| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weijia Zhao, Zonghan Chen, Meng Gua. Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31106479. |
furthermore, it altered the expression of various proteins associated with cell growth (ki67, p21, cyclin a, cyclin e, and cyclin-dependent kinase 2), migration (matrix metalloproteinase-2 [mmp-2], mmp-9, and tissue inhibitor of metalloproteinase-1), apoptosis (poly[adp-ribose] polymerase 1 and caspase 3), and drug resistance (p-glycoprotein 1, lung resistance-related protein 1, growth arrest and dna damage-45α, glutathione s-transferase π, and heat shock protein 27) in paclitaxel-resistant osteosarcoma cells. |
2020-09-14 |
2023-08-13 |
human |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
long noncoding rna malat-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the jnk signaling pathway. |
2020-09-14 |
2023-08-13 |
rat |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
in this current study, we explored the chondroprotective effects of long noncoding rna (lncrna) malat-1 on cell proliferation, apoptosis, and matrix metabolism in il-1β-induced inflammation in articular chondrocytes. |
2020-09-14 |
2023-08-13 |
rat |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
taken together these results, lncrna malat-1 blocked the activation of the jnk signaling pathway; thereby, il-1β-induced inflammation in articular chondrocytes was reduced with enhanced chondrocyte proliferation and suppressed chondrocyte apoptosis and extracellular matrix degradation. |
2020-09-14 |
2023-08-13 |
rat |
| Jianhong Qiang, Tingting Lv, Zhenbiao Wu, Xichao Yan. Down-regulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting nuclear factor-κB signaling. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31239367. |
the viability, colony formation, apoptosis, migration, invasion, and the levels of interleukin (il)-6, and matrix metalloproteinase 3 (mmp-3) were detected. |
2020-09-11 |
2023-08-13 |
human |
| Wenmei Zhang, Yanna Li, Xin Xi, Guangfa Zhu, Shenghao Wang, Yan Liu, Man Son. MicroRNA‑15a‑5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP‑2 signaling pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894295. |
in addition, the overexpression of mir‑15a‑5p reduced pasmc proliferation, induced apoptosis, promoted the activity of caspase‑3/9, induced the protein expression of b‑cell lymphoma 2‑associated x protein (bax), decreased the expression of b‑cell lymphoma 2 (bcl‑2), increased inflammation, as indicated by the expression of tumor necrosis factor‑α (tnf)‑α and interleukin (il)‑1β, il‑6 and il‑18, suppressed the protein expression of vascular endothelial growth factor (vegf), and promoted the protein expression levels of phosphorylated (p)‑p38 mitogen‑activated protein kinase (p38) and matrix metalloproteinase (mmp)‑2 in the pasmcs of rats with mct‑induced pah. |
2020-09-11 |
2023-08-13 |
rat |
| Yihui Tu, Tong Ma, Tao Wen, Tao Yang, Long Xue, Minwei Cai, Fangxin Wang, Mengying Guan, Huaming Xu. MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6. Biochemical and biophysical research communications. vol 523. issue 1. 2020-09-10. PMID:31831175. |
overexpression of mir-377-3p enhanced chondrocyte proliferation and restrained apoptosis and signs of cartilage matrix degradation and of an inflammatory response. |
2020-09-10 |
2023-08-13 |
Not clear |
| Yihui Tu, Tong Ma, Tao Wen, Tao Yang, Long Xue, Minwei Cai, Fangxin Wang, Mengying Guan, Huaming Xu. MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6. Biochemical and biophysical research communications. vol 523. issue 1. 2020-09-10. PMID:31831175. |
overexpression of itga6 reversed the effects of mir-377-3p on il-1β-caused chondrocyte apoptosis, cartilage matrix degradation, and the inflammatory response. |
2020-09-10 |
2023-08-13 |
Not clear |
| Pingping Hu, Dong Fang, Liping Shen, Huangao Zhou, Rui Shao, Miao Chen, Chenghu Yao, Yang Shi, Qian Che. Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer. Journal of biomaterials applications. vol 34. issue 4. 2020-09-09. PMID:31195918. |
fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and d-dimer. |
2020-09-09 |
2023-08-13 |
Not clear |
| Mitali Ray, Michael V Autier. Regulation of pro- and anti-atherogenic cytokines. Cytokine. vol 122. 2020-09-09. PMID:29221669. |
cytokines mediate atherogenesis by stimulating expression of numerous proteins necessary for induction of a host of cellular responses, including inflammation, extravasation, proliferation, apoptosis, and matrix production. |
2020-09-09 |
2023-08-13 |
Not clear |
