| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timoklia Orfanidou, Dimitrios Iliopoulos, Konstantinos N Malizos, Aspasia Tsezo. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196777. |
chondrocytes' hypertrophy includes metabolic changes, matrix remodelling, proliferation and apoptosis, characteristics associated with the progression of osteoarthritis. |
2011-12-23 |
2023-08-12 |
human |
| Cecília García-Pérez, Timothy G Schneider, György Hajnóczky, György Csordá. Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points. American journal of physiology. Heart and circulatory physiology. vol 301. issue 5. 2011-12-23. PMID:21856920. |
propagation of ryanodine receptor (ryr2)-derived ca(2+) signals to the mitochondrial matrix supports oxidative atp production or facilitates mitochondrial apoptosis in cardiac muscle. |
2011-12-23 |
2023-08-12 |
rat |
| Yair Herishanu, Federica Gibellini, Ndegwa Njuguna, Inbal Hazan-Halevy, Mohammed Farooqui, Sarah Bern, Keyvan Keyvanfar, Elinor Lee, Wyndham Wilson, Adrian Wiestne. Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leukemia & lymphoma. vol 52. issue 9. 2011-12-20. PMID:21649540. |
activation of cd44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through mcl-1. |
2011-12-20 |
2023-08-12 |
Not clear |
| Kazutetsu Aoshib. [Roles of apoptosis, cell senescence, and DNA damage in the pathogenetic mechanism of COPD]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 10. 2011-12-16. PMID:22073568. |
pulmonary emphysema is a dynamic phenomenon involving not only the gradual destruction of extracellular matrix by excess of proteases, but also apoptosis, cell proliferation, and senescence. |
2011-12-16 |
2023-08-12 |
Not clear |
| Yuma Hoshino, Shigeo Muro, Michiaki Mishim. [Novel therapeutics for COPD]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 10. 2011-12-16. PMID:22073581. |
the central pathogeneses are inflammation, oxidative stress, apoptosis and excessive proteases which lead to matrix degradation and loss of lung cells. |
2011-12-16 |
2023-08-12 |
Not clear |
| Noor Al-Dasooqi, Joanne M Bowen, Rachel J Gibson, Richard M Logan, Andrea M Stringer, Dorothy M Keef. Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the Dark Agouti rat. International journal of experimental pathology. vol 92. issue 5. 2011-12-13. PMID:21463374. |
extracellular matrix (ecm) components play a vital role in maintaining mucosal barrier integrity by regulating cellular apoptosis, proliferation and differentiation of overlying epithelial cells. |
2011-12-13 |
2023-08-12 |
rat |
| Bozena Czarkowska-Paczek, Katarzyna Wesołowska, Jacek Przybylsk. [Physical exercise prevents osteoporosis]. Przeglad lekarski. vol 68. issue 2. 2011-12-13. PMID:21751519. |
this pathway is important in osteocytes to prevent apoptosis and transmit the signals to other bone cells, and in osteoblasts for differentiation, proliferation and synthesis of bone matrix. |
2011-12-13 |
2023-08-12 |
Not clear |
| Geert C van Almen, Melissa Swinnen, Paolo Carai, Wouter Verhesen, Jack P M Cleutjens, Jan D'hooge, Fons K Verheyen, Yigal M Pinto, Blanche Schroen, Peter Carmeliet, Stephane Heyman. Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. Journal of molecular and cellular cardiology. vol 51. issue 3. 2011-12-12. PMID:21624372. |
surviving dox-treated tsp-2-ko mice had depressed cardiac function compared to wt animals, accompanied by increased cardiomyocyte apoptosis and matrix damage. |
2011-12-12 |
2023-08-12 |
mouse |
| Yanwen Qin, Guo-Ping Sh. Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases. Pharmacology & therapeutics. vol 131. issue 3. 2011-12-07. PMID:21605595. |
during the pathogenesis of atherosclerosis, abdominal aortic aneuryms, and associated complications, cysteinyl cathepsins and mast cell tryptases and chymases participate importantly in vascular cell apoptosis, foam cell formation, matrix protein gene expression, and pro-enzyme, latent cytokine, chemokine, and growth factor activation. |
2011-12-07 |
2023-08-12 |
mouse |
| Min-Fang Guo, Jie-Zhong Yu, Cun-Gen M. Mechanisms related to neuron injury and death in cerebral hypoxic ischaemia. Folia neuropathologica. vol 49. issue 2. 2011-12-07. PMID:21845535. |
there have been many theories on pathogenesis of neuron injury and death in cerebral hypoxic ischaemia, such as the toxicity of excitatory amino acid, no, the production of oxygen free radicals, chondriosome injury, complement component, injury of immunological inflammation, matrix metalloproteinase, dopamine, ca2+ overloading, cell apoptosis and so on. |
2011-12-07 |
2023-08-12 |
Not clear |
| Jessica Kendrick, Michel Choncho. The role of phosphorus in the development and progression of vascular calcification. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 58. issue 5. 2011-12-07. PMID:21956015. |
