| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sulochana Priya, Perumana R Sudhakara. Cell survival, activation and apoptosis of hepatic stellate cells: modulation by extracellular matrix proteins. Hepatology research : the official journal of the Japan Society of Hepatology. vol 38. issue 12. 2011-07-14. PMID:18637147. |
cell survival, activation and apoptosis of hepatic stellate cells: modulation by extracellular matrix proteins. |
2011-07-14 |
2023-08-12 |
Not clear |
| Teru Hideshima, Noopur Raje, Paul G Richardson, Kenneth C Anderso. A review of lenalidomide in combination with dexamethasone for the treatment of multiple myeloma. Therapeutics and clinical risk management. vol 4. issue 1. 2011-07-14. PMID:18728702. |
lenalidomide: directly triggers growth arrest and/or apoptosis of drug resistant mm cells; inhibits binding of mm cells to bone marrow (bm) extracellular matrix proteins and stromal cells; modulates cytokine secretion and inhibits angiogenesis in the bm milieu; and augments host anti-tumor immunity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Adam P Rago, Anthony P Napolitano, Dylan M Dean, Peter R Chai, Jeffrey R Morga. Miniaturization of an Anoikis assay using non-adhesive micromolded hydrogels. Cytotechnology. vol 56. issue 2. 2011-07-14. PMID:19002845. |
anoikis is a specific form of apoptosis resulting from the loss of cellular attachment to extracellular matrix or other cells. |
2011-07-14 |
2023-08-12 |
human |
| M Soor. A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review. The open dentistry journal. vol 2. 2011-07-14. PMID:19088876. |
tetracyclines are effective in reducing inflammation by inhibiting matrix metalloproteinases, preventing excessive angiogenesis, inhibiting apoptosis and stimulating bone formation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Minaxi Jhawer, David Kelsen, Manish Sha. Incorporation of biologic therapies in the management of gastroesophageal cancers. Gastrointestinal cancer research : GCR. vol 1. issue 2 Suppl. 2011-07-14. PMID:19343157. |
such targets include cell growth regulators (human epidermal growth factor like receptor, ki-67), vascular modulators (vascular endothelial growth factor), cell cycle checkpoint modulators (p16, p21, cyclin d1, cyclindependent kinases), apoptosis promoters (p53, bax, bcl-2), and cell proliferators, tissue invasion and metastasis potentiators (matrix metalloproteinase, e-cadherin, gastrin 17). |
2011-07-14 |
2023-08-12 |
human |
| Howard A Levine, Michael W Smiley, Anna L Tucker, Marit Nilsen-Hamilto. A mathematical model for the onset of avascular tumor growth in response to the loss of p53 function. Cancer informatics. vol 2. 2011-07-14. PMID:19458766. |
the wild type p53 protein regulates apoptosis, cell expression of growth factor and matrix metalloproteinase, which are regulatory functions that many mutant p53 proteins do not possess. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hideo A Baba, Jeremias Wohlschlaege. Morphological and molecular changes of the myocardium after left ventricular mechanical support. Current cardiology reviews. vol 4. issue 3. 2011-07-14. PMID:19936192. |
aside from describing the morphological changes associated with "reverse cardiac remodeling", this review will focus on signal transduction, transcriptional regulation, apoptosis, cell stress proteins, matrix remodeling, inflammatory mediators and aspects of neurohormonal activation in the failing human heart before and after ventricular unloading. |
2011-07-14 |
2023-08-12 |
human |
| Amanda M Nelson, Wei Zhao, Kathryn L Gilliland, Andrea L Zaenglein, Wenlei Liu, Diane M Thibouto. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermato-endocrinology. vol 1. issue 3. 2011-07-14. PMID:20436886. |
the temporal changes in gene expression in patient skin noted with isotretinoin substantiate many previously reported effects of isotretinoin and other retinoids, suggesting a model wherein isotretinoin induces apoptosis leading to reduced sebaceous gland size, decreased expression of lipid metabolizing enzymes and increased matrix remodeling during acne resolution. |
2011-07-14 |
2023-08-12 |
Not clear |
| Radha Munagala, Farrukh Aqil, Ramesh C Gupt. Promising molecular targeted therapies in breast cancer. Indian journal of pharmacology. vol 43. issue 3. 2011-07-14. PMID:21713084. |
several other targeted agents currently under evaluation in preclinical and clinical trials include inhibitors of epidermal growth factor receptor (egfr), dual egfr and her2 inhibitors, vegf/vegfr inhibitors, and agents that interfere with crucial signaling pathways such as pi3k/akt/mtor and ras/mek/erk; agents against other tyrosine kinases such as src, insulin-like growth factor (igf)/igf-receptor (igfr); agents that promote apoptosis such as poly adp ribose polymerase inhibitors; agents that target invasion and metastasis such as matrix metalloproteinases inhibitors and others. |
2011-07-14 |
2023-08-12 |
human |
| Marta Alonso, Peter P Chiou, Jo-Ann Leon. Development of a suicidal DNA vaccine for infectious hematopoietic necrosis virus (IHNV). Fish & shellfish immunology. vol 30. issue 3. 2011-07-13. PMID:21232606. |