| Joon Seok Lee, Jong Seong Kim, Jeong Woo Lee, Kang Young Choi, Jung Dug Yang, Byung Chae Cho, Eun Jung Oh, Tae Jung Kim, Ung Hyun Ko, Jennifer H Shin, Sewha Jeon, Yong Jig Lee, Ho Yun Chun. Effect of Keratinocytes on Myofibroblasts in Hypertrophic Scars. Aesthetic plastic surgery. vol 43. issue 5. 2020-09-04. PMID:31346713. |
myofibroblasts play a central role in matrix formation and wound contraction during wound healing and undergo apoptosis at the end of the healing. |
2020-09-04 |
2023-08-13 |
Not clear |
| Yue Hu, Zhipeng Gui, Yuning Zhou, Lunguo Xia, Kaili Lin, Yuanjin X. Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free radical biology & medicine. vol 145. 2020-09-02. PMID:31550528. |
cartilage matrix degradation, production of proinflammatory mediators, chondrocyte apoptosis and activation of macrophages in the synovial are involved in oa pathogenesis. |
2020-09-02 |
2023-08-13 |
rat |
| Li Wenzhao, Ni Jiangdong, Song Deye, Ding Muliang, Wang Junjie, Huang Xianzhe, Yan Mingming, Huang Ju. Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. Cell cycle (Georgetown, Tex.). vol 18. issue 18. 2020-09-01. PMID:31313630. |
in the current study, we used quantitative real-time pcr(q-pcr) to detect them rna levels of collagen type ii alpha 1(col2a1), aggrecan, mmp3(matrix metallopeptidase 3), mmp13, adamts4 and adamts5; enzyme-linked immunosorbent assay(elisa) was used to detect the content of il-1β and calpain protein; cell apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling(tunel) assay and flow cytometryanalysis; western blot and immunofluorescence assays were applied to assess the expression of hmgb1; lastly autophagic activity was mainly verified by monodansylcadaverine (mdc) staining. |
2020-09-01 |
2023-08-13 |
mouse |
| Y Kakiuchi, T Yurube, K Kakutani, T Takada, M Ito, Y Takeoka, Y Kanda, S Miyazaki, R Kuroda, K Nishid. Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction. Osteoarthritis and cartilage. vol 27. issue 6. 2020-08-31. PMID:30716534. |
pharmacological inhibition of mtorc1 but not mtorc2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through akt and autophagy induction. |
2020-08-31 |
2023-08-13 |
human |
| Chia-Ter Chao, Hsiang-Yuan Yeh, Tzu-Hang Yuan, Chih-Kang Chiang, Huei-Wen Che. MicroRNA-125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31301111. |
specific mirnas are involved in the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition of endothelial cells and/or vascular smooth muscle cells. |
2020-08-28 |
2023-08-13 |
Not clear |
| Surinder M Soond, Maria V Kozhevnikova, Andrey A Zamyatni. 'Patchiness' and basic cancer research: unravelling the proteases. Cell cycle (Georgetown, Tex.). vol 18. issue 15. 2020-08-27. PMID:31213124. |
while extracellular cathepsins are generally believed to be of central importance in tumour progression, through their ability to modulate the architecture of the extracellular matrix, intracellular cathepsins have been established as being of extreme significance in mediating cell death through apoptosis. |
2020-08-27 |
2023-08-13 |
Not clear |
| Jun Long, Xiaobo Wang, Xianfa Du, Hehai Pan, Jianru Wang, Zemin Li, Hui Liu, Xudong Li, Zhaomin Zhen. JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix. Arthritis research & therapy. vol 21. issue 1. 2020-08-27. PMID:31619270. |
jag2/notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix. |
2020-08-27 |
2023-08-13 |
Not clear |
| Lei Li, Guohua Lv, Bing Wang, Lei Kuan. XIST/miR-376c-5p/OPN axis modulates the influence of proinflammatory M1 macrophages on osteoarthritis chondrocyte apoptosis. Journal of cellular physiology. vol 235. issue 1. 2020-08-25. PMID:31215024. |
in the present study, we reveal that the overexpression of osteopontin (opn), a cytokine, and a matrix protein involved in arthritis and chondrocyte apoptosis in oa, could exacerbate the inflammatory microenvironment in oa via promoting the production of proinflammation cytokines and the levels of degradative enzymes in m1 macrophages, therefore, enhancing the cytotoxicity of m1 macrophage on chondrocytes. |
2020-08-25 |
2023-08-13 |
Not clear |
| Suravi Majumder, Lu Ren, Sathnur Pushpakumar, Utpal Se. Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade. Cellular signalling. vol 61. 2020-08-21. PMID:31085234. |
hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through akt/foxo1 signalling cascade. |
2020-08-21 |
2023-08-13 |
Not clear |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
the akt signaling pathway regulates cellularity and matrix production in ivds and its inactivation is known to contribute to a catabolic shift and increased cell loss via apoptosis. |
2020-08-20 |
2023-08-13 |
mouse |