| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanlin Piao, Dehai Yi. Mechanism underlying treatment of diabetic kidney disease using Traditional Chinese Medicine based on theory of Yin and Yang balance. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 38. issue 5. 2020-03-27. PMID:32185999. |
however, the persistent abnormal overactivation of reactions causes secondary cell dysfunction, cell apoptosis, increased extracellular matrix (ecm) secretion, and eventually renal fibrosis. |
2020-03-27 |
2023-08-13 |
Not clear |
| Feng Tian, Junhu Wang, Zhanhua Zhang, Jie Yan. miR-107 modulates chondrocyte proliferation, apoptosis, and extracellular matrix synthesis by targeting PTEN. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-03-25. PMID:31933853. |
mir-107 modulates chondrocyte proliferation, apoptosis, and extracellular matrix synthesis by targeting pten. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jai-Jen Tsai, Jiann-Hwa Chen, Cheng Hsien Chen, Jing-Gung Chung, Fei-Ting Hs. Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma in vivo. Environmental toxicology. vol 35. issue 2. 2020-03-16. PMID:31714653. |
in addition, expression of phospho-erk (p-erk), nf-κb p65 (ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (mmp-9), vascular endothelial growth factor (vegf), x-linked inhibitor of apoptosis protein (xiap), and cyclind1 were all significantly decreased by magnolol. |
2020-03-16 |
2023-08-13 |
Not clear |
| Hao Li, Haochen Xu, Hongyan Wen, Tianlong Liu, Yingying Sun, Ning Xiao, Congxia Bai, Jing Ge, Xuliang Wang, Li Song, Yan Song, Yinhui Zhang, Jingzhou Che. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 3. 2020-03-10. PMID:30516406. |
lh3 overexpression was sufficient to enhance bm integrity, inhibit matrix metalloproteinase activity, attenuate microglial activation and leukocyte infiltration, and reduce vsmc apoptosis before ich. |
2020-03-10 |
2023-08-13 |
mouse |
| João Pedro Ferreira, Job Verdonschot, Timothy Collier, Ping Wang, Anne Pizard, Christian Bär, Jens Björkman, Alessandro Boccanelli, Javed Butler, Andrew Clark, John G Cleland, Christian Delles, Javier Diez, Nicolas Girerd, Arantxa González, Mark Hazebroek, Anne-Cécile Huby, Wouter Jukema, Roberto Latini, Joost Leenders, Daniel Levy, Alexandre Mebazaa, Harald Mischak, Florence Pinet, Patrick Rossignol, Naveed Sattar, Peter Sever, Jan A Staessen, Thomas Thum, Nicolas Vodovar, Zhen-Yu Zhang, Stephane Heymans, Faiez Zanna. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. Circulation. Heart failure. vol 12. issue 5. 2020-03-09. PMID:31104495. |
these 38 proteins pointed to 4 main network clusters underlying incident hf: (1) inflammation and apoptosis, indicated by the expression of the tnf (tumor necrosis factor)-family members; (2) extracellular matrix remodeling, angiogenesis and growth, indicated by the expression of proteins associated with collagen metabolism, endothelial function, and vascular homeostasis; (3) blood pressure regulation, indicated by the expression of natriuretic peptides and proteins related to the renin-angiotensin-aldosterone system; and (4) metabolism, associated with cholesterol and atherosclerosis. |
2020-03-09 |
2023-08-13 |
Not clear |
| João Pedro Ferreira, Job Verdonschot, Timothy Collier, Ping Wang, Anne Pizard, Christian Bär, Jens Björkman, Alessandro Boccanelli, Javed Butler, Andrew Clark, John G Cleland, Christian Delles, Javier Diez, Nicolas Girerd, Arantxa González, Mark Hazebroek, Anne-Cécile Huby, Wouter Jukema, Roberto Latini, Joost Leenders, Daniel Levy, Alexandre Mebazaa, Harald Mischak, Florence Pinet, Patrick Rossignol, Naveed Sattar, Peter Sever, Jan A Staessen, Thomas Thum, Nicolas Vodovar, Zhen-Yu Zhang, Stephane Heymans, Faiez Zanna. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. Circulation. Heart failure. vol 12. issue 5. 2020-03-09. PMID:31104495. |
