| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hironobu Ih. Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis. Journal of dermatological science. vol 49. issue 2. 2008-03-06. PMID:17628443. |
tgf-beta regulates diverse biological activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix synthesis. |
2008-03-06 |
2023-08-12 |
Not clear |
| Lars Gullestad, Erik Oie, Thor Ueland, Arne Yndestad, Pål Aukrus. The role of statins in heart failure. Fundamental & clinical pharmacology. vol 21 Suppl 2. 2008-03-06. PMID:18001320. |
beneficial effects include attenuation of cardiac hypertrophy, improvement in endothelial function, anti-inflammatory effects, reduction in the activity of matrix metalloproteinases, reduction in apoptosis, interference with neurohormones, and improved homeostasis. |
2008-03-06 |
2023-08-12 |
human |
| Aoi Nabata, Masatoshi Kuroki, Hiroto Ueba, Shigemasa Hashimoto, Tomio Umemoto, Hiroshi Wada, Takanori Yasu, Muneyasu Saito, Shin-Ichi Momomura, Masanobu Kawakam. C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis. vol 196. issue 1. 2008-02-29. PMID:17531242. |
c-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: implications for the destabilization of atherosclerotic plaque. |
2008-02-29 |
2023-08-12 |
human |
| Vanda Szlávik, János Vág, Károly Markó, Kornél Demeter, Emília Madarász, Imre Oláh, Tivadar Zelles, Brian C O'Connell, Gábor Varg. Matrigel-induced acinar differentiation is followed by apoptosis in HSG cells. Journal of cellular biochemistry. vol 103. issue 1. 2008-02-29. PMID:17541949. |
here we investigated the changes in cell proliferation and apoptosis upon terminal differentiation of hsg cells in matrigel, an extracellular matrix derivative. |
2008-02-29 |
2023-08-12 |
human |
| Mabrouka Doghman, Tatiana Karpova, Giovanna Assis Rodrigues, Malika Arhatte, Juliana De Moura, Luciane R Cavalli, Virginie Virolle, Pascal Barbry, Gerard P Zambetti, Bonald C Figueiredo, Leslie L Heckert, Enzo Lall. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Molecular endocrinology (Baltimore, Md.). vol 21. issue 12. 2008-02-26. PMID:17761949. |
gene expression profiling showed that an increased sf-1 dosage regulates transcripts involved in steroid metabolism, the cell cycle, apoptosis, and cell adhesion to the extracellular matrix. |
2008-02-26 |
2023-08-12 |
mouse |
| Christian C Kazanecki, Dana J Uzwiak, David T Denhard. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. Journal of cellular biochemistry. vol 102. issue 4. 2008-02-26. PMID:17910028. |
osteopontin (opn) plays roles in a variety of cellular processes from bone resorption and extracellular matrix (ecm) remodeling to immune cell activation and inhibition of apoptosis. |
2008-02-26 |
2023-08-12 |
Not clear |
| Yee H Looi, David J Grieve, Anjana Siva, Simon J Walker, Narayana Anilkumar, Alison C Cave, Michael Marber, Mark J Monaghan, Ajay M Sha. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension (Dallas, Tex. : 1979). vol 51. issue 2. 2008-02-26. PMID:18180403. |
nox2(-/-) mice exhibited less cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis; reduced increases in expression of connective tissue growth factor and procollagen 1 mrna; and smaller increases in myocardial matrix metalloproteinase-2 activity than wt mice. |
2008-02-26 |
2023-08-12 |
mouse |
| Yao-Hong Song, Bao-Shi Li, Xiang-Min Chen, Hui Ca. Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. International journal of molecular medicine. vol 21. issue 1. 2008-02-25. PMID:18097624. |
ethanol extract from epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. |
2008-02-25 |
2023-08-12 |
rat |
| Yao-Hong Song, Bao-Shi Li, Xiang-Min Chen, Hui Ca. Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. International journal of molecular medicine. vol 21. issue 1. 2008-02-25. PMID:18097624. |
in conclusion, epi-ext ameliorates lv dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with chf. |
2008-02-25 |
2023-08-12 |
rat |
| Narong Bunyaratave. [Experience of vitamin K2 in Thailand]. Clinical calcium. vol 17. issue 11. 2008-02-21. PMID:17982197. |
vitamin k(2) has dual actions, stimulates osteoblastic functions, for synthesis of osteocalcin, osteonectin and other matrix bone proteins, in addition, new finding, in stem cell culture found osteoblast producing gene expression of collagen type 1, the other action, vitamin k(2) contains mild antiresorpion by inducing the osteoclastic apoptosis. |
2008-02-21 |
2023-08-12 |
Not clear |
| Javier Muñoz-Luque, Josefa Ros, Guillermo Fernández-Varo, Sònia Tugues, Manuel Morales-Ruiz, Carlos E Alvarez, Scott L Friedman, Vicente Arroyo, Wladimiro Jiméne. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. The Journal of pharmacology and experimental therapeutics. vol 324. issue 2. 2008-02-19. PMID:18029545. |
