| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qichang Zheng, Shanglong Liu, Zifang Son. Mechanism of arterial remodeling in chronic allograft vasculopathy. Frontiers of medicine. vol 5. issue 3. 2012-01-31. PMID:21964706. |
this review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury, accumulation of smooth muscle-like cells in the neointimal, medial smooth muscle cell apoptosis, adventitial fibrosis, and deposition of extracellular matrix. |
2012-01-31 |
2023-08-12 |
Not clear |
| Ligia J Dominguez, Giovanna Di Bella, Mario Belvedere, Mario Barbagall. Physiology of the aging bone and mechanisms of action of bisphosphonates. Biogerontology. vol 12. issue 5. 2012-01-30. PMID:21695491. |
bisphosphonates (bps) are widely prescribed anti-resorptive agents that inhibit osteoclasts attachment to bone matrix and enhance osteoclast apoptosis. |
2012-01-30 |
2023-08-12 |
Not clear |
| Silvia Caggia, Massimo Libra, Grazia Malaponte, Venera Cardil. Modulation of YY1 and p53 expression by transforming growth factor-β3 in prostate cell lines. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21807531. |
these cytokines play very important roles during development, as well as in normal physiological and disease processes, by regulating a wide array of cellular processes, such as cell growth, differentiation, migration, apoptosis, and extracellular matrix production. |
2012-01-30 |
2023-08-12 |
human |
| Katrin Lochner, Andreas Fritsche, Anika Jonitz, Doris Hansmann, Petra Mueller, Brigitte Mueller-Hilke, Rainer Bade. The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles. International journal of molecular medicine. vol 28. issue 6. 2012-01-26. PMID:21850366. |
furthermore, a reduced matrix synthesis and an induced apoptosis rate can be observed. |
2012-01-26 |
2023-08-12 |
human |
| Mignon M G Ackermans, Huiqing Zhou, Carine E L Carels, Frank A D T G Wagener, Johannes W Von den Hof. Vitamin A and clefting: putative biological mechanisms. Nutrition reviews. vol 69. issue 10. 2012-01-25. PMID:21967161. |
excessive vitamin a may disturb all three stages of palatogenesis: 1) during shelf outgrowth, it may decrease cell proliferation and thus prevent tissue development; 2) it may prevent shelf elevation by affecting extracellular matrix composition and hydration; and 3) during shelf fusion, it may affect epithelial differentiation and apoptosis, which precludes the formation of a continuous palate. |
2012-01-25 |
2023-08-12 |
Not clear |
| V Iu Harbuzova, O V Atama. [Matrix Gla-protein and its role in vascular wall calcification]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 57. issue 4. 2012-01-20. PMID:22167840. |
four possible mechanisms of anticalcinogenic action of mgp are described: binding with calcium ions and crystals of hydroxyapatite, binding to extracellular matrix components, interaction with bone morphogenetic protein (bmp-2) and elimination the effects of the latter, participation in the regulation of apoptosis. |
2012-01-20 |
2023-08-12 |
Not clear |
| Lei Zhang, Ming-fang Liao, Lei Tian, Si-li Zou, Qing-sheng Lu, Jun-min Bao, Yi-fei Pei, Zai-ping Jin. Overexpression of interleukin-1β and interferon-γ in type I thoracic aortic dissections and ascending thoracic aortic aneurysms: possible correlation with matrix metalloproteinase-9 expression and apoptosis of aortic media cells. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. vol 40. issue 1. 2012-01-13. PMID:21349736. |
overexpression of interleukin-1β and interferon-γ in type i thoracic aortic dissections and ascending thoracic aortic aneurysms: possible correlation with matrix metalloproteinase-9 expression and apoptosis of aortic media cells. |
2012-01-13 |
2023-08-12 |
Not clear |
| Yu Deng, Biao Chen, Yongjian Qi, Jacques Magdalou, Hui Wang, Liaobin Che. The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro. Toxicology and applied pharmacology. vol 257. issue 1. 2012-01-13. PMID:21903125. |
our data suggest that levofloxacin has cytotoxic effects on acl cells characterized by enhanced apoptosis and decreased extracellular matrix, which suggest a potential adverse effect of fluoroquinolones. |
2012-01-13 |
2023-08-12 |
rabbit |
| Kirk Jensen, Aneeta Patel, Joanna Klubo-Gwiezdzinska, Andrew Bauer, Vasyl Vask. Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis. Endocrine-related cancer. vol 18. issue 5. 2012-01-12. PMID:21813730. |
resistance to anoikis (matrix deprivation-induced apoptosis) is a critical component of the metastatic cascade. |
2012-01-12 |
2023-08-12 |
human |
| E Makrantonaki, C C Zoubouli. [Molecular etiology of skin aging. How important is the genetic make-up?]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. vol 62. issue 8. 2012-01-11. PMID:21681542. |
recent data obtained by expression profiling studies and studies upon progeroid syndromes illustrate that among the most important biological processes involved in skin aging are alterations in dna repair and stability, mitochondrial function, cell cycle and apoptosis, extracellular matrix, lipid synthesis, ubiquitin-induced proteolysis and cellular metabolism. |
2012-01-11 |
2023-08-12 |
Not clear |
| Ning-Qiang Ma, Li-Li Liu, Jie Min, Jun-Wei Wang, Wei-Feng Jiang, Yan Liu, Yan-Guo Feng, Hai-Chuan Su, Ying-Ming Feng, He-Long Zhan. The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis. Clinical & experimental metastasis. vol 28. issue 8. 2012-01-10. PMID:21785830. |
