wang, Xinjie Li, Yisheng Wang, Yuebai Li, Guoqiang Zha. MicroRNA-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731885. |
microrna-192 inhibits the proliferation, migration and invasion of osteosarcoma cells and promotes apoptosis by targeting matrix metalloproteinase-11. |
2020-09-30 |
2023-08-13 |
Not clear |
| Sai Wang Seto, Dennis Chang, Hosen Kiat, Ning Wang, Alan Bensoussa. Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm. Frontiers in cardiovascular medicine. vol 5. 2020-09-30. PMID:29732374. |
multiple mechanisms are involved in the development and progression of aaa, including chronic inflammation, oxidative stress, vascular smooth muscle (vsmc) apoptosis, immune cell infiltration and extracellular matrix (ecm) degradation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Gabriela Sofía Gómez-Macías, María Lourdes Garza-Rodríguez, Raquel Garza-Guajardo, Daniela Monsiváis-Ovalle, Jesús Ancer-Rodríguez, Hugo Alberto Barrera-Saldaña, Oralia Barboza-Quintan. Overexpression of the matrix metalloproteinase 11 gene is a potential biomarker for type 1 endometrial cancer. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963184. |
metalloproteinase matrix 11 (mmp11) is a member of the matrix metalloproteinase family, which are able to degrade extracellular matrix components, and may serve a central function in the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Tian Li, Kewei Xu, Yifan Li. Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP-9 signaling pathways in human bladder cancer cells. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127910. |
salidroside induced autophagy, promoted the protein expression of nucleoporin p62 and the microtubule-associated proteins 1a/1b light chain 3b, suppressed phosphoinositide 3-kinase (pi3k) and phosphorylated protein kinase b (p-akt) expression, inhibited matrix metalloproteinase-9 (mmp-9) expression and increased that of bcl-2-associated x protein, which functions as an apoptosis regulator in t24 cells. |
2020-09-30 |
2023-08-13 |
human |
| Sang Hwan Kim, Ji Hye Lee, Jong Taek Yoo. Expression of matrix metalloproteinases to induce the expression of genes associated with apoptosis during corpus luteum development in bovine. PeerJ. vol 7. 2020-09-30. PMID:30729068. |
expression of matrix metalloproteinases to induce the expression of genes associated with apoptosis during corpus luteum development in bovine. |
2020-09-30 |
2023-08-13 |
cattle |
| Shu-Hai Chen, Bing-Yuan Zhang, Bin Zhou, Cheng-Zhan Zhu, Le-Qi Sun, Yu-Jie Fen. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. American journal of cancer research. vol 9. issue 1. 2020-09-30. PMID:30755808. |
pni occurs through changes in nerve cells and supporting cells in the background of cancer; change and migration of the perineural matrix; enhancement of the viability, mobility, and invasiveness of the tumor cells; injury and regeneration of nerve cells; interaction, chemotactic movement, contact, and adherence of the nerve cells and the tumor cells; escape from autophagy, apoptosis, and immunological surveillance of tumor cells; and so on. |
2020-09-30 |
2023-08-13 |
Not clear |
| Joseph P Miller, Brandon H Borde, Francois Bordeleau, Matthew R Zanotelli, Danielle J LaValley, Dylan J Parker, Lawrence J Bonassar, Susan C Pannullo, Cynthia A Reinhart-Kin. Clinical doses of radiation reduce collagen matrix stiffness. APL bioengineering. vol 2. issue 3. 2020-09-30. PMID:31069314. |
cells receive mechanical cues from their extracellular matrix (ecm), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. |
2020-09-30 |
2023-08-13 |
Not clear |
| Negar Sharifi, Anneh Mohammad Gharrav. Shear bioreactors stimulating chondrocyte regeneration, a systematic review. Inflammation and regeneration. vol 39. 2020-09-30. PMID:31410225. |
