| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salma Chaudhury, Andrew J Car. Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies. Journal of shoulder and elbow surgery. vol 21. issue 2. 2012-05-16. PMID:22244062. |
pathways that are believed to contribute to rotator cuff tendinopathies include extracellular matrix remodeling, angiogenesis, changes in metabolism, apoptosis, and stress-related genes. |
2012-05-16 |
2023-08-12 |
Not clear |
| Dutmanee Seriwatanachai, Nateetip Krishnamra, Narattaphol Charoenphandh. Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22405773. |
a recent investigation in lactating rats has provided evidence that the lactogenic hormone prolactin (prl) increases endochondral bone growth and bone elongation, presumably by accelerating apoptosis of hypertrophic chondrocytes in the growth plate and/or subsequent chondrogenic matrix mineralization. |
2012-05-16 |
2023-08-12 |
mouse |
| Vivek R Yadav, Sahdeo Prasad, Bokyung Sung, Juri G Gelovani, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwa. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. International journal of cancer. vol 130. issue 9. 2012-05-15. PMID:21702037. |
we also found that akba significantly suppressed nuclear factor-κb (nf-κb) activation in the tumor tissue and expression of proinflammatory (cyclooxygenase-2), tumor survival (bcl-2, bcl-xl, inhibitor of apoptosis (iap-1) and survivin), proliferative (cyclin d1), invasive (intercellular adhesion molecule 1 and matrix metalloproteinase-9) and angiogenic c-x-c (cxc) receptor 4 and vascular endothelial growth factor) biomarkers. |
2012-05-15 |
2023-08-12 |
mouse |
| Monica Teta, Yeon Sook Choi, Tishina Okegbe, Gabrielle Wong, Oliver H Tam, Mark M W Chong, John T Seykora, Andras Nagy, Dan R Littman, Thomas Andl, Sarah E Milla. Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (Cambridge, England). vol 139. issue 8. 2012-05-14. PMID:22434867. |
however, mutant matrix cells exhibited apoptosis and dna damage and hair follicles rapidly degraded. |
2012-05-14 |
2023-08-12 |
mouse |
| Constanze Buhrmann, Ali Mobasheri, Franziska Busch, Constance Aldinger, Ralf Stahlmann, Azadeh Montaseri, Mehdi Shakibae. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. The Journal of biological chemistry. vol 286. issue 32. 2012-05-11. PMID:21669872. |
the anti-inflammatory effects of curcumin included down-regulation of gene products that mediate matrix degradation (matrix metalloproteinase-1, -9, and -13), prostanoid production (cyclooxygenase-2), apoptosis (bax and activated caspase-3), and stimulation of cell survival (bcl-2), all known to be regulated by nf-κb. |
2012-05-11 |
2023-08-12 |
human |
| Ada Congrains, Kei Kamide, Tomohiro Katsuya, Osamu Yasuda, Ryousuke Oguro, Koichi Yamamoto, Mitsuru Ohishi, Hiromi Rakug. CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC. Biochemical and biophysical research communications. vol 419. issue 4. 2012-05-11. PMID:22382030. |
our results suggest that anril splicing variants play a role in coordinating tissue remodeling, by modulating the expression of genes involved in cell proliferation, apoptosis, extra-cellular matrix remodeling and inflammatory response to finally impact in the risk of cardiovascular disease and other pathologies. |
2012-05-11 |
2023-08-12 |
human |
| Maria-Dolores Sanchez-Niño, Milica Bozic, Elizabeth Córdoba-Lanús, Petya Valcheva, Olga Gracia, Merce Ibarz, Elvira Fernandez, Juan F Navarro-Gonzalez, Alberto Ortiz, Jose Manuel Valdiviels. Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy. American journal of physiology. Renal physiology. vol 302. issue 6. 2012-05-09. PMID:22169009. |
immunohistochemistry showed that calcitriol and paricalcitol reduced mcp-1 and il-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell nf-κb activation, apoptosis, and extracellular matrix deposition. |
2012-05-09 |
2023-08-12 |
human |
| Jay H Travers. Using biomaterials to improve the efficacy of cell therapy following acute myocardial infarction. Journal of cardiovascular translational research. vol 5. issue 1. 2012-05-08. PMID:22090349. |
a major impediment appears to be limited retention and engraftment of the transplanted cells, in part due to loss of the extracellular matrix (ecm) following ami that can lead to apoptosis of the delivered cells through the mechanism of anoikis. |
2012-05-08 |
2023-08-12 |
Not clear |
| C-R Pradeep, W J Köstler, M Lauriola, R Z Granit, F Zhang, J Jacob-Hirsch, G Rechavi, H B Nair, B T Hennessy, A M Gonzalez-Angulo, R R Tekmal, I Ben-Porath, G B Mills, E Domany, Y Yarde. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21743488. |
when grown in extracellular matrix as three-dimensional spheroids, control cells developed a hollow lumen, but her2-overexpressing cells populated the lumen by evading apoptosis. |
2012-05-04 |
2023-08-12 |
Not clear |
| Jing-Jing Cui, Dong Wang, Fei Gao, Yue-Rong L. Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage. Cell biochemistry and biophysics. vol 62. issue 1. 2012-05-04. PMID:22006254. |
to explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (mmp-9) after intracerebral hemorrhage (ich) in rats. |
2012-05-04 |
2023-08-12 |
rat |
| Stefan Dudli, Daniel Haschtmann, Stephen J Ferguso. Fracture of the vertebral endplates, but not equienergetic impact load, promotes disc degeneration in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 5. 2012-05-01. PMID:22025207. |
markers for dd (cell viability, apoptosis, necrosis, matrix remodeling, and inflammation) were monitored for 28 days post-trauma in the annulus fibrosus (af) and nucleus pulposus and compared to non-impacted control discs. |
2012-05-01 |
2023-08-12 |
rabbit |
| Ghulam Mohammad, Renu A Kowlur. Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567393. |
in the pathogenesis of diabetic retinopathy, h-ras (a small molecular weight g-protein) and matrix metalloproteinase-9 (mmp9) act as pro-apoptotic, accelerating the apoptosis of retinal capillary cells, a phenomenon that predicts its development and the activation of mmp9 is under the control of h-ras. |
2012-04-25 |
2023-08-12 |
mouse |
| Sudeep Kumar, Rajdeep Banerjee, Nilay Nandi, Abul Hasan Sardar, Pradeep Da. Anoikis potential of Entameba histolytica secretory cysteine proteases: evidence of contact independent host cell death. Microbial pathogenesis. vol 52. issue 1. 2012-04-20. PMID:22032908. |
mammalian epithelial, endothelial and various other cell types, upon their detachment from the extracellular matrix (ecm) undergo a specialized kind of apoptosis, known as anoikis. |
2012-04-20 |
2023-08-12 |
human |
| Päivi M Järvinen, Marjukka Myllärniemi, Hester Liu, Henna M Moore, Outi Leppäranta, Kaisa Salmenkivi, Katri Koli, Leena Latonen, Arja M Band, Marikki Laih. Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis. Journal of cellular physiology. vol 227. issue 6. 2012-04-19. PMID:21882188. |
transforming growth factor-β (tgf-β) is a diverse cytokine regulating growth, apoptosis, differentiation, adhesion, invasion, and extracellular matrix production. |
2012-04-19 |
2023-08-12 |
Not clear |
| Mingqing Li, William Y Ki. Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:21155973. |
these include pvhl's ability to regulate apoptosis and senescence as well as its role in the maintenance of primary cilium and orchestrating the deposition of the extracellular matrix. |
2012-04-16 |
2023-08-12 |
Not clear |
| Claudia Jäger, Christiane Brenner, Jüri Habicht, Reinhard Wallic. Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro- a pilot study. Experimental dermatology. vol 21. issue 1. 2012-04-16. PMID:22151394. |
whereas in the presence of hyaluronic acid, nctf135(®) and nctf135ha(®) , cell proliferation was comparable to control cultures; however, with higher expression of collagen type-1, matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, addition of soluvit(®) n and meso-bk led to apoptosis and/or necrosis of human fibroblasts. |
2012-04-16 |
2023-08-12 |
human |
| Alon Hendel, Dawn Cooper, Thomas Abraham, Hongyan Zhao, Michael F Allard, David J Granvill. Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 21. issue 1. 2012-04-12. PMID:21296596. |
granzyme b, a proapoptotic serine protease, is abundant in advanced, unstable atherosclerotic plaques, and it is suggested to contribute to plaque instability by inducing vascular smooth muscle cells apoptosis and by degrading plaque extracellular matrix. |
2012-04-12 |
2023-08-12 |
human |
| Cho-Yun Chung, Young-Lan Park, Young-A Song, Eun Myung, Kyu-Yeol Kim, Gi-Hoon Lee, Ho-Seok Ki, Kang-Jin Park, Sung-Bum Cho, Wan-Sik Lee, Young-Do Jung, Kyung-Keun Kim, Young-Eun Jo. Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells. Digestive diseases and sciences. vol 57. issue 2. 2012-04-12. PMID:21901254. |
altered recepteur d'origine nantais (ron) expression transduces signals inducting invasive growth phenotype that includes cell proliferation, migration, matrix invasion, and protection of apoptosis in human cancer cells. |
2012-04-12 |
2023-08-12 |
human |
| Carlos E de Andrea, Malgorzata I Wiweger, Judith V M G Bovée, Salvatore Romeo, Pancras C W Hogendoor. Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Archiv : an international journal of pathology. vol 460. issue 1. 2012-04-12. PMID:22116208. |
endochondral chondrocytes undergo sequences of cell division, matrix secretion, cell hypertrophy, apoptosis, and matrix calcification/mineralisation. |
2012-04-12 |
2023-08-12 |
Not clear |
| Chiara Sassoli, Lucia Formigli, Francesca Bini, Alessia Tani, Roberta Squecco, Chiara Battistini, Sandra Zecchi-Orlandini, Fabio Francini, Elisabetta Meacc. Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction. Journal of cellular and molecular medicine. vol 15. issue 11. 2012-04-10. PMID:21199328. |
treatment with exogenous s1p attenuated the ec-induced tissue damage, protecting skeletal muscle fibre from apoptosis, preserving satellite cell viability and affecting extracellular matrix remodelling, through the up-regulation of matrix metalloproteinase 9 (mmp-9) expression. |
2012-04-10 |
2023-08-12 |
Not clear |