at present study, we decrease cnaα expression in sbc-5 by lentiviral vector-mediated rnai and found that down regulation of cnaα gene expression can decrease the proliferation and colony formation rate, impede the cell cycle progression, reduce the cell migration and invasion, and inhibit cells adhering to bone matrix, but not change the apoptosis rate of sbc-5 in vitro. |
2012-01-10 |
2023-08-12 |
mouse |
| Shahrzad Ossare. Vascular calcification in chronic kidney disease: mechanisms and clinical implications. Iranian journal of kidney diseases. vol 5. issue 5. 2012-01-10. PMID:21876304. |
other mechanisms are formation of matrix vesicles and cellular apoptosis, with generation of hydroxyapatite crystals within vesicles and apoptotic bodies. |
2012-01-10 |
2023-08-12 |
Not clear |
| Li Liu, Jing Wu, Chen Wu, Ying Wang, Rong Zhong, Xinyu Zhang, Wen Tan, Shaofa Nie, Xiaoping Miao, Dongxin Li. A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer. vol 117. issue 22. 2012-01-09. PMID:21523769. |
matrix metalloproteinase-1 (mmp-1), an interstitial collagenase, plays an important role in the breakdown of extracellular matrix and mediates pathways of apoptosis, angiogenesis, and immunity. |
2012-01-09 |
2023-08-12 |
Not clear |
| Eva Karamitopoulou, Inti Zlobec, Ioannis Panayiotides, Efstratios S Patsouris, George Peros, George Rallis, Christos Lapas, Petros Karakitsos, Luigi M Terracciano, Alessandro Lugl. Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Human pathology. vol 42. issue 12. 2012-01-09. PMID:21664646. |
twenty proteins from different signaling pathways (epidermal growth factor receptor [egfr], phosphorylated extracellular signal regulated kinase [perk], receptor for hyalouronic acid mediated motility [rhamm], raf-1 kinase inhibitor protein [rkip], β-catenin, e-cadherin, phosphorylated ak transforming [pakt], p16, p21, ki-67, b-cell lymphoma-2 [bcl2], vascular endothelial growth factor, apoptosis protease activating factor 1 [apaf-1], mucin1 [muc1], ephrin b2 receptor [ephb2], matrix metalloproteinase 7 [mmp7], phosphorylated mothers against decapentaplegic 2 [psmad2], caudal type homeobox transcription factor 2 [cdx2], laminin5γ2, and mammalian sterile 20-like kinase 1 [mst1]) involved in colorectal cancer progression were studied immunohistochemically on 220 well-characterized patients using a multiple-punch tissue microarray including 437 and 430 samples from the tumor center and the invasive front, respectively. |
2012-01-09 |
2023-08-12 |
Not clear |
| Joshua M Spin, Mark Hsu, Junya Azuma, Maureen M Tedesco, Alicia Deng, Justin S Dyer, Lars Maegdefessel, Ronald L Dalman, Philip S Tsa. Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm. Physiological genomics. vol 43. issue 17. 2012-01-09. PMID:21712436. |
ontologic analysis revealed widespread upregulation of inflammatory, immune, and matrix remodeling genes with ang ii treatment, among other pathways such as apoptosis, cell cycling, angiogenesis, and p53 signaling. |
2012-01-09 |
2023-08-12 |
mouse |
| Rupalatha Maddala, Bharesh K Chauhan, Christopher Walker, Yi Zheng, Michael L Robinson, Richard A Lang, Ponugoti V Ra. Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Developmental biology. vol 360. issue 1. 2012-01-05. PMID:21945075. |
additionally, the rac1 cko lenses were characterized by a shortened epithelial sheet, reduced levels of extracellular matrix (ecm) proteins and increased apoptosis. |
2012-01-05 |
2023-08-12 |
mouse |
| Peijian Tong, Chengliang Wu, Hongting Jin, Qiang Mao, Nanze Yu, Jonathan D Holz, Letian Shan, Hui Liu, Luwei Xia. Gene expression profile of steroid-induced necrosis of femoral head of rats. Calcified tissue international. vol 89. issue 4. 2012-01-03. PMID:21833848. |
the known genes can be divided into several families according to their biological functions, such as oxidative stress, apoptosis, signal transduction, angiogenesis, extracellular matrix, lipid metabolism, and transcription related genes. |
2012-01-03 |
2023-08-12 |
rat |
| Rajamma Mathe. Pulmonary hypertension: current therapy and future prospects. Cardiovascular & hematological agents in medicinal chemistry. vol 9. issue 3. 2012-01-03. PMID:21838666. |
the main effects are loss of vascular relaxation response, increased cell proliferation and impaired apoptosis, matrix deposition, obstruction in the small pulmonary arteries, right ventricular hypertrophy; and eventually leading to right heart failure and death. |
2012-01-03 |
2023-08-12 |
Not clear |
| Xian Wu Cheng, Zhe Huang, Masafumi Kuzuya, Kenji Okumura, Toyoaki Murohar. Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications. Hypertension (Dallas, Tex. : 1979). vol 58. issue 6. 2012-01-03. PMID:21986502. |
these studies have provided direct evidence implicating cathepsins in atherosclerosis-based vascular disease through the activation, liberation, and modification of angiogenic growth factors, cytokines, and proteases associated with lipid metabolism, cell events (migration, invasion, proliferation, and apoptosis), angiogenesis, and matrix protein remodeling. |
2012-01-03 |
2023-08-12 |
mouse |
| Byong Hoon Yoo, Yanfei Wang, Mete Erdogan, Takehiko Sasazuki, Senji Shirasawa, Laurent Corcos, Kanaga Sabapathy, Kirill V Rose. Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells. The Journal of biological chemistry. vol 286. issue 45. 2011-12-27. PMID:21903589. |
resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade adjacent tissues, and metastasize to distant organs. |
2011-12-27 |
2023-08-12 |
mouse |