mechanism of shear stress on chondrocyte, briefly can be hypothesized as (1) altered expression of aggrecan and collagen type ii, (2) altered cartilage oligomeric matrix protein (comp) serum levels, consequently, organizing the arrangement binding of glycosaminoglycans, integrins, and collagen, (3) induction of apoptosis signals, (4) altered expression of integrin. |
2020-09-30 |
2023-08-13 |
human |
| Xuyang Zhang, Jian Chen, Bao Huang, Jiasheng Wang, Zhi Shan, Junhui Liu, Yilei Chen, Shengyun Li, Shunwu Fan, Fengdong Zha. Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration. Frontiers in physiology. vol 10. 2020-09-30. PMID:31649558. |
obesity mediates apoptosis and extracellular matrix metabolic imbalances via mapk pathway activation in intervertebral disk degeneration. |
2020-09-30 |
2023-08-13 |
human |
| Frank Murphy, Julian Waung, Jane Collins, Michael JP Arthur, Hideaki Nagase, Derek Mann, R Christopher Benyon, John P Iredal. N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. Comparative hepatology. vol 3 Suppl 1. 2020-09-30. PMID:14960160. |
timp-1 has also been shown to have a key role because of its ability to inhibit apoptosis of hsc via matrix metalloproteinase (mmp) inhibition. |
2020-09-30 |
2023-08-12 |
rat |
| Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyay. Galectin-3: a potential target for cancer prevention. Trends in carbohydrate research. vol 3. issue 2. 2020-09-30. PMID:25484547. |
protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mirae Park, Hyeyoung Ki. Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review. Journal of cancer prevention. vol 22. issue 1. 2020-09-30. PMID:28382280. |
dha shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting wnt/β-catenin signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Maren Schoepp, Anda Jana Ströse, Jörg Haie. Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment. Cancers. vol 9. issue 6. 2020-09-30. PMID:28538690. |
in summary, deregulated mirs affect various intracellular functional complexes, such as transcriptional factors, extracellular matrix, cytoskeleton, emt/met regulation, soluble factors, tyrosine kinase and g-protein signaling, apoptosis and cell cycle & differentiation, but also formation and composition of the extracellular microenvironment. |
2020-09-30 |
2023-08-13 |
Not clear |
| Muhammad Omer Jamil, Mary S Jerome, Deborah Miley, Katri S Selander, Francisco Rober. A pilot study of zoledronic acid in the treatment of patients with advanced malignant pleural mesothelioma. Lung Cancer (Auckland, N.Z.). vol 8. 2020-09-30. PMID:28652837. |
in preclinical studies, nitrogen-containing bisphosphonates (zoledronic acid) inhibit growth of mesothelioma cells by different mechanisms: inhibition of mevalonate pathway, inhibition of angiogenesis, activation of apoptosis through caspase activation, and alteration in activity of matrix metalloproteinases, thereby affecting invasiveness of cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Daniela Melchiorre, Mirko Manetti, Marco Matucci-Cerini. Pathophysiology of Hemophilic Arthropathy. Journal of clinical medicine. vol 6. issue 7. 2020-09-30. PMID:28672826. |
both cytokines and matrix metalloproteinases and hydroxyl radicals may induce chondrocyte apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang, Jiang-Feng W. The roles of microRNA families in hepatic fibrosis. Cell & bioscience. vol 7. 2020-09-30. PMID:28680559. |
during the process of hepatic fibrosis, mir-29 family primarily induces cell apoptosis by modulating phosphatidylinositol 3-kinase/akt signaling pathway and regulates extracellular matrix accumulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yingqiu Xie, Aidana Mustafa, Adina Yerzhan, Dalmira Merzhakupova, Perizat Yerlan, Askarbek N Orakov, Xiao Wang, Yi Huang, Lixia Mia. Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment. Cell death discovery. vol 3. 2020-09-30. PMID:28811933. |
matrix metalloproteinase (mmp) is defined as an endopeptidase in the extracellular matrix (ecm), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. |
2020-09-30 |
2023-08-13 |
Not clear |