| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Mo Gu, Seung Oe Lim, Young Min Park, Guhung Jun. A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion. The FEBS journal. vol 275. issue 12. 2008-07-10. PMID:18489585. |
furthermore, comparison analysis of wild-type occludin (occ(wt)) and occ(deltae9) revealed that exon 9 played important roles in the induction of mitochondria-mediated apoptosis and the inhibition of invasion, along with the downregulation of matrix metalloproteinase expression. |
2008-07-10 |
2023-08-12 |
Not clear |
| Michelle L Bowie, Catherine Ibarra, Victoria L Seewal. IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis. Advances in experimental medicine and biology. vol 617. 2008-07-10. PMID:18497060. |
here, we show that both tamoxifen (tam) and three-dimensional prepared extracellular matrix culture (3-d recm) induce apoptosis in hmec cells with acute loss of p53 [*p53(-) hmecs] through induction of interferon regulatory factor-1 (irf-1). |
2008-07-10 |
2023-08-12 |
human |
| Anthony J Valentijn, John-Paul Upton, Andrew P Gilmor. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18307410. |
in the present study, we have examined endogenous bax in epithelial cells undergoing anoikis, a physiologically relevant form of apoptosis that occurs when normal cells lose contact with the ecm (extracellular matrix). |
2008-07-03 |
2023-08-12 |
Not clear |
| Terumi Takahara, Feng Xue, Massimiliano Mazzone, Yutaka Yata, Kazunobu Nonome, Masami Kanayama, Kengo Kawai, Alberto M Pisacane, Shiro Takahara, Xiao-Kang Li, Paolo M Comoglio, Toshiro Sugiyama, Paolo Michiel. Metron factor-1 prevents liver injury without promoting tumor growth and metastasis. Hepatology (Baltimore, Md.). vol 47. issue 6. 2008-07-03. PMID:18506889. |
we show that (1) mf-1 and hgf stimulate hepatocyte proliferation in vitro; (2) mf-1 and hgf protect primary hepatocytes against fas-induced and drug-induced apoptosis; (3) hgf but not mf-1 induces scattering and matrigel invasion of carcinoma cell lines in vitro; (4) hgf but not mf-1 promotes migration and extracellular matrix invasion of endothelial cells in vitro; (5) mf-1 and hgf prevent ccl(4)-induced acute liver injury as measured by alanine aminotransferase (alt) levels, histology, terminal deoxynucleotidyl transferase-mediated nick-end labeling (tunel) analysis, and phospho-histone-3 immunostaining; (6) mf-1 and hgf attenuate liver fibrosis caused by chronic ccl(4) intoxication and promote regeneration as measured by sirius red staining, alpha-smooth muscle actin immunostaining, and ki-67 analysis; (7) hgf but not mf-1 promotes tumor growth, angiogenesis, and metastasis in a variety of xenograft models; (8) hgf but not mf-1 promotes intrahepatic dissemination of hepatocarcinoma cells injected orthotopically. |
2008-07-03 |
2023-08-12 |
mouse |
| Ina Hadshiew, Kirsten Barre, Enikö Bódó, Wolfgang Funk, Ralf Pau. T-oligos as differential modulators of human scalp hair growth and pigmentation: a new "time lapse system" for studying human skin and hair follicle biology in vitro? Archives of dermatological research. vol 300. issue 4. 2008-07-01. PMID:18239924. |
after only 48 h, t-oligos induced a fourfold increase in pigmentation of human anagen vi hair bulbs, while hair matrix keratinocyte proliferation was reduced by 65%, without apparent changes in hair bulb cell apoptosis. |
2008-07-01 |
2023-08-12 |
human |
| Kazunori Hamamura, Yunlong Liu, Hiroki Yokot. Microarray analysis of thapsigargin-induced stress to the endoplasmic reticulum of mouse osteoblasts. Journal of bone and mineral metabolism. vol 26. issue 3. 2008-07-01. PMID:18470663. |
little is known about molecular pathways that can potentially lead to stress-induced apoptosis or homeostasis of extracellular matrix (ecm) molecules. |
2008-07-01 |
2023-08-12 |
mouse |
| K L Posey, Y Yang, A C Veerisetty, S K Sharan, J T Hech. Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations. Cellular and molecular life sciences : CMLS. vol 65. issue 5. 2008-06-17. PMID:18193163. |
these model systems have revealed several important features of the psach cellular pathology: unfolded protein response activation, upregulation of apoptosis and inappropriate assembly of matrix network in the rer. |
2008-06-17 |
2023-08-12 |
mouse |
| Soheila Sharghi-Namini, Huapeng Fan, K N Sulochana, Padma Potturi, Wei Xiang, Yap-Seng Chong, Zhengyuan Wang, He Yang, Ruowen G. The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor. Biochemical and biophysical research communications. vol 371. issue 2. 2008-06-16. PMID:18433719. |
in this study, we show that the first tsr domain of the extracellular matrix protease adamts5, unlike the second tsr, has anti-angiogenic activities where it inhibits endothelial cell tube formation on matrigel, reduces cell proliferation and attachment, while promoting cell apoptosis and migration, all in a dose-dependent manner. |
2008-06-16 |
2023-08-12 |
Not clear |
| Oliver Seifert, Ardeshir Bayat, Robert Geffers, Kirstin Dienus, Jan Buer, Sture Löfgren, Andreas Matusse. Identification of unique gene expression patterns within different lesional sites of keloids. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 16. issue 2. 2008-06-11. PMID:18282266. |