at the end of treatment, mean arterial pressure and portal pressure were measured, and liver samples were obtained to evaluate infiltrate of mononuclear cells, hepatic apoptosis, alpha-smooth muscle actin (sma) expression, collagen content, and matrix metalloproteinase (mmp)-2 abundance in all animals. |
2008-02-19 |
2023-08-12 |
human |
| Becky A Mercer, Jeanine M D'Armient. Emerging role of MAP kinase pathways as therapeutic targets in COPD. International journal of chronic obstructive pulmonary disease. vol 1. issue 2. 2008-02-19. PMID:18046891. |
however, recent research suggests that constitutive or aberrant activation of map kinases contributes to several copd-associated phenotypes, including mucus overproduction and secretion, inflammation, cytokine expression, apoptosis, t cell activation, matrix metalloproteinase production, and fibrosis. |
2008-02-19 |
2023-08-12 |
Not clear |
| V I Lapsha, V N Guri. [Ultrastructural changes in the right atrium in rats during E. coli lipopolysaccharide-induced systemic inflammation]. Morfologiia (Saint Petersburg, Russia). vol 132. issue 5. 2008-02-15. PMID:18198674. |
contractile cardiomyocytes showed signs of early-stage apoptosis (accumulation of small mitochondria with electrone dense matrix, cytoplasmic invagination into the nucleus, formation of apoptotic bodies). |
2008-02-15 |
2023-08-12 |
rat |
| Francesco Roselli, Paolo Livrea, Emilio Jirill. Voltage-gated sodium channel blockers as immunomodulators. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221194. |
furthermore, in jurkat cell line vgsc appear to be involved in cell volume regulation, migration in artificial matrix and cell death by apoptosis. |
2008-02-15 |
2023-08-12 |
mouse |
| Hae-Young Lee, Hyun-Jung You, Joo-Yun Won, Seock-Won Youn, Hyun-Jai Cho, Kyung-Woo Park, Woong-Yang Park, Jeong-Sun Seo, Young-Bae Park, Kenneth Walsh, Byung-Hee Oh, Hyo-Soo Ki. Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arteriosclerosis, thrombosis, and vascular biology. vol 28. issue 2. 2008-02-14. PMID:18063811. |
forkhead factor, foxo3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. |
2008-02-14 |
2023-08-12 |
Not clear |
| A M Magro, A D Magro, C Cunningham, M R Mille. Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells. Neoplasma. vol 54. issue 6. 2008-02-12. PMID:17949236. |
in summary, the data presented here indicate that disruption of the actin-vinculin-cell-cytoskeleton matrix of the ln18 glioblastoma is a component of the mk886 induced apoptosis. |
2008-02-12 |
2023-08-12 |
Not clear |
| Shaker A Mous. Cell adhesion molecules: potential therapeutic & diagnostic implications. Molecular biotechnology. vol 38. issue 1. 2008-02-11. PMID:18095189. |
the role of cell adhesion molecules (cam) and extracellular matrix proteins (ecm) in various pathological processes including angiogenesis, thrombosis, apoptosis, cell migration & proliferation are well documented. |
2008-02-11 |
2023-08-12 |
Not clear |
| Hai Tian, Massimo Cimini, Paul W M Fedak, Svetlana Altamentova, Shafie Fazel, Ming-Li Huang, Richard D Weisel, Ren-Ke L. TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction. Journal of molecular and cellular cardiology. vol 43. issue 6. 2008-02-07. PMID:17945252. |
at various time points over the following 28-day period, left ventricular structure and function (by echocardiography, pressure-volume measurements and morphometry), mmp levels and activity, blood vessel density, cell proliferation, apoptosis, matrix structure, and inflammatory cytokine levels were assessed in both groups. |
2008-02-07 |
2023-08-12 |
mouse |
| Maria P Yavropoulou, John G Yovo. The role of the Wnt signaling pathway in osteoblast commitment and differentiation. Hormones (Athens, Greece). vol 6. issue 4. 2008-02-06. PMID:18055419. |
studies of knockout and transgenic mouse models for wnt pathway components have demonstrated that canonical signaling regulates most aspects of osteoblast physiology including commitment, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption. |
2008-02-06 |
2023-08-12 |
mouse |
| Jeffrey C Horowitz, David S Rogers, Richard H Simon, Thomas H Sisson, Victor J Thannicka. Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis. American journal of respiratory cell and molecular biology. vol 38. issue 1. 2008-02-05. PMID:17656680. |
plasmin treatment induced fibroblast apoptosis in a time- and dose-dependent manner in association with proteolytic degradation of extracellular matrix proteins, as detected by the release of soluble fibronectin peptides. |
2008-02-05 |
2023-08-12 |
mouse |