the suicidal vaccine consists of two operons: i) an inducible fish promoter, the interferon regulatory factor 1a promoter (pirf1a), driving the expression of the ihnv viral glycoprotein (g) gene that induces protection, and ii) a zncl(2) inducible fish promoter, the metallothionein promoter (pmt), driving the expression of the ihnv matrix (m) protein that induces apoptosis. |
2011-07-13 |
2023-08-12 |
Not clear |
| Lusine Aghajanova, Linda C Giudic. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reproductive sciences (Thousand Oaks, Calif.). vol 18. issue 3. 2011-07-11. PMID:21063030. |
the extracellular matrix proteoglycan versican (vcan), which regulates cell proliferation and apoptosis, was the most highly expressed gene in severe versus mild disease. |
2011-07-11 |
2023-08-12 |
human |
| Laura E Phipps, Satoshi Hino, Ruth J Musche. Targeting cell spreading: a method of sensitizing metastatic tumor cells to TRAIL-induced apoptosis. Molecular cancer research : MCR. vol 9. issue 3. 2011-07-11. PMID:21296861. |
in this study, we show that interfering with a cell's ability to attach and spread onto a matrix can sensitize tumor cells to trail-induced apoptosis in vitro. |
2011-07-11 |
2023-08-12 |
human |
| Francisco J Blanco, Ignacio Rego, Cristina Ruiz-Romer. The role of mitochondria in osteoarthritis. Nature reviews. Rheumatology. vol 7. issue 3. 2011-07-05. PMID:21200395. |
this mitochondrial dysfunction may affect several pathways that have been implicated in cartilage degradation, including oxidative stress, defective chondrocyte biosynthesis and growth responses, increased cytokine-induced chondrocyte inflammation and matrix catabolism, cartilage matrix calcification, and increased chondrocyte apoptosis. |
2011-07-05 |
2023-08-12 |
human |
| Chunxia Su, Bo Su, Liang Tang, Yinmin Zhao, Caicun Zho. Effects of collagen iv on cisplatin-induced apoptosis of non-small cell lung cancer cells. Cancer investigation. vol 25. issue 7. 2011-07-01. PMID:17952737. |
we investigated the expression of extracellular matrix proteins and the effects of collagen iv on cisplatin-induced apoptosis in cisplatin-sensitive and -resistance lung cancer cells. |
2011-07-01 |
2023-08-12 |
Not clear |
| Chunxia Su, Bo Su, Liang Tang, Yinmin Zhao, Caicun Zho. Effects of collagen iv on cisplatin-induced apoptosis of non-small cell lung cancer cells. Cancer investigation. vol 25. issue 7. 2011-07-01. PMID:17952737. |
extracellular matrix may provide protection against cisplatin-induced apoptosis of lung cancer cells. |
2011-07-01 |
2023-08-12 |
Not clear |
| I H Bellayr, X Mu, Y L. Biochemical insights into the role of matrix metalloproteinases in regeneration: challenges and recent developments. Future medicinal chemistry. vol 1. issue 6. 2011-07-01. PMID:20161478. |
mmps are very important enzymes that actively participate in remodeling the extracellular matrix by degrading certain constituents, along with promoting cell proliferation, migration, differentiation, apoptosis and angiogenesis. |
2011-07-01 |
2023-08-12 |
Not clear |
| D Kumar, F Schatz, R M Moore, B M Mercer, N Rangaswamy, J M Mansour, C J Lockwood, J J Moor. The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro. Placenta. vol 32. issue 3. 2011-07-01. PMID:21300402. |
biochemical evidence of remodeling and apoptosis; immunoreactive matrix metalloproteinase 9 (mmp9), tissue inhibitor of matrix metalloproteinase 3 (timp3) and cleaved poly (adp-ribose) polymerase (c-parp) levels in tissue extracts, were determined by western blot and densitometry. |
2011-07-01 |
2023-08-12 |
Not clear |
| Thorsten Jung, Wolfgang Gross, Margot Zölle. CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21372142. |
thus, cd44v6 promotes motility and apoptosis resistance via its involvement in assembling a matrix that, in turn, triggers activation of signaling cascades, which proceeds, independent of the initiating receptor-ligand interaction, in a concerted action via cd44v6. |
2011-07-01 |
2023-08-12 |
human |
| Chrishan S Samuel, Sofia Cendrawan, Xiao-Ming Gao, Ziqiu Ming, Chongxin Zhao, Helen Kiriazis, Qi Xu, Geoffrey W Tregear, Ross A D Bathgate, Xiao-Jun D. Relaxin remodels fibrotic healing following myocardial infarction. Laboratory investigation; a journal of technical methods and pathology. vol 91. issue 5. 2011-06-29. PMID:21221074. |
rlx significantly inhibited the mi-induced progression of cardiac fibrosis over 7 and 30 days, which was associated with a reduction in tgf-β1 expression, myofibroblast differentiation, and cardiomyocyte apoptosis in addition to a promotion of matrix metalloproteinase-13 levels and de novo blood vessel growth (all p<0.05 vs respective measurements from mi+veh mice). |
2011-06-29 |
2023-08-12 |
mouse |
| Harry A Otun, Gendie E Lash, Barbara A Innes, Judith N Bulmer, Katsuhiko Naruse, Therese Hannon, Roger F Searle, Stephen C Robso. Effect of tumour necrosis factor-α in combination with interferon-γ on first trimester extravillous trophoblast invasion. Journal of reproductive immunology. vol 88. issue 1. 2011-06-28. PMID:21112094. |
we have previously demonstrated that ifn-γ inhibits evt invasion via a mechanism partially dependent on an increase in evt apoptosis and decreased secretion of matrix metalloproteinase (mmp)-2. |
2011-06-28 |
2023-08-12 |
Not clear |