the apoptosis inhibitor aven was found to be up-regulated at the active margin of keloids, while apoptosis-inducing genes such as adam12 and genes inducing extracellular matrix (ecm) degradation such as matrix metalloproteinase-19 were up-regulated in the regressing keloid center. |
2008-06-11 |
2023-08-12 |
human |
| Judit Marsillach, Natàlia Ferré, Jordi Camps, Anna Rull, Raul Beltran, Jorge Jove. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17938867. |
chronic liver diseases are accompanied by changes in the biochemical pathways related to the regulation of apoptosis and extra-cellular matrix deposition. |
2008-06-10 |
2023-08-12 |
rat |
| Judit Marsillach, Natàlia Ferré, Jordi Camps, Anna Rull, Raul Beltran, Jorge Jove. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17938867. |
ccl(4) administration over 12 weeks was associated with significant changes in b-cell leukemia/lymphoma 2, procollagen type i alpha 2, matrix metalloproteinases 3 and 8, tissue inhibitors of metalloproteinases 1, 2, and 3 and the inhibitor of apoptosis 4 gene expressions. |
2008-06-10 |
2023-08-12 |
rat |
| Judit Marsillach, Natàlia Ferré, Jordi Camps, Anna Rull, Raul Beltran, Jorge Jove. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17938867. |
recovery after ccl(4) cessation was associated with changes in procollagen type i alpha 2, matrix metalloproteinase 7, tissue inhibitors of metalloproteinases 1 and 2, inhibitor of apoptosis 4, and survivin gene expressions. |
2008-06-10 |
2023-08-12 |
rat |
| Y B Shi, Q Li, S Damjanovski, T Amano, A Ishizuya-Ok. Regulation of apoptosis during development: input from the extracellular matrix (review). International journal of molecular medicine. vol 2. issue 3. 2008-06-05. PMID:9855698. |
regulation of apoptosis during development: input from the extracellular matrix (review). |
2008-06-05 |
2023-08-12 |
mouse |
| Juan L Contreras, Guadalupe Bilbao, Cheryl A Smyth, Devin E Eckhoff, Xiao L Jiang, Stacie Jenkins, Francis T Thomas, David T Curiel, Judith M Thoma. Cytoprotection of pancreatic islets before and early after transplantation using gene therapy. Kidney international. vol 61. issue 1 Suppl. 2008-06-03. PMID:11841618. |
apoptosis has been documented in pi after extracellular matrix removal, during culture time, after exposure to proinflammatory cytokines, hypoxic conditions before islet revascularization, and rejection. |
2008-06-03 |
2023-08-12 |
mouse |
| Juan L Contreras, Guadalupe Bilbao, Cheryl A Smyth, Devin E Eckhoff, Xiao L Jiang, Stacie Jenkins, Francis T Thomas, David T Curiel, Judith M Thoma. Cytoprotection of pancreatic islets before and early after transplantation using gene therapy. Kidney international. vol 61. issue 1 Suppl. 2008-06-03. PMID:11841618. |
bcl-2 transfection ex vivo protects islets from apoptosis induced by disruption of the islet extracellular matrix during pancreatic digestion. |
2008-06-03 |
2023-08-12 |
mouse |
| Isabel Zvibel, Dan Bar-Zohar, Yoel Kloog, Ran Oren, Shimon Rei. The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. Digestive diseases and sciences. vol 53. issue 4. 2008-06-03. PMID:17934818. |
the effect of ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. |
2008-06-03 |
2023-08-12 |
rat |
| Hui Xing, Yang Cao, Danhui Weng, Wenming Tao, Xiaohong Song, Wei Wang, Li Meng, Gang Xu, Jianfeng Zhou, Shixuan Wang, Ding M. Fibronectin-mediated activation of Akt2 protects human ovarian and breast cancer cells from docetaxel-induced apoptosis via inhibition of the p38 pathway. Apoptosis : an international journal on programmed cell death. vol 13. issue 2. 2008-06-03. PMID:18158623. |
although multiple mechanisms have been implicated in chemoresistance, recent evidence has suggested that the attachment of cells to extracellular matrix proteins such as fibronectin (fn) may mediate the signals that participate in cell survival and resistance to apoptosis. |
2008-06-03 |
2023-08-12 |
human |
| Alexander Scott, Håkan Alfredson, Sture Forsgre. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 5. 2008-05-19. PMID:18050306. |
excessive free glutamate is expected to impact a variety of autocrine and paracrine functions important in the development of tendinosis, including tenocyte proliferation and apoptosis, extracellular matrix metabolism, nociception, and blood flow. |
2008-05-19 |
2023-08-12 |
Not clear |
| Atsuyasu Sato, Yuma Hoshino, Tomijiro Hara, Shigeo Muro, Hajime Nakamura, Michiaki Mishima, Junji Yodo. Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. The Journal of pharmacology and experimental therapeutics. vol 325. issue 2. 2008-05-19. PMID:18256171. |
compared with c57bl6/j mice, trx-transgenic mice had significantly less inflammation, oxidative damage, and apoptosis, as well as decreased levels of matrix metalloprotease-12 mrna and serum tnf-alpha. |
2008-05-19 |
2023-08-12 |
mouse |
| N Zhang, J Li, R Luo, J Jiang, J-A Wan. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 116. issue 2. 2008-05-15. PMID:18286426. |
studies have demonstrated mscs transplantation can prevent apoptosis of ischemic heart via upregulation of akt and enos and inhibit myocardial fibrosis of dilated cardiomyopathy by decreasing the expression of matrix metalloproteinase (mmp) in rat models. |
2008-05-15 |
2023-08-12 |
rat |