conclusions clusters of biomarkers associated with mechanistic pathways leading to hf were identified linking inflammation, apoptosis, vascular function, matrix remodeling, blood pressure control, and metabolism. |
2020-03-09 |
2023-08-13 |
Not clear |
| Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortie. Mitoprotective therapy preserves chondrocyte viability and prevents cartilage degeneration in an ex vivo model of posttraumatic osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020-03-06. PMID:29469223. |
further, ss-31 prevented impact-induced chondrocyte apoptosis, cell membrane damage, and cartilage matrix degeneration. |
2020-03-06 |
2023-08-13 |
cattle |
| Yiting Lou, Jun Wu, Jinxi Liang, Chengwei Yang, Kuo Wang, Jianshun Wang, Xiaoshan Gu. Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy. International immunopharmacology. vol 75. 2020-03-05. PMID:31306979. |
the administration of sestrin2-sirna significantly decreased autophagy and reversed the protective effect of eupatilin against chondrocyte apoptosis and degradation of the cartilage matrix. |
2020-03-05 |
2023-08-13 |
Not clear |
| William Durant. The Emerging Role of l-Glutamine in Cardiovascular Health and Disease. Nutrients. vol 11. issue 9. 2020-03-05. PMID:31487814. |
by serving as a substrate for the synthesis of dna, atp, proteins, and lipids, gln drives critical processes in vascular cells, including proliferation, migration, apoptosis, senescence, and extracellular matrix deposition. |
2020-03-05 |
2023-08-13 |
Not clear |
| Naoya Kond. [Development of Novel Nuclear Medical Imaging Probes for Quantification of Matrix Metalloproteinases in Diseases]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 140. issue 1. 2020-03-05. PMID:31902888. |
matrix metalloproteinases (mmps) regulate various cellular functions, such as motility, invasion, differentiation, and apoptosis. |
2020-03-05 |
2023-08-13 |
Not clear |
| Masahiro Nakahashi, Mariko Esumi, Yasuaki Tokuhash. Detection of apoptosis and matrical degeneration within the intervertebral discs of rats due to passive cigarette smoking. PloS one. vol 14. issue 8. 2020-02-28. PMID:31454348. |
based on these findings, we hypothesized that passive cigarette smoking-induced stress stimuli first affect the cep through blood flow due to the histological proximity, thereby stimulating chondrocyte apoptosis and reduction of the extracellular matrix (ecm). |
2020-02-28 |
2023-08-13 |
rat |
| Madhura Patankar, Sinikka Eskelinen, Anne Tuomisto, Markus J Mäkinen, Tuomo J Karttune. KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells. Molecular medicine reports. vol 20. issue 5. 2020-02-28. PMID:31545494. |
in a number of types of cancer, anoikis, a form of apoptosis induced by loss of extracellular matrix (ecm) attachment, is disturbed. |
2020-02-28 |
2023-08-13 |
Not clear |
| Rajkiran Reddy Banala, Satish Kumar Vemuri, Ghulam Hassan Dar, Vijayanand Palanisamy, Murahari Penkulinti, M V Surekha, A V Gurava Reddy, Madhusudhana Rao Nalam, Gpv Subbaia. Efficiency of dual siRNA-mediated gene therapy for intervertebral disc degeneration (IVDD). The spine journal : official journal of the North American Spine Society. vol 19. issue 5. 2020-02-27. PMID:30439528. |
the pathophysiology of disc degeneration involves apoptosis of nucleus pulposes cells and degradation of extra cellular matrix (ecm). |
2020-02-27 |
2023-08-13 |
Not clear |
| Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Den. The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease. Journal of diabetes research. vol 2019. 2020-02-27. PMID:31534972. |
the pathological features of dkd are the hypertrophy of mesangial cells, apoptosis of podocytes, glomerular basement membrane (gbm) thickening, accumulation of extracellular matrix (ecm), glomerular sclerosis, and tubulointerstitial fibrosis. |
2020-02-27 |
2023-08-13 |
Not clear |
| Mohammad M Al-Qatta. A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis. BioMed research international. vol 2019. 2020-02-26. PMID:31637260. |
the final step is the suppression of retinoic acid in the interdigital mesenchyme leading to suppression of both apoptosis and extracellular matrix (ecm) degradation, resulting in syndactyly. |
2020-02-26 |
2023-08-13 |
Not clear |
| Xiao-Feng Xu, Jian-Jiang Wang, Li Ding, Jin-Song Ye, Li-Juan Huang, Lan Tao, Feng Gao, Yong J. Suppression of BMX-ARHGAP fusion gene inhibits epithelial-mesenchymal transition in gastric cancer cells via RhoA-mediated blockade of JAK/STAT axis. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30216523. |
epithelial-mesenchymal transition (emt) is an important biological process involving the process by which malignant tumor cells obtain the ability of migration, invasion, resistance of apoptosis, and degradation in the extracellular matrix. |
2020-02-25 |
2023-08-13 |
mouse |
| Nadezhda I Kozlova, Galina E Morozevich, Natalia A Ushakova, Albert E Berma. Implication of integrin α2β1 in anoikis of SK-Mel-147 human melanoma cells: a non-canonical function of Akt protein kinase. Oncotarget. vol 10. issue 19. 2020-02-25. PMID:30956761. |
suppression of anoikis, a kind of apoptosis caused by disruption of contacts between cell and extracellular matrix, is an important prerequisite for cancer cell metastasis. |
2020-02-25 |
2023-08-13 |
human |
| Sara Mendes, Filipa Timóteo-Ferreira, Henrique Almeida, Elisabete Silv. New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment. Oxidative medicine and cellular longevity. vol 2019. 2020-02-21. PMID:31341539. |
invading evts are required to perform a scope of functions: move, adhere, proliferate, differentiate, interact, and digest the extracellular matrix (ecm); tolerate hypoxia; transform the maternal spiral arteries; and die by apoptosis. |
2020-02-21 |
2023-08-13 |
Not clear |
| Timóteo Abrantes De Lacerda Almeida, Marcelo Volpon Santos, Luiza Da Silva Lopes, Gunjan Goel, Renato Leonardo De Freitas, Priscila De Medeiros, José Alexandre Crippa, Hélio Rubens Machad. Intraperitoneal cannabidiol attenuates neonatal germinal matrix hemorrhage-induced neuroinflamation and perilesional apoptosis. Neurological research. vol 41. issue 11. 2020-02-20. PMID:31378168. |
intraperitoneal cannabidiol attenuates neonatal germinal matrix hemorrhage-induced neuroinflamation and perilesional apoptosis. |
2020-02-20 |
2023-08-13 |
Not clear |
| Qiuyue Peng, Aishu Luo, Zihao Zhou, Wenhua Xuan, Ming Qiu, Qin Wu, Lingxiao Xu, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wan. Interleukin 29 inhibits RANKL-induced osteoclastogenesis via activation of JNK and STAT, and inhibition of NF-κB and NFATc1. Cytokine. vol 113. 2020-02-19. PMID:30001863. |
although il-29 did not affect the viability and apoptosis of raw264.7 cells, it inhibited multinucleated cells in the differentiation of osteoclastogenesis, the bone-resorbing activity of mature osteoclasts and osteoclastic specific genes expression including trap, cathepsin k (ctsk), nuclear factor of activated t-cells, cytoplasmic 1 (nfatc1), c-fos and matrix metallopeptidase 9 (mmp-9). |
2020-02-19 |
2023-08-13 |
human |