hyperphosphatemia appears to be involved in a number of mechanisms that trigger and advance the progression of vascular calcification, including (1) transition of vascular smooth muscle cells (vsmcs) from a contractile to an osteochondrogenic phenotype and mineralization of vsmc matrix through sodium-dependent phosphate cotransporters, (2) induction of vsmc apoptosis, (3) inhibition of monocyte/macrophage differentiation into osteoclast-like cells, (4) elevation of fibroblast growth factor 23 levels, and (5) decreases in klotho expression. |
2011-12-07 |
2023-08-12 |
Not clear |
| Salih Gencer, Meliha Burcu Irmak Yazicioğl. Differential response of gastric carcinoma MKN-45 and 23132/87 cells to H2O2 exposure. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. vol 22. issue 2. 2011-12-06. PMID:21796550. |
in this study, we investigated and compared the effects of hydrogen peroxide on the survival, apoptosis, accumulation of oxidative stress, and matrix metalloprotein-7 gene expression on human gastric carcinoma mkn-45 and 23132/87 cells. |
2011-12-06 |
2023-08-12 |
human |
| M Shakibaei, C Buhrmann, A Mobasher. Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro. Histology and histopathology. vol 26. issue 9. 2011-12-05. PMID:21751149. |
pro-inflammatory cytokines such as interleukin-1β (il-1β) have been identified as the main initiators of tendinopathies, stimulating inflammation, apoptosis and extracellular matrix (ecm) degradation. |
2011-12-05 |
2023-08-12 |
human |
| Xian-Yang Qin, Feifei Wei, Jun Yoshinaga, Junzo Yonemoto, Masaru Tanokura, Hideko Son. siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. FEBS letters. vol 585. issue 20. 2011-12-02. PMID:21945317. |
in this study, we used small interfering rna techniques to knockdown arnt2 expression in mcf7 human breast cancer cells, and found that an almost 40% downregulation of arnt2 mrna expression increased the expression of sensitive to apoptosis gene (3.36-fold), and decreased the expression of von hippel-lindau (0.27-fold) and matrix metalloproteinase-1 (0.35-fold). |
2011-12-02 |
2023-08-12 |
human |
| Carla M Thomas, Rachel Murray, Mohammed Shari. Chondrocyte apoptosis determined by caspase-3 expression varies with fibronectin distribution in equine articular cartilage. International journal of rheumatic diseases. vol 14. issue 3. 2011-12-01. PMID:21816026. |
the purpose of this study was to investigate associations between the extent of chondrocyte apoptosis and expression of the articular cartilage (ac) extracellular matrix (ecm) molecules, cartilage oligomeric matrix protein (comp) and fibronectin. |
2011-12-01 |
2023-08-12 |
Not clear |
| Yuanting Zhao, Qiande Liao, Yong Zhu, Haitao Lon. Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. Clinical orthopaedics and related research. vol 469. issue 11. 2011-11-30. PMID:21656314. |
endothelin-1 (et-1) participates in a wide range of cancer-relevant processes including cell proliferation, inhibition of apoptosis, matrix remodeling, bone deposition, and metastases. |
2011-11-30 |
2023-08-12 |
Not clear |
| A Boutten, D Goven, E Artaud-Macari, J Boczkowski, M Bona. NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease. Trends in molecular medicine. vol 17. issue 7. 2011-11-29. PMID:21459041. |
several convergent destructive mechanisms such as oxidative stress, alveolar cell apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic obstructive pulmonary disease (copd) development. |
2011-11-29 |
2023-08-12 |
human |
| Magdalena Groblewska, Agnieszka Tycińska, Barbara Mroczko, Włodzimierz Musiał, Maciej Szmitkowsk. [The role of matrix metalloproteinases in cardiovascular diseases]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 30. issue 178. 2011-11-29. PMID:21595165. |
they are one of the most important proteolytic enzymes which digest components of the extracellular matrix and take part in many physiological processes, such as apoptosis or angiogenesis. |
2011-11-29 |
2023-08-12 |
Not clear |
| H Charlie Peters, Thomas J Otto, J Tyler Enders, Wu Jin, Berton R Moed, Zijun Zhan. The protective role of the pericellular matrix in chondrocyte apoptosis. Tissue engineering. Part A. vol 17. issue 15-16. 2011-11-21. PMID:21457093. |
the protective role of the pericellular matrix in chondrocyte apoptosis. |
2011-11-21 |
2023-08-12 |
Not clear |
| H Charlie Peters, Thomas J Otto, J Tyler Enders, Wu Jin, Berton R Moed, Zijun Zhan. The protective role of the pericellular matrix in chondrocyte apoptosis. Tissue engineering. Part A. vol 17. issue 15-16. 2011-11-21. PMID:21457093. |
this study was designed to quantify the role of the pericellular matrix (pcm) in chondrocyte apoptosis using chondrons, which are a cartilage functional unit including a chondrocyte and its associated pcm. |
2011-11-21 |
2023-08-12 |
Not clear |